The invention provides a general method for synthesizing 2,4-hexadiene dinitrile derivatives with various substituents: first, 1,4-dihalo-1,3-butadiene derivatives and cyanide Copper is mixed, and N, N-dimethylformamide solvent is added to reflux, and the reaction product is concentrated and purified to obtain 2,4-hexadiene dinitrile derivatives. The synthesis method of the present invention adopts the oxidation addition / reduction elimination reaction of a continuous organohalogen reagent to cuprous cyanide, which is scientific and reasonable, the raw materials are easy to obtain, the application range is wide, the separation yield is high, the experimental equipment and operation are simple and easy, Easy to industrialize.