Extraction method of apigenin, pharmaceutical composition for treating diabetes and application thereof

An extraction method, apigenin technology, is applied in the direction of drug combination, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as treatment hidden worries, prolonged residence time, and decreased immunity of patients
CN103641807AActive Publication Date: 2014-03-19南通大学技术转移中心有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
南通大学技术转移中心有限公司
Publication Date
2014-03-19

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Abstract

The invention relates to the pharmaceutical technical field. The extraction method of apigenin comprises the steps of 1) enzymatically hydrolyzing celery which is taken as a substrate for 10 hours at 30-35 DEG C through a mixing solution of apigenin which is 33-37% and glucosidase which is 43-47% in mass percentage concentration; and 2) ultrasonically extracting enzymatic hydrolysate obtained from the step 1) through an ethanol solution of 70%, condensing an extracting solution, extracting respectively through petroleum ether and ethyl acetate, evaporating the extracting solution, dissolving through ethanol of 70%, and separating and extracting through a high performance liquid chromatograph. The pharmaceutical composition for treating diabetes consists of apigenin and glucobay at mass ratio of 1: (2-5). The extraction method, which extracts apigenin through a multi-enzymatic process, greatly improves extraction yield. The pharmaceutical composition disclosed by the invention not only can effectively control blood sugar but also can avoid circumstances of low blood sugar and rapid weight loss of a patient due to simple use of a diabetes medicine.
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Description

technical field

[0001] The invention relates to the technical field of pharmacy, in particular to a method for extracting apigenin, a pharmaceutical composition added with apigenin for treating diabetes and an application thereof. Background technique

[0002] With the improvement of people's living standards, diabetes has become a global public health problem, and it has also caused direct problems to the health of our people. Diabetes itself can not only cause death, but also its complications such as foot rot, diabetic nephropathy, high blood pressure, and cardiovascular disease have expanded the harm of diabetes to all areas of the human body. Currently, there are 246 million people with diabetes worldwide, of which type 2 diabetes accounts for 90%. China currently estimates that there are 92.4 million people with diabetes over the age of 20, ranking among the highest in the world. Therefore, the treatment and prevention of diabetes has become an urgent problem. In ad...

Claims

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