33results about How to "High transdermal efficiency" patented technology

The invention discloses a long-acting viscose dispersing type transdermal patch and a preparing process thereof and belongs to the medical technical field. The transdermal patch is mainly prepared from bulk pharmaceutical chemicals (such as non-steroid anti-inflammatory drug ibuprofen and salt form thereof, naproxen and salt form thereof, ketoprofen, indometacin and salt form thereof), a penetration enhancer (menthol, oleic acid, medium chain triglyceride, propylene glycol monolaurate, azone, propylene glycol and the like), a dispersing solvent (water, acetone, ethanol, carbinol, ethyl acetate and the like), a polyacrylate pressure-sensitive adhesive (crylic acid, butyl acrylate, crylic acid 2-ethylhexyl ester and the like), a backing layer and a release liner. The long-acting viscose dispersing type transdermal patch and the preparing process thereof have the advantages that drugs can be released from a matrix continuously for 12-48 h, the number of drug residues is low, transdermic absorption property is excellent, and dosing frequency and dosing amount can be reduced; skin irritation is avoided, and adhesion and compliance are high; main drugs and additives are stable in a viscose mechanism; preparing technology is simple, and pollution is avoided.

The invention discloses metformin hydrochloride cream and a preparation method of the metformin hydrochloride cream. The metformin hydrochloride cream is prepared from the following components: metformin hydrochloride as the active ingredient, an oil-phase solid ingredient, a consistency regulator, a humectant, an emulsifying agent, a skin penetration enhancer, a pH regulator, a preservative, a stabilizer, an aromatic and water, specifically, the metformin hydrochloride cream is prepared from the following components in percentage by mass: 0.1%-10% of metformin hydrochloride, 1%-15% of the oil-phase solid ingredient, 5%-20% of the consistency regulator, 3%-10% of the humectant, 0.5%-5% of the emulsifying agent, the skin penetration enhancer, the pH regulator, the preservative, the stabilizer and the aromatic with the corresponding mass percentages, the balance of water. The invention provides the metformin hydrochloride cream having good skin penetration effect of the active ingredients and high stability, through optimization of the skin penetration enhancer for the cream, the skin penetration efficiency of metformin hydrochloride is improved, and the side effects caused by the medicine are greatly reduced while the blood sugar concentration in the body of a patient is effectively reduced.

The present invention discloses a transdermal delivery based pharmaceutical composition. The composition comprises a compound as shown in a formula (I) or pharmaceutically acceptable salt thereof, a macromolecular dispersing carrier material, a hot melting protecting agent and an optional fluxing agent. A preparation method of the transdermal delivery based pharmaceutical composition comprises thesteps of micronizing the compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof, the macromolecular dispersing carrier material and the hot melting protecting agent, optionally adding the fluxing agent, mixing the components uniformly, and performing hot melting extrusion and micronizing to obtain microparticles of the compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof. In addition, the invention provides an application of the pharmaceutical composition. The transdermal delivery based pharmaceutical composition can enable the compound as shown in the formula (I) to be quickly absorbed, so that the purpose of calming before anesthesia is achieved, breathing is not affected, and the adverse psychological effects on children dueto intramuscular injection or intravenous injection are avoided. Meanwhile, the pharmaceutical composition also can be used for preventing and/or treating hyperactivity.

The invention relates to a cell infiltration enhancing peptide, a composition comprising the cell infiltration enhancing peptide and combination thereof, peptide factors and optional ATP and application of the composition in cosmetics or skin care products. The invention further relates to a preparation method of the composition. The cell infiltration enhancing peptide and the combination thereofcan effectively enhance a transdermal effect of the peptide factors and other active large molecules, and then beauty and skin care effects of the peptide and the combination thereof can be better achieved.

The invention discloses a composition for treating acne. The composition is prepared from the following components in percentage by mass: 29 to 33 percent of peony seed oil, 48 to 54 percent of bletilla striata polysaccharide and 15 to 19 percent of aloe polysaccharide, wherein the sum of the mass percent of all the components is 100 percent. The invention also discloses the external gel of the composition and a preparation method of the external gel. The composition for treating the acne, disclosed by the invention, is based on the compatibility theory of traditional Chinese medicine and is prepared by selecting the peony seed oil, the bletilla striata polysaccharide and the aloe polysaccharide as raw materials; meanwhile, a preparation of the composition, namely nano emulsion gel, with the characteristics of high penetration efficiency and delayed release is obtained. The drawbacks of skin irritation and drug resistance in existing local administration of the acne are overcome; in addition, the composition has the characteristics of safety, no toxicity and good effects; meanwhile, comprehensive utilization of oil peony, bletilla striata polysaccharide and aloe resources is improved, the industrial chain is extended and certain social benefits are produced.

The invention relates to a soothing vitality cream using a phase A, a phase A1, a phase B, a phase C, a phase D, a phase E, a phase F and a phase G as raw materials. The cream is prepared by steps ofextraction, purification, multiple mixing, emulsification, homogenization and the like. The soothing vitality cream has beneficial effects: the soothing vitality cream is prepared by combining the ginger from the Mariesiya plateau and several kinds of plant extracts and has a good soothing effect; the body dryness can be soothed; the nutrition required by the skin can be supplemented; the vitalityis provided; the skin of the body becomes fine and smooth to show the charm and the natural luster.

The invention discloses a pharmaceutical composition for transdermal administration. The pharmaceutical composition contains tapentadol or a pharmaceutically acceptable salt thereof, a polymer dispersion carrier material, a hot-melt protective agent and an optional solubilizer. A preparation method of the pharmaceutical composition includes the following steps: mixing the tapentadol or the pharmaceutically acceptable salt thereof, the polymer dispersion carrier material, the hot-melt protective agent and the optional solubilizer, performing hot-melt extrusion, and performing micronization to obtain the microparticles of the tapentadol or the pharmaceutically acceptable salt thereof. The pharmaceutical composition for the transdermal administration can make the tapentadol or the pharmaceutically acceptable salt thereof rapidly absorbed, and achieve the purpose of sedation before anesthesia without affecting breathing, thereby avoiding the adverse psychological effects of intramuscular injection or intravenous injection acupuncture on children; and at the same time, the pharmaceutical composition can also be used to prevent and/or treat and delay the development of Parkinson disease.

According to the preparation method of the silica gel plaster, the silica gel plaster is composed of a base material layer, an adhesive layer and a traditional Chinese medicine microcapsule transdermal absorbent, the base material layer is a backing layer, and the adhesive layer is prepared from polymerized silica gel formed by polydimethylsilane, vinyl polysiloxane and cellulose and the traditional Chinese medicine microcapsule transdermal absorbent. The traditional Chinese medicine microcapsule transdermal absorbent is composed of a traditional Chinese medicine extract, propylene glycol, menthol, azone and fumed silica. The unique superiority of the silica gel is fully utilized, the silica gel is fused into a traditional plaster patch through technical improvement, the problem that the silica gel and alcohol substances are insoluble is well solved through a saturated cellulose technology, and the silica gel plaster patch is free of irritation, low in allergy rate, good in skin affinity and free of toxic and side effects. When the plaster patch is stripped from the skin, pain and pain caused by taking down body hair together are avoided, the silica gel has a good moist feeling on the surface of the skin, body surface moisture can be prevented from being evaporated, cuticles can be better softened, medicine can be better absorbed, and the treatment effect of the medicine can be achieved through a tendon channel.

The invention relates to a pulse mask device, comprising a mask body and a pulse control host, wherein the mask body comprises an inner layer, an outer layer and a conductive layer; the conductive layer is arranged between the inner layer and the outer layer and comprises a non-woven fabric and conductive electrode layers on two sides of the non-woven fabric; the pulse control host comprises a positive electrode output end and a negative electrode output end; the mask body comprises a forehead portion, an electrode connecting portion is separately formed close to the forehead portion at the upper ends of the conductive electrode layers on the two sides, the pulse control host is arranged outside the forehead portion of the mask body, and the positive electrode output end and the negative electrode output end of the pulse control host are respectively electrically connected with the electrode connecting portions on the two sides of the forehead portion.

The invention discloses a pharmaceutical composition for transdermal administration. The pharmaceutical composition comprises sufentanil or a pharmaceutically acceptable salt thereof, a polymer dispersion carrier material, a hot-melt protective agent and an optional solubilizer. The pharmaceutical composition for transdermal administration is obtained by the following steps: mixing the sufentanilor the pharmaceutically acceptable salt thereof, the polymer dispersion carrier material, the hot-melt protective agent and the optional solubilizer, performing hot-melt extrusion and micronization toobtain microparticles of the sufentanil or the pharmaceutically acceptable salt of the sufentanil. In addition, the invention provides a preparation method and application of the above pharmaceuticalcomposition. According to the pharmaceutical composition for transdermal administration, the sufentanil can be quickly absorbed, the purpose of treating postoperative pain without affecting breathingcan be achieved, and adverse psychological effects of intramuscular injection or intravenous injection acupuncture on patients can be avoided; and at the same time, the pharmaceutical composition canbe used to prevent and/or treat postherpetic neuralgia.

The invention discloses a medical transdermal patch. The patch sequentially comprises a backing layer, a viscose layer I, a skeleton layer, a viscose layer II and an anti-viscose layer from top to bottom. The skeleton layer is characterized by being made from, by weight, 40-50 parts of a isoborneyl acrylate/isoimperhol/glycerin monooleate/polyethylene glycol monoallyl ether/1-allyl-3-methylimidazole chloride/ 6-O-allyl-beta-cyclodextrin copolymer, 8-12 parts of active ingredients, 4-6 parts of DL-aminocaprolactam amidated alginate, 8-12 parts of a penetration enhancer, 0.01-0.03 part of fusionprotein, and 1-2 parts of transdermal functional Chinese herbal extracts. The medical transdermal patch has an excellent transdermal effect, the air permeability is good, the storage stability is good, no irritation is caused to the skin, drug release can be effectively controlled, the patch takes effect rapidly and the treatment effect is good.

The invention provides a transdermal penetration-promoting composition for improving the transdermal absorption effect of timolol. The transdermal penetration-promoting composition is prepared from 65-98wt% of albolene and 2-35wt% of wax substances. The transdermal penetration-promoting composition can achieve the cumulative penetration amount of timolol of about 92.61 micrograms per square centimeter within 8 hours without additionally using other conventional transdermal penetration-promoting agents, the transdermal absorption promoting effect is remarkable, the skin irritation is low, and the safety is higher.