6results about How to "High transdermal efficiency" patented technology

The invention discloses a modified deacetylated chitosan composition as well as a preparation method and application thereof. The modified deacetylated chitosan composition comprises a modified deacetylated chitosan carrier and an active matter, the modified deacetylated chitosan carrier comprises deacetylated chitosan of which the surface is modified with amino acid and / or hydroxyethyl; the active matter carries negative charge groups, and the negative charge groups comprise at least one of carboxyl, sulfo, phosphate and sulfydryl; the mass ratio of the modified deacetylated chitosan carrier to the active matter is 1: (0.1-100). The modified deacetylated chitosan composition provided by the invention can enter the interior of the skin through pores of the skin by utilizing the specific physicochemical properties of the nanoparticles, achieves a good transdermal effect under the condition of not damaging the skin structure, and is natural, safe and high in transdermal efficiency.

The invention relates to the technical field of biomedical materials, in particular to a hydrogel microneedle for skin improvement and a preparation method thereof.The hydrogel microneedle for skin improvement comprises a microneedle matrix and fisetin, the microneedle matrix is a hydrogel matrix, and the fisetin is embedded in the microneedle matrix. According to the hydrogel microneedle for skin improvement, the hydrogel microneedle has good mechanical performance, biocompatibility and degradability, the effect of slowly releasing medicine can be achieved, the hydrogel matrix wraps fisetin, the targeting performance of anti-aging active ingredients can be effectively enhanced, and the anti-aging effect of the skin is improved. The anti-aging agent is slowly released in a corium layer to play an anti-aging role, and has a wide application prospect in medical beauty and skin care products.

The invention discloses a composition with an anti-aging effect and a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition is prepared by compounding a traditional Chinese medicine active component, a moisturizing and permeation promoting component and a repairing and anti-aging auxiliary component, and the traditional Chinese medicine active component is composed of three zymolytes and three fermentation extracts which are respectively prepared from six medicinal and edible traditional Chinese medicine raw materials through differentiated composite enzymolysis and probiotic anaerobic fermentation processes. The problems that traditional Chinese medicine extracts are low in transdermal absorption rate, poor in bioavailability and insufficient in cosmetic system stability are solved, active ingredients are small-molecularized through process optimization, a multi-target synergistic anti-aging system is formed by matching with functional components, the anti-aging and repairing composition has excellent anti-aging and repairing effects, physical and chemical stability and skin safety, and the anti-aging and repairing composition has a good application prospect. The composition is suitable for various skin types and can be widely applied to preparation of anti-aging repair cosmetics.

This invention relates to a dual-frequency ultrasonic transdermal penetration enhancement device, its control method, and its application. The dual-frequency ultrasonic transdermal penetration enhancement device includes: a rectification and voltage regulation unit for adjusting the input power supply voltage to a preset voltage range; a dual-frequency signal generation unit for generating a first frequency signal and a second frequency signal respectively through two sets of DDS waveform generators; an impedance matching unit for adjusting the output impedance to match the input impedance of the ultrasonic transducer; a detection feedback unit for acquiring voltage and current signals and calculating the phase difference and the effective value of the current; and a control unit for obtaining the resonant frequency range of the ultrasonic transducer through frequency sweeping, adjusting the driving frequency when the real-time detected phase difference is too large and causes the transducer to deviate from its resonant state, and adjusting the output power to a stable state based on the error between the effective value of the current and a preset target value. This invention simultaneously increases cavitation effect and promotes molecular diffusion, thereby effectively improving drug transdermal efficiency.

The application discloses a composition with anti-aging efficacy and a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition is compounded by a traditional Chinese medicine active component, a moisturizing and penetration promoting component and a repair and anti-aging auxiliary component, wherein the traditional Chinese medicine active component is composed of three kinds of enzymolysis products and three kinds of fermentation extracts prepared respectively by differential complex enzymolysis and probiotic anaerobic fermentation process of six kinds of medicinal and edible traditional Chinese medicine raw materials. The application solves the pain points of low transdermal absorption rate, poor bioavailability and insufficient stability of the traditional Chinese medicine extract in the cosmetic system, realizes the small molecule of the active ingredient through process optimization, forms a multi-target point synergistic anti-aging system by matching the functional components, has excellent anti-aging repair efficacy, physical and chemical stability and skin safety, is suitable for various skin qualities, and can be widely applied to the preparation of anti-aging and repair cosmetics.

The application relates to a preparation method of MMP-13 response nanoparticles loaded with PDRN, and belongs to the technical field of biological medicines. In order to solve the problems of low transdermal efficiency of polydeoxyribonucleotide, poor stability under conventional storage conditions, and the fact that a traditional delivery system cannot distinguish between aging and normal tissues, leading to insufficient concentration at a target site and low bioavailability, the application provides MMP-13 response nanoparticles loaded with PDRN. By introducing a natural and safe response unit and a cross-linking strategy, an innovative full-chain solution and solid data support are provided for the development of the next generation of intelligent anti-aging cosmetics which are precise in targeting, efficient in anti-aging, and excellent in stability.