15 results about "Thiazole derivative" patented technology

This invention belongs to the field of pharmaceutical synthesis technology, specifically relating to indomethacin derivatives, their synthesis methods, and applications. The derivatives possess the chemical structures described in formulas (I), (II), and (III). This invention is the first to propose a series of novel indomethacin derivatives. Furthermore, this invention also proposes a synthesis method for indomethacin derivatives, using 5-hydroxy-1-indanone as a base material, to obtain the indomethacin derivatives of this invention through a series of reactions. This synthesis method yields high-yield products that are easily separated, making it the optimal method for preparing the indomethacin derivatives of this invention. Bioassays have confirmed that the indomethacin derivatives provided by this invention exhibit good toxic activity against aphids, spider mites, and armyworms, and can be applied to the control of plant pests.

The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to application of nitrothiazole derivatives and hydrochloride and sulfate thereof in preparation of medicines for treating intestinal infection of poultry and livestock. The nitrothiazole derivatives synthesized by the present application have high biological activity at the cell level, and have good biological activity on bacterial enteritis of poultry and livestock, especially chicken, pig, sheep and deer, and have high application value.

The application relates to a preparation method and application of a 2-acyl benzothiazole compound, which comprises the following steps: placing sulfur ylide in a sealed tube, adding a solvent to dissolve, and obtaining a first reaction system; adding nitrosobenzene into the first reaction system, stirring at a certain temperature for a certain time, and obtaining a second reaction system; adding sodium hydrosulfide, dimethyl sulfoxide, a metal salt, potassium persulfate and an alkali into the second reaction system, heating and stirring in the sealed tube to react, and obtaining a third reaction system; and carrying out post-treatment on the third reaction system to obtain the 2-acyl benzothiazole compound.The application has the advantages that the reaction condition is mild, the price of the sodium hydrosulfide sulfur source is low, and the reaction yield is high; the substrate applicability range is wide, various substrate structures can tolerate the reaction condition, and the 2-acyl benzothiazole derivative with diversified structures can be rapidly prepared.

The application relates to methods and intermediates for synthesizing the thiazole derivative Coumpound (1) useful in treating and / or inhibiting the development or progression of diseases or disorders caused by, or associated with, herpes virus infection.

The invention belongs to the technical field of medicinal chemistry and pharmacology, and particularly relates to a flavanone thiazole derivative as well as a preparation method and application thereof. The structural formula of the flavanone thiazole derivative is shown in the specification, and in the structural formula, R represents one of 2-iodophenyl, 2, 4-dichlorophenyl, 4-fluorophenyl, 2-bromobenzyl, 4-bromophenyl, 2-bromophenyl, 4-chlorobenzyl and 4-methylphenyl. The flavanone thiazole derivative is a flavanone thiazole ring-fused derivative, and pharmacological research shows that the compound has high liver cancer cell proliferation inhibition activity and can be applied to preparation of drugs for preventing and treating liver cancer.

Provided are a crystal form of a thiazole derivative inhibitor, and a preparation method therefor and the use thereof. Particularly provided are a crystal form of a compound as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and the use thereof as an inhibitor in the treatment of autoimmune diseases.

The application relates to the technical field of organic synthetic chemistry, and particularly discloses a 2-acyl benzothiazole derivative and a preparation method thereof. The method takes benzothiazole compounds and aromatic aldehyde compounds as substrates, takes polyacid such as phosphomolybdic acid as a catalyst, and generates the 2-acyl benzothiazole derivative through cross-dehydrogenative coupling in an organic solvent under the conditions of air or oxygen atmosphere and light irradiation. The application does not need a transition metal catalyst and an alkaline additive, uses oxygen as a terminal oxidant, the catalyst can be recycled and reused, the reaction condition is mild, the operation is simple, the applicable range of the substrate is wide, the chemical selectivity is high, and the product yield can reach 85%. The method overcomes the limitations of safety, selectivity and scale of the prior art, and provides an efficient, economical and environment-friendly new path for the preparation of high-value 2-acyl benzothiazole derivatives in the fields of medicine, pesticide and material science.

The present invention relates to a salt of a thiazole derivative inhibitor, a crystal form thereof, a preparation method therefor and the use thereof. In particular, the present invention relates to a salt of a compound represented by general formula (I), a crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the salt and / or crystal form, and the use thereof as an inhibitor in the treatment of autoimmune diseases.

This invention relates to the field of composite panels and discloses a wear-resistant and UV-resistant fiberglass-silicon core composite panel and its preparation method. The composite panel comprises melamine-faced paper, fiberglass mat, and calcium silicate board impregnated with adhesive. The adhesive includes deionized water, melamine-formaldehyde resin, modified aluminum hydroxide, organosilicon flexibility agent, and coupling agent. The modified aluminum hydroxide is prepared by reacting a functional modifier, N,N'-bis-(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine with benzophenone derivatives and pyridylthiazole derivatives, with 3-chloropropyltriethoxysilane and grafted onto aluminum hydroxide. The organosilicon flexibility agent is prepared by modifying phenyl hydrogen-containing silicone oil with allyl polyoxyethylene ether and glycidyl methacrylate. This invention achieves an integrated structure of the panel, maintaining a surface free of blistering and cracking under complex environmental conditions, with the overall material intact and without delamination, and possessing good antibacterial, fire-resistant, and UV-resistant properties.

The application relates to methods and intermediates for synthesizing the thiazole derivative Compound 1 useful in treating and / or inhibiting the development or progression of diseases or disorders caused by, or associated with, herpes virus infection. (I)

An object of the present disclosure is to provide a rubber composition from which a crosslinked rubber molded product having good softness and excellent resilience performance can be obtained. The present disclosure provides a rubber composition containing (a) a base rubber, (b) a co-crosslinking agent, (c) a crosslinking initiator, and (d) a salt of a benzothiazole derivative, wherein (d) the salt of the benzothiazole derivative includes a compound represented by the formula (1) in which a sulfur atom S2 constituting a thiocarbonyl group has a Mulliken charge of −0.190 or more.[In the formula (1), R1 to R4 are identical to or different from each other, and represent an electron-withdrawing group or a hydrogen atom, S1 and S2 represent a sulfur atom, X represents a cation component, n is an integer ranging from 1 to 4, and at least one of R1 to R4 bonding to the identical benzene ring is an electron-withdrawing group when n is 2 or more.]

The invention relates to a gallic amide bridged thiazole derivative as well as a preparation method and application thereof. The invention discloses a novel gallic acid derivative, namely a gallic amide bridged thiazole derivative, and a preparation method and application of the gallic amide bridged thiazole derivative. The gallic amide bridged thiazole derivative disclosed by the invention is a novel compound and has important significance on synthesis and discovery of anti-inflammatory drugs.

The embodiment of the invention discloses a 5-nitrothiazole derivative, a pharmaceutical composition and application. The 5-nitrothiazole derivative in the embodiment of the invention is a compound with a structure as shown in a formula I or an isomer, a prodrug, a stable isotope derivative, a hydrate, a solvate and a pharmaceutically acceptable salt thereof; the 5-nitrothiazole derivative is prepared by taking 2-bromo-5-nitrothiazole as a raw material through a nucleophilic substitution reaction, the synthesis process is simple, the yield is high, and industrial production is easy to realize; the 5-nitrothiazole derivative provided by the embodiment of the invention can effectively inhibit the growth of micro-aerobic bacteria, especially has a remarkable inhibition effect on helicobacter pylori (drug-resistant strains and / or sensitive strains), and can directly enhance the treatment effect on helicobacter pylori infection. Therefore, the 5-nitrothiazole derivative has a relatively good application prospect in preparation of antibacterial drugs.

The invention relates to the technical field of herbicides, in particular to a herbicide and a preparation method and application thereof.The herbicide is prepared from, by weight, 10%-20% of benzothiazole derivatives, 1%-20% of auxiliary active ingredients, 1%-5% of synergists, 0.1%-30% of accelerants, 30%-70% of carriers and 5%-15% of surface active auxiliaries, and the sum of the mass fraction of all the ingredients is 100%; wherein the benzothiazole derivative is 2-hydroxy-5-methoxyl-N-methylbenzothiazole or an agricultural acceptable salt thereof, and the auxiliary active component comprises one or more of 2, 4-dichlorphenoxyacetic acid, p-nitrobenzaldehyde and acetonyl acetone. According to the herbicide provided by the invention, the benzothiazole derivative is used as a main active component and is matched with the auxiliary active component for use, so that efficient prevention and removal can be realized under the condition of low dosage, and the synergistic synergist and the accelerant are added, so that wetting, permeation and uptake and conduction of the active component on weed leaves are facilitated; the pesticide effect taking speed is increased; the lasting period is prolonged.

This application relates to a photoactive polyoxometalate-based metal-organic framework composite material, its preparation method, and its application, belonging to the field of photocatalytic materials technology. The preparation method of this application's photoactive polyoxometalate-based metal-organic framework composite material includes the following steps: stirring copper salt, a photosensitive ligand, and silicotungstic acid in a mixed solvent, then carrying out a hydrothermal reaction, cooling to room temperature, crystal precipitation, and washing and drying to obtain the photoactive polyoxometalate-based metal-organic framework composite material. The photoactive polyoxometalate-based metal-organic framework composite material provided in this application exhibits excellent performance in the CDC reaction for the synthesis of benzo(naphthalene)thiazole, achieving moderate to high yields, and providing a promising heterogeneous photocatalytic strategy for the green and efficient synthesis of benzo(naphthalene)thiazole derivatives.