Thiazole derivative

A derivative, thiazole technology, applied in the fields of hair growth agent and hair follicle cell growth promoter, can solve the problems such as no report on the inhibitory effect of activin receptor-like kinase 5, no thiazolyl imidazole compound, etc.
CN1956979AInactive Publication Date: 2007-05-02TAISHO PHARMACEUTICAL CO LTD
14 Cites 10 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TAISHO PHARMACEUTICAL CO LTD
Publication Date
2007-05-02
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

A thiazolylimidazole derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient, wherein: X 1 and X 2 are different from each other and represent a sulfur atom or a carbon atom; R 1 represents a phenyl group; a substituted phenyl group; a phenyl group condensed with a hetero aromatic ring; a pyridyl group; or a pyridyl group condensed with a hetero aromatic ring; R 2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms substituted with 1 to 5 halogen atoms, an alkoxy group having 1 to 6 carbon atoms, an alkanoyl group having 1 to 5 carbon atoms, or a hydroxyalkyl group having 1 to 6 carbon atoms, A represents a group which is represented by the formula (II). The present invention provides an inhibitory substance against ALK5 which is a TGF- type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a compound capable of inhibiting TGF-beta type I receptor activin receptor-like kinase 5 (ALK5). The present invention also relates to a hair follicle cell growth promoter, a hair growth agent and a hair growth agent, all of which contain an ALK5 function inhibitor as an active ingredient. Background technique

[0002] Transforming growth factor-beta (TGF-beta), activin, BMP, etc. are molecules belonging to the TGF-beta superfamily. TGF-β has two distinct signaling receptors (type I and type II), both of which have serine / threonine kinase domains in their respective cells. Once TGF-β binds to the receptor, the type I receptor is phosphorylated by the type II receptor, thereby being activated, thus transmitting the signal to the nucleus through the Smad2 / 3 pathway or the TAB1 / TAK1 pathway.

[0003] Obviously, TGF-β has many physiological effects, and it is well known that one of them is that TGF-β has the property of accumulat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More