Use of thiazole derivatives and analogues in the treatment of cancer

A technology of derivatives and cancer, applied in the field of application of thiazole derivatives and analogs in the treatment of cancer, can solve problems such as the application of compounds that are not mentioned

Inactive Publication Date: 2008-10-01
BETAGENON AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

which does not mention or suggest the use of the compound in the treatment of cancer

Method used

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  • Use of thiazole derivatives and analogues in the treatment of cancer
  • Use of thiazole derivatives and analogues in the treatment of cancer
  • Use of thiazole derivatives and analogues in the treatment of cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0291] 5-Benzyl-2-(phenylimino)thiazolidin-4-one

Embodiment 2

[0293] 5-(4-Methylbenzyl)-2-(4-chlorophenylimino)thiazolidin-4-one

Embodiment 3

[0295] 5-(4-Chlorobenzyl)-2-(4-chlorophenylimino)thiazolidin-4-one

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PUM

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Abstract

There is provided a use of a compound of formula (I), wherein X, Y, T, W, A1, A2 R1, R5 and R6 have meanings given in the description for the manufacture of a medicament for the treatment of cancer.

Description

technical field [0001] The present invention relates to new medical uses of certain compounds, some of which are new and / or not previously known to be useful as medicines. In particular, the invention relates to the use of said compounds in the treatment of cancer. Background technique [0002] Elevated plasma free fatty acids (FFAs) stimulate pancreatic β-cells and are a cause of hyperinsulinemia. [0003] Excessive obesity is associated with increased risk of cancer progression in varying degrees, such as colorectal adenoma, breast cancer (postmenopausal), endometrial cancer, kidney cancer, esophageal adenocarcinoma, ovarian cancer, prostate cancer, pancreatic cancer, gallbladder cancer , liver cancer and cervical cancer (Calle and Kaaks (2004), Nature Reviews Cancer, 4, 579-591). [0004] Existing research has linked hyperinsulinemia, among other conditions, to the incidence of colon cancer and lethal breast and prostate cancer. [0005] In prostate cancer, hyperinsuli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/426A61K31/421A61P35/00
Inventor 雅各布·韦斯特曼比约恩·埃里克森吉多·库兹克里斯琴·赫德伯格
Owner BETAGENON AB
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