5-(4-chlorophenylmethyl)-4-tertiary butyl thiazole derivatives and preparation method and application thereof

Abstract

The invention discloses 5-(4-chlorophenylmethyl)-4-tertiary butyl thiazole derivatives (I), which has the following structural formula as shown in the specification of the invention, wherein X1 in a formula I is selected from hydrogen, hydroxyl group, methoxy group, nitro group, amino group and chlorine; X2 is selected from hydrogen, nitro group, amino group, methoxy group, chlorine, bromine and iodine; X3 is selected from hydrogen, methyl group, ethyl group, nitro group, methoxy group, chlorine, bromine, amino group and dimethylamino group; and X4 is selected from hydrogen, nitro group, amino group, methoxy group, chlorine, bromine and iodine. The 5-(4-chlorophenylmethyl)-4-tertiary butyl thiazole derivatives (I) have favorable inhibition activity on human cervical cancer cells, human liver cancer cells, human nasal and oral cancer cells and the like and can be used for preparing anti-tumor medicines.

Description

technical field The present invention relates to novel compounds and their preparation methods and applications, in particular to 5-(4-chlorobenzyl)-4-tert-butylthiazole derivatives and their preparation methods and applications. Background technique Among China's 1.3 billion people, one million people die of cancer every year, about 2 million need treatment, and about 1.3 million die. Cancer has become a major killer of human beings. Thiazole compounds have anticonvulsant, antiviral, antibacterial and insecticidal effects. Shao Ling et al. described 4-aryl-5-triazolylthiazole-2-imine compounds, and the results of biological activity assays showed that some of the compounds had bactericidal activity against P. ). Michael etc. have described 2-aminothiazole class breast cancer drug (Bioorg&Med.Chem.2004,12,1029); Acta Sinica, 2006, 41:727). Lin et al. described that Schiff bases have selective inhibitory effect on COX-2 (Bioorg & Med Chem, 2008, 16(5):2697). He Daohang ...

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Problems solved by technology

There is no research report on the preparation and antitumor activity of 5-(4-chlorobenzyl)-4-tert-butylthiazole derivative (I)

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