73 results about "Heterocyclic amine" patented technology

The invention belongs to the technical field of barbecue meat product processing, and particularly relates to a method for inhibiting cancerogen content in a fresh meat roasting process, which comprises the following steps: (1) adding liquorice into water, and boiling to obtain a liquorice extracting solution; (2) adding the fresh meat into the licorice root extracting solution, and pickling to obtain the pickled fresh meat; and (3) baking the pickled fresh meat. Polyphenols substances rich in the licorice extract are utilized to inhibit decomposition of protein, fat and the like in the baking process of the fresh meat, reduce generation of free radicals and inhibit conversion of precursor substances of polycyclic aromatic hydrocarbons, N-nitrosamines and heterocyclic amines, so that generation of the polycyclic aromatic hydrocarbons, the N-nitrosamines and the heterocyclic amines is inhibited. The method is easy and convenient to operate, raw and auxiliary materials are easy to obtain, the production cost is low, the content of polycyclic aromatic hydrocarbon, N-nitrosamine and heterocyclic amine in the baked fresh meat can be greatly reduced, and the baked meat product is safer to eat.

The invention belongs to the technical field of aquatic product processing, and discloses a method for reducing heterocyclic amine in grilled fish. According to the invention, the mixture of onion and ginger is used as the pickling liquid, and one or more of carrageenan, xanthan gum, sodium carboxymethyl cellulose and tea polyphenol is / are used as the film forming liquid, so that the generation of heterocyclic amine in the grilled fish can be effectively inhibited; and meanwhile, the meat can be prevented from being in direct contact with grease, and the loss of water and other nutrients or flavor substances in food materials is inhibited, so that the food quality is improved. The method is simple to operate and has a wide application prospect.

The invention relates to a preparation method of an antibacterial high-temperature-resistant PE plastic product, and belongs to the technical field of high polymer materials. The antibacterial high-temperature-resistant PE plastic product is prepared by blending, melting and extruding the heat-resistant antibacterial additive and the ultra-high molecular weight polyethylene, and has good mechanical properties, heat resistance, flame retardance and antibacterial property. Wherein the heat-resistant antibacterial additive contains a triazine chain segment, a pyrazine chain segment, a heterocyclic amine side chain and a metronidazole side chain, and the group chain segments have a synergistic effect. After the polybutadiene chain segment in the heat-resistant antibacterial additive and the propylene metronidazole are subjected to olefin metathesis reaction, double bonds in the polybutadiene chain segment are changed into carbon-carbon single bonds to form a carbon-carbon single bond structure which is the same as that of polypropylene, so that the affinity of the heat-resistant antibacterial additive and the ultra-high molecular weight polyethylene is improved; the heat-resistant antibacterial additive is prevented from being non-uniformly dispersed in the PE plastic product, so that the improvement of the heat-resistant flame-retardant property and the antibacterial property is influenced.

The invention relates to a magnetic nano material for efficient enrichment and rapid desorption of heterocyclic amine as well as a preparation method and application of the magnetic nano material. The magnetic nano material is of a core-shell structure and sequentially comprises a Fe3O4 magnetic inner core, a magnetic core shell, a magnetic core shell and a magnetic core shell from inside to The surface of the Fe3O4 magnetic core is coated with the polydopamine intermediate layer; and the cysteine functional shell is bonded on the surface of the polydopamine intermediate layer. The Fe3O4 magnetic inner core provides magnetic responsiveness, the polydopamine middle layer provides strong adsorption sites, the cysteine functional shell provides specific recognition, the Fe3O4 magnetic inner core, the polydopamine middle layer and the cysteine functional shell have a synergistic effect, the adsorption effect on various common heterocyclic amines is good, and especially due to the introduction of the cysteine functional shell, the magnetic responsiveness is improved. The specific recognition of heterocyclic amine is obviously enhanced, the interference of other impurities in a food matrix is effectively reduced, and the purification effect is outstanding; and the device can be repeatedly used while the enrichment efficiency is ensured, so that the cost is reduced.

The invention discloses a liquid-liquid phase change absorbent and application thereof. The liquid-liquid phase change absorbent comprises the following components in percentage by mass: 20-50% of a main absorbent, 15-65% of a phase splitting agent, 1-15% of a crystallization inhibitor and 0-40% of water, wherein the total mass of the main absorbent is 100%; the crystallization inhibitor includes a combination of a carbonate and a heterocyclic amine. The phase change absorbent disclosed by the invention can be used for capturing CO2, can keep liquid-liquid phase change in a relatively wide temperature range, and can effectively inhibit crystallization, so that liquid-solid phase change can be avoided.

In order to overcome the problem of insufficient improvement of aging resistance of phenolic resin due to introduction of a modifier into existing phenolic resin, the invention provides modified phenolic resin which comprises the following components: a phenolic resin prepolymer and modified inorganic particles, wherein the modified inorganic particles are selected from inorganic particles treated by nitrogen heterocyclic amine; the inorganic particles comprise one or more of zirconium dioxide, molybdenum disulfide and boron carbide. Meanwhile, the invention further discloses a preparation method of the modified phenolic resin, a sealing material for a capacitor and the capacitor. The modified phenolic resin provided by the invention has excellent aging resistance, and is beneficial to improving the safety and prolonging the service life of a capacitor.

This invention provides a method for simultaneously detecting 17 heat-processing hazards in 4 categories, comprising: adding n-hexane to the sample, mixing thoroughly, discarding the n-hexane phase, extracting acrylamide, 5-hydroxymethylfurfural, and free heterocyclic amines using dimethyl ketone and ultrasound-assisted extraction, collecting the supernatant, and purifying it; simultaneously transferring the precipitate to another tube, reducing it with sodium tetrahydroborate, hydrolyzing it with hydrochloric acid to release bound heterocyclic amines and late-stage glycosylation products, and performing UPLC-MS / MS analysis. This invention is the first to propose a two-step extraction method for simultaneously determining 17 heat-processing hazards in 4 categories within 7 minutes using UPLC-MS / MS. The accuracy, precision, detection limit, quantitation limit, and recovery rate of the method were verified, and all test indicators met the requirements. This method is applicable to the determination of heat-processing hazards in four types of food matrices: high starch, high protein, high fat, and high sugar.

The present invention provides heterocyclylamine derivatives of Formula I:wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

The invention discloses a preparation method and a packaging and storing method of flaxseed powder, and belongs to the technical field of food engineering.By controlling the stir-frying time, the stir-frying temperature, the salt addition amount and the sieving particle size, the heterocyclic amine content is controlled in the flaxseed powder preparation process, meanwhile, good taste is obtained, and the flaxseed powder is good in taste and good in taste. When the stir-frying temperature is 131 DEG C, the stir-frying time is 14.5 min, and the salt addition amount is 0.94%, the optimized parameters of the flaxseed powder preparation technology are obtained. The invention further discloses a flaxseed powder storage method which can well solve the problem that flaxseed powder cannot be stored in the storage process of the flaxseed powder. In order to solve the problem that harmful substances such as heterocyclic amine are continuously generated and accumulated due to continuous occurrence of Maillard reaction and glycosylation reaction of protein and fat in the flaxseed powder, the preparation and storage method of the flaxseed powder disclosed by the invention not only can ensure the taste and flavor of the flaxseed powder, but also can prolong the storage time of the flaxseed powder and maintain the taste and flavor of the flaxseed powder, so that the flaxseed powder has a good market prospect. The method is of great significance to development and application of flaxseeds.

The invention relates to the field of food detection, and particularly discloses a method for detecting heterocyclic amine substances in food. The detection method specifically comprises the following steps: sampling a target to-be-detected food, and performing pretreatment to obtain a to-be-detected sample; the method comprises the following steps: mixing a to-be-detected sample with acetonitrile, mixing with inorganic salt, centrifuging to obtain a sample extracting solution, blow-drying the extracted liquid nitrogen, redissolving, adding sporopollen for physical adsorption, and centrifuging to remove supernate to obtain the sporopollen adsorbed with heterocyclic amine substances; and adding an organic solvent into the sporopollen adsorbed with the heterocyclic amine substances for elution and centrifugation, and taking supernate for HPLC-MS / MS detection to obtain qualitative and quantitative analysis results of the heterocyclic amine substances contained in the food to be detected. According to the application, the heterocyclic amine adsorption efficiency is remarkably enhanced by utilizing the hydrogen-bond interaction, pi-pi and hydrophobic interaction of sporopollen, the convenience of detection of various heterocyclic amines in food is effectively improved, and the sensitivity and the accuracy are high.

The application discloses a method for reducing the content of heterocyclic amines and advanced glycation end products in grilled meat products by using plasma-activated water pretreatment. The method mainly comprises the following steps: treating distilled water by using cold plasma to prepare plasma-activated water; soaking raw meat in the plasma-activated water for pretreatment; grinding the soaked raw meat into meat patties, and then performing high-temperature grilling to obtain grilled meat products. The raw meat is pretreated by using plasma-activated water, and then high-temperature grilling is performed, so that the content of heterocyclic amines and advanced glycation end products in the grilled meat products is reduced, the grilled meat products are safer to eat, the method is simple to operate and low in cost, the method can be integrated into common steps (such as cleaning and marinating) of meat product processing, and the method can be applied to factory production; meanwhile, the sensory quality of the grilled meat products is not affected; and the method completely conforms to the development trend of natural, green and healthy.

The invention discloses a method for inhibiting formation of heterocyclic amine in roasted mutton and maintaining flavor by exogenous sulfur-containing amino acid, and belongs to the technical field of food processing.The method comprises the following steps that basic marinade is added into an aqueous solution of sulfur-containing amino acid to obtain marinade, the marinade is evenly smeared on the surface of diced meat, and the diced meat is placed in a sealed bag to be refrigerated and pickled; and after pickling is finished, baking is performed. According to the method, the specific influence of the exogenous sulfur-containing amino acid on the Maillard reaction path is researched, so that the effective inhibition of the heterocyclic amine and the good maintenance of the flavor are realized, and the effect of collaborative optimization is achieved. The method not only has significant new health value, but also has process feasibility and economic high benefits, and contributes to an innovative solution to the field of meat processing.

The application discloses a kind of composite dried meat and a preparation method thereof.The preparation raw material is beef and chicken, and the mass ratio of the amount of beef and chicken is 1:(1-3).The composite dried meat of the application uses beef and chicken as the preparation raw material, has the chewiness of beef and the tender taste of chicken, overcomes the defects that single beef jerky is hard and single chicken jerky has no chewiness, and the addition of sugarcane molasses and rosemary extract during preparation effectively inhibits the generation of heterocyclic amines, further improves the taste of dried meat, and increases the safety of consumption.

The invention relates to an N-(1H-pyrazol-3-yl) heterocyclic amine derivative, a preparation method thereof and application of a pharmaceutical composition containing the derivative in medicine. Specifically, the invention relates to N-(1H-pyrazol-3-yl) heterocyclic amine derivatives as shown in a general formula (I), a preparation method and pharmaceutically acceptable salts thereof, and application of the N-(1H-pyrazol-3-yl) heterocyclic amine derivatives and the pharmaceutically acceptable salts thereof as therapeutic agents, especially as PLK4 inhibitors, and definitions of substituent groups in the general formula (I) are the same as those in the specification.

The invention relates to the technical field of food, in particular to an EGCG (epigallocatechin gallate) and beta-lactoglobulin compound, a preparation method thereof and application of the EGCG and beta-lactoglobulin compound in reducing heterocyclic amine in fried food. The EGCG and beta-lactoglobulin compound is prepared from EGCG and beta-lactoglobulin; the weight ratio of EGCG to beta-lactoglobulin is (5: 1)-(1: 5). The EGCG and the beta-lactoglobulin are compounded to form a stable EGCG and beta-lactoglobulin compound, so that the activity and the stability of polyphenol are effectively improved, and the content of heterocyclic amine in fried food can be effectively reduced.

The invention discloses a method for detecting heterocyclic amine in fried food, and belongs to the technical field of heterocyclic amine detection. According to the method, the deep-fried sample is pretreated by selecting an enzymolysis method, and accurate analysis and detection of the protein-bound heterocyclic amine in the deep-fried food are realized through an efficient and mild sample preparation method. The method effectively realizes simultaneous detection of free and protein-bound heterocyclic amines, comprehensively evaluates the content of heterocyclic amines in food, and provides technical support for food safety risk evaluation. The method provided by the invention is suitable for analysis and detection of binding-state heterocyclic amine in various fried foods, and has a wide practical application prospect.

The invention belongs to the technical field of compound synthesis, and particularly relates to a synthetic method of an azacyclo-amine derivative, which comprises the following steps: in the presence of mixed alkali and an organic solvent, reacting a compound # imgabs0 # as shown in a formula I with pyrrolidine or piperidine to generate an azacyclo-amine derivative # imgabs1 # as shown in a formula II, in which R1 is selected from # imgabs2 # and X is selected from halogen; r2 is selected from # imgabs3; R3 is selected from the following groups: # imgabs4; and the mixed alkali is a combination of organic alkali and inorganic alkali. Compared with the existing synthesis method, the method provided by the invention has the advantages of simple operation steps, high product yield and no need of dangerous raw materials through one-step reaction.

The invention discloses a CoCu-based bimetallic oxide catalyst, a preparation method of the CoCu-based bimetallic oxide catalyst and a preparation method of 2, 5-furandicarboxylic acid. The preparation method of the catalyst comprises the following steps: mixing a Co precursor, a Cu precursor, a heterocyclic dicarboxylic acid compound, a heterocyclic amine compound containing more than two nitrogen atoms and a carbon material in a solvent, reacting, and roasting to obtain the CoCu-based bimetallic oxide catalyst. The preparation method of the 2, 5-furandicarboxylic acid comprises the following step: carrying out catalytic oxidation reaction on 5-hydroxymethylfurfural in the presence of the catalyst, an oxidant and water to obtain the 2, 5-furandicarboxylic acid. The catalyst adopts the non-noble metal, can efficiently catalyze and oxidize the 5-hydroxymethylfurfural to prepare the 2, 5-furandicarboxylic acid, and has the advantages of mild reaction conditions, less non-noble metal consumption, high conversion rate of the 5-hydroxymethylfurfural, high yield of the 2, 5-furandicarboxylic acid and the like.

To provide a pseudo-dog smell composition which generates a smell similar to a dog smell generated when a dog is kept indoors, for example.SOLUTION: A pseudo-dog smell composition according to an embodiment of the present invention includes: one or more aliphatic saturated hydrocarbons having a carbon number in a range of 8 or more and 20 or less; one or more aliphatic aldehydes having a carbon number in a range of 6 or more and 18 or less; one or more aliphatic monocarboxylic acids having a carbon number in a range of 3 or more and 9 or less; and one or more heterocyclic amines selected from pyrrolines, pyridines, and pyrazines which are optionally substituted with a lower alkyl group or acetyl group.SELECTED DRAWING: None

The application relates to a method for improving the flavor of meat products and reducing the content of heterocyclic amines based on soybean polysaccharides, which comprises the following steps: mixing soybean dietary fiber with deionized water, stirring and extracting after adjusting the pH, and separating the solid phase through solid-liquid separation; mixing the obtained solid phase with deionized water, extracting after adjusting the pH, and separating the liquid phase through solid-liquid separation, concentrating, and obtaining concentrated liquid; mixing the obtained concentrated liquid with alcohol, separating the solid phase through solid-liquid separation, drying, crushing and sieving the obtained solid phase, and obtaining soybean polysaccharides; mixing the obtained soybean polysaccharides with meat paste, stirring uniformly, pressing and shaping, and baking, and obtaining meat products. The soybean polysaccharides are extracted from soybean dietary fiber, added into meat products to improve the flavor variety of the meat products, reduce the content of heterocyclic amines, and further obtain healthy and delicious heat-processed meat products.

The present invention relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same. The compound according to the present invention is useful in the prevention or treatment of inflammatory diseases, autoimmune diseases or cancers. In Chemical Formula 1, Y1, R1, A, R2, k, Y2, L, X and R3 are as defined in the specification. [Chemical Formula 1]

The present invention discloses an environment-friendly graphite heavy oil and grease cleaning agent suitable for aluminum alloy forming, which relates to the technical field of cleaning agents. The environment-friendly graphite heavy oil and grease cleaning agent suitable for aluminum alloy forming prepared by the present invention comprises the following components by mass percentage: 9-11% of a weak alkaline substance, 22-24% of deoiling microspheres, 2-4% of a corrosion inhibitor, 2-6% of an abrasive, and 55-65% of deionized water; the weak alkaline substance includes any one or a combination of at least two of diethylamine, triethylamine, ethanolamine, diethanolamine or dicyclohexylamine; the abrasive is 80-100 nm nano-silica; the corrosion inhibitor includes any one or a combination of at least two of thiourea, heterocyclic amine, sodium molybdate or sodium metasilicate; the deoiling microspheres are obtained by wrapping an oil-phase solution of 4-carboxybenzaldehyde with poly-N-isopropylacrylamide gel; the cleaning agent prepared by the present invention has good deoiling performance and good corrosion prevention performance.

The invention belongs to the technical field of meat product processing, and discloses a meat composite curing agent as well as a preparation method and application thereof. The meat composite pickling agent comprises the following raw materials in parts by weight: 20-30 parts of roxburgh rose pomace enzymatic hydrolysate, 5-10 parts of mushroom peptide, 3-6 parts of celery powder, 0.5-1.5 parts of compound bacterium powder, 10-15 parts of spice powder and 8-12 parts of auxiliary materials. Wherein a preparation method of the rosa roxburghii tratt fruit residue enzymatic hydrolysate comprises the following steps: adding rosa roxburghii tratt fruit residues into a tea polyphenol solution, carrying out enzymolysis treatment after ultrasonic treatment, and filtering to obtain filtrate; the celery powder is obtained by drying celery stems at low temperature and then crushing the dried celery stems. The meat composite curing agent contains various micromolecular bioactive substances, can effectively permeate into meat tissues when being used for curing meat, reduces generation of typical harmful substances such as heterocyclic amine and benzopyrene in high-temperature processing processes such as baking and deep-frying, and simultaneously endows meat products with coordinated fragrance, rich levels and fine taste.

An aspect of the present disclosure relates to a dispersant composition for an electrode of a power storage device. The dispersant composition contains an acrylic polymer (A), an amine compound (B) with a boiling point of 200° C. or less, and an organic solvent (C). The acrylic polymer (A) contains a constitutional unit a represented by the following formula (1). The compound (B) is at least one amine compound selected from the group consisting of a secondary aliphatic amine, a tertiary aliphatic amine, an aromatic amine, and a heterocyclic amine.

The application discloses a processing method for reducing heterocyclic amines in barbecue meat while maintaining characteristic flavor, and belongs to the technical field of food processing. The application solves the technical problems of high heterocyclic amine generation in the high-temperature roasting process of the existing barbecue method and insufficient flavor caused by simply reducing the temperature. The method comprises the following steps: soaking fresh meat pieces in a phosphate buffer solution containing glucose oxidase and catalase for low-temperature treatment after the fresh meat is cut into pieces; preparing a flavor precursor coating liquid composed of xylose, cysteine, glycine, peanut oil and water and performing high-speed shear emulsification treatment; immersing the drained meat pieces in the coating liquid to make the surface uniformly adhere; and then placing the coated meat pieces in a far-infrared oven for roasting while inserting a probe type thermometer to monitor the center temperature. The application is mainly used in the field of barbecue meat processing and can effectively reduce the generation of heterocyclic amines while effectively maintaining the characteristic flavor of the roasted meat.

The invention belongs to the field of detection, and particularly relates to a method for testing and analyzing heterocyclic amine compounds in food. The invention provides a method for testing heterocyclic amine compounds in food. The method comprises the following steps: unfreezing, homogenizing and uniformly mixing, centrifuging, purifying, performing liquid chromatography-mass spectrometry / mass spectrometry analysis and the like. The 14 heterocyclic amine compounds in food can be efficiently and accurately detected through a specific organic solvent, a purification small column and optimized centrifugation, purification and elution conditions. The method has the advantages of low detection limit (5 mu g / kg), high recovery rate (greater than or equal to 85%), strong anti-interference capability and the like, is suitable for content analysis of heterocyclic amine in a complex food matrix, and provides powerful support for food quality and safety monitoring.

A lubricating oil composition including 60 to 95 mass% of one or more base oils, and 5 to 40 mass% of three or more additives, wherein the at least three additives comprise: from 0.01 to 0.5 mass% of an unhindered heterocyclic amine corrosion inhibitor, from 0.1 to 5 mass% of an organic friction modifier, and from 0.01 to 2 mass% of an inorganic friction modifier. Also disclosed is a method of reducing friction in a crankcase or improving the efficiency of an internal combustion engine using the lubricating oil composition. Also disclosed is a concentrate including the unhindered heterocyclic amine corrosion inhibitor, the organic friction modifier, and the inorganic friction modifier.

The present invention relates to a novel heterocyclic amine derivative represented by the following chemical formula 1 and a pharmaceutical composition containing the same, wherein the compounds according to the present invention can be usefully used for the prevention or treatment of inflammatory diseases, autoimmune diseases, or cancer. [Case 1] In the above chemical formula 1, the descriptions of Y1, R1, A, R2, k, Y2, L, X, and R3 are as defined in the specification.

The MeIQx inhibitor is prepared from the following raw materials in parts by weight: 2.5 to 10 parts of gallic acid, 10 to 15 parts of allicin, 5 to 8 parts of black pepper extract, 2 to 5 parts of curcumin and 6 to 9 parts of compound spice. The gallic acid, the allicin, the black pepper extract, the curcumin and the compound spice are all natural components, through the synergistic effect of the components, the inhibiting effect on MeIQx is remarkably enhanced, the inhibiting effect on heterocyclic amine precursors and intermediates is achieved, and the obvious inhibiting effect on MeIQx generated in the high-temperature processing process of aquatic products is achieved.

The present disclosure relates to a process preparing a zeolitic material having an AEI-type framework structure, wherein the framework structure comprises SiO2 and X2O3 and X is a trivalent element, and wherein the process comprises:(1) preparing a mixture comprising one or more cationic structure directing agents comprising a heterocyclic amine ring, seed crystals, and a first zeolitic material comprising SiO2 and X2O3 in its framework structure and having an FAU-type framework structure; and(2) heating the mixture to obtain a second zeolitic material comprising SiO2 and X2O3 in its framework structure and having an AEI-type framework structure.