42 results about "Heterocyclic amine" patented technology

The invention relates to a magnetic nano material for efficient enrichment and rapid desorption of heterocyclic amine as well as a preparation method and application of the magnetic nano material. The magnetic nano material is of a core-shell structure and sequentially comprises a Fe3O4 magnetic inner core, a magnetic core shell, a magnetic core shell and a magnetic core shell from inside to The surface of the Fe3O4 magnetic core is coated with the polydopamine intermediate layer; and the cysteine functional shell is bonded on the surface of the polydopamine intermediate layer. The Fe3O4 magnetic inner core provides magnetic responsiveness, the polydopamine middle layer provides strong adsorption sites, the cysteine functional shell provides specific recognition, the Fe3O4 magnetic inner core, the polydopamine middle layer and the cysteine functional shell have a synergistic effect, the adsorption effect on various common heterocyclic amines is good, and especially due to the introduction of the cysteine functional shell, the magnetic responsiveness is improved. The specific recognition of heterocyclic amine is obviously enhanced, the interference of other impurities in a food matrix is effectively reduced, and the purification effect is outstanding; and the device can be repeatedly used while the enrichment efficiency is ensured, so that the cost is reduced.

In order to overcome the problem of insufficient improvement of aging resistance of phenolic resin due to introduction of a modifier into existing phenolic resin, the invention provides modified phenolic resin which comprises the following components: a phenolic resin prepolymer and modified inorganic particles, wherein the modified inorganic particles are selected from inorganic particles treated by nitrogen heterocyclic amine; the inorganic particles comprise one or more of zirconium dioxide, molybdenum disulfide and boron carbide. Meanwhile, the invention further discloses a preparation method of the modified phenolic resin, a sealing material for a capacitor and the capacitor. The modified phenolic resin provided by the invention has excellent aging resistance, and is beneficial to improving the safety and prolonging the service life of a capacitor.

This invention provides a method for simultaneously detecting 17 heat-processing hazards in 4 categories, comprising: adding n-hexane to the sample, mixing thoroughly, discarding the n-hexane phase, extracting acrylamide, 5-hydroxymethylfurfural, and free heterocyclic amines using dimethyl ketone and ultrasound-assisted extraction, collecting the supernatant, and purifying it; simultaneously transferring the precipitate to another tube, reducing it with sodium tetrahydroborate, hydrolyzing it with hydrochloric acid to release bound heterocyclic amines and late-stage glycosylation products, and performing UPLC-MS / MS analysis. This invention is the first to propose a two-step extraction method for simultaneously determining 17 heat-processing hazards in 4 categories within 7 minutes using UPLC-MS / MS. The accuracy, precision, detection limit, quantitation limit, and recovery rate of the method were verified, and all test indicators met the requirements. This method is applicable to the determination of heat-processing hazards in four types of food matrices: high starch, high protein, high fat, and high sugar.

The application discloses a method for reducing the content of heterocyclic amines and advanced glycation end products in grilled meat products by using plasma-activated water pretreatment. The method mainly comprises the following steps: treating distilled water by using cold plasma to prepare plasma-activated water; soaking raw meat in the plasma-activated water for pretreatment; grinding the soaked raw meat into meat patties, and then performing high-temperature grilling to obtain grilled meat products. The raw meat is pretreated by using plasma-activated water, and then high-temperature grilling is performed, so that the content of heterocyclic amines and advanced glycation end products in the grilled meat products is reduced, the grilled meat products are safer to eat, the method is simple to operate and low in cost, the method can be integrated into common steps (such as cleaning and marinating) of meat product processing, and the method can be applied to factory production; meanwhile, the sensory quality of the grilled meat products is not affected; and the method completely conforms to the development trend of natural, green and healthy.

The application discloses a kind of composite dried meat and a preparation method thereof.The preparation raw material is beef and chicken, and the mass ratio of the amount of beef and chicken is 1:(1-3).The composite dried meat of the application uses beef and chicken as the preparation raw material, has the chewiness of beef and the tender taste of chicken, overcomes the defects that single beef jerky is hard and single chicken jerky has no chewiness, and the addition of sugarcane molasses and rosemary extract during preparation effectively inhibits the generation of heterocyclic amines, further improves the taste of dried meat, and increases the safety of consumption.

The invention relates to an N-(1H-pyrazol-3-yl) heterocyclic amine derivative, a preparation method thereof and application of a pharmaceutical composition containing the derivative in medicine. Specifically, the invention relates to N-(1H-pyrazol-3-yl) heterocyclic amine derivatives as shown in a general formula (I), a preparation method and pharmaceutically acceptable salts thereof, and application of the N-(1H-pyrazol-3-yl) heterocyclic amine derivatives and the pharmaceutically acceptable salts thereof as therapeutic agents, especially as PLK4 inhibitors, and definitions of substituent groups in the general formula (I) are the same as those in the specification.

The invention discloses a CoCu-based bimetallic oxide catalyst, a preparation method of the CoCu-based bimetallic oxide catalyst and a preparation method of 2, 5-furandicarboxylic acid. The preparation method of the catalyst comprises the following steps: mixing a Co precursor, a Cu precursor, a heterocyclic dicarboxylic acid compound, a heterocyclic amine compound containing more than two nitrogen atoms and a carbon material in a solvent, reacting, and roasting to obtain the CoCu-based bimetallic oxide catalyst. The preparation method of the 2, 5-furandicarboxylic acid comprises the following step: carrying out catalytic oxidation reaction on 5-hydroxymethylfurfural in the presence of the catalyst, an oxidant and water to obtain the 2, 5-furandicarboxylic acid. The catalyst adopts the non-noble metal, can efficiently catalyze and oxidize the 5-hydroxymethylfurfural to prepare the 2, 5-furandicarboxylic acid, and has the advantages of mild reaction conditions, less non-noble metal consumption, high conversion rate of the 5-hydroxymethylfurfural, high yield of the 2, 5-furandicarboxylic acid and the like.

To provide a pseudo-dog smell composition which generates a smell similar to a dog smell generated when a dog is kept indoors, for example.SOLUTION: A pseudo-dog smell composition according to an embodiment of the present invention includes: one or more aliphatic saturated hydrocarbons having a carbon number in a range of 8 or more and 20 or less; one or more aliphatic aldehydes having a carbon number in a range of 6 or more and 18 or less; one or more aliphatic monocarboxylic acids having a carbon number in a range of 3 or more and 9 or less; and one or more heterocyclic amines selected from pyrrolines, pyridines, and pyrazines which are optionally substituted with a lower alkyl group or acetyl group.SELECTED DRAWING: None

The application relates to a method for improving the flavor of meat products and reducing the content of heterocyclic amines based on soybean polysaccharides, which comprises the following steps: mixing soybean dietary fiber with deionized water, stirring and extracting after adjusting the pH, and separating the solid phase through solid-liquid separation; mixing the obtained solid phase with deionized water, extracting after adjusting the pH, and separating the liquid phase through solid-liquid separation, concentrating, and obtaining concentrated liquid; mixing the obtained concentrated liquid with alcohol, separating the solid phase through solid-liquid separation, drying, crushing and sieving the obtained solid phase, and obtaining soybean polysaccharides; mixing the obtained soybean polysaccharides with meat paste, stirring uniformly, pressing and shaping, and baking, and obtaining meat products. The soybean polysaccharides are extracted from soybean dietary fiber, added into meat products to improve the flavor variety of the meat products, reduce the content of heterocyclic amines, and further obtain healthy and delicious heat-processed meat products.

The present invention relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same. The compound according to the present invention is useful in the prevention or treatment of inflammatory diseases, autoimmune diseases or cancers. In Chemical Formula 1, Y1, R1, A, R2, k, Y2, L, X and R3 are as defined in the specification. [Chemical Formula 1]

The invention belongs to the technical field of meat product processing, and discloses a meat composite curing agent as well as a preparation method and application thereof. The meat composite pickling agent comprises the following raw materials in parts by weight: 20-30 parts of roxburgh rose pomace enzymatic hydrolysate, 5-10 parts of mushroom peptide, 3-6 parts of celery powder, 0.5-1.5 parts of compound bacterium powder, 10-15 parts of spice powder and 8-12 parts of auxiliary materials. Wherein a preparation method of the rosa roxburghii tratt fruit residue enzymatic hydrolysate comprises the following steps: adding rosa roxburghii tratt fruit residues into a tea polyphenol solution, carrying out enzymolysis treatment after ultrasonic treatment, and filtering to obtain filtrate; the celery powder is obtained by drying celery stems at low temperature and then crushing the dried celery stems. The meat composite curing agent contains various micromolecular bioactive substances, can effectively permeate into meat tissues when being used for curing meat, reduces generation of typical harmful substances such as heterocyclic amine and benzopyrene in high-temperature processing processes such as baking and deep-frying, and simultaneously endows meat products with coordinated fragrance, rich levels and fine taste.

The application discloses a processing method for reducing heterocyclic amines in barbecue meat while maintaining characteristic flavor, and belongs to the technical field of food processing. The application solves the technical problems of high heterocyclic amine generation in the high-temperature roasting process of the existing barbecue method and insufficient flavor caused by simply reducing the temperature. The method comprises the following steps: soaking fresh meat pieces in a phosphate buffer solution containing glucose oxidase and catalase for low-temperature treatment after the fresh meat is cut into pieces; preparing a flavor precursor coating liquid composed of xylose, cysteine, glycine, peanut oil and water and performing high-speed shear emulsification treatment; immersing the drained meat pieces in the coating liquid to make the surface uniformly adhere; and then placing the coated meat pieces in a far-infrared oven for roasting while inserting a probe type thermometer to monitor the center temperature. The application is mainly used in the field of barbecue meat processing and can effectively reduce the generation of heterocyclic amines while effectively maintaining the characteristic flavor of the roasted meat.

A lubricating oil composition including 60 to 95 mass% of one or more base oils, and 5 to 40 mass% of three or more additives, wherein the at least three additives comprise: from 0.01 to 0.5 mass% of an unhindered heterocyclic amine corrosion inhibitor, from 0.1 to 5 mass% of an organic friction modifier, and from 0.01 to 2 mass% of an inorganic friction modifier. Also disclosed is a method of reducing friction in a crankcase or improving the efficiency of an internal combustion engine using the lubricating oil composition. Also disclosed is a concentrate including the unhindered heterocyclic amine corrosion inhibitor, the organic friction modifier, and the inorganic friction modifier.

The present invention relates to a novel heterocyclic amine derivative represented by the following chemical formula 1 and a pharmaceutical composition containing the same, wherein the compounds according to the present invention can be usefully used for the prevention or treatment of inflammatory diseases, autoimmune diseases, or cancer. [Case 1] In the above chemical formula 1, the descriptions of Y1, R1, A, R2, k, Y2, L, X, and R3 are as defined in the specification.

The application provides a preparation method and application of an aqueous composite electrolyte, which comprises uniformly mixing an aqueous zinc salt and a water-soluble heterocyclic amine organic additive; adding deionized water and continuously stirring until dissolution, and then standing until the pH value is stable to obtain the aqueous composite electrolyte. The additive can improve the stability of the aqueous electrolyte, and the zincophilic group in the organic additive molecule can form a coordination bond with zinc ions, so that the additive molecules can be adsorbed on the surface of a zinc electrode, balance the electric field distribution on the electrode surface, prevent the non-uniform deposition of zinc ions on the electrode surface, reduce the dendrite growth caused by the excessive local electric field, improve the utilization rate of zinc, and effectively improve the performance of the battery. After the additive molecules are adsorbed on the surface of the zinc electrode, a part of the active sites for the hydrogen evolution reaction on the electrode surface can be covered, the hydrogen evolution reaction can be inhibited, the generation of by-products can be reduced, the coulombic efficiency can be improved, and the corrosion resistance and cycle stability of the zinc negative electrode can be effectively improved.

This invention discloses a method for preparing a nitrogen-containing heterocyclic D-A type COF photocatalyst and its application. The specific steps are as follows: Step S1, an aldehyde ligand and an amino ligand are added to a Pyrex reaction tube at a molar ratio of 2:3. The aldehyde ligand is a trialdehyde pyrogallol, and the amino ligand is an aromatic amine compound containing a nitrogen-containing heterocyclic ring. Step S2, a mixed organic solvent composed of mesitylene and 1,4-dioxane is added to the Pyrex reaction tube from Step S1, and an aqueous acetic acid solution is added as a catalyst to obtain mixture a. Step S3, the Pyrex reaction tube containing mixture a from Step S2 is ultrasonically treated to form a uniform suspension. This invention relates to the field of functional materials and photocatalysis technology. The structure is precisely designed, and the nitrogen-containing heterocyclic ring significantly modulates the D-A effect. In this invention, the 1,3,5-trihydroxypyrogallol and the nitrogen-containing heterocyclic amine ligand are covalently linked to form a donor-acceptor (D-A) structure with a significant electron push-pull effect within a covalent organic framework.

The invention discloses a recombinant omega-transaminase mutant and application thereof, relates to the technical field of biochemistry, and discloses plasmids and recombinant cells of the recombinant omega-transaminase mutant, and the nucleotide sequence of a coding gene of the mutant is shown as SEQ ID No.4. According to the application of the mutant of the recombinant omega-transaminase in synthesis of the chiral N-heterocyclic amine intermediate, a buffer solution, a substrate, a cofactor, an amino donor and a catalyst are sequentially added into a reaction system for reaction, and the chiral N-heterocyclic amine intermediate is generated. The activity and stereoselectivity of the omega-transaminase mutant obtained through enzyme engineering modification are obviously improved. The recombinant omega-transaminase catalyst can catalytically synthesize five chiral N-heterocyclic amines with high added values, the reaction conversion rate can reach 99% at most, and the optical purity of the product can reach 99% or above.

The invention discloses a thermosetting adhesive composition. The thermosetting adhesive composition contains an epoxy resin, an elastomer, and a curing accelerator. The curing accelerator is a compound that produces a heterocyclic amine compound by heating.

The present invention provides an acidic gas absorbent that absorbs a large amount of carbon dioxide, efficiently separates and recovers it, and has low emission compared to other amines, as well as an acidic gas removal device and acidic gas removal method using the same. [Solution] The acidic gas absorbent of the embodiment comprises a heterocyclic amine compound represented by the following formula (1) and a low molecular weight polyol compound. JPEG2026084925000006.jpg2787 [In the formula, R 1 Each of these independently represents a hydrogen atom, a hydroxyl group, and a hydroxyalkyl group or aminoalkyl group having 1 to 6 carbon atoms, R 2 R represents a hydroxyalkyl group or aminoalkyl group having 2 to 6 carbon atoms. 1 and R 2 At least one of them contains a hydroxyalkyl group or an aminoalkyl group.

The invention discloses beta-glucuronidase, a nucleotide sequence of a gene of the beta-glucuronidase and application of the beta-glucuronidase, the gene of the beta-glucuronidase and a protein sequence of the beta-glucuronidase are related to food-borne hazardous substances, and the beta-glucuronidase capable of efficiently and specifically activating cancerogens such as heterocyclic amine HAAs is constructed. The inhibitor designed aiming at the enzyme can reduce interference on intestinal effective microbial communities and human body GUS activity to the maximum extent, side effects are smaller, a research and development basis is provided for further high-throughput drug screening, computer-aided drug design and antibody drug development, and the inhibitor has a great application prospect.

The present invention provides: aggregated particles which exhibit high dispersibility not only under acidic conditions of pH 2 or higher but lower than pH 7 but also under alkaline conditions of pH 7 to pH 9 inclusive; an aggregated particle dispersion liquid; a coating material containing the particles; methods for producing the aggregated particles, the dispersion liquid, and the coating material; and a method for forming an antiviral surface.　The present invention specifically provides: aggregated particles in which silica nanoparticles each having an amino group on the surface thereof or silica nanoparticles each containing an aluminum compound and ceria nanoparticles having a boron compound, a heterocyclic amine, nitric acid, acetic acid, or phthalic acid adsorbed on the surfaces thereof are aggregated; an aggregated particle dispersion liquid; a coating material containing the particles; methods for producing the aggregated particles, the dispersion liquid, and the coating material; and a method for forming an antiviral surface.

The invention relates to the technical field of meat product processing, in particular to an antioxidant composition and a processing method of sauced black pork, and the antioxidant composition is prepared by compounding curcumin, a grape seed extract, a pteridium aquilinum extract and sodium ascorbate. The processing method of the sauced black pork using the antioxidant composition comprises the following steps: 1) cutting: cutting the cleaned streaky pork into long strips with the same size; (2) pickling with sauce: adding sauce into the raw meat, adding an antioxidant composition at the same time, and performing vacuum tumbling and pickling; the method comprises the following steps of (1) pickling pork, (2) drying: pickling the pork, (3) drying the pickled pork in a drying room, (4) air-drying: transferring the dried pork to an air-drying room, and (5) cooking: putting the air-dried sample into a cooking bag, and cooking to finally obtain the sauced black pork product of which the content of heterocyclic amine and advanced glycosylation end products is obviously reduced.

This invention discloses a series of isoflavulol amine copolymers, their preparation methods, and their antibacterial applications. This series of compounds uses fulvulin as the parent compound, converting fulvulin into isoflavulin. Then, isoflavulin, as the lipophilic moiety, is linked to various aliphatic amines and heterocyclic amines via alkyl linkages of different lengths, synthesizing a series of isoflavulol amine copolymers. Further structural optimization can be performed by introducing methyl groups at the nitrogen atom site to form nitrogen cations. The isoflavulol amine copolymers prepared by this invention exhibit good antibacterial effects against Staphylococcus aureus ATCC 29213 and various methicillin-resistant Staphylococcus aureus (MRSA), and possess advantages such as good water solubility, low biotoxicity, and high yield, showing promise for further development into semi-synthetic antibacterial drugs for clinical use.

This invention relates to the field of food additives and food safety control, specifically disclosing a chitosan membrane loaded with galangal essential oil, its preparation method, and its application. The method includes: (1) first contacting an ethanol-water solution of moringa alcohol-soluble protein with a pectin-water solution to obtain a protein-pectin dispersion; (2) second contacting galangal essential oil with the protein-pectin dispersion to obtain a galangal essential oil emulsion; (3) dissolving chitosan, corn starch, and citric acid in water I, followed by gelatinization, and then adding glycerol for a third contact to obtain a membrane solution; (4) fourth contacting the galangal essential oil emulsion with the membrane solution, casting it into a film, and then drying and equilibrating it to obtain a chitosan membrane loaded with galangal essential oil. The method provided by this invention can improve the loading and protective capacity of essential oils, significantly enhance the inhibitory effect on bound heterocyclic amines, and improve the edible safety of heat-processed plant-based meat products.

The invention discloses a preparation method and application of a nitrogen heterocyclic ring D-A type COFs photocatalyst, and the specific steps are as follows: step S1, an aldehyde ligand and an amino ligand are added into a Pyrex reaction tube according to a molar ratio of 2: 3, the aldehyde ligand is trialdehyde phloroglucinol, and the amino ligand is a nitrogen heterocyclic ring-containing arylamine compound; step S2, continuously adding a mixed organic solvent composed of mesitylene and 1, 4-dioxane into the Pyrex reaction tube in the step S1, and adding an acetic acid aqueous solution as a catalyst to obtain a mixture a; and S3, performing ultrasonic treatment on the Pyrex reaction tube filled with the mixture a in the step S2 to form a uniform suspension. The invention relates to the technical field of functional materials and photocatalysis. The structural design is accurate, and the nitrogen heterocycle obviously regulates and controls the D-A effect. In the invention, the 1, 3, 5-trihydroxy phloroglucinol is covalently connected with the N-heterocyclic amine ligand, and a donor-acceptor (D-A) structure with a remarkable electron push-pull effect is formed in a covalent organic framework.

The invention relates to the technical field of food processing, in particular to a preparation method and application of zein-citrus pectin nanoparticles loaded with galangin. The preparation method comprises the following steps: providing a zein solution, and carrying out first mixing treatment on galangin powder and the zein solution to obtain a galangin-zein solution; dropwise adding the galangin-zein solution into a continuously stirred water phase, and concentrating to remove ethanol, so as to obtain a galangin-loaded zein nanoparticle dispersion liquid; providing a citrus pectin solution, carrying out second mixing treatment on the citrus pectin solution and the zein nanoparticle dispersion liquid loaded with galangin, and then carrying out post-treatment to obtain the zein-citrus pectin nanoparticles loaded with galangin, the nanoparticles are applied to the sauced products for the first time, the heterocyclic amine content in the sauced meat products is effectively reduced, and the safety of the sauced meat products is improved.

The invention relates to a preparation method, application and application of a nitrogen heterocyclic amine compound as a ubiquitin-specific protease 1 inhibitor, and particularly discloses a compound as shown in a formula (I), an optical isomer, a tautomer or pharmaceutically acceptable salt of the compound, and application of the compound as the ubiquitin-specific protease 1 inhibitor.

The invention discloses an azacyclo-amine compound as well as a pharmaceutical composition and application thereof. The structural formula of the compound is shown in the formula (I), and the invention further relates to a stereoisomer, a diastereoisomer, an enantiomer, a tautomer, a solvate, pharmaceutically acceptable salt, a prodrug or a mixture of the stereoisomer, the diastereoisomer, the enantiomer, the tautomer, the solvate and the pharmaceutically acceptable salt. The compound can effectively inhibit HPK1 activity and phosphorylation of downstream linker protein SLP76, improve the autoimmune function of a body and weaken the immune escape effect of tumor cells, and has wide application prospects in preparation of drugs for treating and / or preventing tumors related to HPK1 inhibition.

This invention relates to the field of high-performance epoxy resins, providing an epoxy resin and its preparation method that combine good storage stability, rapid curing, and high mechanical properties. The system uses a nitrogen-containing heterocyclic amine compound as a curing agent. At room temperature, the nitrogen atoms in the heterocycle inhibit the reactivity of the amino groups by forming hydrogen bonds, thus imparting good storage stability to the system. Under intermediate temperature conditions, the hydrogen bonds are broken, and the highly reactive amino groups rapidly initiate ring-opening reactions of the epoxy groups, achieving efficient curing in a short time, significantly improving processing efficiency and reducing energy consumption. After curing, strong hydrogen bond interactions form in the resin network, increasing network density and giving the material excellent mechanical properties and a high glass transition temperature. This invention effectively solves the problem of balancing mechanical properties and storage stability in single-component, rapid-curing epoxy resin systems, providing a new approach for developing epoxy resin materials with long latency, intermediate-temperature rapid curing, and high mechanical properties.

This technology provides a way to efficiently decompose polyurethane foam. [Solution] A method for producing a decomposition composition obtained by reacting polyurethane foam with a composition containing compound A and compound B, wherein compound A is a polyhydric alcohol, compound B is a metal carboxylate salt or a heterocyclic amine compound, and the amount of compound A added is greater than 100 parts by mass per 100 parts by mass of polyurethane foam.