52 results about "Heterocyclic amine" patented technology

The invention relates to a magnetic nano material for efficient enrichment and rapid desorption of heterocyclic amine as well as a preparation method and application of the magnetic nano material. The magnetic nano material is of a core-shell structure and sequentially comprises a Fe3O4 magnetic inner core, a magnetic core shell, a magnetic core shell and a magnetic core shell from inside to The surface of the Fe3O4 magnetic core is coated with the polydopamine intermediate layer; and the cysteine functional shell is bonded on the surface of the polydopamine intermediate layer. The Fe3O4 magnetic inner core provides magnetic responsiveness, the polydopamine middle layer provides strong adsorption sites, the cysteine functional shell provides specific recognition, the Fe3O4 magnetic inner core, the polydopamine middle layer and the cysteine functional shell have a synergistic effect, the adsorption effect on various common heterocyclic amines is good, and especially due to the introduction of the cysteine functional shell, the magnetic responsiveness is improved. The specific recognition of heterocyclic amine is obviously enhanced, the interference of other impurities in a food matrix is effectively reduced, and the purification effect is outstanding; and the device can be repeatedly used while the enrichment efficiency is ensured, so that the cost is reduced.

The invention discloses a liquid-liquid phase change absorbent and application thereof. The liquid-liquid phase change absorbent comprises the following components in percentage by mass: 20-50% of a main absorbent, 15-65% of a phase splitting agent, 1-15% of a crystallization inhibitor and 0-40% of water, wherein the total mass of the main absorbent is 100%; the crystallization inhibitor includes a combination of a carbonate and a heterocyclic amine. The phase change absorbent disclosed by the invention can be used for capturing CO2, can keep liquid-liquid phase change in a relatively wide temperature range, and can effectively inhibit crystallization, so that liquid-solid phase change can be avoided.

In order to overcome the problem of insufficient improvement of aging resistance of phenolic resin due to introduction of a modifier into existing phenolic resin, the invention provides modified phenolic resin which comprises the following components: a phenolic resin prepolymer and modified inorganic particles, wherein the modified inorganic particles are selected from inorganic particles treated by nitrogen heterocyclic amine; the inorganic particles comprise one or more of zirconium dioxide, molybdenum disulfide and boron carbide. Meanwhile, the invention further discloses a preparation method of the modified phenolic resin, a sealing material for a capacitor and the capacitor. The modified phenolic resin provided by the invention has excellent aging resistance, and is beneficial to improving the safety and prolonging the service life of a capacitor.

This invention provides a method for simultaneously detecting 17 heat-processing hazards in 4 categories, comprising: adding n-hexane to the sample, mixing thoroughly, discarding the n-hexane phase, extracting acrylamide, 5-hydroxymethylfurfural, and free heterocyclic amines using dimethyl ketone and ultrasound-assisted extraction, collecting the supernatant, and purifying it; simultaneously transferring the precipitate to another tube, reducing it with sodium tetrahydroborate, hydrolyzing it with hydrochloric acid to release bound heterocyclic amines and late-stage glycosylation products, and performing UPLC-MS / MS analysis. This invention is the first to propose a two-step extraction method for simultaneously determining 17 heat-processing hazards in 4 categories within 7 minutes using UPLC-MS / MS. The accuracy, precision, detection limit, quantitation limit, and recovery rate of the method were verified, and all test indicators met the requirements. This method is applicable to the determination of heat-processing hazards in four types of food matrices: high starch, high protein, high fat, and high sugar.

The present invention provides heterocyclylamine derivatives of Formula I:wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

The invention relates to the field of food detection, and particularly discloses a method for detecting heterocyclic amine substances in food. The detection method specifically comprises the following steps: sampling a target to-be-detected food, and performing pretreatment to obtain a to-be-detected sample; the method comprises the following steps: mixing a to-be-detected sample with acetonitrile, mixing with inorganic salt, centrifuging to obtain a sample extracting solution, blow-drying the extracted liquid nitrogen, redissolving, adding sporopollen for physical adsorption, and centrifuging to remove supernate to obtain the sporopollen adsorbed with heterocyclic amine substances; and adding an organic solvent into the sporopollen adsorbed with the heterocyclic amine substances for elution and centrifugation, and taking supernate for HPLC-MS / MS detection to obtain qualitative and quantitative analysis results of the heterocyclic amine substances contained in the food to be detected. According to the application, the heterocyclic amine adsorption efficiency is remarkably enhanced by utilizing the hydrogen-bond interaction, pi-pi and hydrophobic interaction of sporopollen, the convenience of detection of various heterocyclic amines in food is effectively improved, and the sensitivity and the accuracy are high.

The application discloses a method for reducing the content of heterocyclic amines and advanced glycation end products in grilled meat products by using plasma-activated water pretreatment. The method mainly comprises the following steps: treating distilled water by using cold plasma to prepare plasma-activated water; soaking raw meat in the plasma-activated water for pretreatment; grinding the soaked raw meat into meat patties, and then performing high-temperature grilling to obtain grilled meat products. The raw meat is pretreated by using plasma-activated water, and then high-temperature grilling is performed, so that the content of heterocyclic amines and advanced glycation end products in the grilled meat products is reduced, the grilled meat products are safer to eat, the method is simple to operate and low in cost, the method can be integrated into common steps (such as cleaning and marinating) of meat product processing, and the method can be applied to factory production; meanwhile, the sensory quality of the grilled meat products is not affected; and the method completely conforms to the development trend of natural, green and healthy.

The invention discloses a method for inhibiting formation of heterocyclic amine in roasted mutton and maintaining flavor by exogenous sulfur-containing amino acid, and belongs to the technical field of food processing.The method comprises the following steps that basic marinade is added into an aqueous solution of sulfur-containing amino acid to obtain marinade, the marinade is evenly smeared on the surface of diced meat, and the diced meat is placed in a sealed bag to be refrigerated and pickled; and after pickling is finished, baking is performed. According to the method, the specific influence of the exogenous sulfur-containing amino acid on the Maillard reaction path is researched, so that the effective inhibition of the heterocyclic amine and the good maintenance of the flavor are realized, and the effect of collaborative optimization is achieved. The method not only has significant new health value, but also has process feasibility and economic high benefits, and contributes to an innovative solution to the field of meat processing.

The application discloses a kind of composite dried meat and a preparation method thereof.The preparation raw material is beef and chicken, and the mass ratio of the amount of beef and chicken is 1:(1-3).The composite dried meat of the application uses beef and chicken as the preparation raw material, has the chewiness of beef and the tender taste of chicken, overcomes the defects that single beef jerky is hard and single chicken jerky has no chewiness, and the addition of sugarcane molasses and rosemary extract during preparation effectively inhibits the generation of heterocyclic amines, further improves the taste of dried meat, and increases the safety of consumption.

The invention relates to an N-(1H-pyrazol-3-yl) heterocyclic amine derivative, a preparation method thereof and application of a pharmaceutical composition containing the derivative in medicine. Specifically, the invention relates to N-(1H-pyrazol-3-yl) heterocyclic amine derivatives as shown in a general formula (I), a preparation method and pharmaceutically acceptable salts thereof, and application of the N-(1H-pyrazol-3-yl) heterocyclic amine derivatives and the pharmaceutically acceptable salts thereof as therapeutic agents, especially as PLK4 inhibitors, and definitions of substituent groups in the general formula (I) are the same as those in the specification.

The invention belongs to the technical field of compound synthesis, and particularly relates to a synthetic method of an azacyclo-amine derivative, which comprises the following steps: in the presence of mixed alkali and an organic solvent, reacting a compound # imgabs0 # as shown in a formula I with pyrrolidine or piperidine to generate an azacyclo-amine derivative # imgabs1 # as shown in a formula II, in which R1 is selected from # imgabs2 # and X is selected from halogen; r2 is selected from # imgabs3; R3 is selected from the following groups: # imgabs4; and the mixed alkali is a combination of organic alkali and inorganic alkali. Compared with the existing synthesis method, the method provided by the invention has the advantages of simple operation steps, high product yield and no need of dangerous raw materials through one-step reaction.

The invention discloses a CoCu-based bimetallic oxide catalyst, a preparation method of the CoCu-based bimetallic oxide catalyst and a preparation method of 2, 5-furandicarboxylic acid. The preparation method of the catalyst comprises the following steps: mixing a Co precursor, a Cu precursor, a heterocyclic dicarboxylic acid compound, a heterocyclic amine compound containing more than two nitrogen atoms and a carbon material in a solvent, reacting, and roasting to obtain the CoCu-based bimetallic oxide catalyst. The preparation method of the 2, 5-furandicarboxylic acid comprises the following step: carrying out catalytic oxidation reaction on 5-hydroxymethylfurfural in the presence of the catalyst, an oxidant and water to obtain the 2, 5-furandicarboxylic acid. The catalyst adopts the non-noble metal, can efficiently catalyze and oxidize the 5-hydroxymethylfurfural to prepare the 2, 5-furandicarboxylic acid, and has the advantages of mild reaction conditions, less non-noble metal consumption, high conversion rate of the 5-hydroxymethylfurfural, high yield of the 2, 5-furandicarboxylic acid and the like.

To provide a pseudo-dog smell composition which generates a smell similar to a dog smell generated when a dog is kept indoors, for example.SOLUTION: A pseudo-dog smell composition according to an embodiment of the present invention includes: one or more aliphatic saturated hydrocarbons having a carbon number in a range of 8 or more and 20 or less; one or more aliphatic aldehydes having a carbon number in a range of 6 or more and 18 or less; one or more aliphatic monocarboxylic acids having a carbon number in a range of 3 or more and 9 or less; and one or more heterocyclic amines selected from pyrrolines, pyridines, and pyrazines which are optionally substituted with a lower alkyl group or acetyl group.SELECTED DRAWING: None

The application relates to a method for improving the flavor of meat products and reducing the content of heterocyclic amines based on soybean polysaccharides, which comprises the following steps: mixing soybean dietary fiber with deionized water, stirring and extracting after adjusting the pH, and separating the solid phase through solid-liquid separation; mixing the obtained solid phase with deionized water, extracting after adjusting the pH, and separating the liquid phase through solid-liquid separation, concentrating, and obtaining concentrated liquid; mixing the obtained concentrated liquid with alcohol, separating the solid phase through solid-liquid separation, drying, crushing and sieving the obtained solid phase, and obtaining soybean polysaccharides; mixing the obtained soybean polysaccharides with meat paste, stirring uniformly, pressing and shaping, and baking, and obtaining meat products. The soybean polysaccharides are extracted from soybean dietary fiber, added into meat products to improve the flavor variety of the meat products, reduce the content of heterocyclic amines, and further obtain healthy and delicious heat-processed meat products.

The present invention relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same. The compound according to the present invention is useful in the prevention or treatment of inflammatory diseases, autoimmune diseases or cancers. In Chemical Formula 1, Y1, R1, A, R2, k, Y2, L, X and R3 are as defined in the specification. [Chemical Formula 1]

The invention belongs to the technical field of meat product processing, and discloses a meat composite curing agent as well as a preparation method and application thereof. The meat composite pickling agent comprises the following raw materials in parts by weight: 20-30 parts of roxburgh rose pomace enzymatic hydrolysate, 5-10 parts of mushroom peptide, 3-6 parts of celery powder, 0.5-1.5 parts of compound bacterium powder, 10-15 parts of spice powder and 8-12 parts of auxiliary materials. Wherein a preparation method of the rosa roxburghii tratt fruit residue enzymatic hydrolysate comprises the following steps: adding rosa roxburghii tratt fruit residues into a tea polyphenol solution, carrying out enzymolysis treatment after ultrasonic treatment, and filtering to obtain filtrate; the celery powder is obtained by drying celery stems at low temperature and then crushing the dried celery stems. The meat composite curing agent contains various micromolecular bioactive substances, can effectively permeate into meat tissues when being used for curing meat, reduces generation of typical harmful substances such as heterocyclic amine and benzopyrene in high-temperature processing processes such as baking and deep-frying, and simultaneously endows meat products with coordinated fragrance, rich levels and fine taste.

An aspect of the present disclosure relates to a dispersant composition for an electrode of a power storage device. The dispersant composition contains an acrylic polymer (A), an amine compound (B) with a boiling point of 200° C. or less, and an organic solvent (C). The acrylic polymer (A) contains a constitutional unit a represented by the following formula (1). The compound (B) is at least one amine compound selected from the group consisting of a secondary aliphatic amine, a tertiary aliphatic amine, an aromatic amine, and a heterocyclic amine.

The application discloses a processing method for reducing heterocyclic amines in barbecue meat while maintaining characteristic flavor, and belongs to the technical field of food processing. The application solves the technical problems of high heterocyclic amine generation in the high-temperature roasting process of the existing barbecue method and insufficient flavor caused by simply reducing the temperature. The method comprises the following steps: soaking fresh meat pieces in a phosphate buffer solution containing glucose oxidase and catalase for low-temperature treatment after the fresh meat is cut into pieces; preparing a flavor precursor coating liquid composed of xylose, cysteine, glycine, peanut oil and water and performing high-speed shear emulsification treatment; immersing the drained meat pieces in the coating liquid to make the surface uniformly adhere; and then placing the coated meat pieces in a far-infrared oven for roasting while inserting a probe type thermometer to monitor the center temperature. The application is mainly used in the field of barbecue meat processing and can effectively reduce the generation of heterocyclic amines while effectively maintaining the characteristic flavor of the roasted meat.

A lubricating oil composition including 60 to 95 mass% of one or more base oils, and 5 to 40 mass% of three or more additives, wherein the at least three additives comprise: from 0.01 to 0.5 mass% of an unhindered heterocyclic amine corrosion inhibitor, from 0.1 to 5 mass% of an organic friction modifier, and from 0.01 to 2 mass% of an inorganic friction modifier. Also disclosed is a method of reducing friction in a crankcase or improving the efficiency of an internal combustion engine using the lubricating oil composition. Also disclosed is a concentrate including the unhindered heterocyclic amine corrosion inhibitor, the organic friction modifier, and the inorganic friction modifier.

The present invention relates to a novel heterocyclic amine derivative represented by the following chemical formula 1 and a pharmaceutical composition containing the same, wherein the compounds according to the present invention can be usefully used for the prevention or treatment of inflammatory diseases, autoimmune diseases, or cancer. [Case 1] In the above chemical formula 1, the descriptions of Y1, R1, A, R2, k, Y2, L, X, and R3 are as defined in the specification.

The MeIQx inhibitor is prepared from the following raw materials in parts by weight: 2.5 to 10 parts of gallic acid, 10 to 15 parts of allicin, 5 to 8 parts of black pepper extract, 2 to 5 parts of curcumin and 6 to 9 parts of compound spice. The gallic acid, the allicin, the black pepper extract, the curcumin and the compound spice are all natural components, through the synergistic effect of the components, the inhibiting effect on MeIQx is remarkably enhanced, the inhibiting effect on heterocyclic amine precursors and intermediates is achieved, and the obvious inhibiting effect on MeIQx generated in the high-temperature processing process of aquatic products is achieved.

The application provides a preparation method and application of an aqueous composite electrolyte, which comprises uniformly mixing an aqueous zinc salt and a water-soluble heterocyclic amine organic additive; adding deionized water and continuously stirring until dissolution, and then standing until the pH value is stable to obtain the aqueous composite electrolyte. The additive can improve the stability of the aqueous electrolyte, and the zincophilic group in the organic additive molecule can form a coordination bond with zinc ions, so that the additive molecules can be adsorbed on the surface of a zinc electrode, balance the electric field distribution on the electrode surface, prevent the non-uniform deposition of zinc ions on the electrode surface, reduce the dendrite growth caused by the excessive local electric field, improve the utilization rate of zinc, and effectively improve the performance of the battery. After the additive molecules are adsorbed on the surface of the zinc electrode, a part of the active sites for the hydrogen evolution reaction on the electrode surface can be covered, the hydrogen evolution reaction can be inhibited, the generation of by-products can be reduced, the coulombic efficiency can be improved, and the corrosion resistance and cycle stability of the zinc negative electrode can be effectively improved.

This invention discloses a method for preparing a nitrogen-containing heterocyclic D-A type COF photocatalyst and its application. The specific steps are as follows: Step S1, an aldehyde ligand and an amino ligand are added to a Pyrex reaction tube at a molar ratio of 2:3. The aldehyde ligand is a trialdehyde pyrogallol, and the amino ligand is an aromatic amine compound containing a nitrogen-containing heterocyclic ring. Step S2, a mixed organic solvent composed of mesitylene and 1,4-dioxane is added to the Pyrex reaction tube from Step S1, and an aqueous acetic acid solution is added as a catalyst to obtain mixture a. Step S3, the Pyrex reaction tube containing mixture a from Step S2 is ultrasonically treated to form a uniform suspension. This invention relates to the field of functional materials and photocatalysis technology. The structure is precisely designed, and the nitrogen-containing heterocyclic ring significantly modulates the D-A effect. In this invention, the 1,3,5-trihydroxypyrogallol and the nitrogen-containing heterocyclic amine ligand are covalently linked to form a donor-acceptor (D-A) structure with a significant electron push-pull effect within a covalent organic framework.

The invention discloses a recombinant omega-transaminase mutant and application thereof, relates to the technical field of biochemistry, and discloses plasmids and recombinant cells of the recombinant omega-transaminase mutant, and the nucleotide sequence of a coding gene of the mutant is shown as SEQ ID No.4. According to the application of the mutant of the recombinant omega-transaminase in synthesis of the chiral N-heterocyclic amine intermediate, a buffer solution, a substrate, a cofactor, an amino donor and a catalyst are sequentially added into a reaction system for reaction, and the chiral N-heterocyclic amine intermediate is generated. The activity and stereoselectivity of the omega-transaminase mutant obtained through enzyme engineering modification are obviously improved. The recombinant omega-transaminase catalyst can catalytically synthesize five chiral N-heterocyclic amines with high added values, the reaction conversion rate can reach 99% at most, and the optical purity of the product can reach 99% or above.

The invention relates to the technical field of food detection sampling, and provides sampling equipment for detecting the heterocyclic amine content of meat products and a detection method.The sampling equipment comprises a rack, a material bearing table is erected on the rack, and the material bearing table is used for bearing meat product samples; the jacking and pressing frame is arranged on the rack in a lifting and sliding manner, the jacking and pressing frame is located above the material bearing table, and an abutting and pressing plate is arranged at the bottom of the jacking and pressing frame and can be driven by the jacking and pressing frame to move downwards so as to flatten meat product samples on the material bearing table; the cutter is horizontally arranged on the jacking frame in a sliding manner, the plate surface of the cutter is arranged in the horizontal direction, and the cutter can horizontally slide so as to cut meat product samples below the pressing plate in a layered manner. According to the sampling equipment for detecting the heterocyclic amine content of the meat product, the relative lifting motion of the material bearing table and the jacking frame is matched with the flattening effect of the abutting plate on meat product samples, a flat cutting datum plane is provided for the cutter, and the problem that stripping is not thorough or excessive due to the sample form difference during manual slitting is solved.

The present invention employs a resist composition in which a resin component, the solubility of which with respect to a developing solution changes by the action of an acid, includes a polymer having a group represented by formula (I-1) at a terminal of the main chain thereof. In formula (I-1), R1 is a hydrocarbon group having 1-10 carbon atoms, Z is a cyano group or a hydrocarbon group having 1-10 carbon atoms, and R1 and Z may be bonded to each other to form a ring. X is a divalent linking group. R2 is an amino group represented by formula (R2-1) or a heteroaryl group represented by formula (R2-2). In the formula (R2-1), R101 and R102 are each chain hydrocarbon groups or are bonded to each other to form a heterocyclic group derived from a heterocyclic amine. In the formula (R2-2), Rar represents an aromatic ring derived from a heterocyclic amine, and the nitrogen atom in the formula is not bonded to a hydrogen atom. According to such a resist composition, the effect of reducing roughness and the exposure margin are enhanced.

The invention discloses a thermosetting adhesive composition. The thermosetting adhesive composition contains an epoxy resin, an elastomer, and a curing accelerator. The curing accelerator is a compound that produces a heterocyclic amine compound by heating.

The present invention provides an acidic gas absorbent that absorbs a large amount of carbon dioxide, efficiently separates and recovers it, and has low emission compared to other amines, as well as an acidic gas removal device and acidic gas removal method using the same. [Solution] The acidic gas absorbent of the embodiment comprises a heterocyclic amine compound represented by the following formula (1) and a low molecular weight polyol compound. JPEG2026084925000006.jpg2787 [In the formula, R 1 Each of these independently represents a hydrogen atom, a hydroxyl group, and a hydroxyalkyl group or aminoalkyl group having 1 to 6 carbon atoms, R 2 R represents a hydroxyalkyl group or aminoalkyl group having 2 to 6 carbon atoms. 1 and R 2 At least one of them contains a hydroxyalkyl group or an aminoalkyl group.

The invention discloses beta-glucuronidase, a nucleotide sequence of a gene of the beta-glucuronidase and application of the beta-glucuronidase, the gene of the beta-glucuronidase and a protein sequence of the beta-glucuronidase are related to food-borne hazardous substances, and the beta-glucuronidase capable of efficiently and specifically activating cancerogens such as heterocyclic amine HAAs is constructed. The inhibitor designed aiming at the enzyme can reduce interference on intestinal effective microbial communities and human body GUS activity to the maximum extent, side effects are smaller, a research and development basis is provided for further high-throughput drug screening, computer-aided drug design and antibody drug development, and the inhibitor has a great application prospect.

The invention relates to the field of food, and particularly discloses a method for removing heterocyclic amine substances in edible oil and application of the method. The removing method comprises the following steps: decoloring, degreasing and desugaring natural pollen particles to obtain a sporopollen adsorbing material; and fully mixing the agaricus bisporus adsorbing material with edible oil, and carrying out solid-liquid separation to obtain the edible oil without the heterocyclic amine substances. Experimental results show that at least 12 heterocyclic amines in edible oil can be effectively removed through the agaricus bisporus adsorbing material, and the removal rate of part of substances reaches up to 95% or above. Meanwhile, no negative influence is generated on the quality and flavor of the edible oil. The efficient heterocyclic amine removal technology not only improves the safety of the edible oil, but also retains the original nutritional ingredients and unique flavor of the edible oil.