8 results about "Dorsal roots" patented technology

The invention discloses a method for inducing dorsal root node satellite glial cells to be reprogrammed into neurons by using a small molecule compound and application of the method. The small molecule compound composition is prepared from ISX-9, RO4929097, CHIR99021, VPA, RepSox, Forskolin, SC79 and VC, and growth factors BDNF, GDNF, NT-3 and NGF beta, neuron culture additives B27 and N2 additives are added at the same time, so that survival and maturation of neurons are promoted and induced. Wherein each component is a safe and low-cost small molecule compound and a neurotrophic factor, and the pharmaceutical composition and the growth factor can be used for reprogramming rat dorsal root ganglion satellite glial cells into neurons with specific phenotypes and functional characteristics in vitro. And a new seed cell is provided for basic research of clinical nerve injury diseases and clinical cell treatment development.

The invention relates to an ejaculation control nerve regulation and control method and device based on electric pulse dynamic adjustment, and belongs to the field of medical instrument electronic products, and the method comprises the steps: S1, judging whether the positions of two electrodes are effective stimulation positions or not according to the collected contact resistance of the two electrodes at the dorsal root of the penis for stimulating the dorsal root of the penis; if so, entering the next step; otherwise, adjusting the positions of the two electrodes until the effective positions are judged, and then entering the next step; s2, selecting at least one working mode of a high-frequency mode, a low-frequency mode, a frequency mixing mode, a frequency mixing group mode and a modulation frequency mixing mode, and outputting electric pulse signals corresponding to the frequency modes to the dorsal root nerves of the penis through the two electrodes for electrical stimulation; s3, in the electrical stimulation process, according to the collected contact resistance values of the two electrodes, the output energy of the electric pulse signal is dynamically adjusted, and the dynamic balance of the charging and discharging process is controlled; therefore, the effectiveness and safety of electrical stimulation are ensured. The ejaculation control nerve regulation is safer and more effective.

Systems, devices, and methods for affecting a patient's organ function by innervating one or more organs of the patient are described herein. Innervating one or more organs of the patient is induced via electrical stimulation to nerve fibers, such as afferent nerve fibers, of one or more of the patient's dorsal roots. Electrical stimulation to dorsal root nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the dorsal root nerve fibers.

The present invention relates to a neuromodulation / neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: —at least one control unit (12) configured and arranged to provide stimulation data, and—at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to deliver epidural electrical stimulation to the spinal cord of said mammal, according to said stimulation data, wherein the at least one stimulation unit (14) includes a biocompatible implantable lead (18) configured and arranged to cover at least a portion of the spinal cord of said mammal to deliver epidural electrical stimulation to the dorsal roots innervating the spastic muscles to target neuronal circuitry responsible for spastic episodes.

The present invention relates to a neuromodulation / neurostimulation system (100) for restoring motor function of an upper limb and / or a lower limb of a patient (P) suffering from spinal cord injury (SCI) and / or other neurological conditions and promoting neurological restoration, the system (100) comprising: a processing unit (10) configured and adapted to provide stimulation commands; an implantable or external stimulation unit (12) configured and adapted to deliver neuromodulation therapy, in particular electrical epidural stimulation (EES), to the dorsal root of the spinal cord (SC) of the patient (P); at least one implantable or external pulse generator (14), the at least one implantable or external pulse generator being operatively connected to the stimulation unit (12); an implantable neural sensor (16), the implantable neural sensor comprising an electronic component configured and adapted to detect a cerebral electrocorticogram (ECoG) signal representing a motor intent of the patient (P) from a sensory motor cortex (C) of the patient (P), wherein the processing unit (10), the stimulation unit (12) and the implantable neural sensor (16) are operatively connected to define a cerebrospinal cord interface (BSI), and wherein the processing unit (10) is configured and adapted to: preferably collect the ECoG signals from the sensory motor cortex (C) in real time and decode the ECoG signals into corresponding motor intent of the patient (P); the decoded motion intent is converted, preferably in real time, into a corresponding stimulation command, and the stimulation command is forwarded, preferably in real time, to the at least one pulse generator (14).

Provided herein are compositions and methods for retargeting viral particles, e.g., adeno-associated virus (AAV) particles, to p75NTR-expressing cells using p75NTR-targeting ligands. AAV adapted accordingly may be a viable gene therapy platform to target nervous system cells (e.g., dorsal root ganglia, trigeminal ganglia, etc.) for the treatment or prevention of pain, itch, or a neurological disease or disorder in a subject in need thereof.

Devices, systems, and techniques for determining medical lead placement are described. In one example, a system includes sensing circuitry configured to detect, via a lead, a bioelectric signal of the patient, wherein the lead comprises one or more electrodes, and wherein the lead is configured to be located in an epidural space of a patient and displaced laterally from a dorsal horn of the patient. Additionally, the system includes processing circuitry configured to determine, based on the bioelectric signal, a proximity of each electrode of the one or more electrodes to a dorsal root of the patient; and output information indicative of the proximity of each electrode of the one or more electrodes to the dorsal root.

A micro liquid thermal regulator (MLTR) utilizes closed-loop cooling and micro-channel technology to deliver targeted pain suppression. The system comprises a source of cooling liquid supplying the cooling liquid to a conduit that carries the cooling liquid to a neural cooling element. The neural cooling element has a cooling surface that is cooled by the cooling liquid supplied by the conduit, and is configured for placement in an area of nerve tissue in the organism such that the cooling surface cools the nerve tissue and reduces pain. Implanted onto ganglia, e.g., the dorsal root ganglia (DRG), the MLTR can reduce the temperature to as low as 10° C., effectively modulating internal molecular channel activity and reducing pain perception.