21 results about "Dorsal roots" patented technology

The invention discloses an anesthesia anatomy display and interaction method based on virtuality and reality combination, and relates to the technical field of anesthesia monitoring, and the method comprises the steps: carrying out the registration of a three-dimensional anatomy model and a real-time space coordinate system, marking a high-risk region through a nerve excitement index, and generating a dynamic risk marking graph; according to the dynamic risk marker graph, generating a real-time tactile feedback gain vector through spinal dorsal root gating algorithm and three-dimensional gain field synthesis calculation; and gradient tactile signal output is driven based on the real-time tactile feedback gain vector, impedance data is acquired in real time for characteristic analysis, and when it is detected that impedance characteristics abnormally change, a safe path correction instruction is generated and a nerve contact identifier is triggered. The problem that in the prior art, individual nerve excitation states and dynamic changes cannot be reflected by depending on static and universal anatomical models is effectively solved, and the safety and accuracy of anesthesia operation are improved.

The invention discloses a method for inducing dorsal root node satellite glial cells to be reprogrammed into neurons by using a small molecule compound and application of the method. The small molecule compound composition is prepared from ISX-9, RO4929097, CHIR99021, VPA, RepSox, Forskolin, SC79 and VC, and growth factors BDNF, GDNF, NT-3 and NGF beta, neuron culture additives B27 and N2 additives are added at the same time, so that survival and maturation of neurons are promoted and induced. Wherein each component is a safe and low-cost small molecule compound and a neurotrophic factor, and the pharmaceutical composition and the growth factor can be used for reprogramming rat dorsal root ganglion satellite glial cells into neurons with specific phenotypes and functional characteristics in vitro. And a new seed cell is provided for basic research of clinical nerve injury diseases and clinical cell treatment development.

The invention relates to an ejaculation control nerve regulation and control method and device based on electric pulse dynamic adjustment, and belongs to the field of medical instrument electronic products, and the method comprises the steps: S1, judging whether the positions of two electrodes are effective stimulation positions or not according to the collected contact resistance of the two electrodes at the dorsal root of the penis for stimulating the dorsal root of the penis; if so, entering the next step; otherwise, adjusting the positions of the two electrodes until the effective positions are judged, and then entering the next step; s2, selecting at least one working mode of a high-frequency mode, a low-frequency mode, a frequency mixing mode, a frequency mixing group mode and a modulation frequency mixing mode, and outputting electric pulse signals corresponding to the frequency modes to the dorsal root nerves of the penis through the two electrodes for electrical stimulation; s3, in the electrical stimulation process, according to the collected contact resistance values of the two electrodes, the output energy of the electric pulse signal is dynamically adjusted, and the dynamic balance of the charging and discharging process is controlled; therefore, the effectiveness and safety of electrical stimulation are ensured. The ejaculation control nerve regulation is safer and more effective.

Systems, devices, and methods for affecting a patient's organ function by innervating one or more organs of the patient are described herein. Innervating one or more organs of the patient is induced via electrical stimulation to nerve fibers, such as afferent nerve fibers, of one or more of the patient's dorsal roots. Electrical stimulation to dorsal root nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the dorsal root nerve fibers.

The present invention relates to a neuromodulation / neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: —at least one control unit (12) configured and arranged to provide stimulation data, and—at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to deliver epidural electrical stimulation to the spinal cord of said mammal, according to said stimulation data, wherein the at least one stimulation unit (14) includes a biocompatible implantable lead (18) configured and arranged to cover at least a portion of the spinal cord of said mammal to deliver epidural electrical stimulation to the dorsal roots innervating the spastic muscles to target neuronal circuitry responsible for spastic episodes.

The present invention relates to a neuromodulation / neurostimulation system (100) for restoring motor function of an upper limb and / or a lower limb of a patient (P) suffering from spinal cord injury (SCI) and / or other neurological conditions and promoting neurological restoration, the system (100) comprising: a processing unit (10) configured and adapted to provide stimulation commands; an implantable or external stimulation unit (12) configured and adapted to deliver neuromodulation therapy, in particular electrical epidural stimulation (EES), to the dorsal root of the spinal cord (SC) of the patient (P); at least one implantable or external pulse generator (14), the at least one implantable or external pulse generator being operatively connected to the stimulation unit (12); an implantable neural sensor (16), the implantable neural sensor comprising an electronic component configured and adapted to detect a cerebral electrocorticogram (ECoG) signal representing a motor intent of the patient (P) from a sensory motor cortex (C) of the patient (P), wherein the processing unit (10), the stimulation unit (12) and the implantable neural sensor (16) are operatively connected to define a cerebrospinal cord interface (BSI), and wherein the processing unit (10) is configured and adapted to: preferably collect the ECoG signals from the sensory motor cortex (C) in real time and decode the ECoG signals into corresponding motor intent of the patient (P); the decoded motion intent is converted, preferably in real time, into a corresponding stimulation command, and the stimulation command is forwarded, preferably in real time, to the at least one pulse generator (14).

The invention discloses an implantable electrode and a system for treating hypertension by adopting the same. The implantable electrode for treating hypertension comprises a catheter, a stimulating electrode slice, a guide wire and an insulating film, the two stimulating electrode plates are arranged on the two sides of the exterior of the catheter respectively, are connected with the exterior through guide wires arranged in the catheter respectively and are used for emitting current to stimulate nerves according to external signals; one end of the insulating film is arranged outside the catheter and located between the two stimulating electrode slices and used for wrapping the stimulating electrode slices making contact with the nerves and the outside of the nerves so that the stimulating electrode slices can be insulated from the outside. The invention discloses a system for treating hypertension by adopting an implantable electrode. The system comprises an implantable electrical stimulation device, a blood pressure monitoring device and a remote analysis monitoring platform. According to the implantable electrode and the system for treating hypertension by adopting the implantable electrode disclosed by the invention, extremely low-intensity electrical stimulation is given to renal sympathetic nerve introduced nerve fibers in dorsal root nerves through the stimulation electrode to inhibit the activity of the nerve fibers, so that the blood pressure of a patient is kept relatively stable, and the risk of complications caused by blood pressure fluctuation is reduced; the medicine taking amount of a hypertensive patient can be greatly reduced, and even the hypertensive patient may stop taking hypertensive medicines.

A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and / or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and / or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal.

Provided herein are compositions and methods for retargeting viral particles, e.g., adeno-associated virus (AAV) particles, to p75NTR-expressing cells using p75NTR-targeting ligands. AAV adapted accordingly may be a viable gene therapy platform to target nervous system cells (e.g., dorsal root ganglia, trigeminal ganglia, etc.) for the treatment or prevention of pain, itch, or a neurological disease or disorder in a subject in need thereof.

The invention discloses an application of a gene inhibitor in preparation of a medicine for treating diseases caused by neurite overgrowth, and the gene inhibitor inhibits the growth of neurite by inhibiting the expression of Tribbles homologous protein 3 pseudokinase. The invention proposes and verifies that the inhibitor can effectively inhibit growth and regeneration of dorsal root ganglion for the first time, and provides a new direction for research and development of drugs for treating neuropathic pain and autism spectrum disorders.

The present invention relates generally to compositions and methods for modulating cell activity using multi-characteristic opsin proteins (MCOs). In addition, the present invention provides methods of treating conditions associated with dorsal root ganglion (DRG), anterior clasps cortex (ACC), or spinal cord activity, including neuropathic pain. Particular embodiments include methods of modulating an inhibitory pathway to inhibit chronic neuropathic pain. The method may use a photosensitive optogenetic actuator with inhibitory neuron specificity. Embodiments also include an optogenetic pain regulator device that can regulate the frequency and intensity of optogenetic stimulation.

The present disclosure provides sequences that reduce the expression of operably linked transgenes in dorsal root ganglion cells and / or hepatocytes. In some aspects, the sequences may be employed in gene therapy vectors to off-target expression of a therapeutic transgene in the dorsal root ganglion and / or hepatocytes of a subject.

Provided herein are compositions and methods for retargeting viral particles, e.g., adeno-associated virus (AAV) particles, to p75NTR-expressing cells using p75NTR-targeting ligands. AAV adapted accordingly may be a viable gene therapy platform to target nervous system cells (e.g., dorsal root ganglia, trigeminal ganglia, etc.) for the treatment or prevention of pain, itch, or a neurological disease or disorder in a subject in need thereof.

Devices, systems, and techniques for determining medical lead placement are described. In one example, a system includes sensing circuitry configured to detect, via a lead, a bioelectric signal of the patient, wherein the lead comprises one or more electrodes, and wherein the lead is configured to be located in an epidural space of a patient and displaced laterally from a dorsal horn of the patient. Additionally, the system includes processing circuitry configured to determine, based on the bioelectric signal, a proximity of each electrode of the one or more electrodes to a dorsal root of the patient; and output information indicative of the proximity of each electrode of the one or more electrodes to the dorsal root.

The invention relates to the technical field of spine CT image processing, in particular to a deep learning-based dorsal root ganglion positioning method under foramen intervertebrale radiography. The method comprises the following steps: inputting a plurality of spine CT images of a user at different scanning angles into a neural network model to obtain a neural recognition region of each spine CT image and image areas of dorsal root ganglions in corresponding compression states at different scanning angles; performing de-overlapping processing based on gray activation differences of the plurality of pooling layers to determine an actual outer boundary of the neural recognition region; according to the corresponding relation between the image area of each spine CT image and the intervertebral space, the position of the actual outer boundary inner dorsal root ganglion is subjected to credibility labeling; according to the credibility labeling result of the position where the dorsal root ganglion is located, the dorsal root ganglion of the user is visually displayed. According to the invention, the technical problem that the identification accuracy is influenced by similar tissues around the dorsal root ganglion can be reduced.

The application discloses a thoracic dorsal root ganglion positioning method based on ultrasonic scanning and relates to the technical field of image recognition, and comprises the following steps: acquiring a magnetic resonance scanning image of a horizontal cross section of an intervertebral foramen / intervertebral space of a target thoracic vertebra segment, measuring the magnetic resonance scanning image, and acquiring a first distance; setting a needle insertion scheme and a second distance based on the first distance, pleural information and rib information; pre-scanning a target puncture area of a patient through ultrasonic waves, marking a dorsal root ganglion position and an ultrasonic probe position, and presetting a puncture point based on the second distance to complete thoracic dorsal root ganglion positioning. The application presets a puncture path and a needle insertion point according to a pleural position in the magnetic resonance scanning image (the pleura is avoided during the puncture process); measures a vertical distance from the needle insertion point to a surface projection line of a spinous process connecting line in the magnetic resonance image, and positions the puncture point on the surface of the patient in advance according to the vertical distance.

The invention discloses an application of an SIX family homologous box gene 4 inhibitor in preparation of drugs for promoting growth of neurons of a peripheral nervous system, and the inhibitor inhibits expression of the SIX family homologous box gene 4 through nucleic acid molecules loaded by a carrier so as to realize regulation and control of the neurons of the peripheral nervous system. The invention provides and verifies for the first time that inhibition of expression of the SIX family homologous box gene 4 can promote growth of neurons of the peripheral nervous system, effective regeneration of dorsal root ganglions is realized, recovery of related functions is accelerated, and a new direction is provided for research and development of drugs for treating traumatic or disease injuries of neurons of the peripheral nervous system.

Methods of treating a genetic disorder and assessing AAV-induced dorsal root ganglia (DRG) toxicity in a subject are provided.

A micro liquid thermal regulator (MLTR) utilizes closed-loop cooling and micro-channel technology to deliver targeted pain suppression. The system comprises a source of cooling liquid supplying the cooling liquid to a conduit that carries the cooling liquid to a neural cooling element. The neural cooling element has a cooling surface that is cooled by the cooling liquid supplied by the conduit, and is configured for placement in an area of nerve tissue in the organism such that the cooling surface cools the nerve tissue and reduces pain. Implanted onto ganglia, e.g., the dorsal root ganglia (DRG), the MLTR can reduce the temperature to as low as 10° C., effectively modulating internal molecular channel activity and reducing pain perception.

Provided herein are methods of expressing tripeptidyl peptidase 1 (TPP1) in neurons. Also provided herein are modified adeno-associated viruses (AAVs) encoding TPP1 under the control of a promoter operable in neuronal or ventricular membrane cells rather than in the dorsal root ganglion.

The invention provides a spinal cord puncture type electrode and an abnormal tissue monitoring system, and relates to the technical field of spinal cord dorsal root marrow entering region damage operation treatment, the spinal cord puncture type electrode is used for puncturing to a spinal cord dorsal root marrow entering region in the spinal cord dorsal root marrow entering region damage operation, and the spinal cord puncture type electrode comprises an electrode puncture head; the electrode puncture head is provided with a plurality of detection sites which are distributed in a two-dimensional mode in the transverse axis direction and the longitudinal axis direction, and the detection sites are used for collecting nerve electrophysiological signals in the length direction and the depth direction of a marrow entering area in the spinal cord dorsal root marrow entering area ablation operation; an intraoperative electrophysiology monitoring device in communication connection with the spinal cord puncture type electrode is used for receiving the nerve electrophysiology signals and confirming the abnormal tissue position of the spinal cord dorsal root marrow entering area according to the nerve electrophysiology signals and the positions of the multiple detection sites in the spinal cord dorsal root marrow entering area. Quantifiable, quantifiable and objective guidance of the lesion depth is realized, the surgical curative effect is improved, and complications are slowed down.