3 results about "Dorsal roots" patented technology

Systems, devices, and methods for affecting a patient's organ function by innervating one or more organs of the patient are described herein. Innervating one or more organs of the patient is induced via electrical stimulation to nerve fibers, such as afferent nerve fibers, of one or more of the patient's dorsal roots. Electrical stimulation to dorsal root nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the dorsal root nerve fibers.

The present invention relates to a neuromodulation / neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: —at least one control unit (12) configured and arranged to provide stimulation data, and—at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to deliver epidural electrical stimulation to the spinal cord of said mammal, according to said stimulation data, wherein the at least one stimulation unit (14) includes a biocompatible implantable lead (18) configured and arranged to cover at least a portion of the spinal cord of said mammal to deliver epidural electrical stimulation to the dorsal roots innervating the spastic muscles to target neuronal circuitry responsible for spastic episodes.

Provided herein are compositions and methods for retargeting viral particles, e.g., adeno-associated virus (AAV) particles, to p75NTR-expressing cells using p75NTR-targeting ligands. AAV adapted accordingly may be a viable gene therapy platform to target nervous system cells (e.g., dorsal root ganglia, trigeminal ganglia, etc.) for the treatment or prevention of pain, itch, or a neurological disease or disorder in a subject in need thereof.