8 results about "Zinc finger" patented technology

This disclosure relates to dihydropyrimidine-2,4(1H,3H)-dione-containing polycyclic compounds or pharmaceutically acceptable salts thereof and compositions thereof that effectively reduce or regulate the expression level of broad-space zinc finger motif (WIZ) proteins and / or induce the expression of fetal hemoglobin (HbF), as well as methods for preparing them and their use in the treatment of subjects requiring them.

The application discloses a DNA binding single-zinc finger protein OsDOF22 The application discloses a DNA binding single-zinc finger protein OsDOF22 The nucleotide sequence is shown as SEQ ID NO. 1, and the corresponding protein amino acid sequence is shown as the sequence table SEQ ID NO. 2. The application reports for the first time that OsDOF22 The gene can regulate the growth of primary roots in the germination stage, and experiments show that the mutation of the gene reduces the length of the primary roots of rice, and the overexpression of the gene improves the root growth ability of rice in the germination stage. It is proved that the application OsDOF22 The gene regulates the length of the primary roots of rice in the germination stage, and the use of the gene is helpful to screening and cultivating high-activity rice varieties and is beneficial to the direct seeding rice production.

Methods of inducing rejuvenation in a population of adult glial progenitor cells, and methods of treating a subject having a myelin deficiency are disclosed in this patent application. The method of inducing rejuvenation in a population of adult glial progenitor cells may comprise administering, to the population of adult glial progenitor cells, an effective amount of an agent that suppresses one or more transcription factors selected from the group consisting of (i) zinc finger protein 274 (ZNF274), (ii) Myc-associated factor X (MAX), (iii) E2F transcription factor 6 (E2F6), (iv) zinc finger protein Aiolos (IKZF3), and (v) signal transducer and activator of transcription 3 (STAT3).

The application belongs to the technical field of disease treatment, and discloses TRAFD1 induced activation of CD8+ T cell immune response and application in treatment of pancreatic cancer. It is found in the application that TRAF-type zinc finger domain containing 1 gene (TRAFD1) can be used as a molecular marker for predicting whether a pancreatic cancer patient can benefit from immunotherapy. Meanwhile, TRAFD1 promotes the effect of immunotherapy by affecting the activation and effector function of CD8+ T cells, which has important significance for promoting pancreatic cancer immunotherapy.

Provided herein are isoindolinones, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disorder, disease, or condition mediated by a zinc-figure protein, casein kinase 1α, GSPT1, or PDE6D.

The present disclosure provides a vector containing a target sequence that targets and interferes with Helicase with zinc finger 2 (Helz2), the target sequence comprising one or more of the following sequences:SEQ ID No. 5:5′-GCTATCAAGTCTGTCACTACT-3′;SEQ ID No. 6:5′-GCACGATGCTGTATGGCTTTG-3′;SEQ ID No. 7:5′-GGGCCTCATTGACACTCAAAG-3′.

The present invention relates to a therapeutic peptide comprising a site (IKZF inhibitory site) that inhibits homo- or hetero-dimerization of members of the Ikaros family of zinc finger proteins, wherein the peptide length is in the range of 9 to 100 amino acids, and the amino acid sequence of the IKZF inhibitory site comprises SEQ ID NO: 1 (FTIHM) or SEQ ID NO: 2 (YTIHM). The present invention further relates to an IKZF dimerization inhibitor for use in the treatment of a target cancer, wherein the use comprises administering the IKZF dimerization inhibitor to a target, and the inhibitor inhibits homo- or hetero-dimerization of members of the IKZF family.

This invention relates to a flanking sequence of the rice GAT transformation event GATV3-328-1, its detection primers, and applications. The flanking sequence provided by this invention includes a right flanking sequence as shown in SEQ ID NO.1 and a left flanking sequence as shown in SEQ ID NO.2. This invention provides specific primers SEQ ID NO.9-10 and SEQ ID NO.11-12 for detecting this flanking sequence. PCR amplification of rice DNA samples using these specific primers can specifically indicate whether a T-DNA fragment of pC0309-KhvMaauMCMK5400 has been inserted at the 19881585-19881622 bases of the 6th exon of the zinc finger protein Os09g0511500 on rice chromosome 9. This invention successfully enables the detection and safe management of transgenic rice and its derived lines.