Bio-dialysis therapy using JianShengBao to treat nephropathy uremia uses a preparation which is prepared from, by mass, 30 parts of Radix Astragali, 30 parts of mountain ginseng, 30 parts of wolfberry fruits, 20 parts of Salvia miltiorrhiza, 10 parts of rheum officinale, 20 parts of Herba Plantaginis, 20 parts of unprocessed rehmannia root, 10 parts of Dianthus superbus, 50 parts of balsam pear, 50 parts of watermelons, 50 parts of tomatoes, 50 parts of papaya, 50 parts of luffa, 50 parts of wax gourd, 100 parts of brown sugar and 1000 parts of purified water. Chinese herbal medicines, fruits and vegetables are fermented to effectively reduce toxic components in the microbial composite preparation, the dialysis therapy of patients is effectively realized only through oral administration without toxic or side effects; and the preparation obtained after the fermentation contains a large number of probiotics, biological enzymes and 16 kinds of amino acids, and can supplement nutrients to cells, kill harmful bacteria, promote cell metabolism, promote cell repairing and regeneration, purify blood, promote the repairing and the regeneration of renal cortex and renal medulla cells and promote the recovery of the filtering function and the secreting function of renal cells in order to treat the nephropathy uremia.