5results about How to "Clear activity" patented technology

The invention discloses application of a potential active component 4-methylesculetin of Xiasangju in preparation of a medicine for preventing and treating diabetes, and belongs to the field of medicine. The invention provides an application of 4-methylesculetin in preparation of a medicine for preventing and treating diabetes, which can promote the consumption of glucose by cells, reduce the level of ROS and MDA in liver tissues and increase the level of SOD and GSH-PX in the liver tissues. According to the invention, on the basis of the Xiasangju, the medicinal components of the Xiasangju are researched, the medicinal active components and the administration dosage are defined, the administration safety is improved, and the Xiasangju also plays an important role in preventing and treating diabetic complications.

The invention belongs to the field of power grid systems, and particularly relates to a digital transformation propulsion method for a new energy station. The method comprises: determining a digitized object and an activity; assigning identifiers to objects and activities to construct a set and variables, and defining set elements corresponding to the variables; constructing a logic model by utilizing the variables, and determining association between objects through an association matrix and a directed graph; a layered architecture design system is adopted according to a logic model and comprises a data acquisition layer, a data processing layer and a data application layer, each layer has corresponding functions, test optimization is performed after a component integration system is selected, the system is operated to promote digital transformation of a station, and the operation efficiency and the management level are improved. Digital transformation of the new energy station is promoted by determining digital objects and activities, giving identifiers to construct sets and variables, constructing a logic model and designing a system through a hierarchical architecture, so that the system is comprehensive, the logic is clear, the condition of the station can be accurately reflected, and the operation efficiency and the management level are effectively improved.

This invention discloses a turtle peptide with angiotensin-converting enzyme (ACE) inhibitory activity, its preparation, and its application, belonging to the field of biotechnology. Using turtle as raw material, this invention obtains peptide components with a molecular weight less than 5 kDa through enzymatic hydrolysis and ultrafiltration. Sequencing reveals three peptide sequences with ACE inhibitory activity: AAGPAGGNLN, EAGAQGPPGA, and GARGDK. In vitro activity experiments verified the ACE inhibitory function of the three turtle peptides. The turtle peptide combination prepared by this invention exhibits significant ACE inhibitory activity and can be used to develop functional foods or antihypertensive drugs. Furthermore, the preparation method is environmentally friendly, efficient, and suitable for industrial production.

The invention provides a compound probiotic composition and application thereof in a product for improving intestinal health, the compound probiotic composition is prepared from lactobacillus rhamnosus GG, lactic acid bacteria compound powder, plant lactobacillus GOLDGUT-LP1024 and lactobacillus paracasei GOLDGUT-LC12345, and the lactobacillus rhamnosus GG, the lactic acid bacteria compound powder, the plant lactobacillus GOLDGUT-LC12345 and the lactobacillus paracasei GOLDGUT-LC12345 are added into the compound probiotic composition. The lactic acid bacteria compound powder is prepared by mixing bifidobacterium longum subsp. Longum BORI, lactobacillus acidophilus AD031, bifidobacterium bifidum BGN4, bifidobacterium animalis subsp. Lactis AD011 and bifidobacterium longum subsp. Infantis IBS007; the plant lactobacillus GOLDGUT-LP1024 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the plant lactobacillus GOLDGUT-LP1024 is CGMCC No.28801. The compound probiotic composition provided by the invention can improve the immune function and metabolism function of the intestinal tract so as to improve the health of the intestinal tract and relieve antibiotic-related diarrhea.

This invention discloses the application of *Lactobacillus mucosa* vesicles in the preparation of drugs for treating MAFLD, belonging to the field of microbial medicine. The *Lactobacillus mucosa* strain is deposited at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC NO.37136, and its 16S rDNA gene sequence is shown in SEQ ID NO: 1. The *Lactobacillus mucosa* strain was isolated from fecal samples of healthy adults. This strain exhibits significant antioxidant, anti-inflammatory, and lipid metabolism regulating activities in vitro. Its secreted EVs are non-cytotoxic and non-immunogenic in vivo, and animal experiments have verified its good in vivo safety and liver-targeted enrichment characteristics.