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80 results about "Minodronic acid" patented technology
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Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis. Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity.
Corrosion-inhibiting cleaning compositions for metal layers and patterns on semiconductor substrates
InactiveUS20050176604A1TransistorInorganic/elemental detergent compounding agentsCarboxylic acidPolyamine
A corrosion-inhibiting cleaning composition for semiconductor wafer processing includes an aqueous admixture of at least water, a surfactant and a corrosion-inhibiting compound selected from a group consisting of amino phosphonates, polyamines and polycarboxylic acids. The quantity of the corrosion-inhibiting compound in the admixture is preferably in a range from about 0.0001 wt % to about 0.1 wt % and the quantity of the surfactant is preferably in a range from about 0.001 wt % to about 1.0 wt %. The aqueous admixture may also include sulfuric acid and a fluoride, which act as oxide etchants, and a peroxide, which acts as a metal etchant.
Owner:SAMSUNG ELECTRONICS CO LTD +1
High-purity minodronic acid and preparation method thereof
ActiveCN101531681AFew reaction stepsReduce difficultyMetabolism disorderGroup 5/15 element organic compoundsPyridineIncreased calcium
The invention discloses a high-purity 1-hydroxyl-2-(imidazo(1,2-a) pyridine-3-group) ethylidene-1, 1-diphosphonic acid and a preparation method thereof. The target product of the invention can be applied to the treatment of osteoporosis and hypercalcemia caused by malignant tumor, with higher safety and effectiveness. The preparation method has mild reaction condition and simple post treatment, and can obtain high-purity final products and is easier to implement industrialized production.
Owner:AVENTIS PHARMA HAINAN
Herbicidal composition comprising aminophosphate or aminophosphonate potassium salt
The present invention relates to herbicidal compositions comprising aminophosphate or aminophosphonate salts, particularly to herbicidal compositions comprising an aminophosphate or aminophosphonate potassium salt. Preffered compositions of the invention have a high amount and the aminophosphate or aminophosphonate salt. The invention also relates to compositions of matter (or blend) that are especially useful ingredients for preparing the compositions comprising the aminophosphate or aminophosphonate salts.
Owner:RHODIA OPERATIONS SAS
Herbicidal Composition Comprising and Aminophosphate or Aminophosphonate Salt and a Betaine
The present invention relates to herbicidal compositions comprising an aminophosphate or aminophosphonate salt, particularly to herbicidal compositions comprising a relatively high amount of aminophosphate or aminophosphonate salt and a betaine-based surfactant composition of mater.
Owner:RHODIA CHIME
Environment-friendly high-density solid-free weighting agent and preparation method
ActiveCN104610937AWide range of densitiesReduce pollutionDrilling compositionCarboxylic acidPotassium formate
An environment-friendly high-density solid-free weighting agent comprises components in parts by weight as follows: 0.02-0.05 parts of a dispersant, 0.3-1 part of a tackifier, 0.5-1.2 parts of chelating agent, 0.6-2 parts of a corrosion inhibitor and the balance of soluble weighting materials, wherein the dispersant is one or two of sodium polyacrylate and copolymer of phosphono and carboxylic acid; the tackifier is one or more of chitosan, agar, polyacrylamide, xanthan gum and hydroxypropyl methyl cellulose; the chelating agent is one or two of aminophosphonic acid chelate resin and ethylenediamine tetraacetic acid disodium; the corrosion inhibitor is one or two of multiple polycarboxylate and sodium gluconate; the soluble weighting materials are one or more of potassium formate, potassium citrate, potassium acetate, potassium silicate and potassium sulfate. The process steps are as follows: the raw materials are taken in weight proportion, mixed and uniformly stirred; the raw materials are added to water and dissolved at the high temperature of 70-80 DEG C; a product is evaporated to dryness, and solid is obtained; the obtained solid is ground into powder, and the solid weighting agent is obtained.
Owner:成都西油华巍科技有限公司
Herbicidal composition comprising an aminophosphate or aminophosphonate salt and a viscosity reducing agent
InactiveUS20110009269A1Good surprisingly compatibilityImprove compatibilityBiocideDead animal preservationCompound (substance)Viscosity
The present invention relates to herbicidal compositions comprising an aminophosphate or aminophosphonate salt, particularly to herbicidal compositions comprising a relatively high amount of aminophosphate or aminophosphonate salt. The compositions comprise an additive compound which is a salt.
Owner:RHODIA OPERATIONS SAS
Herbicidal Composition Comprising an Aminophosphate or Aminophosphonate Salt, a Betaine and an Amine Oxide
The present invention relates to herbicidal compositions comprising aminophosphate or aminophosphonate salts, particularly to herbicidal compositions comprising a high amount and aminophosphate or aminophosphonate salts and a betaine surfactant and an amine oxide surfactant.
Owner:RHODIA CHEM SA
Detection method of minodronic acid by using high performance liquid chromatography
InactiveCN103983709AGood tailing factorImprove applicabilityComponent separationPyrophosphateSilica gel
The invention discloses a detection method of minodronic acid by using high performance liquid chromatography. The method includes following chromatogram conditions: employing a mixed solution, which is composed of methanol and an aqueous solution containing sodium acid pyrophosphate and tetra butyl ammonium bromide, as a mobile phase with a volume ratio of the aqueous solution to the methanol ranging from 90:10 to 100:0, wherein the pH value of the aqueous solution is 7.0-8.0, the concentration of the sodium acid pyrophosphate is 0.02-0.04 mol / L and the concentration of the tetra butyl ammonium bromide is 0.272-0.322 g / L; employing octade-cylsilane (ODS) as a packing material, setting a flow velocity of a high performance liquid chromatography instrument to be 0.8-1.2 ml / min, a detection wavelength to be 218-282 nm and a sample size being 5-50 [mu]l. With the detection method, separation degrees, between a main peak and a neighboring impurity peak, in both a to-be-tested sample and a raw material are more than 1.5; and main peak column efficiencies in both the to-be-tested sample and the raw material are more than 3000. The detection method is good in trailing factor and system applicability.
Owner:Yung Shin Pharm Ind (Kunshan) Co Ltd
Treatment method for molybdenum-containing acid wastewater generated in production of ammonium molybdate
InactiveCN102701509ASimple processing methodEasy to operateAmmonium nitratesWater/sewage treatment by ion-exchangeSlagChelating resin
The invention discloses a treatment method for molybdenum-containing acid wastewater generated in production of ammonium molybdate, belonging to the technical field of wastewater treatment. The method comprises the following steps of: leading the molybdenum-containing acid wastewater to pass through an amino methylene phosphonic chelating resin column; collecting to obtain an effluent 1; sequentially adding ammonia water and slag into the effluent 1; naturally setting to obtain a supernatant; leading the supernatant to pass through the amino methylene phosphonic chelating resin column; collecting to obtain an effluent 2; evaporating and crystallizing the effluent 2; naturally cooling and filtering to obtain a filtering liquid and a filtering cake; drying the filtering cake to obtain ammonium nitrate; adding the filtering liquid into the effluent 2; and recycling the filtering liquid to realize treatment of the molybdenum-containing acid wastewater generated in production of the ammonium molybdate. According to the method, molybdenum and copper in the wastewater can be comprehensively recovered to obtain by-product ammonium nitrate, zero emission of the wastewater is realized, and the method has wide application prospect.
Owner:西部鑫兴金属材料有限公司
Method for preparing minodronic acid intermediate
ActiveCN102250090ARaw materials are easy to getRaw materials are cheap and easy to getOrganic chemistryAcetic acidPyridine
The invention relates to the field of medicine synthesis, in particular to a method for preparing a minodronic acid intermediate 2-(imidazo[1,2-a]pyridin-3-yl)acetic acid (I). The method is characterized by comprising the following steps of: performing condensation on 3-bromoimidazo[1,2-a]pyridine (II) and diethyl malonate to obtain 2-(imidazo[1,2-a]pyridin-3-yl)diethyl malonate (III); and hydrolyzing and performing decarboxylation to obtain the 2-(imidazo[1,2-a]pyridin-3-yl)acetic acid (I). The method has the advantages of cheap and readily available raw materials, a few reaction steps, simple operation, high product quality, low cost, suitability for industrial production and the like.
Owner:广东宏远集团药业有限公司
Aminophosphonic acid compound for nuclear medicine and its preparing process
InactiveCN1369499AEasy to operateThe reaction conditions are easy to achieveGroup 5/15 element organic compoundsPhosphorous acidAlcohol
An aminophosphonic acid compound used for nuclear medicine is prepared through adding amine and phosphoruc acid to reactor, dropping concentrated acid and formaldehyde, reaction, cooling, and precipitation in water or absolute alcohol. It along with Tc, Re, Or Sm can be used to prepare medicine for treating cancers.
Owner:INST OF NUCLEAR PHYSICS & CHEM CHINA ACADEMY OF
Amino phosphonic acid compound and preparation method and application thereof
The invention discloses an amino phosphonic acid compound and further discloses a preparation method of the amino phosphonic acid compound. The general formula of the compound is shown as the formula(I) (Please see the specifications for the formula). The amino phosphonic acid compound is prepared through the mode that 3,7-dimethyl-2,6-octadienal, aniline or aniline containing a substituent group, and phosphorous acid are subjected to a Mannich reaction under the action of acid catalysts. The amino phosphonic acid compound can be used as a floatation collector of ilmenite, bauxite, fluorite ores, rare earth ores or collophanite and has the characteristics of good selectivity, high water solubility, good dispersibility and the like, and the flotation recovery rate can be increased by 2-16percent points. The preparation method adopts a one-pot synthesis method, operation is easy to control, the product yield is high, and industrial production is easy.
Owner:BLUESTAR LEHIGH ENG INST CO LTD
Minodronic acid tablets and preparation method thereof
ActiveCN102949358AImprove technical effectGood water solubilityOrganic active ingredientsSkeletal disorderMedicineFiller Excipient
The invention belongs to the field of pharmaceutical preparation, and specifically relates to minodronic acid tablets and a preparation method thereof. With large amounts of experiments, proportions of auxiliary materials and hydroxypropyl beta-cyclodextrin are determined, and tablets containing minodronic acid and hydroxypropyl beta-cyclodextrin are prepared. The tablets are composed of minodronic acid, hydroxypropyl beta-cyclodextrin, a filling material, a disintegrating agent, a lubricant, and other pharmaceutically acceptable auxiliary materials. During a preparation process, hydroxypropyl beta-cyclodextrin and minodronic acid are added in a water solution form into mixed powder of the filling material and the disintegrating agent. The dissolution rate of the tablets provided by the invention is substantially improved, such that rapid dissolution and absorption of minodronic acid in gastrointestinal-tract bodily fluids is facilitated. The preparation process is simple, and operation is convenient, such that the method is suitable for industrialized productions.
Owner:SHANDONG NEWTIME PHARMA
Herbicidal composition comprising an aminophosphate or aminophosphonate salt and a viscosity reducing agent
InactiveCN101932236ALow viscosityEasy to pourBiocideDead animal preservationChemical compositionViscosity
The present invention relates to herbicidal compositions comprising an aminophosphate or aminophosphonate salt, particularly to herbicidal compositions comprising a relatively high amount of aminophosphate or aminophosphonate salt. The compositions comprise an additive compound which is a salt.
Owner:RHODIA OPERATIONS SAS
Preparation method of minodronic acid
InactiveCN104497048AReduce usageShort routeGroup 5/15 element organic compoundsPhosphorylationBromine
The invention discloses a preparation method of minodronic acid. The preparation method comprises the following steps: performing acetal hydrolysis on a compound I to obtain a compound II, performing closed-loop treatment and hydrolysis on the compound II and 2-aminopyridine to obtain a compound III, and finally, performing phosphorylation on the compound III to obtain a compound IV. By adopting the preparation method disclosed by the invention, highly toxic chemical reagents including sodium cyanide or bromine and the like are avoided, the reaction conditions are mild and controllable, the reaction steps are relatively short, the yield is relatively high, and the cost is relatively low, so that the preparation method is suitable for industrial production.
Owner:HARBIN PHARMA GROUP TECH CENT
Pretreatment method of minodronic acid in plasma sample based on derivatization on solid-phase extraction column and detection method
InactiveCN109917030ASame retention time and chemistryHigh speedComponent separationPretreatment methodNitrogen
Owner:NANJING HEALTHNICE MEDICAL TECH +2
Method for separating and detecting minodronic acid
The application relates to a method for separating and detecting minodronic acid. The method adopts a reverse-phase chromatographic column through high performance liquid chromatography, and uses a buffer solution of pH=2-7.5 containing sodium alkylsulfonate as mobile phase A, and Methanol or acetonitrile was used as mobile phase B, the detection wavelength was 215nm, and linear gradient elution was used for separation and detection.
Owner:TIANJIN HANKANG PHARMA BIOTECH
Preparation method of minodronic acid for treating osteoporosis
ActiveCN105175446AEasy to separateEasy to purifyGroup 5/15 element organic compoundsCopper nitrateEthyl Chloride
The invention discloses a preparation method of minodronic acid for treating osteoporosis. The preparation method comprises the following steps of firstly, reacting a compound as shown in a formula (I) with 2-aminopyridine to obtain a compound as shown in a formula (II); secondly, hydrolyzing the compound as shown in the formula (II) obtained in the first step to obtain a compound as shown in a formula (III); thirdly, phosphorylating the compound as shown in the formula (III) obtained in the second step to obtain the minodronic acid, wherein X is chlorine or bromine, and R is alkyl radicals of C1 to C4; in the first step, a reaction promotor M is added and consists of one or more substances selected from zinc nitrate, silver nitrate and copper nitrate and one or more substances selected from glycine and alanine. According to the preparation method, the yield of a key intermediate in a preparation process of the minodronic acid can be greatly improved; the preparation method has the advantages of few side products, easiness in purification, mild conditions and higher reaction speed, and is suitable for large-scale production and popularization.
Owner:嘉善县魏塘资产管理有限公司
Preparation method of minodronic acid for treating osteoporosis
InactiveCN105837635AFacilitate the cyclization reactionHigh yieldGroup 5/15 element organic compoundsEthyl acetateHydrolysis
The invention discloses a preparation method of minodronic acid for treating osteoporosis .The preparation method comprises the following steps that 1, 4-bromine ethyl acetoacetate and 2-aminopyridine perform contact reaction in the present of a compound shown in a formula (I) and DIEA to obtain 2-(imidazo[1,2-alpha] pyridine-3-yl) ethyl acetate; 2, the 2-(imidazo[1,2-alpha] pyridine-3-yl) ethyl acetate obtained in the step 1 is hydrolyzed under the alkaline condition to obtain 2-(imidazo[1,2-alpha]pyridine-3-yl)acetic acid; 3, the 2-(imidazo[1,2-alpha]pyridine-3-yl)acetic acid obtained in the step 2 is subjected to phosphorylation to obtain the minodronic acid .The method can greatly improve the yield of the minodronic acid and is mild in condition and higher in reaction speed .
Owner:邱善晓 +2
Polypyrrolidone polishing composition and method
Owner:CMC MATERIALS LLC
Method for preparing compound 2-(imidazo [1, 2-a] pyridine-3-yl) acetonitrile
The invention discloses a method for preparing a compound 2-(imidazo [1,2-a] pyridine-3-yl) acetonitrile, which is a new method for preparing a key intermediate of minodronic acid, comprising the steps of: with a compound 3- imidazo [1, 2-a] pyridine carboxaldehyde with the formula (II) and a compound tosylmethyl isocyanide with the formula (III) as raw materials, carrying out chemical reaction in an organic solvent containing glycol dimethyl ether and an alkaline medium of potassium tert-butoxide or sodium tert-butoxide; separating and purifying to obtain the compound 2-(imidazo [1, 2-a] pyridine-3-base) acetonitrile, wherein the process of the chemical reaction is disclosed in the specification of the invention. In the invention, by means of the method for preparing the compound with the formula (I), the reaction procedure is shortened, the technical process of the whole reaction is simplified, the use of a highly toxic material sodium cyanide is avoided, the operability of the reaction is strong, the yield is high, and the obtained product has high purity, lower cost, and is easy for the application in the industrialized production.
![Method for preparing compound 2-(imidazo [1, 2-a] pyridine-3-yl) acetonitrile](https://images-eureka.patsnap.com/patent_img/1bcb5027-c3fb-471e-86b4-f3fbc755948e/DSA00000410367500011.png "Method for preparing compound 2-(imidazo [1, 2-a] pyridine-3-yl) acetonitrile")
![Method for preparing compound 2-(imidazo [1, 2-a] pyridine-3-yl) acetonitrile](https://images-eureka.patsnap.com/patent_img/1bcb5027-c3fb-471e-86b4-f3fbc755948e/FSA00000410367600011.png "Method for preparing compound 2-(imidazo [1, 2-a] pyridine-3-yl) acetonitrile")
![Method for preparing compound 2-(imidazo [1, 2-a] pyridine-3-yl) acetonitrile](https://images-eureka.patsnap.com/patent_img/1bcb5027-c3fb-471e-86b4-f3fbc755948e/BSA00000410367700011.png "Method for preparing compound 2-(imidazo [1, 2-a] pyridine-3-yl) acetonitrile")
Owner:GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
Liquid injectable formulation of disodium pamidronate
InactiveUS20050182030A1Improve stabilityUseful in treatmentBiocideInorganic non-active ingredientsDiseaseMedicine
The present invention relates to an improved injectable ready-to-use preparation of pamidronate salts, methods for its manufacture and uses of the solution of the invention in the manufacture of pharmaceutical compositions for the treatment of diseases selected from the group of tumour-induced hypercalcaemia, Paget's disease, osteoporosis, bone metastases, or breast cancer. The ready-to-use solution comprises a physiologically acceptable alkaline salt of pamidronate which is water soluble and a physiologically acceptable aqueous solvent having a concentration of between 0.1 and 100 mg / mL, wherein the solution is provided in a sealed non-reactive plastic container.
Owner:APP PHARMA
Minodronic acid medicinal composition and preparation method thereof
InactiveCN103919748AQuality is easy to controlWell mixedOrganic active ingredientsSkeletal disorderMedicineActive component
The invention belongs to the technical field of pharmacy, and relates to a minodronic acid medicinal composition and a preparation method thereof, in particular to a tablet consisting of a crystal form E minodronic acid monohydrate, a filling agent, a bonding agent, a lubricating agent, a disintegrating agent, a coating agent and other acceptable medicinal auxiliary materials. Active components account for 1 percent of the total weight of the minodronic acid tablet prepared by using the method. By mixing through a method for equivalently adding auxiliary materials, the content uniformity of the tablet can be increased effectively, so that the minodronic acid tablet is safe, effective and controllable in quality.
Owner:Yung Shin Pharm Ind (Kunshan) Co Ltd
Preparation method of minodronic acid for treating osteoporosis
InactiveCN105153232AFacilitate the cyclization reactionQuick responseGroup 5/15 element organic compoundsHalogenPyridine
The invention discloses a preparation method of minodronic acid for treating osteoporosis. The method comprises the following steps: (1) reacting a compound expressed by the formula (I) with 2-aminopyridine to obtain a compound expressed as the formula (II); (2) hydrolyzing the compound expressed by the formula (II) obtained by the step (1) to obtain a compound expressed by the formula (III); and (3) phosphorylating the compound expressed by the formula (III) obtained in the step (2) to obtain minodronic acid, wherein the formulae (I), (II) and (III) are described in the specification; in the formulae (I), (II) and (III), X1 and X2 independently represent halogen, and R represents C1-C4 alkyl. Through the method, the yield of key intermediates in the preparation process of minodronic acid can be greatly increased; meanwhile, the method is few in impurities of product, few in by-products and mild in condition, and is suitable for large-scale production and popularization.
Owner:聂红梅 +2
A kind of environment-friendly high-density non-solid phase weighting agent and preparation method thereof
ActiveCN104610937BSuitable for a wide temperature rangeLow viscosityDrilling compositionCarboxylic acidChelating resin
An environment-friendly high-density solid-free weighting agent comprises components in parts by weight as follows: 0.02-0.05 parts of a dispersant, 0.3-1 part of a tackifier, 0.5-1.2 parts of chelating agent, 0.6-2 parts of a corrosion inhibitor and the balance of soluble weighting materials, wherein the dispersant is one or two of sodium polyacrylate and copolymer of phosphono and carboxylic acid; the tackifier is one or more of chitosan, agar, polyacrylamide, xanthan gum and hydroxypropyl methyl cellulose; the chelating agent is one or two of aminophosphonic acid chelate resin and ethylenediamine tetraacetic acid disodium; the corrosion inhibitor is one or two of multiple polycarboxylate and sodium gluconate; the soluble weighting materials are one or more of potassium formate, potassium citrate, potassium acetate, potassium silicate and potassium sulfate. The process steps are as follows: the raw materials are taken in weight proportion, mixed and uniformly stirred; the raw materials are added to water and dissolved at the high temperature of 70-80 DEG C; a product is evaporated to dryness, and solid is obtained; the obtained solid is ground into powder, and the solid weighting agent is obtained.
Owner:成都西油华巍科技有限公司
Minodronic acid tablet and preparation process thereof
ActiveCN104434854AUniform contentEasy to produceOrganic active ingredientsPharmaceutical delivery mechanismLactoseDrug product
The invention relates to a minodronic acid tablet and a preparation process thereof. According to the preparation process, a direct tabletting method is used, Flowac100 type spray-dried lactose is used as a filling agent and polylactic acid is added at the same time, so that the prepared minodronic acid tablet is uniform in content and favorable to release; and compared with the prior art, the direct tabletting method is capable of solving the problem that the minodronic acid tablets obtained via powder direct tableting are easy to crack and not good for coating, so that the medicine quality is ensured.
Owner:哈药集团股份有限公司 +1
Method for synthetizing minodronic acid intermediate and preparing minodronic acid by virtue of one-pot process
InactiveCN104693241AEasy to operateMild reaction conditionsGroup 5/15 element organic compoundsPhosphorous acidPhosphorus tribromide
The invention relates to a preparation technology of a minodronic acid key intermediate 2-{imidazo[1,2-a]pyridine-3-yl}acetic acid (compound 5), and a monohydrate prepared by synthesizing the minodronic acid (6) by employing the intermediate, purifying and refining. The synthesis of the minodronic acid key intermediate has an important effect on the quality of the minodronic acid. The technology comprises the following steps: firstly, with 2-aminopyridine (1) and trans-4-amino-2-ethyl crotonate (2) as raw materials, synthesizing a high-purity minodronic acid intermediate (5) through the treatment such as hydrolysis and acidification, wherein the reactions are finished by one-pot reaction; and then synthesizing the minodronic acid (6) under the action of phosphorous acid and phosphorus tribromide.
Owner:BEIJING VENTUREPHARM BIOTECH
Beta-aminophosphonic acid derivative and preparation method thereof
ActiveCN108727428ARaw materials are easy to getMild reaction conditionsGroup 5/15 element organic compoundsAcid derivativeRoom temperature
The invention discloses a preparation method of a beta-aminophosphonic acid derivative. The preparation method comprises the following steps of dissolving N-(arylvinyl)benzamide, dialkyl phosphite, manganese acetate and potassium carbonate in a solvent, performing reaction at a room temperature to acquire a (2-benzamido-1-arylvinyl)dialkyl phosphonate derivative, and performing reductive hydrolyzation on a compound to acquire the beta-aminophosphonic acid derivative. By using an N-(arylvinyl)benzamide derivative as an initiator, the preparation method is available in raw material and various in preparation method. The preparation method is simple and short in synthetic route, mild in reaction condition, simple in reaction operation and aftertreatment process and better in yield and is suitable for scale production.
Owner:SUZHOU UNIV
Herbicidal composition comprising an aminophosphate or aminophosphonate salt and an n-alkyl-pyrrolidone solvent
InactiveUS20120040832A1Reduce the environmentImprove securityBiocideDead animal preservationOrganic solventAdditive ingredient
The present invention relates to herbicidal compositions comprising an aminophosphate or aminophosphonate salt, for example to herbicidal compositions comprising an aminophosphate or aminophosphonate potassium salt. Preferred compositions of the invention have a high amount and the aminophosphate or aminophosphonate salt. The invention also relates to compositions of matter (or blend) that are especially useful ingredients for preparing the compositions comprising the aminophosphate or aminophosphonate salt. In particular, these ingredients are a surfactant such as an amine oxide surfactant, and an organic solvent comprising an N-alkylpyrrolidone wherein the alkyl group comprises at least 2 carbon atoms.
Owner:RHODIA OPERATIONS SAS
Beta-Hydroxy-Gamma-Aminophosphonates and Methods for the Preparation and Use Thereof
InactiveUS20100087400A1Inhibit carnitine acyltransferasesBiocideNervous disorderDiseaseInsulin dependent diabetes
The present invention provides β-hydroxy-γ-aminophosphonates, β-amino-γ-aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these β-hydroxy-γ-aminophosphonates, β-amino-γ-aminophosphonates, and analogs, and methods of the use of such compounds and compositions in the treatment, amelioration or prevention of pathological conditions, diseases or disorders that are linked with fatty acid metabolism, such as non-insulin dependent diabetes or obesity. The invention also provides processes for the preparation of such compounds and compositions.
Owner:NUCITEC DE C V
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