The invention provides a preparation method of
porphyrin photosensitizer and
anticarcinogen diad, relates to a preparation method of the
diad and solves the technical problems that the
porphyrin photosensitizers cannot kill all
cancer cells under the
light irradiation, the targeting of the
anticarcinogen is insufficient, and toxic or side effects are generated. The method comprises the following steps of: 1, preparing midbodies; and 2, preparing the
porphyrin photosensitizer and
anticarcinogen diad. Because porphyrin and the
metal complex compounds thereof have special affinity on the
cancer cells, the photosensitizers of 4-hydroxyphenyl porphyrin and anticarcinogen are prepared into the diad, the affinity of the porphyrin on the
cancer cells is utilized, so the targeting of the anticarcinogen can be improved, the anti-cancer capability is improved, and in addition, the toxic or
side effect is reduced. The anti-cancer effect of the anticarcinogen overcomes the defect of insufficient anti-cancer capability of the porphyrin
photosensitizer. Under the conditions of light illumination and dark light, two different anti-cancer mechanisms realize the cooperative effect, the
advantage complementation of the anti-cancer effects of the two compounds is realized, the toxic or side effects are reduced under the use condition of the same quantity, and the anti-cancer capability is improved.