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The aim of this study was to investigate the mechanisms of action of Dihydroarteannuin (DHA), a semi-synthesized agent from the starting material artemisinin extracted from the Chinese Traditional Herbs Artemisia annua, on ameliorating the symptoms of lupus on BXSB mice.
Dihydroartemisinin derivatives and methods of making and use thereof
PendingUS20260176286A1Organic active ingredientsOrganic chemistryPharmacophorePharmaceutical Substances
Dihydroartemisinin (“DHA”) derivatives that contain a stereospecific C-10 ether linkage and an aryl pharmacophore moiety are disclosed. In some forms, the DHA derivatives possess anticancer properties that are comparable to or better than the parent DHA and / or an existing anticancer drug (e.g., Cisplatin), and are useful in anticancer treatments (such as ovarian cancer and colon cancer). Methods of synthesizing the DHA derivatives that are cost effective are disclosed. Methods of using the DHA derivatives for treating a cancer, such as ovarian cancer and / or colon cancer, in a subject in need thereof are also disclosed.
Owner:LAB FOR SYNTHETIC CHEM & CHEM BIOLOGY LTD