Dihydroartemisinin oxime-containing phenol derivatives as well as synthesis method and application thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- SOUTHWEST UNIVERSITY
- Publication Date
- 2019-11-22
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
technical field
[0001] The invention relates to the technical field of chemistry and medicine, in particular to a dihydroartemisinin-containing oxime phenol derivative, a synthesis method and an application. Background technique
[0002] Artemisinin is a terpenoid found in the plant Artemisia annua. Dihydroartemisinin (DHA) is the first-generation derivative of artemisinin. It not only has a unique structure, but also shows better pharmaceutical properties than artemisinin. It is an important clinical antimalarial drug. Based on the special structure and excellent activity of DHA, the research on DHA at home and abroad continues. At present, it mainly focuses on the design and synthesis of new DHA derivatives, the exploration of new activities of old molecules of DHA or the activity research of new molecules. So far, many new derivatives of DHA have been synthesized, and some artemisinin derivatives have been used in clinical trials against breast cancer, colorectal cancer,...