Simple phenol conjugates of dihydroartemisinin, synthetic method and application

A technology of dihydroartemisinin and synthesis method, applied in the field of chemical medicine, achieving good application prospects, simple synthesis method, and good Wnt signaling channel activation effect
CN110483547AActive Publication Date: 2019-11-22SOUTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHWEST UNIV
Publication Date
2019-11-22

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Abstract

The invention discloses simple phenol conjugates of dihydroartemisinin, and belongs to the technical field of chemical medicines. The derivatives or racemates, stereoisomers, tautomers and pharmaceutically acceptable salts thereof have the following general formula shown in the specification, wherein n is 2 or 3. The invention also discloses a synthesis method of the conjugates and application ofthe conjugates in antituberculotic, antidiabetic, lipid-lowering and Wnt signaling pathway agonist active drugs.
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Description

technical field

[0001] The invention relates to the technical field of chemistry and medicine, in particular to a simple phenolic conjugate of dihydroartemisinin, its synthesis method and application. Background technique

[0002] Artemisinin is a sesquiterpene lactone compound containing an endoperoxide group extracted from the plant Artemisia annua, and it is a lead compound of a new type of drug with high efficiency and low toxicity. Dihydroartemisinin (DHA) is the first-generation derivative of artemisinin and the main active metabolite of artemisinin in the body. It not only has a unique structure, but also shows better pharmaceutical properties than artemisinin. , is an important clinical antimalarial drug. In view of the advantages of DHA, such as good absorption, wide distribution, rapid excretion and metabolism, high efficiency, low toxicity, etc., as well as the special structure of DHA, the research on DHA continues. At present, it mainly focuses on the design a...

Claims

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