717results about How to "Safe and effective treatment" patented technology

Provided is an IL-15 heterodimeric protein, such as an IL-15 / IL-15Rα heterodimeric protein. The IL-15 heterodimeric protein contains protein (I) and protein (II). Protein (I) is recombinantly produced by combining IL-15 or a variant thereof with a first Fc variant, and protein (II) is a second Fc variant, or recombinantly produced by combining IL-15Rα or a variant thereof with a second Fc variant. The first Fc variant and the second Fc variant are preferably linked via a “Knob-into-Hole” mode. Also provided are methods of using the IL-15 heterodimeric proteins to modulate an immune response. The provided IL-15 heterodimeric proteins have significant anti-tumor activity, better biological activity and prolonged in vivo half-life compared to the IL-15 molecule alone.

The invention discloses a conformal RF ablation electrode of focal prostate cancer, which is composed of conductor and sleeve, wherein the conductor moves in the sleeve pipe, which mates mutually and strictly; the conductor is hollow pipe with multiple fine-hollow core needles on one end; the sub-needles constitutes fan shaped beam with memory ability, which are recessed into sleeve; the handle is loaded on the rear end of conductor and sleeve.

An exposure apparatus for skin treatment or other applications includes a laser diode module controller that is configured to operate one or more laser diodes that are situated to provide optical radiation to an exposure aperture. A two-dimensional position sensor is secured to the exposure aperture and provides an exposure aperture translation signal that is coupled to the laser diode module controller. Delivery of optical radiation to the exposure aperture by the laser diode module controller is based on an exposure aperture translation or velocity that is estimated based on the exposure aperture translation signal. In addition, a clock or timer is coupled to the laser diode module controller to permit selection of laser diode pulse duty cycle or to provide safe or comfortable skin treatment. The two dimensional position sensor can be based on optical sensing such as provided in an optical mouse, and can also provide proximity sensing for safe, efficient operation.

A mobile liquid treatment station and operation methods are disclosed, the station having a mobile treatment unit and separate mobile treatment management unit. A plurality of serial containment compartments at the treatment unit for performance of chemical dosing and solids separation are provided and are monitored with sensors. The management unit includes a plurality of chemical dosing platforms, and a power and processing assembly. A bus links the units for data and control signal transfer and chemical feed lines are connected between the units for transfer of dosing chemicals.

The invention relates to a tumor treatment therapeutic equipment utilizing magnetic thermotherapy, which comprises a central operation controller, an alternating magnetic field generating device, an electrical magnetic induction coil, a therapeutic bed, a water cooling device, an image detector, a temperature observe and control device, accessory equipments, a printer, an operating console, and a power off protecting equipment.

A composite medicine for treating the umatoid arthritis and autoimmune disease contains the sweet worm wood herb's extract (dihydroarteannuin, artesumate, artemether, etc).

A transdermal drug delivery system comprising a steroid as an active agent, wherein the steroid may be clobetasol propionate, betamethasone dipropionate, amcinonide, or loteprednol etabonate. The transdermal drug delivery system also comprises a pressure-sensitive adhesive layer and a support, wherein the steroid is present in the pressure-sensitive adhesive layer, and wherein the pressure-sensitive adhesive layer is provided on a support. The transdermal drug delivery system may be applied onto the eyelid of a patient in need thereof, in order to treat a disease of the eyelid, such as chalazion, blepharitis or meibomian gland dysfunction.

The invention relates to a medicament for treating verruca plana and a preparation method thereof, belonging to the technical field of treatment of verruca plana based on traditional Chinese medicine. The medicament for treating verruca plana is prepared from the following raw materials in parts by weight: 30-45 parts of radix isatidis, 15-20 parts of lithospermum, 30-40 parts of dandelion, 20-30 parts of rhizoma cyperi, 10-15 parts of red paeonia, 20-30 parts of radix astragali, 15-24 parts of radix sophorae subporstratae, 20-30 parts of coix seed, 15-20 parts of equisetum, 20-30 parts of isatis leaf, 30-45 parts of honeysuckle flower, 15-20 parts of kuh-seng and 9-12 parts of phellodendron bark. The preparation method comprises the following steps: a. weighing various raw materials according to required parts by weight: b. putting the weighed raw materials in a medicine tank, and adding water to soak the raw materials; c. decocting with sharp fire until the decoction is boiling, then decocting with soft fire for 20-40 minutes, and filtering out the liquor; and d. adding water into the medicine tank, decocting with sharp fire until the decoction is boiling, then decocting with soft fire for 20-30 minutes, leaching the liquor, and evenly mixing the liquor with the liquor leached for the first time. The medicament for treating verruca plana is a pure traditional Chinese medicine preparation, and is safe to take; no scar is left after the verruca plana heals; and the medicament for treating verruca plana is suitable for patients who suffer from verruca plana which has a long course and is easy to recur.

The invention relates to an oral administration, in particular to a solid composite containing clopidogrel hydrogen sulfate; the solid composite containing clopidogrel hydrogen sulfate comprises the following ingredients by weight part: 100 parts of clopidogrel hydrogen sulfate and 5-100 parts of mixture of liquid paraffin and talcum powder; the composite can realize industrial production of the clopidogrel hydrogen sulfate and solve the problems that related substances of the tablets rises and the dissolution is reduced.

The invention discloses a traditional Chinese medicine for treating heart failure. The traditional Chinese medicine is characterized in that the medicine is prepared by the following components via crushing, sieving and mixing in parts by weight: 250-270 parts of astragalus mongholicus, 100-110 parts of cassia twig, 50-65 parts of rhodiola rosea, 150-160 parts of red sage root, 150-160 parts of rhizoma alismatis, and 150-160 parts of semen lepidii. The traditional Chinese medicine for treating the heart failure can better improve clinical symptoms of the heart failure of the patient caused by deficiency of vital energy and blood stasis, can reduce the congestive heart failure diagnosis standard, can enhance heart function, can improve the living quality of the patient, can increase the actual living ability and living quality of the patient, and can increase distance of walking test in 6 min and display remarkable merit in body recovery of a patient. The traditional Chinese medicine is effective preparation for improving the moving ability of the patient with the heart failure.

The subject invention provides novel compounds and compositions for the safe and effective treatment of gastroesophageal reflux and related conditions. In a preferred embodiment, the compositions of the subject invention comprise esterified cisapride derivatives. These compositions possess potent activity in treating gastroesophageal reflux disease and substantially reduce adverse effects associated with the administration of cisapride. These adverse effects include, but are not limited to, diarrhea, abdominal cramping and elevations of blood pressure and heart rate.

The invention relates to a Chinese medicine for treating allergic dermatitis. The Chinese medicine is prepared from the following medicinal materials in parts by weight: 15-30 parts of astragalus, 10-15 parts of divaricate saposhnikovia root, 10-15 parts of paniculate swallowwort root, 8-12 parts of fried large-head atractylodes rhizome, 10-15 parts of fineleaf schizonepeta herb, 8-12 parts of lightyellow sophora root, 15-20 parts of pearl barley, 10-15 parts of cicada shell, 10-15 parts of mint, 10-15 parts of baikal skullcap root, 8-12 parts of Chinese angelica, 10-15 parts of bunge corydalis herb, 10-15 parts of dandelion and 6-9 parts of liquoric root. As proved by a clinical experiment, the Chinese medicine can be used for treating allergic dermatitis safely and effectively.

Provided is an IL-15 heterodimeric protein, such as an IL-15 / IL-15Rα heterodimeric protein. The IL-15 heterodimeric protein contains protein (I) and protein (II). Protein (I) is recombinantly produced by combining IL-15 or a variant thereof with a first Fc variant, and protein (II) is a second Fc variant, or recombinantly produced by combining IL-15Rα or a variant thereof with a second Fc variant. The first Fc variant and the second Fc variant are preferably linked via a “Knob-into-Hole” mode. Also provided are methods of using the IL-15 heterodimeric proteins to modulate an immune response. The provided IL-15 heterodimeric proteins have significant anti-tumor activity, better biological activity and prolonged in vivo half-life compared to the IL-15 molecule alone.

The invention discloses a method for recovering fluoride ions from wastewater and belongs to the fields of wastewater treatment and resource recovery. The method specifically comprises the following steps: the fluoride ions in the fluorine-containing wastewater are discharged up to standard by resin adsorption; a resin desorption solution is treated with combination of a diffusion dialysis technique and a chemical precipitation method, wherein high-alkali effluent of diffusion dialysis effluent can serve as a resin desorption agent to be recycled to a resin desorption section; for high-fluorine effluent of the diffusion dialysis effluent, the fluoride ions are precipitated and recovered in a form of precipitates with the chemical precipitation method, a filtrate and the fluorine-containingwastewater are mixed in a certain ratio, resin is introduced for defluorination, and the fluoride ions in the wastewater are recovered in the form of high-purity calcium fluoride precipitates after being subjected to resin adsorption separation. In the method, alkali in the resin desorption solution is recovered with the diffusion dialysis technique, so that alkali amount needed by resin desorption is reduced substantially, sewage treatment cost is reduced, and effluent quality is guaranteed.

The invention provides a traditional Chinese medicine composition for treating hyperuricemia. The traditional Chinese medicine composition for treating the hyperuricemia is prepared from, by weight, 15-25 parts of glabrous greenbrier rhizomes, 10-20 parts of yam rhizomes, 10-20 parts of semen coicis, 5-15 parts of radix astragali, 5-15 parts of motherworts, 5-15 parts of herba lysimachiae, 3-7 parts of semen plantaginis, 3-7 parts of salvia miltiorrhiza, 2-8 parts of Chinese rhubarb and 2-8 parts of licorice roots. The traditional Chinese medicine composition uses the pure natural medicinal materials which are wide in source, low in cost, free of toxic and side effects and reasonable in formula, produce the good synergic effect in curative effect and jointly achieve the good swell-eliminating, analgesic, anti-inflammatory and dampness-removing effects. The traditional Chinese medicine composition has the advantages of being fast in effect and high in cure rate, enabling the hyperuricemia not to easily relapse and the like and is suitable for hyperuricemia treatment.

The invention relates to stasis eliminating powder for treating soft tissue injury and cervical spondylosis. The stasis eliminating powder is prepared from the following raw material drugs in parts by weight: 1150 to 1350 parts of dandelion, 400 to 600 parts of rhubarb, 400 to 600 parts of myrrh, 400 to 600 parts of pseudo-ginseng, 400 to 600 parts of Chinese polyphaga, and 725 to 925 parts of geranium wilfordii. The invention also provides application of the stasis eliminating powder. The stasis eliminating powder has the advantages that: the stasis eliminating power is compatible with a principle of Chinese medicament 'monarch, minister, assistant and guide', and has the remarkable effects of dissipating blood stasis to promote menstruation, and alleviating pain and removing stagnation.The stasis eliminating powder is suitable for treating pains, swelling and inflammations caused by cervical spondylosis, osteoarthritis, lumbar muscle strain, lumbar disc herniation, rheumatoid arthritis, hyperosteogeny, gout and scapulohumeral periarthritis, and also can be used for treating symptoms of traumatic injuries, blood stasis, undispersed abdominal stasis and joint stasis. The stasis eliminating powder has less toxic and side effects and good curative effect, contains few medicaments and is suitable for long-term administration, and thus the stasis eliminating powder is a safe and effective medicament.

The present invention pertains to the pharmaceutical field and relates to an antiviral compound drug, in particular to an entecavir drug composition and the anti-HBV usage. The present invention is composed of entecavir, (1s-(1 Alpha, 3 Alpha, 4 Beta))-2-amino-1, 9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purine-6-ketone, monocase compound which is extracted from one or more traditional Chinese medicines and the pharmaceutical excipients. The results of the in vitro and the duck hepatitis B animal model tests show that the present invention has obvious anti-HBV efficacy; at the same time, the present invention also has good hepatoprotective effect. The entecavir drug composition becomes the more safe and effective drug for treating hepatitis B and thus having very broad application prospect and far-reaching social benefits.

The invention relates to a multi-syringe-needle adsorption injection needle. The multi-syringe-needle adsorption injection needle comprises a needle body, a partitioning plate is arranged in the center of the needle body, and the two ends of the needle body are open. The multi-needle-head adsorption injection needle is characterized in that a sucking negative pressure cavity and an injection cavity are formed in the two sides of the partitioning plate respectively, one or more injection syringe needles are evenly fixed to the partitioning plate and extends / extend into the sucking negative pressure cavity, and an air sucking opening is formed in the needle body and communicated with the sucking negative pressure cavity. A seal plate is arranged inside the injection cavity, a medicine cavity is formed by the seal plate and the partitioning plate, a medicine inlet tube used for injecting medicine into the medicine cavity is arranged on the seal plate, and injection holes are formed in the partitioning plate and used for being communicated with the medicine cavity and the injection syringe needles. In the using process, the liquid medicine is injected to empty air, in this way, the sucking negative pressure cavity is attached to the region to be treated, the injection syringe needles are punctured by a fixed depth through negative pressure, and treatment is completed after the medicine is pushed. Through the multiple syringe needles, large-area even and safe dosing can be achieved, the depth of the part, extending into the nidus, of the injection needle can be accurately controlled, dosing treatment is achieved at the fixed-depth position, and the multi-syringe-needle adsorption injection needle has obvious advantages and is suitable for application and popularization.

Methods for preventing or treating a viral infection in a subject are described that include administering N-glycolylneuraminic acid or a derivative thereof to the subject.

The invention belongs to the technical field of a traditional Chinese medicine and discloses a traditional Chinese medicinal composition for treating acne. The traditional Chinese medicinal composition is prepared from the following raw materials: honeysuckle, wild chrysanthemum, dandelion, oldenlandia diffusa, root of red-rooted salvia, astragalus membranaceus, Chinese violet, houttuynia cordata, radix isatidis and raw coix seed. The traditional Chinese medicinal composition disclosed by the invention adopts natural Chinese herbs, and follows therapeutic principles of clearing away heat, detoxifying, and promoting blood circulation and diuresis on the basis of understanding pathogenesis and pathology of heat, dampness, stasis and toxicity; the traditional Chinese medicinal composition, strictly adhering to etiology and pathogenesis of acne and researching such dosage forms as pill, capsule and granule through a modern preparation process, not only retains a curative effect of a traditional Chinese medicinal decoction but also facilitates patients; the traditional Chinese medicinal composition has the advantages of convenient and safe taking, convenient carrying and the like; the traditional Chinese medicinal composition, after being taken, can regulate internal secretion of human body, clear away heat and toxic materials, and promote blood circulation to dissolve stasis; and the traditional Chinese medicinal composition is well targeted and has obvious curative effect.

A mobile liquid treatment station and operation methods are disclosed, the station having a mobile treatment unit and separate mobile treatment management unit. A plurality of serial containment compartments at the treatment unit for performance of chemical dosing and solids separation are provided and are monitored with sensors. The management unit includes a plurality of chemical dosing platforms, and a power and processing assembly. A bus links the units for data and control signal transfer and chemical feed lines are connected between the units for transfer of dosing chemicals.

The invention discloses capsules for treating respiratory tract and digestive tract cancers. The capsules are prepared by taking the following traditional Chinese medicines in parts by weight as active pharmaceutical ingredients: 40-60 parts of ginseng, 8-14 parts of calculus bovis factitious, 40-60 parts of pseudo-ginsheng, 10-15 parts of hairyvein agrimonia herb and bud, 8-10 parts of solanum lyratum, 25-45 parts of Chinese Paris rhizome, 25-45 parts of membranous milkvetch root, 25-45 parts of radix sophorae flavescentis, 8-15 parts of ganoderma, 10-30 parts of dried mushroom, 10-30 parts of glabrous greenbrier rhizome, 40-75 parts of longhairy antenoron herb, 8-12 parts of common dysosmatis rhizome and root, 25-45 parts of barbed skullcap herb, 15-21 parts of salvia chinensis, 18-25 parts of spreading hedyotis herb, 10-15 parts of baical skullcap root, 8-12 parts of licorice, 6-14 parts of Indian Iphigenia bulb, 35-55 parts of indigo, 10-15 parts of black nightshade herb, 10-15 parts of asparagus and 8-10 parts of paniculate swallowwort root. The medicament disclosed by the invention is finely extracted from pure Chinese herbal medicines and has obvious analgesic, calmative and anti-cancer effects; the effect of suppressing respiratory tract and digestive tract tumors can achieve 45%; and the medicament is low in price and is a safe and effective treatment way.

The present invention discloses a traditional Chinese medicine compound preparation for treating rhinitis, the preparation is composed of 14 traditional Chinese medicine raw materials of siberian cocklour fruit, biond magnolia flower, dahurian angelica root, wild chrysanthemum, Chinese magnoliavine fruit, fineleaf schizonepeta herb, platycodon root, divaricate saposhnikovia root, liquoric root, amur corktree bark, common anemarrhena rhizome, weeping forsythiae capsule, ephedra herb and manchurian wildginger. The clinical efficacy and safety evaluations show that the present invention is safe and effective for the treatment of acute and chronic rhinitis. The present invention provides the preparation method.

The invention relates to a traditional Chinese medicine for treating chronic renal failure. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 30 parts of asiatic centella, 10 parts of caulis bambusae in taenian, 30 parts of astragali radix, 12 parts of dodder, 25 parts of serissa serissoide, 15 parts of silkworm excrement, 15 parts of Dangshen and 9 parts of tuber pinellia. Clinic experiments prove that the traditional Chinese medicine can be used for safely and effectively treating the chronic renal failure.

The invention relates to polypeptide with an anti-tumor effect and a preparation method and application of the polypeptide. The anti-tumor polypeptide is composed of 21 amino acids, and the amino acid sequence is shown in SEQ ID No.1. The polypeptide is synthesized through a solid phase chemical synthesis method, the yield is high, the process is stable, and the molecular weight is 2265.15Da. The polypeptide has activity for restraining tumor cell proliferation, invasion and metastasis, is safe and effective for treating tumors and has important application value on clinical anti-tumor therapies.

The invention discloses a traditional Chinese medicine for treating viral influenza. The traditional Chinese medicine is characterized by being prepared from the following medicinal materials in parts by weight: 60 parts of gypsum, 150 parts of houttuynia cordata, 150 parts of platycodon grandiflorum, 60 parts of apricot kernel, 120 parts of chrysanthemum, 150 parts of mulberry leaf, 60 parts of herba schizonepetae, 90 parts of mint, 150 parts of rhizoma phragmitis, 150 parts of fructus forsythia, 90 parts of perilla leaf, 120 parts of rhizoma anemarrhenae, 150 parts of honeysuckle, 90 parts of scutellaria baicalensis, 120 parts of chinese mosla herb, 150 parts of root of kudzu vine, 90 parts of liuyi powder, 150 parts of folium isatidis, 120 parts of shikonin, 150 parts of radix isatidis and 60 parts of liquorice. The clinical test proves that the viral influenza can be safely and effectively treated.

Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.

The present invention relates to a medicine for treatment of skin ulcer. The medicine comprises, by weight, 5-15 parts of selaginella tamariscina, 3-8 parts of borneol, 10-20 of rheum officinale; 5-15 parts of litharge; 5-15 parts of catechu; 10-20 parts of crude fossil fragments; 10-20 parts of Chinese angelica; 3-8 parts of cinnabar; 5-15 parts of frankincense; 3-8 parts of dragon's blood; 4-12 parts of lithospermum; 6-14 parts of Chinese magnoliavine; and 10-16 parts of calamine. Traditional Chinese medicines of the invention are formulated by clinical combination for several times, The medicine has effects of invigorating blood circulation and dispelling slough, relieving pain and promoting regeneration, engendering flesh, astringing sore and solidifying skin, nourishing blood, moistening skin and dispelling turgescence. The medicine is based on systemic treatment, treats both principal and secondary aspect of disease after being used. Proved by hundreds of clinical experiments, the medicine has obvious effects for severe and lingering ulcer, complex wound (such as cutting, stamping contusion, open fracture, and the like), bedsore, lower limb ulcer, and the like. The effective rate achieves 92%. The medicine has high cure rate.

The invention discloses a medicine for treating calculus in a hepatobiliary system and enables the problems that conventional medicines can not remove calculus and dissolve calculus at the same time to be overcome. The medicine is prepared from the following bulk drugs by weight: 20 to 30 of Guangdong desmodium, 20 to 25 of Artemisia capillaris, 15 to 20 of Fructus Gardeniae, 15 to 20 of gentrin knotweed, 15 to 20 of curcuma tuber, 4 to 8 of rheum officinale, 15 to 20 of bitter organe, 15 to 20 of betel nuts, 9 to 12 of toosendan fruit, 6 to 9 of banksia rose, 9 to 12 of chicken's gizzard membrane, 20 to 25 of haw, 9 to 12 of Chinese angelica, 20 to 25 of red sage root, 9 to 12 of radix paeoniae rubrathe, 3 to 6 of mirabilite, 15 to 20 of green tangerine peel and 20 to 25 of dark plum. The medicine provided in the invention is obtained through refined extraction of pure Chinese herbal medicines, has the effects of removing calculus, dissolving calculus and preventing formation of calculus, has a complete calculus removal rate of 43% and a total effective rate of 95.6%, costs little, provides a safe and effective treatment way for old people who are not willing to or cannot have surgery and for patients suffering from cardiovascular and cerebrovascular diseases and is easily accepted by patients.

A segmented RF electrode with one central segment delivering the treatment energy and at least one peripheral segment arranged around the perimeter of the central segment and a temperature control element communicating with the peripheral segment. The electrode is incorporated into an applicator for aesthetic and other skin treatments.