Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:
a compound of Formula I
a compound of Formula II
a compound of Formula III
and a compound of Formula IV
These compounds are useful for the treatment of HIV and AIDS.