Chitosan glycyrrhizic acid nano particle and its preparing method

Abstract

The present invention relates to preparation process of nano chitosan-glycyrrhizic acid particle. Glycyrrhizic acid has the effects of resisting viral hepatitis and chronic hepatitis and destroying HIV cell in blood vessel, but available clinically applied glycyrrhizic acid preparations have the problem of hard absorption. The present invention prepares powdered nano chitosan-glycyrrhizic acid particle through mixing chitosan dissolved in acid aqua and glycyrrhizic acid dissolved in ammonia solution, synthesis under mild condition and freeze drying. The product of the present invention may be re-dispersed in water to form nano particle and has certain targeting and delayed releasing performance. Compared with available marketed oral preparation, the present invention has obviously raised intestinal absorption and bioavailability.

Description

technical field

[0001] The invention is a method for preparing chitosan glycyrrhizinic acid nanoparticles by ion cross-linking reaction. Background technique

[0002] Nanoparticles have many advantages in drug delivery, such as slow release of drugs, thereby prolonging the action time of drugs; achieving the purpose of targeted delivery of drugs; Or avoid adverse reactions; it can improve the stability of the drug, which is beneficial to storage; it is also possible to establish some new routes of administration, including local administration in vivo, mucosal absorption administration, and oral administration of polypeptides. At present, the carriers that can be used to prepare drug nanoparticles mainly include synthetic, biodegradable, high molecular polymers and natural macromolecular systems. Synthetic biodegradable polymers include: polyanhydride, polycaprolactone, polylactic acid, polyglycolic acid and their copolymers. Natural macromolecular systems include proteins...