The present invention relates to a medicine for treatment of skin ulcer. The medicine comprises, by weight, 5-15 parts of selaginella tamariscina, 3-8 parts of borneol, 10-20 of rheum officinale; 5-15 parts of litharge; 5-15 parts of catechu; 10-20 parts of crude fossil fragments; 10-20 parts of Chinese angelica; 3-8 parts of cinnabar; 5-15 parts of frankincense; 3-8 parts of dragon's blood; 4-12 parts of lithospermum; 6-14 parts of Chinese magnoliavine; and 10-16 parts of calamine. Traditional Chinese medicines of the invention are formulated by clinical combination for several times, The medicine has effects of invigorating blood circulation and dispelling slough, relieving pain and promoting regeneration, engendering flesh, astringing sore and solidifying skin, nourishing blood, moistening skin and dispelling turgescence. The medicine is based on systemic treatment, treats both principal and secondary aspect of disease after being used. Proved by hundreds of clinical experiments, the medicine has obvious effects for severe and lingering ulcer, complex wound (such as cutting, stamping contusion, open fracture, and the like), bedsore, lower limb ulcer, and the like. The effective rate achieves 92%. The medicine has high cure rate.