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Polyacrylate-grafted modified gelatin-adhesive and preparation method thereof

A technology of polyacrylate and methacrylic anhydride gelatin, applied in surgical adhesives, applications, medical science, etc., can solve the problems of unsuitable for clinical medical treatment, large damage to human cells, long adhesive time, etc. Polymerization efficiency, short curing time, and low cost effects

Active Publication Date: 2017-11-24
CHENGDU MEDART MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has a long adhesive time, low polymerization rate, and ultraviolet light is more harmful to human cells, so it is not suitable for clinical medical treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of polyacrylate graft modified gelatin-adhesive, comprising the following steps:

[0021] (1) Preparation of methacrylic anhydride gelatin: gelatin and PBS solution are mixed according to 1g: 10ml to form the first mixed solution, and the first mixed solution is stirred and dissolved at 100r / min for 1h; then the molar ratio of gelatin to gelatin is Add 0.08 methacrylic anhydride to the mixed solution, raise the temperature to 50°C, and react at constant temperature for 3 hours to form the second mixed solution, add DPBS solution equal to the PBS solution to the second mixed solution to form the third mixed solution, and mix the third The solution was transferred to the Spectro / Por molecular porous tubular, MWCO12-14000 membrane belt, dialyzed for 5 days, replaced with purified water once a day, freeze-dried, and stored at -20°C;

[0022] (2) Preparation of polyacrylate grafted modified gelatin-adhesive: mix β-cyclodextrin, camphorquinone and water a...

Embodiment 2

[0024] A preparation method of polyacrylate graft modified gelatin-adhesive, comprising the following steps:

[0025] (1) Preparation of methacrylic anhydride gelatin: gelatin and PBS solution are mixed according to 1g: 13ml to form the first mixed solution, and the first mixed solution is stirred and dissolved at 150r / min for 2h; then the molar ratio of gelatin to gelatin is Add 0.1 methacrylic anhydride to the mixed solution, heat up to 50°C, and react at a constant temperature for 3 hours to form the second mixed solution, add PBS solution 4 times the amount of the PBS solution to the second mixed solution to form the third mixed solution, and the third The mixed solution was transferred to the Spectro / Por molecular porous tubular, MWCO12-14000 membrane belt, dialyzed for 5 days, replaced with purified water once a day, freeze-dried, and stored at -20°C;

[0026] (2) Preparation of polyacrylate graft modified gelatin-adhesive: mix starch, β-cyclodextrin, camphorquinone and ...

Embodiment 3

[0028] A preparation method of polyacrylate graft modified gelatin-adhesive, comprising the following steps:

[0029] (1) Preparation of methacrylic anhydride gelatin: gelatin and CB solution are mixed according to 1g: 10ml to form the first mixed solution, and the first mixed solution is stirred and dissolved at 150r / min for 4h; then the molar ratio of gelatin to gelatin is Add 0.12 methacrylic anhydride to the mixed solution, raise the temperature to 50°C, and react at constant temperature for 3 hours to form the second mixed solution, add PBS solution 4 times the amount of CB solution to the second mixed solution to form the third mixed solution, and mix the third The solution was transferred to Spectro / Por molecular porous tubular, MWCO12-14000 membrane belt, dialyzed for 6 days, replaced with purified water once a day, freeze-dried, and stored at -20°C;

[0030] (2) Preparation of polyacrylate grafted modified gelatin-adhesive: mix chitosan, β-cyclodextrin, camphorquinone...

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PUM

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Abstract

The invention relates to polyacrylate-grafted modified gelatin-adhesive and a preparation method thereof. An embedded material which is formed by co-mixing and ultrasonic promoted dissolution of water-soluble polymer containing beta-cyclodextrin and camphorquinone is taken as a photoinitiator; glycerol is taken as a medium to provide more active hydroxyl free radicals; methacrylic acid modified grafted gelatin, acrylate monomer and a cross-linking agent polyethyleneglycol dimethacrylate promote the adhesive to form hydrogel under illumination of blue light with wavelength of 420-480 nm and light intensity of 1200-2000 mw / cm<2>, so that the curing and adhering effect is achieved. The adhesive provided by the invention has the characteristics of being high in photopolymerization efficiency, good in adhesion performance, non-toxic to human body, and the like, can be widely applied to sealing and bleeding-stopping of various acute open wounds, adhering and sealing of operative incisions or holes, and recovering, adhering and fixing of non-open fracture.

Description

technical field [0001] The invention belongs to the technical field of medical adhesive preparation, and relates to a polyacrylate graft modified gelatin-adhesive and a preparation method thereof. Background technique [0002] Gelatin hydrogel is a biodegradable biomaterial with good biocompatibility, which has been widely used as pharmaceutical and biomedical materials such as capsule shells, but its aqueous solution has a low melting temperature and melts into a liquid state at 35 °C , and its Young's modulus of elasticity in the frozen state is relatively small, not impact-resistant, poor toughness and other shortcomings hinder the application of gelatin in the field of medical materials. Although the "instant adhesive" based on cyanopropionate has a very short curing time, it is brittle and has poor biodegradability, and may even affect the safety of users due to the production of toxic degradation products. Therefore, consideration of factors such as bonding strength, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F291/12C08F291/06C08F220/28C08F220/06C08F2/48A61L24/10A61L24/06A61L24/00
CPCA61L24/001A61L24/06A61L24/104C08F2/48C08F283/065C08F289/00C08L51/00C08L51/08
Inventor 张晓金王军张伟杨满孙琳琳吴建梁国超
Owner CHENGDU MEDART MEDICAL SCI CO LTD
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