Orthopaedic metal implant loaded with slow release antibiotic and preparation method thereof

Abstract

The invention discloses an orthopaedic metal implant loaded with slow release antibiotic, composed of a matrix (1) and slow release antibiotic layer (2) covered on the matrix; wherein the matrix (1) is titanium alloy, or stainless steel or cobalt molybdenum alloy, and the slow release antibiotic layer (2) is a PDLLA coating combined with antibiotic. The preparation method includes pretreatment ofthe matrix (1), confection of antibiotic solution and sedimentation of the coating. The orthopaedic metal implant loaded with slow release antibiotic of the invention improves anti infection capacity,ensures continuity of implanted bone and repaired bone in period I after debridement or focus clearing of bone defect caused by open fracture and other reasons and also can prevent tubercle germ infection. PDLLA can be well absorbed by organism. Slow-release antibiotic can maintain release for a period of time, thus antibiotic effective concentration in local part can be maintained for a long time, and side effect of whole body medicine application is avoided while infection is effectively prevented and treated at the local part.

Description

technical field [0001] The invention belongs to medical orthopedic metal implants, in particular to an orthopedic metal implant loaded with slow-release antibiotics and a preparation method thereof. Background technique [0002] In daily life, the infection rate after open fracture surgery is 3-29%. In wartime firearm injuries, due to serious tissue damage and pollution, there are a large number of bacteria within 0.5cm around the ballistic trajectory, even if the bone and soft tissue are infected after debridement. The infection rate is still as high as 25% to 40%, and if internal fixation is used, the infection rate will increase by more than 30%. In open fractures, especially wartime gunshot wounds, bone defects and bacterial contamination are often present at the same time. [0003] For open fractures with both bone defects and bacterial contamination of bone defects, the general traditional treatment method is: first use surgical methods such as thorough debridement or...

AI Technical Summary

Problems solved by technology

In recent years, there have been products such as polymethylmethacrylate (PMMA) antibiotic chain beads and antibiotic-loaded bone cement with local slow-release of antibiotics. Although these products have anti-infection ability, their carriers are not bone graft materials, so it is difficult to provide The body absorbs and needs to be taken out again by surgery; the method of combining antibiotics with osteogenic materials such as hydroxyapatite and bone growth factors to make the method of slow-release antibiotics while implanting bone graft materials such as hydroxyapatite has a biological phase. The capacity is not as good as that of tissue engineered bone, and its antibacterial properties are ineffective against the presence of drug-resistant bacteria and biofilms. The simple method of mixing antibiotics with tissue engineered bone only increases the local antibiotic concentration, and the release process cannot be truly effective. Long-term maintenance of antibiotic concentration, especially in the face of the plight of drug-resistant bacteria and biofilm, the release of antibiotics in the above way is even more ineffective

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