Orthopaedic metal implant loaded with slow release antibiotic and preparation method thereof

An antibiotic and sustained-release technology, applied in the field of orthopaedic metal implants carrying sustained-release antibiotics and their preparation, can solve the problems that the biocompatibility is not as good as tissue engineering bone, increase the concentration of antibiotics, and are not bone grafting materials, etc., to improve anti-infection. ability, avoiding side effects, preventing infection

Inactive Publication Date: 2010-02-10
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there have been products such as polymethylmethacrylate (PMMA) antibiotic chain beads and antibiotic-loaded bone cement with local slow-release of antibiotics. Although these products have anti-infection ability, their carriers are not bone graft materials, so it is difficult to provide The body absorbs and needs to be taken out again by surgery; the method of combining antibiotics with osteogenic materials such as hydroxyapatite and bone growth factors to make the method of slow-release antibiotics while implanting bone graft materials such as hydrox

Method used

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  • Orthopaedic metal implant loaded with slow release antibiotic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Orthopedic metal implants loaded with slow-release antibiotics were prepared by the following steps:

[0025] A. Pretreatment of substrate 1: substrate 1 is polished with 400, 600, and 800# metallographic sandpaper in sequence until there are no obvious scratches on the surface, then soaked in acetone for degreasing for 6 hours, and then put in acetone with a volume ratio of 1:1, Ultrasonic cleaning in isopropanol mixed solution for 20 minutes, rinsed with distilled water after taking out, dried and then soaked in Piranha solution for 6 hours, taken out and dried for later use, wherein Piranha solution is 98% concentration of H 2 SO 4 and H 2 o 2 Mixed composition, H 2 SO 4 :H 2 o 2 The volume ratio is 7:3.

[0026] B. Preparation of antibiotic solution: Dissolve 2g of PDLLA in 10ml of ethyl acetate and fully dissolve it to obtain the ethyl acetate solution of PDLLA. Separately prepare 0.2g of clindamycin in the antibiotic, dissolve it in 1ml of distilled water a...

Embodiment 2

[0030] A. Pretreatment of substrate 1: substrate 1 is polished with 400, 600, and 800# metallographic sandpaper in sequence until there are no obvious scratches on the surface, then soaked in acetone for 4 hours to degrease, and then put in acetone with a volume ratio of 1:0.5, Ultrasonic cleaning in isopropanol mixture solution for 10min, rinse with distilled water after taking out, dry and then soak in Piranha solution for 4h, take out and dry for later use, wherein Piranha solution is 98% H 2 SO 4 and H 2 o 2 Mixed composition, H 2SO 4 :H 2 o 2 The volume ratio is 7:3.

[0031] B. Preparation of antibiotic solution: Dissolve 1g of PDLLA in 5ml of ethyl acetate and fully dissolve it to obtain the ethyl acetate solution of PDLLA. Separately prepare 0.1g of isoniazid in the antibiotic, dissolve it in 0.5ml of distilled water and mix evenly, then add acetone After 2ml of milky white appears, add the prepared ethyl acetate solution of PDLLA, stir for 20min to obtain antib...

Embodiment 3

[0035] A. Pretreatment of substrate 1: substrate 1 is polished with 400, 600, and 800# metallographic sandpaper in sequence until there are no obvious scratches on the surface, then soaked in acetone for 8 hours to degrease, and then put in acetone with a volume ratio of 1:1.5, Ultrasonic cleaning in isopropanol mixture for 30 minutes, rinsed with distilled water after taking out, dried, then soaked in Piranha solution for 8 hours, taken out and dried for later use, wherein Piranha solution is 98% concentration of H 2 SO 4 and H 2 o 2 Mixed composition, H 2 SO 4 :H 2 o 2 The volume ratio is 7:3.

[0036] B. Preparation of antibiotic solution: Dissolve 3g of PGA in 15ml of ethyl acetate and fully dissolve it to obtain the ethyl acetate solution of PGA. Separately prepare 0.3g of rifampicin in the antibiotic, dissolve it in 1.5ml of distilled water and mix evenly, then add 5ml of acetone After the milky white color appears, add the prepared PGA ethyl acetate solution and ...

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Abstract

The invention discloses an orthopaedic metal implant loaded with slow release antibiotic, composed of a matrix (1) and slow release antibiotic layer (2) covered on the matrix; wherein the matrix (1) is titanium alloy, or stainless steel or cobalt molybdenum alloy, and the slow release antibiotic layer (2) is a PDLLA coating combined with antibiotic. The preparation method includes pretreatment ofthe matrix (1), confection of antibiotic solution and sedimentation of the coating. The orthopaedic metal implant loaded with slow release antibiotic of the invention improves anti infection capacity,ensures continuity of implanted bone and repaired bone in period I after debridement or focus clearing of bone defect caused by open fracture and other reasons and also can prevent tubercle germ infection. PDLLA can be well absorbed by organism. Slow-release antibiotic can maintain release for a period of time, thus antibiotic effective concentration in local part can be maintained for a long time, and side effect of whole body medicine application is avoided while infection is effectively prevented and treated at the local part.

Description

technical field [0001] The invention belongs to medical orthopedic metal implants, in particular to an orthopedic metal implant loaded with slow-release antibiotics and a preparation method thereof. Background technique [0002] In daily life, the infection rate after open fracture surgery is 3-29%. In wartime firearm injuries, due to serious tissue damage and pollution, there are a large number of bacteria within 0.5cm around the ballistic trajectory, even if the bone and soft tissue are infected after debridement. The infection rate is still as high as 25% to 40%, and if internal fixation is used, the infection rate will increase by more than 30%. In open fractures, especially wartime gunshot wounds, bone defects and bacterial contamination are often present at the same time. [0003] For open fractures with both bone defects and bacterial contamination of bone defects, the general traditional treatment method is: first use surgical methods such as thorough debridement or...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/54A61L27/58A61L27/06A61L27/04
Inventor 费军余洪俊
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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