Anti-infective functionalized surfaces and methods of making same

a functionalized surface and anti-infective technology, applied in the field of substrates with anti-infective surfaces, can solve problems such as limited materials, and achieve the effects of reducing the incidence of deep infection, preventing pin-site infections, and reducing the potential for infection

Inactive Publication Date: 2010-08-26
ORTHOBOND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0023]Devices made in accordance with the present disclosure provide a multitude of clinical benefits. For example, in partially external devices, anti-infective surfaces thereof may kill bacterial species at the device-skin interface, thus preventing pin-site infections. Devices including an anti-infective surface may prevent the colonization by infectious species of implanted surfaces, potentially reducing the incidence of deep infection, especially in high-risk populations. In catheters and shunts with anti-infective surfaces the potential for infection is minimized by killing bacteria traveling up the intubated pathway into the patient. Another example is in total hip arthroplasties; anti-infective hip stems may kill bacterial...

Problems solved by technology

This procedure yields a molecular adhesion species that is bound to the surface of...

Method used

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  • Anti-infective functionalized surfaces and methods of making same
  • Anti-infective functionalized surfaces and methods of making same
  • Anti-infective functionalized surfaces and methods of making same

Examples

Experimental program
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Effect test

example 1

Metallization of Activated Polymers

[0068]Activated polymers of polyimides, aramides and Gore-Tex composites were produced as follows:

[0069]Formation of a zirconia thin film on polymer substrate:

[0070]All reagents were obtained from Aldrich and were used as received unless otherwise noted. PET, PEEK, and nylon 6 / 6 were obtained from Goodfellow, Inc. Acetonitrile was dried over CaH2; and tetrahydrofuran (THF) was dried over KOH overnight. Both were distilled prior to use. Surface modified samples were analyzed using a Midac M25 10C interferometer equipped with a surface optics SOC4000 SH specular reflectance head attachment. Fluorimetry experiments utilized a Photon Technology International Fluorescence Spectrometer.

[0071]Polymer substrates (nylon 6 / 6, PET or PEEK) were placed in a deposition chamber equipped with two stopcocks for exposure either to vacuum or to the vapor of zirconium tetra(tert-butoxide). The chamber was evacuated at 10−3 ton for 1 hour and polymer slides were expos...

example 2

Electroless Plating of Copper

[0075]A sample of Kapton treated first with the zirconium-based adhesion layer, then copper sulfate, and then diethylamineborane as described in Example 1 was placed in a copper plating bath at 60° C. under nitrogen. The bath consisted of 0.1 M trisodium citrate dihydrate, 1.2 M ethylenediamine, 0.1 M copper sulfate hydrate, 0.03 M ferrous sulfate hydrate, 6.4×10−4 M 2,2-dipyridine, 1.2 M NaCl, and sufficient sulfuric acid to give pH=6. A small amount of PEG 200 (2.5 mg) was added to a 50 ml bath.

example 3

Polymer Metallization

[0076]The zirconium oxide / alkoxide adhesion layer nucleates the growth of copper metal on PET and Kapton® polyimide film surfaces; this approach provides a basis for patterned metallization of polymer-based device substrates.

[0077]The adhesion layer can serve as a matrix to enable polymer surface metallization. In a typical procedure Kapton® polyimide film was coated with a 5 nm thick layer of adhesion layer and was then soaked in a 200 mM aqueous solution of CuSO4. Samples were rinsed in deionized water, and EDX analysis confirmed the presence of Cu and S. After subsequent (slow) reduction by dimethylamine borane (1M, aqueous, 6 hrs, 50° C.), metallic copper was formed. Metallization was also done using an adhesion layer patterned on Kapton® polyimide film. The metallized surface was subjected to sonication in water and physical rubbing with a Q-tip, which was followed by EDX. In this way it was shown that patterns of both Zr and Cu on the Kapton® polyimide fil...

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Abstract

Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61 / 155,324, filed Feb. 25, 2009, the entirety of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to substrates with anti-infective surfaces. In particular, methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents.BACKGROUND OF THE INVENTION[0003]An activated, or functionalized, layer that is bonded or otherwise disposed on the surface of a substrate is useful as an interface between the substrate and other materials such as organic or metallic materials. This functionalized layer allows the substrate to react with and to bind to the organic or metallic material.[0004]The need for control of infection is a vital concern for many, from public health officials, hospital and school administrators and the like, to private citizens. T...

Claims

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Application Information

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IPC IPC(8): A01N59/00A01N59/08A01N43/66A01N59/02A01N59/14A01N59/12A01N31/02A01N31/08A01N31/14A01N37/52A01N59/16A01N59/18A01N59/20A01N59/06A01N37/18A01N43/50A01N43/08A01N43/20A01N57/00C23C14/34B05D1/18C23C16/40
CPCA01N25/08A01N25/10A01N59/16A01N59/20A01N31/12A61P31/00A61L2/16A61L27/28A61L2202/21A61L31/022A61L31/16A61L2300/208A61L2300/404C07F9/3821
Inventor CLEVENGER, RANDELLSCHWARTZ, JEFFREY
Owner ORTHOBOND
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