The invention discloses a novel coaxial electrostatic
spinning stent coupling piezoelectric stimulation and AVT, the morphology of the
stent simulates an
extracellular matrix, adhesion, growth and differentiation of cells are facilitated, and a space is provided for growth of new blood vessels and new bones; the coaxial electrostatic
spinning stent takes an artificial
high polymer material as a matrix, is good in
biological safety and can be degraded
in vivo, and a degradation product is non-toxic; a clinical
drug AVT for promoting
angiogenesis is loaded in a
fiber shell layer, and the defects that various
angiogenesis promoting factors are high in price, short in half-life period, insufficient in potential safety and the like are overcome; the piezoelectric material ZnO for promoting osteogenic differentiation is loaded on the
fiber core layer, various defects of external electrical stimulation equipment are avoided, the osteogenic differentiation is continuously promoted by collecting
masticatory muscle force and converting the
masticatory muscle force into piezoelectric stimulation, meanwhile,
angiogenesis is promoted in combination with
early release of AVT, and finally, vascularized
bone regeneration of lower jawbone defects is promoted. According to the invention, the source of required materials is sufficient, the preparation technology is simple, the cost is low, the
biological safety is good, and the potential clinical application prospect is achieved.