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67 results about "Early release" patented technology

The early release is carried out only by a court in the manner prescribed by law. A distinction is made between early release and release from serving punishment because the term has been reduced by a ruling (decree) of an appellate or supervisory court or through amnesty or pardon.

Method used for preparing microcarrier/polymer composite scaffold by electro-deposition

InactiveCN103405809ADoes not cause early releaseDoes not cause activityProsthesisTissue repairPolymer scaffold
The invention relates to a method used for preparing a microcarrier/polymer composite scaffold by electro-deposition. The method comprises following steps: the surface of a microcarrier is modified, so that the surface of the microcarrier is positively charged; the microcarrier is loaded with a bioactive component so as to obtain the functional microcarrier; the functional microcarrier is delivered into an organic solvent, and the mixture is treated by ultrasonic and is stirred so as to obtain an electro-deposition solution with a concentration of 0.1 to 1.0mg/ml; a polymer scaffold is prepared, an electrode provided with the polymer scaffold is taken as a cathode, and a blank electrode is taken as an anode; the cathode and the anode are delivered into the electro-deposition solution, and the electro-deposition solution is stirred for electro-deposition so as to obtain the composite scaffold; and the composite scaffold is washed and dried in the air so as to obtain the microcarrier/polymer composite scaffold. Preparation time is short; reaction conditions are mild; and it is impossible to cause early release or inactivation of the bioactive component loaded on the microcarrier. The microcarrier/polymer composite scaffold is capable of simulating the multiple interaction of cells in the body, ECM and growth factors, and providing an ideal environment for tissue therapy and tissue repair.
Owner:DONGHUA UNIV

Drug sustained and controlled release microparticle preparation for treating intestinal diseases, and preparation method thereof

The present invention discloses a drug sustained and controlled release microparticle preparation for treating intestinal diseases. The preparation comprises: a pill core containing the drug, wherein the pill core contains 5-aminosalicylic acid and an assistant material; an isolation layer for providing a smooth and flat surface for the microparticle and preventing the drug from penetrating into a sustained release coating layer, wherein the penetration of the drug into the sustained release coating layer can affect the release effect, the used material of the isolation layer comprises one or a plurality of materials selected from a water-soluble polymer and an anti-adhesion agent; the sustained release coating layer for slowly releasing the drug, wherein different drug release levels can be achieved through adjusting the thickness of the sustained release coating layer, the used material of the sustained release coating layer mainly adopts a sustained-release material; an enteric-coating layer, the enteric-coating layer is provided for avoiding the early release of the drug in gastric juice, reducing stimulation of the main drug to stomach, increasing the local concentration of the drug in the lesion location, the used material of the enteric-coating layer mainly adopts a polymer enteric material. The invention further discloses a preparation method for the microparticle preparation. According to the present invention, the drug and the sustained release coating material are uniformly dispersed on the surface of the pellet, such that the problem of mixing uniformity of the assistant material and the main drug can be effectively solved.
Owner:PIVOT PHARMA TECH SHANGHAI

Multi-layer drug sustain-release nano fiber membrane and preparation method thereof

The invention discloses a multi-layer drug sustain-release nano fiber membrane and a preparation method thereof. The inner layer and outer layer of the multi-layer membrane are both composed of a polymer A nano fiber with a good biological compatibility, and the middle layer is a drug-carrying nano fiber which is prepared by blending curcumin (CM) and a polymer B with a good biological compatibility. The preparation method comprises the following steps: dissolving the polymer A into a solvent, subjecting the polymer A to an electrostatic spinning process so as to prepare the inner layer, then subjecting a mixed solution of the polymer B and CM to an electrostatic spinning process, continuously depositing the mixed solution on the inner layer so as to obtain the middle layer, finally subjecting the polymer A to an electrostatic spinning process for a second time, and continuously depositing the polymer A on the middle layer so as to obtain the outer layer. The membrane preparation method is simple, can effectively relieve the burst release phenomenon in the early release stage, and can control the drug release by changing the thickness of the polymer A. Taking polymer A-polylactic acid (PLA), and polymer B-cellulose acetate (CA) as an example, the in vitro drug release test results have shown that the drug release rate of the multi-layer drug-carrying membrane is both less than that of a single layer drug loaded membrane no matter after 1 hour or after 240 hours.
Owner:JIANGNAN UNIV

Implant conveying system

ActiveCN108186176AAvoid the risk of sheddingAvoid the disadvantage of not being able to adjust the release positionStentsEarly releaseHooking
The invention discloses an implant conveying system, which comprises an inner sheath canal, an inner sheath core pipe which runs through the inner sheath canal and distal end of which extends out of the inner sheath canal, and an outer sheath canal which movably sleeves the exterior of the inner sheath canal and defines a cavity with the inner sheath core pipe, and further comprises at least one hooking unit which is fixed to the outer surface of the inner sheath core pipe, wherein the at least one hooking unit comprises at least two flexible hooking pieces; each hooking piece comprises a fixed part which is connected to the outer surface of the inner sheath core pipe and a deformed part which is connected to the fixed part; and the free end of each deformed part can get bent relative to the fixed part and the free end, when being accommodated within the cavity between the outer sheath canal and the inner sheath core pipe, is matched with the fixed part, so that a hook-shaped object isdefined. According to the implant conveying system provided by the invention, an implant can be fixed to the inner sheath core pipe via the at least one hooking unit, so that the implant is limited from moving. Therefore, in an implant conveying process, the implant is prevented getting deviated from the inner sheath core pipe; and in a release process, early release of the implant can be avoidedwhen the release position of the implant needs to be adjusted.
Owner:LIFETECH SCIENTIFIC (SHENZHEN) CO LTD

Shield machine suitable for high crustal stress soft rock stratum

The invention provides a shield machine suitable for high crustal stress soft rock stratum. The machine comprises a cutter device and a shield body, the shield body is internally provided with a frontshield partition plate, the front shield partition plate is provided with an advanced tunneling passage, the advanced tunneling passage is internally provided with an advanced tunneling device, the advanced tunneling device includes an advanced tunneling cutter, a spiral blade shaft, a guide rail, advanced tunneling drive, an advanced support device and an advanced propulsion device, the advancedtunneling cutter is connected to the spiral blade shaft, the spiral blade shaft is connected to an advanced drive device, the advanced propulsion device is arranged between the advanced drive deviceand the advanced support device, the advanced support device is supported on the shield body, and the guide rail is arranged at the advanced tunneling passage. The machine has the advantages that themachine not only facilitates the early release of the energy accumulated in a rock body, but also utilizes an expansion and contraction function of the shield body to achieve secondary stress release,and achieves integrated construction of horseshoe-shaped full-section excavation, slag discharge and lining machinery of the high crustal stress soft rock stratum.
Owner:CHINA RAILWAY ENGINEERING EQUIPMENT GROUP CO LTD

Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems

In one embodiment, the invention provides a method of regenerating organs and tissues in a subject suffering from one or more organ or tissue manifestations of glucose supply side associated metabolic syndrome, the method comprising: (a) confirming that the subject suffers from or is at risk for suffering from organ and/or tissue damage associated with a glucose supply side associated metabolic syndrome; and (b) co-administering to the subject an effective amount of a pharmaceutical composition comprising a first and optionally a second active composition, said first active composition comprising an ileal brake hormone releasing substance encapsulated within an enteric coating which releases said substance within said subject's ileum and ascending colon causing release of at least one ileal brake hormone from L-cells of said subject, said optional second active composition being formulated in immediate and/or early release form in an over coating onto said enteric coating, wherein said second composition is beneficial to at least one aspect of said subject's metabolic syndrome manifestations. Coadministration methods with a second pharmaceutical composition are also disclosed.
Owner:NEW SCI HLDG +1

Catalytic combustion improver for blast furnace coal injection and application method thereof

The invention discloses a catalytic combustion improver for blast furnace coal injection and an application method thereof. The catalytic combustion improver is prepared from the following raw materials in percentage by mass through milling and mixing: 1-5% of ferrocene or potassium permanganate, rare metal catalysts including 1-2% of lanthanum oxide and cerium oxide, 30-35% of calcium peroxide, 15-20% of magnesium peroxide, 15-20% of active manganese dioxide and 1-3% of copper sulfate, and a carrier including 15-20% of calcium carbonate or dolomite, wherein the particle size of the product is 0.076 mm, and the content is greater than or equal to 95%. The catalytic combustion improver for blast furnace coal injection, disclosed by the invention, is used in a pulverized coal mass rate of 0.4-0.45%, the particle size of pulverized coal is required to be 0.076 mm, and the content of pulverized coal is required to be greater than or equal to 50%. According to the invention, through prompting the early release of coal chemical energy, the combustion efficiency of pulverized coal is increased, and the purposes of saving energy and reducing consumption are achieved. After a catalytic combustion improver product disclosed by the invention is added into pulverized coal, through a chemical reaction, C-C bonds in the pulverized coal are forcedly fractured, therefore, the ignition temperature of the pulverized coal is reduced, and the pulverized coal is completely combusted in a short time.
Owner:MAANSHAN JIUPENG JIATENG MACHINERY IND

Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems

In one embodiment, the invention provides a method of regenerating organs and tissues in a subject suffering from one or more organ or tissue manifestations of glucose supply side associated metabolic syndrome, the method comprising: (a) confirming that the subject suffers from or is at risk for suffering from organ and / or tissue damage associated with a glucose supply side associated metabolic syndrome; and (b) co-administering to the subject an effective amount of a pharmaceutical composition comprising a first and optionally a second active composition, said first active composition comprising an ileal brake hormone releasing substance encapsulated within an enteric coating which releases said substance within said subject's ileum and ascending colon causing release of at least one ileal brake hormone from L-cells of said subject, said optional second active composition being formulated in immediate and / or early release form in an over coating onto said enteric coating, wherein said second composition is beneficial to at least one aspect of said subject's metabolic syndrome manifestations. Coadministration methods with a second pharmaceutical composition are also disclosed.
Owner:杰罗米申塔格 +1

Slump resisting and water reducing type polycarboxylic acid slump resisting agent and preparation method thereof

The invention discloses a slump resisting and water reducing type polycarboxylic acid slump resisting agent and a preparation method thereof. The slump resisting and water reducing type polycarboxylicacid slump resisting agent is prepared from 100 parts of polyether, 4.5 to 6.1 parts of unsaturated carboxylic acid, 0.3 to 0.6 part of a chain transfer agent, 0.1 to 0.4 part of an initiator, 0.3 to0.5 part of an oxidant, 160 to 172 parts of deionized water and 12 to 16 parts of hydroxyethyl acrylate. The slump resisting and water reducing type polycarboxylic acid slump resisting agent disclosed by the invention has the advantages of low production temperature, simple synthesis method, low process requirement, environmental friendliness, high efficiency and convenience for batch production.The slump resisting and water reducing type polycarboxylic acid slump resisting agent can improve the workability of concrete under a condition of a low mixing amount, and also has an extremely goodwater reducing effect to achieve slump resisting and water reducing effects. According to the preparation method, a solution A and a solution B are separately produced by adopting raw materials, and 20% of deionized water is used; then the dropwise adding time is controlled stage by stage, and 60% of deionized water is used; a test result shows that the slump resisting effect of the slump resisting and water reducing type polycarboxylic acid slump resisting agent is good; the workability of the concrete can be maintained by early release and later release, and even the short-time later workability is higher.
Owner:北京时代思动科技有限公司

Medicine controlled timing-released calcium phosphate cement powder containing various medicines

The invention relates to medicine controlled timing-released calcium phosphate cement powder containing various medicines. The powder is prepared by precipitating and blending long-term released medicines with one component in the calcium phosphate cement powder, and carrying out polymer packaging to obtain packaging powder; and directly blending the packaging powder with other calcium phosphate components in the calcium phosphate cement powder and early released medicines, or blending the packaging powder with the early released medicines, a precipitate blend powder of another component in the calcium phosphate cement powder and other components in the calcium phosphate cement powder. The powder is applicable to filling and repairing bone defects, and the early released medicines and thelong-term released medicines carried by the powder can be released at different time sequences at the local bone defect for combined administration; the curative effect can be enhanced by a synergistic effect so as to promote bone healing and increase the clinical success rate of filling and repairing the bone defect; moreover, the side effect of the medicines on human bodies can be reduced, and thus the powder meets the clinical requirements for bone filling and repairing materials.
Owner:SOUTHWEST JIAOTONG UNIV
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