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Multi-layer drug sustain-release nano fiber membrane and preparation method thereof

A nanofiber film and nanofiber technology, which is applied in the direction of drug combination, antibacterial drugs, antineoplastic drugs, etc., to achieve the effect of good shape, prolonged action time and smooth surface

Inactive Publication Date: 2014-02-26
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the defects that CM is insoluble in water and easy to decompose, the drug-loaded nanofibers are made by wrapping CM in the middle layer polymer, thereby improving the hydrophobic properties of CM, prolonging the action time of CM, and improving the bioavailability of CM, multilayer The structure prolongs the diffusion distance of the drug, improves the initial burst release phenomenon of the drug release, and can control the sustained release of the drug by changing the thickness of the inner and outer polymers

Method used

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  • Multi-layer drug sustain-release nano fiber membrane and preparation method thereof
  • Multi-layer drug sustain-release nano fiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Dissolve the weighed CA and CM in a mixed solvent of acetone and dimethylacetamide (volume ratio 3:2), and prepare the CA concentration to be 13%, and the CM concentration to be 10% to 30% (w / w) drug-loaded spinning solution, the weighed PLA was dissolved in the mixed solvent of dichloromethane and dimethylformamide (volume ratio 7: 3), and the spinning solution with 8% PLA concentration was prepared .

[0020] (2) Inject the PLA spinning solution into the syringe of the electrospinning device, fix it on the micro-syringe pump, adopt the plate collection method, set the receiving time to 2h, and the process parameters are, voltage 18kV, flow rate 1.0ml / h, The distance is 17cm, and the first layer of PLA nanofibers is obtained, namely figure 1 The lowest level in the middle.

[0021] (3) After the first layer is spun, according to the method of (2), the drug-loaded spinning solution is then continued to be electrospun in the same way, the receiving time is set to ...

Embodiment 2

[0025] (1) Dissolve the weighed CA and CM in a mixed solvent of acetone and dimethylacetamide (volume ratio 3:2), and prepare the CA concentration to be 13%, and the CM concentration to be 10% to 30% (w / w) drug-loaded spinning solution, the weighed PLA was dissolved in the mixed solvent of dichloromethane and dimethylformamide (volume ratio 7: 3), and the spinning solution with 8% PLA concentration was prepared .

[0026] (2) Inject the PLA spinning solution into the syringe of the electrospinning device, fix it on the micro-syringe pump, adopt the plate collection method, set the receiving time to 5h, and the process parameters are, voltage 18kV, flow rate 1.0ml / h, With a distance of 17 cm, the first layer of PLA nanofibers was obtained.

[0027] (3) After the first layer is spun, according to the method of (2), the drug-loaded spinning solution is then continued to be electrospun in the same way, the receiving time is set to 18h, the process parameters are 18kV, and the fl...

Embodiment 3

[0031] (1) Dissolve the weighed CA and CM in a mixed solvent of acetone and dimethylacetamide (volume ratio 3:2), and prepare the CA concentration to be 13%, and the CM concentration to be 10% to 30% (w / w) drug-loaded spinning solution, the weighed PLA was dissolved in the mixed solvent of dichloromethane and dimethylformamide (volume ratio 7: 3), and the spinning solution with 8% PLA concentration was prepared .

[0032] (2) Inject the PLA spinning solution into the syringe of the electrospinning device, fix it on the micro-syringe pump, adopt the plate collection method, set the receiving time to 7h, and the process parameters are, voltage 18kV, flow rate 1.0ml / h, With a distance of 17 cm, the first layer of PLA nanofibers was obtained.

[0033] (3) After the first layer is spun, according to the method of (2), the drug-loaded spinning solution is then continued to be electrospun in the same way, the receiving time is set to 18h, the process parameters are 18kV, and the fl...

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Abstract

The invention discloses a multi-layer drug sustain-release nano fiber membrane and a preparation method thereof. The inner layer and outer layer of the multi-layer membrane are both composed of a polymer A nano fiber with a good biological compatibility, and the middle layer is a drug-carrying nano fiber which is prepared by blending curcumin (CM) and a polymer B with a good biological compatibility. The preparation method comprises the following steps: dissolving the polymer A into a solvent, subjecting the polymer A to an electrostatic spinning process so as to prepare the inner layer, then subjecting a mixed solution of the polymer B and CM to an electrostatic spinning process, continuously depositing the mixed solution on the inner layer so as to obtain the middle layer, finally subjecting the polymer A to an electrostatic spinning process for a second time, and continuously depositing the polymer A on the middle layer so as to obtain the outer layer. The membrane preparation method is simple, can effectively relieve the burst release phenomenon in the early release stage, and can control the drug release by changing the thickness of the polymer A. Taking polymer A-polylactic acid (PLA), and polymer B-cellulose acetate (CA) as an example, the in vitro drug release test results have shown that the drug release rate of the multi-layer drug-carrying membrane is both less than that of a single layer drug loaded membrane no matter after 1 hour or after 240 hours.

Description

technical field [0001] The invention relates to a medical drug slow-release film and a preparation method thereof, in particular to a multilayer drug slow-release nanofiber film loaded with antibacterial and anticoagulant drug curcumin (CM) and a preparation method thereof. Background technique [0002] Electrospinning technology is used to prepare drug-loaded nanofibers. The device is simple and the cost is low. The prepared nanofibers have small diameter, high porosity and large specific surface area, which can greatly improve the bioavailability of drugs. At the same time, the fiber-shaped drugs The dosage form also has good physical strength and processing performance. The polymer and the drug are dissolved together to obtain a homogeneous solution in the same direction, and the drug is evenly dispersed in the nanofibers during the spinning process, which can protect the drug from being eroded and degraded by gastric acid and enzymes during the process of entering the hu...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/12A61K47/34A61K47/38D04H13/00A61P31/04A61P7/02A61P35/00
Inventor 王鸿博秦静雯万玉芹高卫东傅佳佳
Owner JIANGNAN UNIV
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