89 results about "Tissue therapy" patented technology

Balloon cannula systems may be used for accessing and visualizing the spine and related methods of treatment, including a forward-looking balloon system for creating a working space and the balloon system having atraumatic dissection capability to allow visualization in spine. The devices and methods described may be used, for example, to perform annulus repair, herniated disc excision, and denervation of neurological tissue; to dispense pharmacological agents and/or cell or tissue therapy agents; to diagnose disc degeneration and bony degeneration, spinal stenosis, and nucleus decompression, and to perform disc augmentation.

Systems and methods for non-thermal ablation of tissue are provided. A non-implantable minimally invasive system for treatment of tissue in a body via direct current ablation is provided including a catheter, a plurality of electrodes for deployment through the catheter, a power source for applying power to the electrodes, and a fixation element for maintaining the catheter in a treatment position during treatment of the tissue. A minimally invasive method for treating tissue in a body via direct current ablation is provided including inserting a catheter into the body such that a portion of the catheter remains outside of the body, deploying a fixation element to fix the catheter in a treatment position, deploying a plurality of electrodes through the catheter, applying power to the plurality of electrodes, using the electrodes to apply a current to the tissue, and removing the catheter from the body.

An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.

Described generally herein are tissue therapy devices, which may comprise a sealant layer and a suction apparatus. The sealant layer functions so as to create a sealed enclosure between it and the surface of a patient by forming, preferably, an airtight seal around an area of tissue that requires negative pressure therapy. The tissue therapy device may comprise a suction apparatus. The suction apparatus is typically in fluid communication with the sealant layer and functions so as to reduce the amount of pressure present underneath the sealant layer. The reduced pressure is self-created by the suction apparatus. Together the sealant layer and the suction apparatus preferably create a closed reduced pressure therapy system. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of the air molecules under the sealant layer.

A system and method for performing tissue therapy may include applying a reduced pressure to a tissue site of a patient. A fluid parameter associated with applying a reduced pressureto the tissue site may be sensed. An audible fluid leak location sound may be generated in response to sensing the fluid parameter. The audible fluid leak location sound may be altered in response to sensing that the fluid parameter changes. By altering the audible fluid leak location sound in response to sensing a change of the fluid parameter, a clinician may detect location of a fluid leak at the drape by applying force to the drape. The force applied to the drape may be a clinician pressing a finger onto an edge of the drape.

In various embodiments, a device is provided comprising a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being the same or greater than the first pressure. In various embodiments, a method comprising fabricating a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being at or greater than the first pressure, disposing the balloon on an elongate member having a lumen, placing the lumen in fluid communication with an interior volume of the balloon.

In methods and devices for treatment of tissue of a patient, one or more applicators is positioned adjacent to the tissue to be treated. A cold plasma and radiofrequency energy are applied to the tissue. A negative pressure may be used to draw the tissue towards and/or into contact with the energy delivery elements.

The invention relates to a method used for preparing a microcarrier/polymer composite scaffold by electro-deposition. The method comprises following steps: the surface of a microcarrier is modified, so that the surface of the microcarrier is positively charged; the microcarrier is loaded with a bioactive component so as to obtain the functional microcarrier; the functional microcarrier is delivered into an organic solvent, and the mixture is treated by ultrasonic and is stirred so as to obtain an electro-deposition solution with a concentration of 0.1 to 1.0mg/ml; a polymer scaffold is prepared, an electrode provided with the polymer scaffold is taken as a cathode, and a blank electrode is taken as an anode; the cathode and the anode are delivered into the electro-deposition solution, and the electro-deposition solution is stirred for electro-deposition so as to obtain the composite scaffold; and the composite scaffold is washed and dried in the air so as to obtain the microcarrier/polymer composite scaffold. Preparation time is short; reaction conditions are mild; and it is impossible to cause early release or inactivation of the bioactive component loaded on the microcarrier. The microcarrier/polymer composite scaffold is capable of simulating the multiple interaction of cells in the body, ECM and growth factors, and providing an ideal environment for tissue therapy and tissue repair.

The invention provides a cartridge assembly to couple a tissue treatment device with an electrosurgical unit, with the cartridge assembly operable with a power delivery apparatus and a fluid delivery apparatus of the electrosurgical unit. The invention also provides an electrosurgical unit comprising a power delivery apparatus and a fluid delivery apparatus operable with the cartridge assembly and a system thereof.

An applicator includes at least one RF electrode coupled to an RF generator. The at least one RF electrode has protrusions each with a curvature radius which is equal to or greater than a curvature radius of an outer edge of the at least one RF electrode.

Systems and methods for applying energy to treat body areas having fat deposits are disclosed in which treatment energy is applied to a patient with a plurality of energy applicators each in contact with a target body subarea of the patient's skin, thereby heating the skin and underlying tissue, including fat. The temperature of fat tissue of each target body subarea may be sensed, and the application of energy to the corresponding energy applicator may be terminated if the temperature exceeds a maximum temperature for the subarea, which may be individually defined by a system user.

The invention relates to the use of CD14⁺ monocytes for the production of dendritic cells.

The invention comprises the use of CD14⁺ monocytes isolated from peripheral circulating blood for obtaining, by differentiation, at least one mixed population of Langerhans cells and interstitial dendritic cells, both Langerhans cells and interstitial dendritic cells being preconditioned and undifferentiated, and/or differentiated and immature, and/or mature, and/or interdigitated. The invention comprises their use in suspension, monolayer and three-dimensional cell and tissue models. The invention comprises the use of these cells and of these models as study models for the assessment of immunotoxicity/immunotolerance, for the development of cosmetic and pharmaceutical active principles and for the development and implementation of methods of cell and tissue therapy.

Described herein are dressings comprising a composite island comprising a polyurethane or foam layer coupled to an absorbent layer comprising non-woven gelling fibers. Also described herein are dressings comprising an absorbent layer comprising carboxymethyl cellulose fibers and a backing layer coupled to the absorbent layer. In the respective dressings, the absorbent layer is not elastically deformable under tissue treatment conditions, whereas the polyurethane or foam layer and the backing layer are substantially elastically deformable under tissue treatment conditions. The coupling of the absorbent layer to the polyurethane/foam layer or backing layer renders the coupled structure or the entire dressing substantially elastically deformable under tissue treatment conditions. Methods of eliminating, minimizing, or reducing edema are also described herein.

Described herein are dressings for incision management comprising a dressing layer that comprises: an elastic layer such as a hydrocolloid or foam layer; and an absorbent layer coupled, for example by lamination, to the elastic layer and which comprises: (i) from about 45% to about 90% carboxymethyl cellulose fibers; and (ii) from about 10% to about 55% elastic reinforcing fibers. Though the elastic layer may be substantially elastically deformable under tissue treatment conditions and the absorbent layer may be not elastically deformable under tissue treatment conditions, the coupling together of the elastic layer and the absorbent layer may result in a dressing layer, and advantageously a dressing, that is substantially elastically deformable under tissue treatment conditions. Methods for manufacturing such dressings and of eliminating, minimizing, or reducing edema using such dressings are also described herein.