51 results about "Tissue therapy" patented technology

A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The parameter curve includes inflections that correspond to changes in the fluid parameter. Based on the inflections, the system can determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

Described here are devices, systems, and methods for treating tissue. In some variations, a method of treating a target tissue may comprise advancing a tissue treatment system and a visualization device to the target tissue of a patient. The tissue treatment system may comprise a tissue treatment device comprising an elongate body such as an endoscope, an inflatable balloon including an electrode array. The balloon may comprise a non-tapered distal end, one or more pleats and releasable fasteners configured to ensure a controlled unfolding inflation sequence of the pleats to achieve an expanded configuration, and a controlled folding deflation sequence to achieve a collapsed configuration.

The end effector assembly includes first and second jaw members and an electrode. One or both of the jaw members are movable from a spaced-out position to a close position relative to the other for grasping tissue. The electrode is supported by the second jaw member, extends longitudinally along the second jaw member, and protrudes from the second jaw member. The electrode includes a conductive element and an electrically insulating coating. The conductive element defines a long basal surface, first and second long sides, a proximal end portion, and a distal end portion, all covered by the electrically insulating coating. The conductive element further defines a long tissue treatment surface opposite the long basal surface, which is left exposed, thereby exciting the conductive element with RF energy to concentrate the RF energy on the exposed long tissue treatment surface.

An electrosurgical system includes an electrosurgical generator configured to supply electrosurgical energy, and an electrosurgical instrument capable of delivering the electrosurgical energy for treating tissue, such as a tissue sealing operation and a tissue cutting operation. A controller module is configured to receive at least a first initiation request for a the tissue sealing operation. In some instances, the controller module is configured to receive a second initiation request for a tissue cutting operation. The controller module is configured to controllably operate the electrosurgical generator to selectively supply energy for the tissue sealing operation or the tissue cutting operation.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Medical devices, systems and related methods for tissue treatment and manipulation are described. An exemplary medical system includes device including a catheter, at least one arm, and one or more pull wires. The catheter having a central longitudinal axis and including a catheter lumen. The arm is positioned at a distal end of the catheter with a proximal end of arm pivotally connected to the catheter and a distal end of the arm forming a free end. The pull wire(s) extend to the distal end of the catheter. The arm includes a first configuration where the arm is generally parallel with the central longitudinal axis and a second configuration where the pull wire(s) urges the free end radially outward. The medical system further includes an accessory medical device including a shaft slidably received within the catheter lumen.

The application discloses a method for treating premature ejaculation by using high-frequency muscle-bone ultrasonic guiding razor needle to release the connective tissue of the dorsal nerve of penis, and belongs to the technical field of minimally invasive treatment of male sexual dysfunction. The method can accurately distinguish the course, branch and adjacent blood vessel level of the dorsal nerve of penis and mark the safe needle insertion area through real-time imaging of high-frequency muscle-bone ultrasound. A 0.4mm razor needle is used to perform longitudinal push-cut release in the interspace of the dorsal nerve of penis under the whole-process monitoring of ultrasound, so as to release the adhesion of the loose connective tissue under the skin and the high-tension structure. Then, transverse push-cut release is performed in the coronal sulcus area, so as to reduce the local sensory afferent excitability and prolong the ejaculation latency. The application realizes visual operation in the whole process, has small trauma and is controllable and accurate, does not damage the main stem of the nerve and the blood vessel, can stably improve the symptoms of premature ejaculation and is suitable for clinical standardization and popularization.

: A system for predicting tissue treatment settings and response of tissue is described. When executed by the processor, instructions cause the processor to: (a) receive measured nitric oxide (NO) tissue data from a personal healthcare device; (b) apply a trained computational model to predict an NO response, and based on the predicted NO response, predict tissue treatment settings; (c) compare the predicted treatment settings to a safety limit; (d) when the comparison of the predicted treatment settings is equal to or below the safety limit, update the predicted treatment settings and carrying out the tissue treatment at the predicted treatment settings; and (e) when the comparison of the prediction is greater than the safety limit, adjust the tissue treatment settings, update weights of the trained computational model, and repeat (c) through (e). A method and a tangible, non-transitory computer readable medium to make the predictions are also disclosed.

Systems and methods utilizing RF energy to treat a patient's skin or other target tissues are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which RF energy can be selectively controlled to facilitate heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, all by way of non-limiting examples. In various aspects, the systems may include a flexible applicator comprising a plurality of layers, the plurality of layers comprises a first dielectric layer, a second dielectric layer, and a conductive layer, wherein the first dielectric layer and the second dielectric layer sandwich the conductive layer, the plurality of layers define a plurality of kerfs, an inner region and N regions extending from the inner region, wherein the plurality of kerfs divide the applicator into N regions.

An energizing garment comprising a compressive material configured to be worn by a user for therapeutic lymphatic drainage and tissue massage. The garment includes watershed fingers secured to watershed portions of the material that overlie lymphatic watershed regions of the user's body, and massage fingers secured to non-watershed portions that overlie non-watershed regions. The watershed fingers are arranged in a variable density pattern to encourage lymph flow through watershed areas, while massage fingers are arranged in a consistent density pattern to create fluid pathways directing flow from non-watershed regions toward watersheds. The compressive material applies targeted pressure to drive the fingers against the skin and underlying tissues, energizing the tissues to release fluid and smooth the skin. The garment can be formed as various clothing items including shirts, pants, shorts, jumpsuits, or leotards, providing a wearable therapeutic solution for lymphatic system stimulation and tissue treatment.

A method of treating a soft palate in a patient may involve advancing a tissue treatment portion of a soft palate treatment device through the patient's mouth, contacting a treatment surface of the tissue treatment portion with mucosal tissue of the soft palate, and delivering energy from the tissue treatment portion through the mucosal tissue to a target tissue in the soft palate beneath to the mucosal tissue, to change at least one property of the target tissue. The method may further involve cooling the mucosal tissue with a cooling member on the treatment surface of the tissue treatment portion and removing the tissue treatment portion from the mouth.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Treatment planning systems are also provided for preparing and implementing a digital treatment plan. The treatment planning can include dividing a target tissue volume into a plurality of treatment locations, and controlling the speed, and pattern of movement between these tissue locations.

A system for treating tissue of a patient's anatomy at a target site. A localizer generates location data associated with the anatomy. A display unit overlays visual content on the anatomy within a field of view observable by a user. A visualization program on a computing device generates a virtual reference frame, identifies viable and non-viable approaches for fixation elements to engage tissue and secure a stabilizer relative to the target site based on patient-specific imaging data, arranges a virtual viability model within the virtual reference frame based on the location data and comprising viable portions associated with viable approaches and non-viable portions associated with non-viable approaches, and renders the virtual viability model in the visual content displayed by the display unit overlaid onto the anatomy within the field of view to assist the user in visualizing at least one of viable approaches and non-viable approaches.

An apparatus to treat a patient, the apparatus comprises a carrier having a proximal end and a distal end, an optical fiber to couple to a light source, a fluid delivery element comprising a nozzle having an orifice on the distal end, and an alignment structure to align the optical fiber with the orifice. A distance extends between the alignment structure and the orifice, such that the light beam emitted from the optical fiber diverges so as to allow energy transmission and fluid flow through the orifice. In some embodiments, the apparatus to ablate tissue comprises a source of pressurized fluid, and the nozzle is coupled to the source of pressurized fluid to release a fluid stream.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. The systems and methods herein are configured to measure and display forces acting upon the therapy treatment head during a procedure. In some aspects, buoyancy forces from the acoustic coupling medium are also accounted for.

The application discloses preparation of a core-shell structure hydrogel and application of the core-shell structure hydrogel in preparation of a magnetic control flexible micro robot, and belongs to the technical field of biomedical soft micro robot. The application adopts a core-shell structure to construct a hydrogel micro robot, wherein, a vanadium disulfide nanosheet rich in sulfur defects is used as a functional inner core, and has magnetic response and photoacoustic imaging capacity; a polyacrylamide polymer chain is used as a flexible outer shell, free radical initiation is carried out on the surface of the vanadium disulfide through vanadium-sulfur dynamic coordination bonds, and simple amide bond hydrogen bond crosslinking endows the hydrogel with three-dimensional printable performance. The prepared flexible micro robot can realize precise controllable movement under the action of an external magnetic field, and can realize robot posture monitoring and navigation positioning functions with the aid of photoacoustic imaging capacity, and has good application prospect in the fields of drug delivery, minimally invasive surgery and tissue treatment.

A tissue treatment system configured to ablate a tissue, the system comprising: (a) a clamp assembly comprising a first jaw mechanism and a second jaw mechanism configured to receive and compress a tissue therebetween; (b) a first electrode disposed on the first jaw mechanism and configured to contact the tissue; and (c) a second electrode disposed on the second jaw mechanism and configured to contact the tissue, where the first electrode and the second electrode are configured so that at least one of an ablation energy output of the first electrode and an ablation energy output of the second electrode is automatically adjusted to accommodate variable tissue thicknesses between the first electrode and the second electrode.

A histotripsy therapy system configured for tissue treatment, which may include any number of features, is provided. Systems and methods providing effective, non-invasive and minimally invasive therapeutic, diagnostic, and research procedures are provided herein. Systems and methods are provided to facilitate real-time monitoring of delivered dose and tissue dissection. Techniques may include monitoring received acoustic cavitation emission signals or using dMRI.

A tissue treatment device comprises an upper housing (12) for receiving a container (20) with a treatment medium; an actuatable valve structure (16) to which the container can connect to dispense the treatment medium, the valve structure connected to the upper housing and comprising a channel (24) and an orifice (26) at an end of the channel; and a lower housing (14) extending from the upper housing to a distal end (28), the lower housing comprising an opening (32) at the distal end to receive tissue. The channel and / or lower housing is configured to direct treatment medium toward a side of tissue extending through the opening into the housing.

A tissue treatment catheter includes a catheter shaft having a fluid lumen in fluid communication with an interior of a balloon, and a guidewire lumen. The balloon is mounted on the catheter shaft and contains an ultrasound transducer. An isolation tube extends through the ultrasound transducer and into the guidewire lumen. A proximal tube end of the isolation tube is between a distal shaft end of the catheter shaft and a guidewire port of the catheter shaft. Other embodiments are also described and claimed.

An instrument (14) is suitable for treatment of lung tumors and other tissues and a respective apparatus (15) detects the correct positioning of instrument (14) and its two electrodes (19, 20) in a suitable target tissue by observation of two parameters (G1, G2) and particularly their time-dependent change. If the change (V1, V2) of the two parameters (G1, G2) exceeds defined thresholds (S1, S2) respectively, a contact between the instrument and the tissue to be treated and thus also the positioning of the instrument in a desired position can be derived therefrom. This remarkably increases treatment safety.

A fluid transfer unit of a tissue treatment system comprises a supply line, a first pump head having a first epicyclic roller train, wherein the first epicyclic roller train includes a first sun roller and one or more first planet rollers, a return line, and a second pump head having a second epicyclic roller train, wherein the second epicyclic roller train includes a second sun roller and one or more second planet rollers.

A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The system compares the parameter curve of the fluid parameter to a reference curve and, based on the comparison, determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.

A surgical system for treating tissue, the system comprising a surgical device and a control system. The surgical device can include an end effector and a sensor. The end effector can include an active electrode for treating tissue. The sensor can be configured to generate a data signal corresponding to a characteristic of the end effector or the tissue. The control system can be operably coupled to the sensor. The control system can be configured to deliver power to the active electrode and can be configured to adjust the power during a period of time that the data signal is received by the control system.

There is provided in accordance with an exemplary embodiment of the invention a method and / or a device of treating tissue near a first lumen comprising inserting an energy emission element into a second lumen and delivering energy in an amount sufficient to cause one or more spaced apart areas of tissue damage at preselected locations in tissue near the first lumen. There is also provided a method and / or a device for treating a carotid artery wall, for example, to reduce signal conduction. There is also provided a method and / or a device for treating a wall of a lumen in a limb, for example, to increase blood flow. There is also provided a method and / or a device for treating a wall of a heart, for example, to stop abnormal signal propagation.

An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.