7 results about "Cell specific" patented technology

The invention discloses an evaluation method, system and device for cell specific genetic variation disturbance and a storage medium. An integrated single cell data set is used for training a variational auto-encoder, and a high-dimensional gene expression profile is mapped into a cell state vector in a low-dimensional hidden space through an encoder of the variational auto-encoder; freezing parameters of the encoder, training a conditional disturbance module by using training data with a mononucleotide variation tag, and generating conditional variation embedding; performing anti-fact prediction for target cell and target mononucleotide variation, and generating a reference prediction expression profile and a disturbance prediction expression profile through a conditional disturbance module and a decoder of a variational auto-encoder based on the original genotype and the overturned genotype of the target cell; and calculating the difference between the two to obtain the disturbance effect score of the single nucleotide variation in the target cell, and quantitatively describing and predicting the specific disturbance mode of the SNV in different cell states.

To provide a method and system for improving throughput for loading an input matrix into a matrix multiplication unit by increasing a rate at which values from the input matrix are loaded into an array of cells in the matrix multiplication unit.SOLUTION: The method includes receiving a plurality of non-zero input values from a first input matrix, receiving, for each non-zero input value in the plurality of input values, index metadata indicating which of the M * N cells in the array the non-zero input value is to be loaded into, and transmitting the non-zero input value and the index metadata to the M * N cells, and at a particular cell of the M * N cells in the array: The method includes receiving a particular non-zero input value and corresponding indexing metadata, and determining from the corresponding indexing metadata for the particular non-zero input value whether to store the particular non-zero input value in the cell or shift the particular non-zero input value to another cell.SELECTED DRAWING: Figure 4

Described in certain embodiments herein are computer implemented methods, systems, and computer program products that can be used to identify or engineered cell specific cis-regulatory elements (CREs). Also described herein are cell specific CREs and uses thereof.

The invention provides a construction method of an ATAC-seq library for cell specificity. The construction method comprises the following steps: fragmenting a genome of a suspension containing a cell nucleus or a single cell by using Tn5 transposase, and then fixing by using polyformaldehyde; then, specifically combining target nucleic acid by using paired probes, controlling the spacing, connecting the insert fragment and the skeleton to form a single chain ring, generating a long single chain of multiple repetitive units through rolling circle amplification, marking the repetitive units by using a third probe with a detectable signal, and sorting target cells based on the signal; and finally, carrying out decrosslinking on the sorted cells and carrying out PCR (Polymerase Chain Reaction) amplification by using a primer with a sequencing joint to obtain the sequencing library. The library constructed by the method can realize efficient enrichment of target cells in a pre-sequencing stage, and high-quality omics data of the target cells can be directionally obtained, so that open information of chromatin of a target cell type is captured.

A method of determining a mask pattern for a target pattern to be printed on a substrate. The method includes partitioning a portion of a design layout including the target pattern into a plurality of cells with reference to a given location on the target pattern; assigning a plurality of variables within a particular cell of the plurality of cells, the particular cell including the target pattern or a portion thereof; and determining, based on values of the plurality of variables, the mask pattern for the target pattern such that a performance metric of a patterning process utilizing the mask pattern is within a desired performance range.

A system performs optimized execution of cells of a notebook by pruning certain cells from execution while evaluating a particular cell, even though the particular cell depends on the pruned cells. The system generates a directed acyclic graph. The system transforms code of a target cell to include code of one or more source cells. The system receives a request to execute at least a portion of the notebook comprising a cell from the sequence of cells. The system identifies a subset of cells of the sequence of cells for execution based on the directed acyclic graph. The system determines based on various factors whether a source cell can be excluded from execution of the notebook based on properties of the source cell. If the system determines that the source cell can be excluded, the system executes the subset of cells without the source cell.

A terminal according to one embodiment of the present disclosure comprises: a reception unit that receives, in certain units, a specific configuration for accessing a specific cell; and a control unit that controls access to the specific cell on the basis of the specific configuration.