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Intramedullary nail having multifunctional coating and preparation method

A multi-functional coating, intramedullary nail technology, applied in coating, medical science, surgery, etc., can solve the problems of low bonding strength of coating, unable to achieve sustained-release drugs, and low drug loading of ceramic coating, etc. To achieve good bacteriostatic effect, significant bacteriostatic effect, and the effect of increasing concentration

Active Publication Date: 2014-04-09
SUZHOU MINIMALLY INVASIVE SPINAL TRAUMA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are corresponding deficiencies in coating antibiotics on the surface of implants, preparing a single polymer coating on the surface of an alloy, a single ceramic coating, and using nano-ceramic particles to load drugs. For example, a single polymer coating The multi-layer drug loading technology has the phenomenon that the coating bonding strength is not high, and the drug is prone to explosive release; a single ceramic coating has a small amount of drug loading and cannot achieve the effect of sustained drug release; there are certain controversies about the cytotoxicity of nano-silver ; Side slot opening drug-loaded intramedullary nails and related prostheses have the characteristics of inconvenient carrying of the drug-loaded system

Method used

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  • Intramedullary nail having multifunctional coating and preparation method
  • Intramedullary nail having multifunctional coating and preparation method
  • Intramedullary nail having multifunctional coating and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Titanium alloy intramedullary nail, surface porous TiO 2 For the transition layer, the degradable polymer is DL-PLA, and the drug is gentamicin.

[0051] Preparation steps:

[0052] 1. Preparation of porous ceramic transition layer:

[0053] Using micro-arc oxidation technology, a porous ceramic transition layer is prepared on the surface of the titanium alloy substrate, and the bottom layer is dense TiO 2 layer (1-10μm), the upper layer is porous TiO 2 layer (5-20μm), the pore size is 100nm-3μm, the preparation voltage is 100-500V, the voltage changes step by step, the current is 1-3A, the time is 1-20min, and the oxidation solution is silicate, phosphate, etc.

[0054] 2. Preparation of drug solution: First, accurately weigh despun polylactic acid (DL-PLA) (PDL04), dissolve it in tetrahydrofuran (THF), add the prepared aqueous solution of gentamicin to the polymer solution to form DL-PLA , a mixed solution of gentamicin. Spray or dip the prepared drug solution on...

Embodiment 2

[0057] A porous TiO2 transition layer was prepared on the surface of titanium alloy orthopedic implants. The degradable coating was mixed with PLGA and collagen, and the drug was mixed with gentamicin and vancomycin.

[0058] Preparation:

[0059] 1. Preparation of porous ceramic transition layer:

[0060] Micro-arc oxidation technology is used to prepare a porous ceramic transition layer on the surface of the metal substrate, and the bottom layer is dense TiO 2 layer (1-10μm), the upper layer is porous TiO 2 layer (5-20μm), the preparation voltage is 100-500V, the voltage changes step by step, the current is 1-3A, the time is 1-20min, and the oxidizing solution is silicate, phosphate, etc.

[0061] 2. Preparation and preparation of drug solution: firstly, accurately weigh PLGA, dissolve it in tetrahydrofuran (THF), add the prepared mixed aqueous solution of gentamicin and vancomycin to the polymer solution, and form a mixed solution. Spray or dip the prepared drug solution...

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Abstract

The invention relates to the medical instrument field, especially relates to the orthopaedics titanium alloy internal fixation field. The invention provides an intramedullary nail having a multifunctional coating and a preparation method. The intramedullary nail comprises a multifunctional composite medicament coating slow release system, and the slow release system comprises a porous transition layer and a degradable coating containing the medicament. The intramedullary nail integrates the functions of preventing, treating infection and internal fixation as one, and is mainly used for treating adaptation diseases such as open fracture and osteomyelitis, and has the effect for degrading and slowly releasing the medicines.

Description

technical field [0001] The invention relates to the field of medical instruments, in particular to the field of orthopedic titanium alloy internal fixation. Specifically, the present invention relates to an intramedullary nail with a multifunctional coating and a preparation method thereof. Background technique [0002] In recent years, with the development of the transportation industry, the incidence of various fractures caused by traffic accidents has increased significantly. Intramedullary nailing is a widely used method for the treatment of long bone shaft fractures. In developed countries such as Europe and the United States, the application rate of intramedullary nails for the treatment of long bone shaft fractures is over 90%. Since the 1980s, interlocking intramedullary nails are currently the mainstream of application at home and abroad. They can effectively prevent the rotation and shortening of fractures, and can be used for early weight bearing, joint function ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/10A61L31/12A61L31/16
Inventor 耿芳潘礼存张隽林忠
Owner SUZHOU MINIMALLY INVASIVE SPINAL TRAUMA MEDICAL TECH CO LTD
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