59results about How to "Slow down metabolism" patented technology

The invention provides a preservation reagent for mesenchymal stem cells and application of the preservation reagent to preserving the mesenchymal stem cells. The preservation reagent is prepared from 80-100 mmol/L glucose, 40-50 mmol/L mannitol, 24-28 mmol/L dipotassium hydrogen phosphate, 12-16 mmol/L potassium dihydrogen phosphate, 3-4 mmol/L adenine, 1-1.5 mmol/L inosine, 14-18 mmol/L potassium citrate, 35-45 mmol/L ammonium chloride, 75-80 mmol/L sodium chloride and cellular antioxidants. Due to the adoption of the preservation reagent for the mesenchymal stem cells, basic life metabolism of the cells is maintained through glucose, potassium citrate and other few nutrients, and meanwhile no large number of rich nutrients are added so that fast metabolism and proliferation of the cells can be avoided; by means of further assistance of adenine, inosine and mannitol, the shapes and the characters of the cells are maintained, the purposes of protecting cell membranes and enzyme activity are achieved, and the cell activity does not degrade in the preservation process; finally, oxidization damage of the cells is inhibited through the cellular antioxidants, and compared with existing common preservation liquid, the cells have better activity and quality after being preserved.

The invention provides a preserving fluid and a preparation method therefor. The preserving fluid is used for preserving umbilical cords and/or placentas. The preserving fluid comprises 50-60g/L of dextran, 6-7g/L of sodium chloride, 200-250mg/L of calcium chloride, 200-400mg/L of potassium chloride, 1-1.2g/L of glucose and 10-30g/L of human serum albumin. The invention further discloses a preparation method for the preserving fluid. Compared with a conventional preserving fluid, the preserving fluid disclosed by the invention reduces the metabolism amount of umbilical cord tissue cells in a process of preserving the umbilical cords, and also can provide certain basic nutrient substances and energy substances to keep a low metabolism level, so that the cell activity is in a stable state, and the conditions such as shape variation or differentiation due to growth and cultivation are avoided; and moreover, the dextran in the components has an anticoagulation effect and can prevent the blood agglutination, so that the interference on the follow-up separation operation is avoided.

The invention discloses a method for refreshing water-detacted live portunus tritubercularus, which comprises the steps of: 1, purifying the portunus tritubercularus in seawater, and then putting the portunus tritubercularus in the 2-5 DEG C seawater for soaking for 3-5min to ensure that the portunus tritubercularus is in a narcosis state, wherein the 2-5 DEG C seawater contains 0.1 percent of stable vitamin C; 2, putting a moisturizing material in the 2-5 DEG C seawater containing 0.1 percent of stable vitamin C for soaking until the moisturizing material is saturated; and 3, firstly placingan oxygenating agent in a cavity in the middle of a package box, then laying one layer of moisturizing material above the oxygenating agent, placing the portunus tritubercularus above the moisturizing material, placing one layer of moisturizing material, i.e. a second layer of moisturizing material, above the portunus tritubercularus and covering the packaging box by the cover thereof. The methoddisclosed by the invention has the advantages of long survival time of the portunus tritubercularus, capability of effectively ensuring the edible value and enlarging the marketing range, clean surface of the portunus tritubercularus body, and low cost.

The invention discloses a nutrient solution for arranged flowers. The nutrient solution comprises the raw materials in percentage by weight: 0.8-1.2% of saccharose, 0.7-1.4% of glucose, 0.08-0.105% of edible salt, 0.025-0.035% of aspirin, 0.1-0.14% of vitamin C, and the balance of water. Compared with the prior art, the nutrient solution has the following advantages that nutrient components required by arranged flowers are supplied to guarantee normal metabolism of the arranged flowers; the breath speed of the arranged flowers is slowed down, and the aging and withering of the arranged flowers is reduced; and because the activity of microorganism is blocked, the phenomenon of untimely rotting and decaying of the arranged flowers is avoided. By using the nutrient solution for the arranged flowers, the freshness retaining time of the arranged flowers can keep for 20-30 days, and the color is bright and the luster is lovely.

The invention relates to a cornea mid-term preservation liquid. 1000ml of preservation liquid contains 0.5-1.5g of DMEM culture medium, 1-10g of hydroxypropyl methylcellulose, 0.1-10ml of 2-mercaptoethanol, 10-20g of dextran (with the molecular weight of 40000), 1-3ml of nonessential amino acid, 10-32mmol of Hepes buffer solution and 0.01-0.05mmol of dexamethasone, 50-70mg of gentamicin. The pH value of the preservation liquid is 7.2-8.0, and the permeation pressure is 350-400mmol/LH2O. The cornea mid-term preservation liquid not only has good cornea storage quality, but also has the advantage of good cost performance and is the cornea mid-term preservation liquid which is widely applicable to the eye bank at home and abroad.

The method of surviving mussel in no water condition includes the steps of cleaning mussel, gradient temperature lowering treatment, packing and constant storing. Sorted live mussel are set successively into sea water tanks with temperature lowered successively with the last one possessing temperature near 0 deg.c or ¿C10 deg C, packed in the vacuum degree of 0.01-0.1 MPa, and stored and transported at 0-4 deg C. The present invention can maintain the nutritious components of mussel well, has the survival period as long as 7-13 days, simple operation, low cost and low power consumption.

The invention provides a cold seawater spraying ice-temperature alive-keeping device which is suitable for far and short-distance alive-keeping transportation of abalones and can greatly reduce the survival rate of the abalones during the transportation process. According to the cold seawater spraying ice-temperature alive-keeping device disclosed by the invention, an abalone placing disc in an abalone alive-keeping box is utilized as an object for enabling the abalones to attach, so that the abalones can be distributed uniformly and be prevented from extruding mutually; by adopting a low-temperature seawater gradual cooling method, the metabolism speed of the abalones can be gradually inhibited, and the injures to organisms caused by severe changes in temperature can be avoided; during the water circulation cooling process, an ultraviolet lamp is arranged at the top of a seawater storage tank, the ultraviolet lamp is utilized for performing cold seawater sterilization and purification, the abalones are purified by utilizing clean sweater, the survival time of the abalones is ensured, and the device is suitable for long-distance transportation; and a cold seawater aeration way is adopted for ensuring sufficient oxygen in spraying seawater so as to maintain the sufficient oxygen required for survival of the abalones. The device has the characteristics of long alive-keeping time and simple operation process; and furthermore, a centralized control mode is adopted, and the device is suitable for large-scale industrial application.

The invention provides aldehydic acids tetramethylpyrazine esters, compounds of polyaromatics supported Ligusticum wallichii effective compositions, and the process for their preparation, which comprises converting lateral chains into ligustrazine derivatives of reactive groups, bonding with polyacids under the action of dicyclo hexylcar bodiimide (DCCI), so as to join ligustrazine lateral chains with polymers of functional groups through ester linkages.

A carbon fiber electric heating plate floor heating structure comprises an intelligent controller, a power connection wire, a waterproof connector, a heating body provided with a carbon fiber heating wire, a floor layer and a cement layer, wherein the floor layer and the cement layer are bonded together; the cement layer and the heating body provided with the carbon fiber heating wire are bonded together; the waterproof connector is internally provided with the power connection wire and connected with the carbon fiber heating wire in the heating body; the power connection wire extends out of a structure body and is connected with the intelligent controller; the heating body provided with the carbon fiber heating wire comprises a silk screen layer, the carbon fiber heating wire, a heat insulation layer and a reflecting layer; the floor layer is bonded with the cement layer; the cement layer is bonded with the heating body; the silk screen layer is fixed to the lower surface of the heating body for protection; the heat insulation layer is arranged under the silk screen layer; and the reflecting layer is arranged under the heat insulation layer. The floor heating structure has the characteristics that electric energy is adopted, the heating range is wide, a heating system is simple, and the energy conversion rate is high; and heat energy losses are avoided, the comfort degree is high, and intelligent control, safety and environmental protection are achieved.

The invention discloses a modified atmosphere preservation method of fresh-cut green pepper. Precooled fresh-cut green pepper is put in a packaging container; the relative humidity is 91-99% and the temperature is 0 to 4 DEG C in the packaging container; mixed gas of oxygen, carbon dioxide and nitrogen is introduced into the packaging container until the concentration of nitrogen, oxygen and carbon dioxide is 85-95%, 1-8% and 1-6% respectively. According to the method disclosed by the invention, fresh-cut green pepper (the shredded pepper or the diced pepper and the like) is extremely easy to oxidize and discolor to keep the freshness and the unchanged color in 10 days.

The invention belongs to the field of novel nanometer drugs, and discloses an esterase-responsive polycurcumin thiodipropionic acid copolymer prodrug nano-micelle, a preparation method and applications thereof, wherein the esterase-responsive polycurcumin thiodipropionic acid copolymer prodrug nano-micelle comprises, by mass, 28-93.6% of a carrier auxiliary material and 6.4-72% of a curcumin drug,the nano-micelle monomer is an amphiphilic block and comprises a hydrophilic segment and a hydrophobic segment, the hydrophilic block is methoxy polyethylene glycol with a molecular weight of 1500-6000, the hydrophobic chain segment is a curcumin poly prodrug short chain co-polymerized from thiodipropionic acid and an anticancer drug curcumin and having a molecular weight of 800-12000, and a weight ratio of the hydrophilic segment methoxypolyethylene glycol to the curcumin poly prodrug short chain is 0.1-20:1. According to the present invention, the novel nano-micelle monomer can be degradedand reduced under the action of the esterase in the cancer cells to obtain the anticancer drug curcumin bulk drug so as to achieve the precise controlled-release effect.

The invention relates to a neurosteroids type novel GABA (gamma-aminobutyric acid) receptor modulator, pharmaceutically acceptable salt or ester, and application in treating related CNS diseases.The compound provided by the invention has favorable biological activity and an excellent PK property, and the novel compound has a large potential to be used as an CNS disease treatment drug for oraladministration.

The invention discloses a vacuum air-adjusting preservation process for fresh lily scales. The vacuum air-adjusting preservation process comprises the following steps: carrying out preservation storage treatment on a fresh lily raw material; carrying out pretreatment and vacuum air-adjusting treatment on the fresh lily raw material; and finally sealing into a vacuum bowl. According to the process, by virtue of a vacuum air-adjusting fresh keeping technique, the fresh lily raw mateiral is in a gas environment with low oxygen and high nitrogen; the metabolism speed of the fresh cut lily can be further inhibited and the respiration intensity is lowered; and oxidation of the fresh cut lily surface and reproduction of bacteria can be controlled, so that the refreshing time of the fresh cut lily is prolonged to about 15-20 days; meanwhile, by virtue of a polypropylene composite bowl, the vacuum air-adjusting preservation process has good heat sealability and simultaneously has certain gas permeability, so as to keep the gas environment in package in balance within 10 days; by virtue of the package, the fresh cut lily can be effectively protected in the air-adjusting environment which is beneficial to preservation; and squeeze damages in the transport process are avoided.

A method for promoting fruit bearing in advance relates to the technical field of TrivhosantnesKirilouii. The method is characterized in including the following steps of: (1) soaking a cotton rope with the diameter of 5 to 10 cm in medicinal liquid, wherein the medicinal liquid includes the following components, by weight, 0.3 parts of paclobutrazol, 0.3 parts of fly ash, 0.3 parts of borax, 0.2 parts of ethylene, 0.1 parts of colchicines, 1.5 parts of potassium permanganate, 6 parts of monopotassium phosphate, and 100 parts of water; (2) using the cotton rope to tie up the position of a stem of the TrivhosantnesKirilouii, 3 to 5 cm away from and above the root of the TrivhosantnesKirilouii, putting the cotton rope in the position of an inner side of a stem surface of the TrivhosantnesKirilouii, 1 to 3 cm away from the stem face, and using a plastic adhesive tape to stick the outer part of the stem; and (3) using fine needle to evenly insert into the cotton rope inside the stem surface of the TrivhosantnesKirilouii and into an inner part of a stem epidermis of the TrivhosantnesKirilouii, and then removing the fine needle. The method is good in use effects, can prevent the phenomenon that the TrivhosantnesKirilouii cannot flower and bear fruits due to vigorous growth, can promote flowering and fruit-bearing, prevent diseases, and improve economic benefits.

The invention discloses rhizoma dioscoreae enzyme and a preparation method thereof. The rhizoma dioscoreae enzyme is prepared from rhizoma dioscoreae pulp, brown sugar, soybeans, American ginseng powder, dietary fibre, composite strains and purified water by fermenting for a certain time. Rhizoma dioscoreae, medicinal and edible American ginseng and the like are fermented and aged, so that activity of rhizoma dioscoreae and other substances is fully exerted, the substances can be better absorbed by human bodies, and accordingly, digestion and decomposition by intestines and stomach are enhanced, full absorption of nutrient substances is promoted, cells are activated, and metabolism becomes strong; superoxide in the human bodies is fully eliminated, and effects of aging resistance, oxidation resistance and cancer resistance are achieved; the process is simple and easy to implement, the cost is low, and the rhizoma dioscoreae enzyme has high nutritional value and good development prospect.

The invention relates to the field of fruit and vegetable preservation treatment and specifically relates to an automatic device for fruit and vegetable preservation treatment. According to the invention, a cleaning unit, a sterilizing unit, a drying unit and an encapsulating unit are combined to form an automatic production line through an automatic transfer system; and treatment on fruits and vegetables are performed through the cleaning unit, the sterilizing unit, the drying unit, the encapsulating unit, etc. The device provided by the invention has the characteristics of automation, high throughput, easy operation, etc. and solves the fruit and vegetable preservation problems caused by internal reasons like the metabolism of the fruits themselves so that the fruits and the vegetables can be preserved for a long time in a normal-temperature environment.

The invention discloses an ester derivative of high veratryl alcohol and medical treatment application, and belongs to the field of medicines. A compound with biological activity is a compound in a general formula (I) shown in the specification, and salt, a solvate or a hydrate of the compound, wherein X1 is H or COR1, X2 is H or COR2, X3 is H or COR3, but X1, X2 and X3 are not H and 3-pyridyl simultaneously; R1, R2 and R3 are the same as one another or different from one another and are C1-C6 alkyl substituted by R4 or can be substituted by R9 at random and can contain one or more 4-7-membered rings of additional heteroatom of O, S(O)n and NR9; R4 is F, CF3, OR5, NR6R7 or S(O)nR8; R5, R6 and R7 are the same as one another or different from one another and are H or C1-C6 alkyl substituted by R4 at random, or NR6R7 is one or more C4-C6 heterocycle alkyl rings of the heteroatom of O, NR9 and S(O)n; each n is 0 to 2; R8 is C1-C6 alkyl; R9 is C1-C4 alkyl which is defined by R4 or substituted by R4 or halogens at random; and R9 is H or C1-C6 alkyl. The ester derivative has the effect of treating liver diseases, T-cell proliferation related diseases or proinflammatory cytokine mediated diseases.

The invention discloses a solanesol derivative and a preparation method and application thereof. The structure of the solanesol derivative is as shown in the formula, wherein n is smaller than or equal to 114 and greater than or equal to 45 and n is an integer. Through an experiment, SPGS can be self-assembled in a water solution to form a stable nano-micelle structure and the drug loading capacity on CoQ10 can each over 39%. The light stability inspection result of CoQ10 in a preparation shows that the residual amount of CoQ10 in an ethanol solution and a water solution is 54.35% and 28.25% separately after 24h light treatment; the content of the CoQ10 in a CoQ10-SPGC preparation obtained through SPGC entrapment can still reach over 88% of the initial amount; and the stability on light can be obviously improved through SPGC entrapment on the CoQ10. Pharmacokinetic experiments in SD rats show that the bioavailability of the CoQ10 can be improved to over three times that of a CoQ10 naked drug by a CoQ10-SPGC micelle preparation.

The invention discloses a health-care mattress beneficial to the adjustment of the physiological curvature of the spine. The health-care mattress comprises a mattress body, a lining and an outer cover, wherein the mattress body serves as the bottom layer of the mattress; the upper surface of the mattress body is in an unequal-height fluctuating wave form and has at least five curvatures; the curvatures comprise a first curvature matched with the cervical curvature, a second curvature matched with the thoracic curvature, a third curvature matched with the lumbar curvature, a fourth curvature matched with the sacral curvature, and a fifth curvature for supporting the popliteal fossea of double knee joints; the curvatures are arranged in sequence according to the physiological curvature of the spine of a human body; the lining covers the upper surface of the mattress body. The health-care mattress is designed and made by adopting the principle of human engineering and aiming to the physiological curvature of the spine of the human body according to the factors of gender, height, age, body and general situation of a user; the mattress body is made of high-density polyurethane being 729 Shore in hardness and W50-55 degrees in density. The health-care mattress is light and durable, and contributes to maintaining mechanical equilibrium of the spine and paravertebral soft tissues in a rest state.

The invention discloses a rice seed storage method which comprises the steps of: seed sunning, seed selection, disinfection, drying, sealing and stacking. After rice seeds are treated by the steps, the rice seeds are not damaged or deteriorated during a storage process, and the storage time can be effectively extended for 5-7 years without affecting the germination rate and the survival rate of the seeds. The method is widely used in storage of the rice seeds by growers or enterprises, and has low storage cost and good practicability.

The invention relates to a biological and physical dual-preservation storage method for sandwiches. The method includes the following steps that the inner wall of a package container is sprayed with a preservation coating composed of chitosan, tea polysaccharide, peanut skin extract and other biological active substances. The fresh sandwiches are sterilized, pre-cooled and put into the package container, the package container is sealed, mixed gas of carbon dioxide, nitrogen and carbon monoxide is charged into the package container, the humidity in the package container is controlled, and the gas-charging opening is sealed; the proportion of oxygen is lowered to 1% or below, the carbon dioxide is 25-35%, the nitrogen is 65-75%, and the carbon monoxide is 0.5-5%; in the environment with low oxygen and high carbon dioxide, growing and propagating of harmful microorganisms can be effectively restrained, the shelf life of the sandwiches can be prolonged, the environment with the suitable humidity can effectively keep suitable turgor pressure of cells of vegetables and meat in the sandwiches, the small amount of carbon monoxide can keep the color and taste of the vegetables and meat, and the freshness and high quality of the products can be guaranteed.

The invention provides a method for accelerating germination of seed potatoes. The method comprises the following steps that full and health high-quality potatoes with uniform shape and more bud eyesare selected as the seed potatoes; (2) the seed potatoes are washed with a hydrogen peroxide solution with the mass concentration of 3%, are dried in the shade, are put into a basket and are stored ina refrigeration house with the temperature of 0-3 DEG C, and after 30-40 days, the temperature is increased to 8-17 DEG C; (3) after the temperature is increased, the seed potatoes are taken out, aresprayed with a liquid reagent once every 2 hours at the temperature of 18-20 DEG C and are repeatedly sprayed 3-4 times; and (4) the seed potatoes sprayed by the liquid reagent are cut into blocks bykeeping away from the bud eyes, are poured into plant ash soil for uniform turning and are transferred into sandy soil to accelerate germination at normal temperature. The method has the advantages of being simple, high in germination rate and good in effect.