29 results about "Aldehydic Acids" patented technology

The invention discloses a lutein composition for relieving asthenopia and a preparation method of the lutein composition, and belongs to the field of functional foods. Phycocyanin and kelp polyphenol are mixed and react to obtain modified phycocyanin; fucoidin and beta-glucuronidase are mixed and react to obtain modified fucose; mixing the fish collagen peptide and zinc chloride to react to obtain a collagen peptide-zinc chelate; the xanthophyll siliceous cage compound and the modified phycocyanin are mixed and react to obtain a first compound; mixing and reacting the first compound and modified fucose to obtain a second compound; mixing and reacting the second compound, collagen peptide-zinc chelate and krill oil to obtain a lutein compound; mixing and reacting the second compound, collagen peptide-zinc chelate and krill oil, adding trehalose, and mixing and reacting to obtain a xanthophyll compound; and mixing the xanthophyll compound and maltodextrin to obtain the xanthophyll composition.

The compounds of the invention can be used to stabilize biomolecules, particularly in the presence of pH and thermal stress. Formula (I), wherein X is a hexosyl uronic acid or uronic acid amide group. (I).

The invention discloses a method for detecting glucuronic acid in a calcium gluconate bulk drug. The method has high system applicability, has incomparable advantages in specificity, quantitation limit, detection limit, linear range, repeatability and durability, and has high precision.

The invention relates to a uridine diphosphate-glucuronyl transferase mutant and an application of the uridine diphosphate-glucuronyl transferase mutant in catalytic synthesis of glucuronide. The amino acid sequence of the uridine diphosphate-glucuronyl transferase mutant is as shown in SEQ ID NO. 2, and the nucleotide sequence of the coding gene is as shown in SEQ ID NO. 1. The invention provides a uridine diphosphate-glucuronyl transferase mutant with high activity and high stability. Compared with wild uridine diphosphate-glucuronyl transferase, the uridine diphosphate-glucuronyl transferase mutant has mutation of 10 amino acid sites. According to experimental determination, the melting temperature of the mutant is increased by 24 DEG C compared with that of a wild type, the activity is increased to 1.65 times, the expression quantity is increased to 4.2 times, and a powerful tool is provided for enzymatic synthesis of glucuronide compounds.

Compounds comprising a cross-linking moiety and a protecting group are described herein along with their methods of use. The cross-linking moiety may comprise an indoxyl and the protecting group may comprise a sugar (e.g., a glucuronide or glucoside), phosphoester, or sulfoester group. The cross-linking moiety and protecting group may be attached to each other via an oxygen atom, sulfur atom, or linker. In some embodiments, the linker attaching the cross-linking moiety and protecting group is a self-immolative linker. A compound of the present invention may cross-link under physiological conditions and / or in vivo.

The application discloses a kind of high-efficiency interception polyvalent anion and cation nanofiltration membrane and its preparation method and application.The method includes the following preparation process:1) preparation concentration is 0.1-2wt% of apigenin class of substance aqueous solution, and concentration is 0.1-0.5wt% of multi-acid chloride organic phase solution;2) make polymer support membrane in aqueous solution 1-5min, remove the surface excess solution, then immerse into oil phase solution, react 1-15min;3) after reaction, remove the surface excess solution, solidify 5-20min under 60-80 DEG C, obtain the nanofiltration membrane.The application is with apigenin, apigenin-7-o-glucuronide and / or isofraxidin as aqueous monomer, and multi-acid chloride is prepared by interfacial polymerization reaction to obtain negative NF membrane, not only maintain the high interception rate to polyvalent anion, and also have very high interception rate to polyvalent cation, can efficiently permeate monovalent ion, and water flux is larger.

This invention relates to an aqueous emulsion comprising: (A) an ester of fatty acids and polyglycerol having 16 to 22 carbon atoms, an ester of fatty acids and glycerol having 16 to 22 carbon atoms, and a monohydric alcohol having 16 to 22 carbon atoms; (B) a compound having at least two hydroxyl groups and an alkyl group having 16 to 22 carbon atoms and having no phosphorus atoms, or a salt thereof, wherein component (B) is different from component (A); and (C) a cellulose thickener and / or a polysaccharide thickener comprising glucose, glucuronic acid, and rhamnose as the main chain of constituent monosaccharides.

This invention relates to the field of biotechnology, specifically to an inositol oxidase mutant and its application in the production of glucuronic acid. The inositol oxidase mutant provided by this invention is obtained by point mutation of the amino acid sequence shown in the wild-type inositol oxidase. Compared with the wild-type enzyme, the inositol oxidase mutant constructed by this invention exhibits a significant improvement in catalytic efficiency. Furthermore, this invention also provides an engineered strain with site-directed mutagenesis and knockout of the UxaC gene in the chassis cell genome. This strain exhibits higher catalytic activity towards the substrate, with a catalytic efficiency increased by 74.44% compared to the wild-type enzyme. Even at high substrate concentrations, the conversion rate can still reach over 92.09%, with a production intensity as high as 13.23 g / L / h. It possesses extremely strong substrate tolerance and production intensity, significantly reducing the production cost of glucuronic acid and demonstrating significant industrial application potential.

A method for the production of 2,5-furandicarboxylic acid (FDCA) comprising contacting glucose with a catalyst composition under conditions suitable for the formation of glucarate; acidifying glucarate to form glucaric acid; dehydrating glucaric acid to form FDCA; and recovering FDCA. A method for the production of 2,5-furan dicarboxylic acid dimethyl ester (FDME) comprising contacting glucose with a catalyst composition under conditions suitable for the formation of glycolaldehyde; contacting glycolaldehyde with a transition metal oxidation catalyst under conditions suitable for the formation of glucaric acid; esterifying glucaric acid to form glucaric acid methyl ester; dehydrating the glucaric acid methyl ester to form FDME; and recovering FDME.

A method for synthesizing an aluminium-fluoride complex obtainable by reacting together: a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; or a chelate bearing molecule precomplexed with aluminium(III), obtained from treating the chelate bearing molecule with a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; the fluoride being [19F]fluoride or radioactive [18F]fluoride; wherein the counterions of aluminium(III) other than chloride are selected from bromide, iodide, nitrate, phosphate, sulfate, sulphonate, hydroxide, any anionic salt of natural and non-natural amino acids, 2,4-pentanedionate, 8-hydroxyquinoline, acetate, acrylate, ascorbate, aspartate, benzenesulfonate, benzoate, besylate, bitartrate, camphorsulfonate, citrate, decanoate, esylate, fumarate, gentisate, gluconate, glutamate, glutarate, glycinate dihydroxide, glycolate, hexanoate, hydroxynaphthoate, isethionate, lactate, lactobionate, malate, maleate, malonate, mandelate, mesylate, methylsulfate, methylsulfonate, mucate, napsylate, octanoate, oleate, oxalate, pamoate, pantothenate, phthalate, polygalacturonate, propionate, salicylate, stearate, succinate, tartrate, teoclate, toluenesulfonate, trifluoroacetate, trifluoromethanesulfonate, and any combination thereof.

The present disclosure provides drilling fluids including emulsions. The emulsions include an aqueous phase, an oil, an emulsifier composition, and a wetting agent. The emulsifier composition includes an amidoamine. The wetting agent includes a first organic acid. The first organic acid selected from the group consisting of C6-C30 carboxylic acid, C6-C30 alkeynl acid, C6-C30 arylakyl acid, and a C6-C30 cycloalkyl acid. The wetting agent includes an alcohol alkoxylate. A ratio of the oil to the aqueous phase is about 85:15 to about 60:40 of the oil to the aqueous phase

The invention discloses a method for synthesizing a pevitide key intermediate, and relates to the technical field of medicine synthesis. The specific preparation method comprises the following steps: firstly, reacting 2, 3, 4, 6-tetraacetoxy-alpha-D-glucopyranose bromide with 18-hydroxy tert-butyl octadecanoate under the action of a catalyst to generate a glycoside intermediate, and carrying out alkaline hydrolysis on the glycoside intermediate to remove an acetyl protecting group, so as to obtain the 2, 3, 4, 6-tetraacetoxy-alpha-D-glucopyranose. And finally, carrying out oxidation reaction and purification to obtain a target product 18-([beta-D-glucuronic acid-1-yl] oxy) tert-butyl octadecanoate, namely the pevitide key intermediate. According to the preparation method disclosed by the invention, the pevitide key intermediate with relatively high yield and purity can be finally obtained, and the preparation method is simple to operate and has a good application prospect.

The invention relates to oligosaccharides composed of alternating glucuronic and N-acetylglucosamine units, with a β-D-glucuronic, β-D-galacturonic or β-L-altruronic unit at the non-reducing end with a substituent attached by a sulfide bond according to the structural formula (I), (II) or (III), their preparation and method of use. The invention also relates to a pharmaceutical composition comprising the oligosaccharide according to the structural formula (I), (II) or (III). Formulae for abstract (formulae I, II and III) wherein n = 0 to 8; X is O or N-H; Y is H, Na, K or aliphatic, aromatic, linear, branched or cyclic chain C2-C7; R is aliphatic, aromatic, heteroaromatic, linear, branched or cyclic chain C2-C70, optionally with content of N, S, Cl or O atoms.

The present disclosure provides a 3-phenoxybenzoic acid-glucuronic acid conjugate, and a preparation method and use thereof, and belongs to the technical field of pesticide detection. Compared with 3-phenoxybenzoic acid, the 3-phenoxybenzoic acid-glucuronic acid conjugate provided by the present disclosure features structural stability, high specificity, long limit of detection, and high content in urine, and can better serve as a marker that identifies whether an organism is killed due to pyrethroid pesticide poisoning. Namely, the 3-phenoxybenzoic acid-glucuronic acid conjugate can detect whether a toxicant (pyrethroid pesticides) is taken antemortem or exposed postmortem, and has an excellent application prospect in pyrethroid pesticide detection. The present disclosure provides a preparation method of a 3-phenoxybenzoic acid-glucuronic acid conjugate. The preparation method provided by the present disclosure features high product yield, simple operation, wide raw material sources, low costs, and suitability for industrial production.

The invention discloses a method for evaluating electronic waste pollution exposure risk based on a simple function, and the method comprises the following steps: collecting urine of crowds in an electronic waste pollution potential exposure area, centrifuging a urine sample, taking supernate, sequentially adding 1% formic acid, an internal standard solution and a beta-glucuronidase / aryl sulfatase mixed solution, and uniformly stirring; the method comprises the following steps of: performing enzymolysis, extracting and enriching, taking supernate, performing instrumental analysis to obtain the concentrations of 2, 4, 6-TriBP, 2, 4, 5-TriCP and 4-MonoBP in the urine, measuring the concentration of creatinine in the urine, and correcting; constructing three judgment functions, wherein the numbers of the three functions are all 1t; and when 0, judging that the crowd is exposed to the electronic waste. According to the method, geometric visualization and function explicit of decision logic are realized in a mode of combining feature importance analysis and decision boundary projection, and finally three simplified functions which are convenient for practical application and are used for predicting the exposure risk of electronic waste pollution are formed.

This invention relates to the field of pharmaceutical and chemical intermediates technology, and discloses a novel class of substituted phenylethyl-O-β-D-glucuronide compounds. These compounds are generated using substituted phenylethanol as a substrate and 1-fluoro-D-glucuronic acid as a glycosyl donor, catalyzed by β-glucuronyltransferase derived from *E. coli*. The process yield can reach over 95%, and the reaction conditions are mild and environmentally friendly. Substituted phenylethyl-O-β-D-glucuronide can be efficiently used for the determination of β-glucuronidase activity, and its applications are wide-ranging and reliable. The product can meet the needs of pharmaceutical, food, and other fields for β-glucuronidase activity control. It can be used for enzyme activity detection in the auxiliary diagnosis of clinical diseases, and also for enzyme quality control in fruit juice clarification processes in the food industry, drug precursor activation, and glycan structure analysis in the biopharmaceutical field. The product structure has been verified to be accurate by mass spectrometry and 1H NMR spectroscopy, and enzymatic hydrolysis experiments have confirmed its reliable application.

A nanoparticle comprising a diblock polymer comprising a first component covalently bound via a linker to a second component; wherein said first component is an oligomer comprising at least 50 mol% L-5 guluronic acid residues or at least 50 mol% galacturonic acid residues and having a degree of polymerisation n where n is at least 3; said second component is a second polymer having no more than 30 mol% L-guluronic acid residues or galacturonic acid residues and having a degree of polymerisation of at least 4;10 wherein said nanoparticle comprises a chelator such as DOTA; wherein said nanoparticle comprises at least one metal ion such as a radionuclide or Gd ions.

The invention discloses a method for detecting related substances of calcium gluconate. The detection method is a high performance liquid chromatography-electric fog type detection method. Chromatographic conditions are as follows: a chromatographic column takes cation exchange resin as a filler, the evaporation temperature is 50-60 DEG C, the collection frequency is 8-12 Hz, the filtration constant is 4.5-5.5 s, the power function value is 1.8-2.2, the column temperature is 45-55 DEG C, the mobile phase is 0.09-0.11% trifluoroacetic acid solution, and isocratic elution is performed. The method is used; d-glucuronic acid, isomaltohexanoic acid, maltose acid, fructose, D-glucuronic acid lactone, glucose, D-gluconic acid-gamma-lactone, glucaric dialdehyde, D-gluconic acid-delta-lactone, oxalic acid, maltotriose, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2- According to the method, impurities such as 3, 5-hydroxymethyl-2-furaldehyde and the like are well separated from calcium gluconate, and the impurities in the method are relatively good in sensitivity, relatively small in baseline interference, relatively good in specificity and the like, so that the defects in the prior art can be effectively overcome, and related substances in the calcium gluconate can be effectively controlled; the safety, the effectiveness and the quality controllability of various calcium supplements prepared by taking the calcium gluconate as the raw material medicine are ensured.

Compounds of formula (I) are provided, wherein Conjugator is a group capable of bonding a BA and joining the BA to the rest of the compound, Cleavable includes at least one site that can be cleaved by a β-glucuronidase enzyme, Spacer provides distance between Conjugator and Payload, Payload is a cytotoxic agent such as MMAE, and BA is a binding agent.

Provided is a method for producing an aldehyde, with which a target aldehyde can be obtained at a high conversion rate and high selectivity. The method for producing an aldehyde involves a hydrogenation step in which an α,β-unsaturated aldehyde represented by formula (1) is hydrogenated in the presence of a palladium-containing catalyst and a carbonate to obtain an aldehyde represented by formula (2), wherein the amount of the carbonate is 1-2 equivalents relative to the acid content in the α,β-unsaturated aldehyde, and the carbonate is at least one selected from the group consisting of sodium carbonate and potassium carbonate. In the formula, R1 is an alkyl group having 1-6 carbon atoms, and R2 is a hydrogen atom or a methyl group.

The invention provides a preparation method of magnesium isoglycyrrhizinate, and belongs to the technical field of raw material medicine preparation, the preparation method comprises the following steps: taking glycyrrhetinic acid as an initial raw material, carrying out isomerization reaction under an alkaline condition, then recrystallizing to obtain isoglycyrrhetinic acid, and recovering glycyrrhetinic acid; carrying out glucuronization reaction on the isoglycyrrhetinic acid under the action of enzyme to generate isoliquiritigenin, and carrying out salt forming reaction on the isoglycyrrhetinic acid to obtain the magnesium isoglycyrrhizinate. The recovered glycyrrhetinic acid is used as an initial raw material again to prepare the magnesium isoglycyrrhizinate. A brand new magnesium isoglycyrrhizinate preparation route is designed and implemented, no literature report exists at present, glycyrrhetinic acid is adopted as a raw material, the influence of glucuronic acid groups on the refining process is eliminated, the refining efficiency is high, and the molar yield is high.

The invention relates to the field of water treatment, in particular to a boiler water treatment agent and a preparation method thereof. The boiler water treatment agent is prepared from the following raw materials in parts by weight: 30 to 60 parts of modified vermiculite, 5 to 15 parts of glucuronate, 5 to 15 parts of sponge iron particles, 3 to 10 parts of itaconic acid, 15 to 30 parts of trisodium phosphate, 8 to 15 parts of acetoxime, 0.5 to 2 parts of benzotriazole, 5 to 12 parts of acrylic acid-2-acrylamide-2-methylpropanesulfonic acid copolymer and 80 to 120 parts of water. Through full-chain cooperation of all the components in corrosion prevention, scale inhibition, water quality stabilization and preparation processes, a boiler metal base material can be effectively protected, scale formation is blocked, system water quality stability is maintained, the scale inhibitor is suitable for long-term stable operation of medium and high pressure boilers, the service life of the boilers is prolonged, and heat efficiency is improved.

This invention relates to a crosslinking agent for improving the thermal stability of amino substrates and its application. The crosslinking agent for improving the thermal stability of amino substrates is one or more of glucuronic acid, galacturonic acid, glucuronide, methyl glucuronide, and methyl galacturonide. It improves substrate performance by reacting with the amino substrate through Maillard reactions or amidation reactions via its contained active aldehyde, carboxyl, or ester groups. This crosslinking agent exhibits significant crosslinking effect, good biocompatibility, and high permeability.

Dried microcarriers comprising polygalacturonic acid (PGA), or partly esterified pectic acid (PE PGA) with a degree of esterification of 40 mol% or less, or salts of the foregoing, are provided. The dried microcarriers are formed with drying solutions comprising a calcium chelator or a positively charged molecule and require less rehydration solution to rehydrate the microcarriers as compared to currently available pectin-based dried microcarriers. The dried microcarriers of the present disclosure may further comprise a filler and / or a lubricant. The process for making the dried microcarriers requires less volume of alcohol and filler when calcium chelators or positively charged molecules that other existing drying processes.

This invention provides a novel polysaccharide extracted from dried plum (Prunus mume), its preparation method, and its uses. The monosaccharide molar fraction in the Prunus mume polysaccharide is as follows: 0.5%-1.0 mol% fucose, 1.0%-2.0 mol% rhamnose, 35%-37 mol% arabinose, 15%-17 mol% galactose, 9.0%-11 mol% glucose, 2.0%-3.0 mol% xylose, 6%-8 mol% mannose, 23%-25 mol% galacturonic acid, and 1.0%-2.0 mol% glucuronic acid. The Prunus mume polysaccharide isolated and purified by this invention exhibits excellent antioxidant activity. Furthermore, based on the complex acidic heteropolysaccharide structure of the Prunus mume polysaccharide, especially its high proportion of uronic acid and branched structure, it possesses potential for various biological activities and has extremely high industrial utilization value.

The present invention relates to a polymeric compound of glucuronic acid bearing a phenolic hydroxyl moiety (hereinafter referred to as PGU-Ph) and more particularly to a method for the hydrogelation of such a compound. The present invention also relates to the use of the hydrogel structures (particles, films or 3D structures) obtained by this method, in particular as three-dimensional cell culture materials for supporting biological molecules used as active ingredients, for cell colonization or for tissue regeneration.

The oil-in-water emulsion of the present invention comprises: (a) at least one acid selected from the group consisting of alpha hydroxy acids (AHA), beta hydroxy acids (BHA), and polyhydroxyalkanoic acids (PHAs); (b) batyl alcohol; (c) at least one thickener selected from the group consisting of cellulose-based thickeners having an alkyl group with 10 to 30 carbon atoms, and polysaccharide thickeners containing glucose, glucuronic acid, and rhamnose as main chain constituent monosaccharides; and (d) an oil.

The invention discloses a diol preparation method and application, and belongs to the technical field of diol preparation, and the diol preparation method comprises the following steps: in the presence of a basic catalyst, terminal olefin reacts with an oxidizing agent to generate an epoxide; and adding the epoxide into an alkaline solution for reaction to obtain a diol product. According to the method, terminal olefin is epoxidized by adopting an alkaline system, so that the amount of byproducts such as aldehyde, acid and the like generated by excessive oxidation is reduced, and the generation of pungent smell in a diol product is reduced. According to the invention, low-temperature purification is adopted, so that the rectification process of the product with relatively high viscosity and relatively high purification difficulty is reduced; in addition, the yield and the purity of the product in the invention both reach higher levels, and the colorless and odorless requirements of cosmetic additives are met.