141 results about "Aldehydic Acids" patented technology

The invention relates to a method for preparing algin oligosaccharide by using algin lyase Agarivorans albus YKW-34, which is characterized by comprising the following steps: firstly preparing enzyme liquid of the algin lyase Agarivorans albus YKW-34, dissolving algin in water, adding the prepared enzyme liquid into the solution, decomposing the algin for 2 to 180 hours in a water bath at a temperature of 20 to 55 DEG C, raising the temperature to between 60 and 100 DEG C, inactivating the algin, filtering the algin by a film, and condensing, freezing and drying the algin to obtain the algin oligosaccharide. The method has the advantages that a culture medium for preparing the algin lyase has economic and simple compositions; the algin lyase has high yield, unique Na<+> / K<+> ion dependence, superior temperature and pH stability and high specific activity, and can degrade seminose half aldehyde and guluronic acid fragments of the algin at the same time; and the produced algin oligosaccharide with the polymerization degree of 2 to 12 has favorable application prospect.

The invention discloses a carboxylic ester of fucosylated glycosaminoglycan (CEFG) with anticoagulation activity, a pharmaceutically acceptable salt thereof, a preparation method of the CEFG and the pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the CEFG or the salt thereof, and application of the pharmaceutical composition in preparation of anticoagulants. The monosaccharides for preparing the CEFG comprise D-glucuronic acid or D-glucuronate (D-GlcU), D-2-deoxy-2-acetyl galactosamine sulfate (D-GalNAcS) and L-fucose sulfate (L-FucS), wherein the molar ratio of D-GlcU to D-GalNAc to L-Fuc to -OSO3<-> is 1:(1+ / -0.3):(1+ / -0.3):(3.5+ / -0.5); the esterification degree of the D-GlcU is not lower than 20%; and the weight average molecular weight of the CEFG is 3000-20000 Da. The glycosylated chondroitin sulfate esterification derivative has strong anticoagulation activity, and can be applied in preparation of drugs for preventing and / or treating thrombotic diseases.

A method for producing a chondroitin sugar chain comprises at least the following step: a step of allowing “a glucuronic acid donor”, “an N-acetyl galactosamine donor”, “a sugar receptor” and “a bacterial cell enzyme which synthesizes chondroitin” to coexist in a reaction system in the presence of a surfactant. Here, the surfactant is preferably selected from n-nonyl-β-D-thiomaltopyranoside, sucrose monocaproate and sucrose monolaurate. The chondroitin sugar chain has all the following properties 1) to 3): 1) a weight average molecular weight: 50,000 or more when it is measured by gel filtration chromatography, 2) it is completely degraded to disaccharides with chondroitinase ABC, 3) when the sugar chain is decomposed with chondroitinase ABC and the decomposed products are subjected to a disaccharide analysis, substantially all of them correspond to an unsaturated disaccharide unit of chondroitin.

The invention discloses a catalyst for hydro-conversion of a mixture aqueous solution containing alcohol, aldehyde, acid, ester and the like into corresponding alcohols. The catalyst mainly comprises three parts including a main active constituent, an auxiliary and a carrier. The main active constituent is one or more of precious metals including Re, Ru and Pd, the auxiliary is one or more of metals, including Ag, Ni, Cu and the like, or oxides thereof, and the carrier is selected from activated carbon, Al2O3, SiO2 and the like. Under the actions of the catalyst, the mixture aqueous solution containing alcohol, aldehyde, acid, ester and the like in a trickle bed reactor can be converted into a corresponding alcohol aqueous solution in high activity and high selectivity ways under the conditions with certain temperature and pressure.

The invention provides a method for oriented biosynthesis of GAMG, and belongs to the technical fields of biosynthesis and biotransformation. The method comprises the following steps: producing corresponding beta-D-glucuronidase by penicillium purpurogenum stoll in a fermentation medium; adding the obtained beta-D-glucuronidase into conversion solution containing glycyrrhizic acid substrate, orientedly hydrolyzing the glycyrrhizic acid under the action of enzyme, and obtaining a coarse product of GAMG; and performing organic solvent extraction, resin adsorption and purification to obtain a GAMG product. The method takes microbialenzyme as a catalyst, and has high reaction efficiency, no pollution, simple steps, and low cost; and the product is single and has high purity.

The invention discloses a method for preparing a hemicellulose / nano-silver colloid rapidly. The method includes the steps that in a water phase, hemicellulose and silver ammonia solution are subjected to a redox reaction under the microwave condition to generate nano-silver particles; the hemicellulose is extracted from the grass family, the weight-average molecular weight of the hemicellulose is 4.5*104 g / mol-5.5*104 g / mol, and the hemicellulose comprises, by mass percent, the following carbohydrate components: 85-90% of wood sugar, 7.5-12% of arabinose, 0.5-1% of glucose, 0.15-0.65% of galactose, 0.08-0.15% of mannose and 1.05-2.95% of glucuronic acid. The preparation meets the requirement for green chemistry, and the method is a nano-metal preparing method which is green and rapid to implement. A new conception is provided for the green synthesis of nano-silver, the hemicellulose resource is reasonably utilized, and the nano-silver colloid has application prospects in the biological field and the medical field.

The invention discloses a chemical synthetic method of a novel chiral 3,3-disubstituted oxoindole derivative with PTP1B inhibiting action. With diazoisatin, indole, arylamine and aldehyde ester as raw materials, a metal catalyst as catalyst, chiral phosphoric acid as a co-catalyst, an organic solvent as a solvent, and molecular sieve shown in the specification as an additive, a one-step reaction is performed under the condition of 25 degrees centigrade, and the product undergoes column chromatography purification to obtain the target product. The synthetic method has the advantages of high step economy, strong atom economy, high diastereoselectivity and enantioselectivity, high yield, mild reaction condition, and simple and safe operation. The optically pure chiral 3,3-disubstituted oxoindole derivative with two chiral centers synthesized in the invention is an important intermediate in chemical engineering, chemistry and medicines, and has a wide application prospect in the fields of medicines and the chemical engineering.

The invention discloses a novel scutellarin derivative as well as a preparation method and a pharmaceutical composition thereof. The compound is prepared by the two-step reaction of methyl etherification and acetylation of the scutellarin functioning as an initial raw material and the separation and has the chemical name of 4',5,6-trimethoxy-8-(3,4,5-triacetyl-glucuronic acid)-scutellarin. The compound and the pharmaceutical composition thereof can be used for treating cardiovascular and cerebrovascular disease, phlegmasia and tumor and has the advantages of good dissolvability, high bioavailability and remarkable curative effect.

The instant invention provides a crosslinkable aqueous composition, method of producing the same, crosslinked compositions, and method of producing the same. The crosslinkable composition comprising: an aqueous dispersion comprising; (a) water; (b) a polycarbamate comprising at least an average of 2.0 carbamate functional groups; (c) a polyaldehyde comprising at least two aldehyde groups; (d) an acid catalyst; and (e) optionally one or more surfactants; wherein said aqueous dispersion has a pH in the range of less than 7; and wherein said composition is capable of being crosslinked at a temperature in range of less than 80° C. upon substantial removal of water.

The invention relates to a coumarin compound acidulated by glucal and application thereof. The compound has a structure showed in the right formular, wherein R is one of-H, -OH, -CH3, -OCH3, -NH2 or ester group; and R1, R2, R3 and R4 are one of -H, -OH, -CH3, -SH, -OCH3, -NH2 or glucal acid group. The coumarin compound acidulated by the glucal has the activities of resisting arthritic and tumor.

A method for preparing aldehydic acid tanning agent is prepared by taking glutaraldehyde, glyoxalic acid and glyoxalic acid metal as raw material, reduced pressure distilling or reverse-flow removing water and synthesizing aldehydic acid tanning agent under protection of nitrogen gas and alkaline catalyst, pre-tanning deliming softening bare skin by the aldehydic acid tanning agent. It achieves good tanning and absorbing performance, and no pollution.

A method for preparing oligoxylose and alpha-glucose aldehydic acid enzyme is disclosed. It includes: saccharogenic decomposing xylan by combination of xylanase and alpha-glucose aldehydic acid enzyme, expanding and obtainingalpha-glucose aldehydic acid enzyme gene from donor bacteria by PCR, inserting carrier, constructed recombinant plasmid converting into host cell and expressing it, centrifugal obtaining supernatant fluid(enzyme liquid) by centrifugal collecting cell, breaking cell and heat treating. It achieves high zymoprotein output, activity and purification.

The invention provides an oligogalacturonide preparation method which comprises the following steps: 1) preparing pectic acid; 2) preparing a pectin-oligosaccharide mixture by using the pectic acid as the substrate through enzymolysis; and 3) preparing the oligogalacturonide. The invention provides a low-cost, simple and practicable method which can be used for preparing the oligogalacturonide from the pectin-oligosaccharide mixture and can ensure the purity of the oligogalacturonide.

The invention relates to a novel oligomeric active factor beta-oligomeric acid, and a preparation method and application thereof. The beta-oligomeric acid is oligomeric glucuronic acid with the polymerization degree of 4-20, which is prepared by simultaneously degrading plant cellulose and carboxylating 6th-site hydroxy group. The beta-oligomeric acid prepared by the synchronous degradation and carboxylation technique can be used as a novel biological active factor; the beta-oligomeric acid containing polycarboxyl groups is mainly used as a plant growth regulator for non-characteristic regulation of plant nutrients and reproductive growth in agricultural production, thereby enhancing the yield and quality of the crops; and when being used as a microelement chelate stabilizer, the beta-oligomeric acid can effectively enhance the stability of microelements and promote the absorption and utilization of the plants for the microelements.

The invention relates to a preparation method of initial intermediate hexabenzylhexaazaisowurtzitane of a high energy density compound HNIW, comprising the following steps: (1) mixing a solvent with benzylamine and placing the mixture into a reactor; (2) mixing acid catalysts with a glyoxal water solution to prepare an aldehydic acid mixed solution; (3) slowly adding the prepared aldehydic acid mixed solution into the reactor and stirring for reaction; and (4) after dripping the aldehydic acid mixed solution, continuously stirring for reaction until the reaction is completely finished, and then separating to obtain hexabenzylhexaazaisowurtzitane solid products.

The invention discloses fucose-rich exopolysaccharide as well as a preparation method and application thereof. The L-fucose, D-glucose, D-galactose, D-glucuronic acid and a pyruvic acid unit are usedas raw materials. Molar ratio of 2.03: 1 1.00: 1.18: 0.64: 0.67, mw is 3.65 * 10 < 5 > Da; the strain is prepared by fermenting a Kosakonia sp. CCTCC (China Center For Type Culture Collection) M2018092 strain, the acid hydrolysis exopolysaccharide has reducibility and can be used as a reducing agent and a stabilizing agent, nano-silver with uniform size is prepared through a green method, the EPS / nano-silver antibacterial film is further prepared, and the prepared film has an antibacterial effect and has good application potential in the aspect of biodegradable antibacterial films.

The invention provides aldehydic acids tetramethylpyrazine esters, compounds of polyaromatics supported Ligusticum wallichii effective compositions, and the process for their preparation, which comprises converting lateral chains into ligustrazine derivatives of reactive groups, bonding with polyacids under the action of dicyclo hexylcar bodiimide (DCCI), so as to join ligustrazine lateral chains with polymers of functional groups through ester linkages.

The invention discloses an alkaline pectinase mutant with improved specific enzyme activity and heat stability, and belongs to the field of enzyme engineering. Compared with an existing mutant PGL-S1, the specific enzyme activity of the mutant PGL-(GS)3-S1 is improved by 6 times and the half-life period at the temperature of 60 DEG C is prolonged by 1.3 times. Alkaline pectinase can be catalyzed under the alkaline condition, the alpha-1,4 glucosidic bond of polygalacturonic acid is split through the reverse eliminating effect, and the alkaline pectinase mutant can be widely applied to industries such as the food industry, the textile industry and the papermaking industry.

A method for preparing scutellarin by enzymatic hydrolysis skullcap glycoside glucose aldehydic acid is disclosed. Its advantages include no pollution, high percent conversion and high enzyme output.

Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activity and useful for the control of coagulation and as antithrombotic agents are obtained starting from an optionally purified K5 polysaccharide by a process comprising the steps of N-deacetylation / N-sulfation, C5 epimerization, O-oversulfation, selective O-desulfation, 6-O-sulfation, N-sulfation, and optional depolymerization, in which said epimerization is performed with the use of the enzyme glucoronosyl C5 epimerase in solution or in immobilized form in the presence of divalent cations. New, particularly interesting antithrombin compounds are obtained by controlling the reaction time in the selective O-desulfation step and submitting the product obtained at the end of the final N-sulfation step to depolymerization.

The invention relates to a catalyst for the production of unsaturated aldehyde (acid) and a preparation method thereof. The catalyst comprises active components and a heat-transfer medium. The active components are oxides of metals such as molybdenum, bismuth, iron, and the like or composite oxides. The heat transfer medium is silicon dioxide coated metal powder or alloy powder, and the heat conductive performance is excellent. During the catalyst preparation process, a freeze drying mode is adopted, and the burning atmosphere is a mixed gas composed of oxygen and an inert gas according to a certain ratio. The catalyst is applied to the strongly exothermic catalytic oxidation of unsaturated alkene to generate unsaturated aldehyde (acid), especially catalytic reactions of preparing methylacrolein (methacrylic acid) from isobutene; the problem of excess temperature of local hot spots is solved; and at a low hot spot temperature, the catalyst has an excellent unsaturated alkene conversion rate and unsaturated aldehyde (acid) selectivity.

A method of treating alginic acid to produce polyguluronic acids. The method involves: (a) mixing the alginic acid with water and lithium hydroxide in respective amounts sufficient to form a reaction mixture that is an acidic solution comprising at least 5 wt % of the alginic acid; (b) treating the reaction mixture, with addition of a periodic acid or a periodate salt, to effect an oxidation of the alginic acid that results in formation of (i) an oxidized product that, upon acidifying and heating, hydrolyzes into a plurality of components including polyguluronic acids that are substantially free of mannuronic acid contamination, with the polyguluronic acids having an average degree of polymerization of less than 20; and (ii) free iodine; (c) separating the free iodine from the reaction mixture; (d) acidifying and heating the reaction mixture to hydrolyze the oxidized product into the plurality of components; (e) adjusting the pH of the reaction mixture to form a precipitate of the polyguluronic acids; and (f) recovering the precipitate. There is also disclosed a method of treating alginic acid using steps (a), (b) and (c) to form concentrated solutions for use in producing polyguluronic acids.

The invention discloses a beneficiation inhibitor that is prepared from mercaptoacetic acid, sodium silicate and glucuronic acid as raw materials, wherein the weight ratio of the three is (50-100): 1000-1200: 1-2. The invention further discloses a purification method of the molybdenum rough concentrate. The method comprises the steps of gravity separation, regrinding, rough separation, fine separation and scavenging. According to the invention, a part of lead minerals can be removed through pre-gravity separation operation, thus reducing subsequent lead reduction pressure; the galena is strongly inhibited due to strong hydrophilicity of glucuronic acid in the adopted inhibitor, inhibition of copper and sulfur is further ensured by adding mercaptoacetic acid, the sodium silicate is matched,so ore pulp can be effectively dispersed, a strong inhibition effect on lead copper and gangue minerals in the molybdenum rough concentrate is achieved, and the impurity content in the molybdenum concentrate can be effectively reduced.

Provided are a method for producing a fraction containing more than 50% of CH represented by the general formula (1), which comprises at least the step of allowing a glucuronic acid donor, an N-acetylgalactosamine donor, a saccharide receptor, a chondroitin polymerase derived from the Escherichia coli K4 strain, and Mn2+ at a final concentration of 0.02 to 100 mM to coexist, and performing a reaction thereof under conditions of 20 to 40° C. and pH 6 to 8 for 0.5 minutes to 4 hours, and a method for producing a fraction containing more than 50% of CH represented by the general formula (2), which comprises at least the step of performing the reaction under same conditions for 10 hours or longer, which enable industrial scale production of a CH fraction of a controlled even number saccharide and odd number saccharide content ratio by a simple procedure at a low cost.(GlcA-GalNAc)n   (1)GalNAc-(GlcA-GalNAc)n   (2)(In the formula, GlcA represents a glucuronic acid residue, GalNAc represents a N-acetylgalactosamine residue, - represents a glycosidic bond, and n represents an arbitrary integer.)

The invention relates to the technical field of protective agent production, and discloses a production protective agent for high-quality fruits which is composed of the following components in partsby mass: 12-15 parts of chitosan, 5-9 parts of D-glucuronic acid, 2-7 parts of citric acid, 7-11 parts of vitamin C, 7-10 parts of 4-chlorophenoxyacetic acid, 8-13 parts of glycerol, 15-20 parts of golden cypress powder, 36-39 parts of Chinese pulsatilla powder, 5-12 parts of honeysuckle powder, 65-95 parts of water and 3-9 parts of atractylodes macrocephala koidz powder. The screening assembly can be used for screening input powdery materials, so that the powdery materials meet the actual production requirement, the screening process is faster, manual screening is not needed, the screening efficiency is remarkably improved, the transmission device can smash the materials in the box body, the purpose of rapid stirring can be achieved, and the practicability is high. Rapid stirring and fusion of materials in the box body are facilitated, and the production efficiency of the protective agent is improved.

The invention provides a Diwu extract with a mass content of 60%, which mainly comprises Diwu saponins, the four monomers are, 3-O-beta-D-pyran glucuronic acid-oleanolic acid-28-O-alpha-L-pyran rhamnose(1-4)-beta-D-glucopyranose(1-6)-beta-D-glycopyraniside, 3-O-beta-D-glucopyranose aldehyde acid-oleanolic acid-28-O-beta-D-glucopyranose(1-6)-beta-D-glucopyranoside, 3-O-alpha-L-pyran rhamnose(1-2)-beta-D-glucopyranose-oleanolic acid-28-O-alpha-L-pyran rhamnose(1-4)-beta-D-glucopyranose(1-6)-beta-D-glycopyraniside, 3-O-alpha-L-pyran rhamnose(1-2)-alpha-L-Arabinopyranosyl-oleanolic acid-28-O-alpha-L-pyran rhamnose(1-4)-beta-D-glucopyranose(1-6)-beta-D-glycopyraniside. The invention also discloses the process for preparing the abstract.

The invention discloses an efficient, simple and convenient method for preparing cyanidenon-7-O-beta-D-glucuronide. The efficient, simple and convenient method comprises the following steps of: a. smashing an irexis sonchifolia raw material, soaking in 5-10 times amount of saturated lime water for 2-3 times, mixing extracting solutions, filtering, carrying out molecule trapping sequentially by an ultrafiltration membrane and a nanofiltration membrane, adjusting pH of trapped liquid to 3-5, absorbing the trapped liquid by polyamide resin, carrying out gradient elution by an ethanol solution, and concentrating eluent to obtain a concentration solution; and b. purifying the concentration solution by adopting high-speed counter-current chromatography, carrying out online monitoring by an ultraviolet detector, collecting a target component according to an atlas, recovering the reagent, and drying under reduced pressure to obtain the catalpol. The method for preparing the cyanidenon-7-O-beta-D-glucuronide has the advantages that the process operation is simple, the product yield is high, and the industrial amplification is easy.