139 results about "Aldehydic Acids" patented technology

Novel estrogenic compounds of Formula I are provided.wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R1 is selected from the group consisting of hydrogen, sulfate and glucoronate or other esters, and when the wavy line is a double bond, R1 does not exist; R2 is lower alkyl; R3 may be selected from the group consisting of hydrogen, sulfate, or glucuronide or other esters; and R4 through R13 may independently be selected from the group consisting of hydrogen, hydroxy, ketone, lower alkyl, lower alkoxy, halogen, and carbonyl groups and R14 is selected from the group consisting of hydrogen, sulfate and glucoronide and other esters. When R1 is hydroxy, the hydroxy or ester substituent may have either an α or a β orientation. Compositions of matter including compounds of the present invention are also provided as are methods of treating mammals in need of treatment using compounds of the present invention.

Provided are methods of producing 2,5-furandicarboxylic acid (FDCA) from renewable sources such as seaweed, alginate, oligoalginate, pectin, oligopectin, polygalacturonate, galacturonate, and / or oligogalacturonate. The sugars in the renewable sources can be converted into one or more intermediates such as 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU), 4-deoxy-L-threo-5-hexosulose uronate (DTHU), 5-hydroxymethyl furfural (HMF), 2,5-dihydroxymethyl furan (DHMF), and 5-formyl-2-furancarboxylic acid (FFA), which can be converted into FDCA by dehydration and cyclization to produce 5-formyl-2-furancarboxylic acid (FFA), followed by oxidation to produce FDCA. DEHU or DTHU may also be converted into FDCA by oxidation to produce 2,3-dihydroxy-5-oxohexanedioic acid (DOHA), which then undergoes dehydration and cyclization to produce FDCA.

The invention discloses a chemical synthetic method of a novel chiral 3,3-disubstituted oxoindole derivative with PTP1B inhibiting action. With diazoisatin, indole, arylamine and aldehyde ester as raw materials, a metal catalyst as catalyst, chiral phosphoric acid as a co-catalyst, an organic solvent as a solvent, and molecular sieve shown in the specification as an additive, a one-step reaction is performed under the condition of 25 degrees centigrade, and the product undergoes column chromatography purification to obtain the target product. The synthetic method has the advantages of high step economy, strong atom economy, high diastereoselectivity and enantioselectivity, high yield, mild reaction condition, and simple and safe operation. The optically pure chiral 3,3-disubstituted oxoindole derivative with two chiral centers synthesized in the invention is an important intermediate in chemical engineering, chemistry and medicines, and has a wide application prospect in the fields of medicines and the chemical engineering.

The invention relates to a novel oligomeric active factor beta-oligomeric acid, and a preparation method and application thereof. The beta-oligomeric acid is oligomeric glucuronic acid with the polymerization degree of 4-20, which is prepared by simultaneously degrading plant cellulose and carboxylating 6th-site hydroxy group. The beta-oligomeric acid prepared by the synchronous degradation and carboxylation technique can be used as a novel biological active factor; the beta-oligomeric acid containing polycarboxyl groups is mainly used as a plant growth regulator for non-characteristic regulation of plant nutrients and reproductive growth in agricultural production, thereby enhancing the yield and quality of the crops; and when being used as a microelement chelate stabilizer, the beta-oligomeric acid can effectively enhance the stability of microelements and promote the absorption and utilization of the plants for the microelements.

This invention relates to the bioproduction of substituted or unsubstituted phenylacetaldehyde, 2-phenylethanol, phenylacetic acid or phenylethylamine by subjecting a starting material comprising glucose, L-phenylalanine, substituted L-phenylalanine, styrene or substituted styrene to a plurality of enzyme catalyzed chemical transformations in a one-pot reaction system, using recombinant microbialcells overexpressing the enzymes. To produce phenylacetaldehyde from styrene, the cells are modified to overexpress styrene monooxygenase (SMO) and styrene oxide isomerase (SOI). To produce phenylacetic acid from styrene, SMO, SOI and aldehyde dehydrogenase are overexpressed. Alternatively, to produce 2-phenylethanol, SMO, SOI and aldehyde reductase or alcohol dehydrogenase are overexpressed, while to produce phenylethylamine, SMO, SOI and transaminase are overexpressed.

The invention relates to a preparation method of initial intermediate hexabenzylhexaazaisowurtzitane of a high energy density compound HNIW, comprising the following steps: (1) mixing a solvent with benzylamine and placing the mixture into a reactor; (2) mixing acid catalysts with a glyoxal water solution to prepare an aldehydic acid mixed solution; (3) slowly adding the prepared aldehydic acid mixed solution into the reactor and stirring for reaction; and (4) after dripping the aldehydic acid mixed solution, continuously stirring for reaction until the reaction is completely finished, and then separating to obtain hexabenzylhexaazaisowurtzitane solid products.

The invention relates to a catalyst for the production of unsaturated aldehyde (acid) and a preparation method thereof. The catalyst comprises active components and a heat-transfer medium. The active components are oxides of metals such as molybdenum, bismuth, iron, and the like or composite oxides. The heat transfer medium is silicon dioxide coated metal powder or alloy powder, and the heat conductive performance is excellent. During the catalyst preparation process, a freeze drying mode is adopted, and the burning atmosphere is a mixed gas composed of oxygen and an inert gas according to a certain ratio. The catalyst is applied to the strongly exothermic catalytic oxidation of unsaturated alkene to generate unsaturated aldehyde (acid), especially catalytic reactions of preparing methylacrolein (methacrylic acid) from isobutene; the problem of excess temperature of local hot spots is solved; and at a low hot spot temperature, the catalyst has an excellent unsaturated alkene conversion rate and unsaturated aldehyde (acid) selectivity.

The invention relates to the technical field of protective agent production, and discloses a production protective agent for high-quality fruits which is composed of the following components in partsby mass: 12-15 parts of chitosan, 5-9 parts of D-glucuronic acid, 2-7 parts of citric acid, 7-11 parts of vitamin C, 7-10 parts of 4-chlorophenoxyacetic acid, 8-13 parts of glycerol, 15-20 parts of golden cypress powder, 36-39 parts of Chinese pulsatilla powder, 5-12 parts of honeysuckle powder, 65-95 parts of water and 3-9 parts of atractylodes macrocephala koidz powder. The screening assembly can be used for screening input powdery materials, so that the powdery materials meet the actual production requirement, the screening process is faster, manual screening is not needed, the screening efficiency is remarkably improved, the transmission device can smash the materials in the box body, the purpose of rapid stirring can be achieved, and the practicability is high. Rapid stirring and fusion of materials in the box body are facilitated, and the production efficiency of the protective agent is improved.

The invention provides an extraction process of response surface process optimization uralla total flavonoids and an anti-oxidization function. The ethanol concentration, the material-liquid ratio, the extraction time and the extraction time are used as single factors; the extraction rate (percent) of the total flavonoids is used as a response value; the optimization is performed on the extractionprocess through the response surface design tests; an optimum process realizing the ethanol concentration being 49.40 percent, the material-liquid ratio being 30.49mL / g, the extraction time being 91min, the extraction temperature being 71 DEG C, the highest extraction rate being 6.248 percent, and the uralla total flavonoids practical extraction rate being 6.24 percent+ / - 0.04 percent is realized; the LC-MS combined use is used for qualitative analysis; the condition that uralla possibly contains five kinds of compounds such as catechin, rutin, orientoside, luteolin-7-o-D-glucuronic acid andcyanidenon is speculated; the anti-oxidization activity of the total flavonoids is studied; the condition that the total flavonoids have certain clearing capability for clearing away hydroxide radicals, ABTS and DPPH free radicals is discovered; the IC 50 is respectively 0.232, 0.012 and 0.026mg / mL. The result shows that the obvious anti-oxidization capability is realized.