Disclosed is a mastitis treatment traditional Chinese medicine compound meeting the principles of traditional Chinese medicine compatibility. Thoroughly, the compound adopts sanchi flower, brownsheath lilyturf root, cortex albizziae, folium panacis japonici cum caule, Ligusticum wallichii, Codonopsis pilosula, penduliflory elsholtzia herb, threevein aster herb, szechwan chinaberry fruit, rhizoma corydalis, wolfiporia extensa, white atractylodes rhizome, mulberry, vaccariae semen and fructus liquidambaris as monarch and ministerial ingredients for dispersing liver-qi stagnation, regulating qi to disperse stagnation, tonifying spleen, calming mind and promoting lactation; the compound further adopts acutifoliate podocarpium herb, Chinese alangium leaf, catchweed bedstraw herb, petitgrain, oriental bittersweet root, liquoric root, retinervus luffae fructus, dahurian angelica root, milkwort root, honeysuckle, dandelion, silence tenuis, cortex moutan radicis, prepared rehmannia root, angelica sinensis, ricepaperplant pith, carthamus tinctorious, turtle shell and semen zizyphi spinosae as adjuvant ingredients for coordinating, deswelling, relieving pain, promoting blood circulation to restore menstrual flow, clearing heat and toxic, enhancing the effects of the monarch and ministerial ingredients and constraining the toxic and side effects of other drugs. The compound has the functions of deswelling, relieving pain, soothing the liver and qi, nourishing five internal organs, benefiting pneuma, activating blood circulation and promoting lactation and can be applied to mastitis.