The invention discloses health-care sesame oil. The health-care sesame oil is prepared from the following raw materials in parts by weight: 10-20 parts of rice bran oil, 10-20 parts of corn oil, 20-30 parts of olive oil, 8-10 parts of walnut oil, 80-100 parts of sesame oil, 6-8 parts of peanut oil, 8-12 parts of pseudo-ginseng, 6-9 parts of zedoary rhizomes, 8-10 parts of ginseng, 6-8 parts of radix astragali, 2-4 parts of radix ophiopogonis, 1-3 parts of poria cocos, 4-6 parts of Chinese magnoliavine fruits, 2-4 parts of mulberry leaves, 1-2 parts of cassia twigs, 1-2 parts of beautiful sweetgum fruits, 1-3 parts of semen platycladi and 4-6 parts of radix glycyrrhizae preparata. The invention further discloses a preparation method of the health-care sesame oil. The health-care sesame oil disclosed by the invention is mutually matched from various respects of reducing blood viscosity, promoting hemopoiesis, increasing fresh blood, softening blood vessels, strengthening elasticity of blood vessels, preventing the blood vessels from ageing, resisting ageing, reducing the damage of free radicals and improving organism conditions, so that the effect of improving the blood circulation is achieved.