Salvianolic acid A salt complex and preparation method and application thereof

A technology of salvianolic acid and compound, applied in the fields of medicine and pharmacy, can solve the problems of difficulty in ensuring long-term stability, easy to be oxidized, poor stability of salvianolic acid A, etc. Myocardial ischemia-reperfusion injury
CN110403928AInactive Publication Date: 2019-11-05CHIATAI QINGCHUNBAO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHIATAI QINGCHUNBAO PHARMA
Publication Date
2019-11-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a salvianolic acid A salt complex. The salvianolic acid A salt complex is prepared from diad salvianolic acid A and a positive ion, the salvianolic acid A salt complex has the chemical construction (being defined as in the specification); and the salvianolic acid A salt complex has the pharmacological activity of anti-myocardial ischemia treating, anti-myocardial ischemia reperfusion injury treating, and platelet aggregation inhibition, and can be applied to preparation of medicines with the related curative effect. The preparation method of the salvianolic acid A salt complex is simple, easy to produce, and more stable relative to the salvianolic acid A.
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Description

[0001] (1) Technical field

[0002] The invention belongs to the technical field of medicine and pharmacy, and in particular relates to a salvianolic acid A salt complex and a preparation method thereof, and its application in the preparation of drugs for treating myocardial ischemia, myocardial ischemia-reperfusion injury, and platelet aggregation .

[0003] (2) Background technology

[0004] Salvianolic acid A (Salvianic acid A) is a water-soluble phenolic acid compound that was first extracted and isolated from the dry roots and rhizomes of Salvia miltiorrhiza, a labiatae plant, by Professor Li Lianniang in 1984. It has a variety of pharmacological activities. , such as anti-inflammatory, anti-oxidative and neuroprotective effects (Li YJ, Duan CL, Liu JX.Salvianolic acid A promotes the acceleration of neovascularization in the ischemic rat myocardium and the functions of endothelial progenitor cells[J].J Ethnopharmacol,2014,151 :218-227.). With further research, scholars h...

Claims

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