Preventive agent or therapeutic agent for disease caused by abnormal bone metabolism

A technology for abnormal bone metabolism and preventive medicine, which can be used in bone diseases, anti-tumor drugs, drug combinations, etc., and can solve problems such as difficult to find better treatment methods or preventive methods.
CN101808640AInactive Publication Date: 2010-08-18TEIJIN PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TEIJIN PHARMA CO LTD
Publication Date
2010-08-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

It is intended to provide a preventive agent or a therapeutic agent for a disease caused by abnormal bone metabolism, particularly for osteoporosis, which is more effective than ever before. By combined application of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)-phenoxy]pentoxy}-benzamidine or a salt thereof and one or more compounds selected from the group consisting of etidronic acid, clodronic acid, pamidronic acid, tiludronic acid, risedronic acid, minodronic acid, ibandronic acid, zoledronic acid, and salts thereof, a higher bone resorption inhibitory action compared with the administration of a single compound is exhibited, and an excellent preventive effect and therapeutic effect for a disease caused by abnormal bone metabolism, particularly for osteoporosis can be obtained.
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Description

technical field

[0001] The present invention relates to a preventive or therapeutic drug for diseases caused by abnormal bone metabolism, in particular to a preventive or therapeutic drug for osteoporosis, in particular to a drug containing N-hydroxy-4-{5-[4-(5-iso Propyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentyloxy}-benzamidine or its salt and selected from etidronic acid, clodronic acid, pamidronic acid, alternative Diseases caused by abnormal bone metabolism, especially osteoporosis, in which one or more compounds of ludronic acid, risedronic acid, minodronic acid, ibandronic acid, zoledronic acid, and their salts are used as active ingredients prophylaxis or treatment of disease. Background technique

[0002] N-hydroxyl-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentyloxy}- Benzamidine or a salt thereof has a bone resorption inhibiting effect and a bone formation promoting effect, and is expected as a therapeutic or preventive drug for osteoporosis. [0003...

Claims

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