68 results about "Pachymaran" patented technology

The invention relates to the technical field of intelligent food production, in particular to a probiotic plant beverage production method and system.The method comprises the steps that mildewed and damaged areas of penthorum chinense pursh, gastrodia elata and other plant raw materials are recognized and removed, the content of reducing sugar is detected, and a traceability identifier is generated; the preparation method comprises the following steps: compounding lactobacillus plantarum A, lactobacillus plantarum B and lactobacillus paracasei, embedding by adopting a sporopollen-calcium alginate core-shell structure, and adjusting the thickness of a shell layer and the concentration of carboxymethyl pachymaran; correcting Arrhenius equation activation energy Ea through bacterial colony density data so as to calculate the attenuation rate k value in the shelf life; after the fermentation liquor is embedded for the second time, QR code labels are generated for products qualified in primary inspection, and RFID temperature and humidity sensing chips are integrated; and pushing real-time shelf lives of qualified finished products, probiotic flora activity reports and traceability identifiers to consumers. According to the invention, the problems of low efficiency, lag in fermentation regulation, backward traceability technology and isolated intelligent technology of the traditional process are solved.

The invention belongs to the technical field of cosmetics, and discloses skin-tightening and anti-wrinkle essence. The skin-tightening anti-wrinkle essence is prepared from the following raw materials in percentage by mass: 1.5 to 2.5 percent of acetyl hexapeptide-8, 2.0 to 3.0 percent of palmitoyl pentapeptide-4, 3.0 percent of hydroxypropyl tetrahydropyrantriol, 2.0 percent of lipidosome-coated vitamin C ethyl ether, 0.5 percent of resveratrol PLGA microspheres, 0.8 percent of ceramide NP, 1.2 percent of pachymaran, 5.0 percent of glyceryl polyether-26, 0.3 percent of sodium hyaluronate, 0.5 percent of p-hydroxyacetophenone and 1, 3-propanediol, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate and the balance of water. The 1, 2-hexanediol accounts for 0.6%, and the balance is deionized water. Multi-target anti-wrinkle, deep moisturizing and long-acting repairing are achieved by scientifically compounding active ingredients such as acetyl hexapeptide-8 and palmitoyl pentapeptide-4 and combining a lipidosome wrapping technology and a nano-microsphere slow release technology, the preparation process comprises the steps of lipidosome homogenization, nano-microsphere multiple emulsion method and low-temperature emulsification, the ingredient stability and transdermal efficiency are ensured, and the skin care effect is good. Experiments prove that the essence can significantly improve skin elasticity and reduce wrinkles, and has a significant anti-aging effect.

The invention discloses targeted prebiotic plant extraction dietary powder for relieving hyperuricemia and a preparation technology of the targeted prebiotic plant extraction dietary powder, and belongs to the technical field of dietary powder.In a formula of the targeted prebiotic plant extraction dietary powder for relieving hyperuricemia, as a patented bacterial strain, the bacillus coagulans MKSWC01 can directly act on the intestinal tract environment, uric acid precursor substances generated by purine metabolism are degraded in a targeted mode, and generation of uric acid is reduced from the source; the chicory root superfine powder and the mulberry leaf DNJ extract respectively activate kidney excretion protein, inhibit the activity of glycosidase, accelerate discharge of uric acid through urine and block the path of conversion from fructose metabolism to uric acid; the celery seed flavone and the smilax glabra polysaccharide further play an anti-inflammatory role, the deposition risk of urate crystals at joints is reduced, and potential inflammatory response caused by hyperuricemia is relieved. Meanwhile, the resistant dextrin and the xylooligosaccharide serve as prebiotics, nutrients are provided for probiotics to support planting of the probiotics, the overall metabolic environment can be improved by adjusting intestinal flora balance, the pathological link of hyperuricemia is comprehensively covered, and the relieving effect is improved.

The invention relates to a mixed traditional Chinese medicine feed additive for resisting bee mites and a preparation method thereof, and belongs to the technical field of healthy breeding of bees and pest control. The feed additive comprises a radix stemonae extract obtained by compound extraction of radix stemonae, radix sophorae flavescentis and areca catechu, and a syrup matrix composed of ammonium glycyrrhizinate, vitamin C, pachymaran, honey and apple vinegar, when necessary, synergetic components such as forsythiaside, menthol and carboxymethyl chitosan are further added, and microcapsule embedding treatment is performed to enhance the slow release performance. The formula is natural, safe and good in palatability, can effectively prevent and control invasion of Varroa destructor of bee colonies and improve the survival rate of the bee colonies, has a good slow-release effect and oral administration adaptability, and is suitable for long-term stable use in bee farms.

The invention discloses a beverage capable of improving sleep and a preparation method of the beverage, and belongs to the technical field of fermentation engineering technology and health-care food. Through a specific probiotic fermentation system, a natural raw material extracting solution, sodium glutamate and a humulus lupulus extract are jointly fermented, endogenous GABA is efficiently converted and generated, and the endogenous GABA and functional components such as pachymaran, lily polysaccharide and jujuboside form a polymorphic composite system. The GABA in the prepared beverage is high in bioavailability and good in stability, all the components have a synergistic effect through multiple ways such as intestinal brain axis regulation and neurotransmitter regulation, sleep is effectively improved, and meanwhile the beverage has good flavor and storage stability.

The invention provides a sodium hyaluronate gel compound for wound repair and a preparation process of the sodium hyaluronate gel compound, and belongs to the technical field of gel compound preparation. The preparation process comprises the following steps: preparing a pachymaran-antibacterial peptide compound; preparation of catechol graft modified gelatin; preparing oxidized sodium alginate; preparing a sodium alginate compound; and preparing the sodium hyaluronate gel compound. The preparation method comprises the following steps: grafting a catechol group on the side chain of gelatin, and carrying out a coordination effect between ferric ions and the catechol group and a Schiff base reaction between an amino group on the gelatin and an aldehyde group on oxidized sodium alginate to prepare the double dynamic bond cross-linked sodium alginate compound. The pachymaran-antibacterial peptide compound is introduced through total doping of the sodium alginate compound, and then the sodium alginate compound is compounded with sulfhydrylated sodium hyaluronate to prepare the sodium hyaluronate gel compound which has good biocompatibility and efficient antibacterial property and can remarkably promote wound healing.

The invention discloses a polyphenol microcapsule synergistically delivered by double-layer hydrogel embedded probiotics as well as a preparation method and application of the polyphenol microcapsule. The preparation method comprises the following steps: mixing suspension at least containing polyphenol substances with zinc salt and gallic acid for reaction to prepare zinc-gallic acid embedded polyphenol nanoparticles; mixing the zinc-gallic acid embedded polyphenol nanoparticles with probiotics to react, so as to prepare a first solid product; and mixing the first solid product with pachymaran, then adding a solution at least containing quaternized chitosan and sodium tungstate dihydrate, and then preparing the obtained mixed solution into the double-layer hydrogel embedded probiotic synergistic delivery polyphenol microcapsule by adopting an electrospray mode. According to the preparation method disclosed by the invention, the probiotics are embedded by adopting the double-layer hydrogel microcapsule with outer layer removal and inner layer colonization for the first time, so that the protection performance and functionality of the microcapsule are enhanced, efficient embedding and colonization of the probiotics are realized, the activity of the probiotics is effectively prevented from being damaged by high temperature and machinery, and industrial production is facilitated.

The invention relates to the technical field of skin care products, in particular to a sterile plant flower water stock solution and a preparation method and application thereof. The sterile plant flower water stock solution is prepared from the following raw materials in parts by mass: 5 to 30 parts of green rattan flower water, 5 to 30 parts of cancerous bulbophyllum flower water, 5 to 30 parts of strelitzia reginae flower water, 5 to 30 parts of maifangzi flower water, 0.05 to 1 part of pachymaran, 0.01 to 0.05 part of natto gum, 1 to 10 parts of snail mucus extract and 0.75 to 14 parts of elastin. Through a unique synergistic mechanism in the aspects of oxidation resistance, anti-inflammatory relieving and moisturizing and moistening when the green tuberous root flower water, the cancerous cancerous flower water, the strelitzia reginae flower water and the maifang flower water have a synergistic effect, skin inflammation is relieved synergistically from multiple brand-new angles, and red, swollen and pruritus symptoms caused by allergy and stimulation are relieved.

This invention provides a sodium hyaluronate gel complex for wound repair and its preparation process, belonging to the field of gel complex preparation technology. The preparation process includes the following steps: preparation of a Poria cocos polysaccharide-antimicrobial peptide complex; preparation of catechol-grafted modified gelatin; preparation of oxidized sodium alginate; preparation of a sodium alginate complex; and preparation of a sodium hyaluronate gel complex. This invention prepares a sodium alginate complex with double dynamic bond crosslinking by side-linking catechol groups to gelatin, through the coordination between ferric ions and catechol groups, and the Schiff base reaction between the amino groups on gelatin and the aldehyde groups on oxidized sodium alginate. Furthermore, the sodium alginate complex is doped with the Poria cocos polysaccharide-antimicrobial peptide complex. The resulting sodium hyaluronate gel complex, prepared by compounding with thiolated sodium hyaluronate, exhibits good biocompatibility, high antibacterial activity, and significantly promotes wound healing.

The present invention provides a silicone-modified pullulan, the silicone-modified pullulan being an addition reaction product of the following components (a) and (b): (a) pullulan having a water content of 1.0 mass% or less and a calcium content of less than 100 ppm; and (b) isocyanate group-containing silicone represented by formula (1), wherein the silicone-modified pullulan has a calcium content of less than 100 ppm and a content of the urea group-containing silicone represented by formula (2) of less than 2,000 ppm.

The invention belongs to the field of electrochemical energy storage, and particularly relates to a poly (N-hydroxypropyl acrylamide) / hydroxypropyl pachymaran / calcium chloride hydrogel-based polymer electrolyte and a flexible integrated supercapacitor. According to the invention, N-hydroxypropyl acrylamide is used as a polymeric monomer, hydroxypropyl pachymaran is used as a reinforcing modifier, calcium chloride is used as an electrolyte, borax is used as a cross-linking agent, and a'redox-initiated polymerization-ultraviolet ozone surface modification-synchronous stretching coating assembly 'process is adopted to prepare the composite material. According to the invention, a synergistic effect is formed by copolymerization crosslinking and ultraviolet ozone surface modification, the mechanical property of a GPE body is guaranteed by copolymerization crosslinking, the interface adhesion force is synchronously improved by surface modification, the two parts are adapted in the whole process from network construction to interface optimization, and the mechanical strength and the adhesion property are synchronously improved in mechanism.

The invention belongs to the field of medicines, and particularly relates to a quality detection method of a clearing and deacidification mixture. According to the invention, a characteristic spectrum method for simultaneously detecting 10 main active components (paeoniflorin, puerarin, gentiopicroside, loganic acid, astilbin, benzoylpaeoniflorin, resveratrol, rhein, rhizoma dioscoreae septemlobae A and rhizoma dioscoreae septemlobae B) in the mixture is established for the first time, the limitation of single component quality control is overcome, and the overall quality of a medicine can be evaluated more comprehensively and objectively; by optimizing a sample pretreatment process and chromatographic gradient elution conditions, interference of a complex matrix is effectively eliminated, and good separation of each component is ensured. The method is high in specificity, negative, free of interference and capable of accurately recognizing target components.

The invention belongs to the technical field of animal feeds, and relates to a livestock feed with an immunoregulation function and a preparation method thereof. The feed comprises whey powder, fermented soybean meal, konjaku flour, beet pulp, tabletted corn, baked wheat, whey protein, palm oil, synbiotics powder, composite vitamins, composite minerals, calcium propionate, potassium sorbate and sodium selenite, and the synbiotics powder comprises freeze-dried probiotic powder and prebiotics powder. Probiotics in the probiotic freeze-dried powder are fermented saccharomyces cerevisiae and fermented bacillus subtilis, and the prebiotics powder comprises pachymaran, astragalus polysaccharide, inulin and fructo-oligosaccharide. The fermented saccharomyces cerevisiae and the fermented bacillus subtilis are embedded by adopting modified sodium alginate, the modified sodium alginate is modified by adopting glycine, and nano-montmorillonite and a soluble pore-foaming agent are added for optimization. The prepared feed has the function of regulating immunity.

The invention belongs to the technical field of food processing, and provides horse milk powder for improving intestinal health and a preparation technology thereof. The horse milk powder capable of improving intestinal health is prepared from the following components in parts by weight: 60 to 70 parts of whole horse milk powder, 3.0 to 4.0 parts of galactooligosaccharide, 4.0 to 5.0 parts of lactulose, 3.5 to 4.5 parts of beta-glucan, 1.5 to 2.5 parts of inulin, 5.0 to 6.0 parts of complex probiotics, 2.5 to 3.5 parts of pachymaran, 6.5 to 7.5 parts of astragalus polysaccharide and 5.0 to 6.0 parts of calcium carbonate. According to the horse milk powder capable of improving intestinal health disclosed by the invention, medicinal and edible components are added, and probiotics and various prebiotics are compounded, so that the activities of DAO, D-LAC and MPO in intestinal tissues can be remarkably reduced, the contents of acetic acid, propionic acid and butyric acid are increased, and the barrier function of the intestinal tract is improved.

The application discloses application of low-molecular pachyman in preparation of a medicine for simultaneously relieving hyperuricemia and liver and kidney injury, and belongs to the technical field of biological medicine. The application finds through experiments that the low-molecular pachyman has good uric acid lowering effect, and the cytotoxicity result shows that the low-molecular pachyman (0-2000 mu g / mL) has no significant toxicity to liver and kidney cells; meanwhile, the application also finds that the low-molecular pachyman can relieve liver and kidney injury caused by allopurinol and benzbromarone when lowering uric acid. Therefore, the low-molecular pachyman in the application has a good application prospect in relieving hyperuricemia caused by oxypurinol and antagonizing liver and kidney injury caused by drugs.

The invention discloses a composition for female ovary maintenance and a preparation method thereof, and relates to the field of health-care compositions.The preparation method comprises the following steps that pectin and a sweetening agent are evenly mixed and dissolved with water, and a material A is obtained; uniformly mixing the traditional Chinese medicine formula, the material A, the active ingredients, the resistant dextrin, the vitamins, the flavoring agent and the edible essence in sequence; the preparation method comprises the following steps: fixing the volume with purified water, stirring, filtering, filling, sterilizing and packaging to obtain the composition for maintaining the female ovary. Through immobilization of fructo-oligosaccharide and beta-glucosidase and lac enteric targeting, the utilization rate of functional components is increased; pachymaran-raphanin-resveratrol covers immunity, antioxidation and metabolic regulation pathways, and directly strikes the premature ovarian failure core mechanism; in general, through full-chain optimization of delivery-conversion-absorption-metabolism, the efficacy is remarkably improved on the premise of safety.

The invention discloses an eye pad formula for improving eyesight and soothing eyes and a preparation method thereof, and belongs to the field of eyesight maintenance and health care. The formula of the eye patch is prepared from poria cocos, cochinchinensis, pipewort, selfheal, semen cassiae, morning glory, mint, kapur and fleece-flower root through the combination of raw material differentiation pretreatment, staged extraction, aqueous solution mixing and purification, pure cotton cloth infiltration forming, ancient maintenance and modern sterilization. The problems of stickiness and allergy of the traditional paste eye patch are solved, the skin feeling is fresh and cool, and the eye patch is suitable for various skin types and is particularly suitable for summer or oily skin; through differentiated treatment of raw materials by'fresh / sun-drying / drying in the shade 'and staged extraction by'distillation and soaking', plant volatile components (such as cool and refreshing feeling of mint) are reserved, water-soluble nourishing components (such as pachymaran) are fully dissolved out, and the utilization rate of effective components is greatly improved compared with that of a traditional crushing process.

The invention relates to the technical field of bio-based films, in particular to a compostable and degradable bio-based film and a preparation method thereof. The bio-based film prepared by the invention comprises the following components: polyurethane, wherein the polyurethane is obtained by reacting a polyol polymer, a chain extender and an isocyanate compound; the polysaccharide polymer is obtained through a polysaccharide molecule cross-linking reaction; the plant polysaccharide is selected from astragalus polysaccharide, Chinese yam polysaccharide, bletilla striata polysaccharide, pachymaran, soybean polysaccharide, glycyrrhiza polysaccharide, polygonatum polysaccharide, fucoidin or dandelion polysaccharide.

The invention provides a pachymaran composition capable of improving intestinal flora and functions thereof, and relates to the technical field of compositions. The pachymaran composition is obtained by combining pachymaran with puerarin, baicalein and cordyceps polysaccharide, so that intestinal flora and functions of the intestinal flora are remarkably improved. The composition disclosed by the invention gives full play to synergistic interaction, and compared with single pachymaran, the composition disclosed by the invention can further improve the intestinal flora and the function of the intestinal flora.

The application discloses a kind of medicine food homologous sputum-removing and spleen-strengthening compositions and preparation method and application thereof, the composition includes: naringin 120-200 parts, hesperidin 80-100 parts, tuckahoe polysaccharide 150-250 parts, coix seed polysaccharide 80-120 parts, gingerol 10-20 parts, perillaldehyde 5-18 parts, glycyrrhizic acid 10-25 parts and glycyrrhizin flavone 8-24 parts by weight parts.The composition of the application can be prepared into medicine food homologous product, and it is not against disease, but against symptom, and has significant, stable and safe improvement effect on phlegm, throat discomfort, abdominal distension, thick and greasy tongue fur and other phlegm-related symptoms, without obvious toxic and side effects, and meets daily consumption requirements.

The invention discloses degradable environment-friendly corrugated paper glue and belongs to the technical field of glue. The glue is prepared from the following raw materials in parts by mass: 30 to 51.4 parts of starch, 3 to 7 parts of sodium hydroxide, 0.3 to 0.8 part of borax, 0.5 to 3 parts of a stabilizer, 0.5 to 2 parts of carboxymethyl pachymaran, 0.5 to 1 part of tetrasodium iminodisuccinate and 100 to 200 parts of water. Effective preparation of the degradable, environment-friendly and high-adhesion glue for corrugated board production is realized, and ecological transformation of the packaging industry is promoted.

The invention belongs to the technical field of pachymaran extraction, and particularly relates to a pachymaran extraction method and equipment based on steam explosion pretreatment. The equipment comprises a main body, a base, a feeding bin, a smashing bin, a steam explosion bin and a driving assembly. Mutually meshed crushing rollers are arranged in the feeding bin, crushing blades mounted on a driving rod are arranged in the crushing bin, and stirring blades, a supporting assembly, a steam inlet and a steam outlet are arranged in the steam explosion bin; the extraction method comprises the following steps: putting poria cocos into the feeding bin, and crushing the poria cocos into fragments through the crushing roller; the fragments enter a smashing bin and are ground into particles by smashing blades, and the particles fall into a steam explosion bin through a filter plate; introducing high-pressure steam into the bin, rotating the stirring blades to uniformly heat the particles, maintaining the pressure for a period of time, and quickly releasing the pressure to finish explosion; after blasting, discharging the material for subsequent extraction; through the synergistic effect of multi-stage crushing and steam explosion and the design of the stirring blades and the elastic filter plates, uniform treatment of materials is achieved, the polysaccharide yield is increased, and the device is suitable for efficient extraction of pachymaran.

The invention provides a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of hypoglycemic products, and relates to the technical field of traditional Chinese medicines. The invention discloses a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: 4-8 parts of ginseng stem and leaf saponin, 8-16 parts of astragalus polysaccharide, 6-12 parts of astragaloside, 8-16 parts of catalpol, 6-12 parts of rehmannia D, 8-16 parts of verbascoside, 3-5 parts of raspberry polysaccharide, 4-8 parts of ellagic acid, 4-8 parts of pachymaran, 5-10 parts of pachymic acid, 8-16 parts of lycium barbarum polysaccharide, 40-62 parts of schisandra chinensis, 20-40 parts of Chinese yam, 40-62 parts of radix ophiopogonis, 40-62 parts of radix trichosanthis and 40-62 parts of rhizoma alismatis. The traditional Chinese medicine raw materials are pretreated by using the high-voltage pulsed electric field, and then ethanol extraction treatment is performed twice, so that the yield of the traditional Chinese medicine extract is high, and the traditional Chinese medicine composition obtained by mixing the traditional Chinese medicine extract with other active ingredients has an excellent effect of treating type II diabetes mellitus.

The invention discloses poria cocos homogeneous polysaccharide as well as a preparation method and application thereof. The poria cocos homogeneous polysaccharide is separated and purified from poria cocos by combining an anion exchange column chromatography technology and a molecular sieve technology, and in-vitro cell research shows that the poria cocos homogeneous polysaccharide has a relatively strong immune activation effect on macrophages, can enhance the phagocytic effect of the macrophages, and can be used for preparing the immunopotentiator. And a basis is provided for research and development of pachymaran health functional products.

The invention discloses a pharmaceutical composition for improving myocardial injury by regulating autoimmunity and application, and relates to the technical field of biological medicines. The pharmaceutical composition for improving myocardial injury by adjusting autoimmunity comprises paeonol and pachymaran, the mass ratio of the paeonol to the pachymaran is (1-2): (1-2), and the invention further provides application of the pharmaceutical composition for improving myocardial injury by adjusting autoimmunity in preparation of drugs for treating myocardial injury. The traditional Chinese medicine composition can improve myocardial fibrosis, regulate CD4 + T cell immune balance and promote angiogenesis, and effectively solves the problems of poor myocardial repair effect after reperfusion injury after myocardial infarction and immune imbalance in a chronic inflammation stage after myocardial infarction.

The invention discloses a nourishing composition for improving spleen and stomach functions and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The nourishing composition for improving the spleen and stomach functions is prepared from an anti-cracking protective agent, endothelium corneum gigeriae galli, rhizoma atractylodis macrocephalae, rhizoma dioscoreae, cooked jujube pulp, coconut powder, honey and a rosemary extract. The anti-cracking protective agent consists of pachymaran, a sodium alginate solution, citric acid and papain; the pachymaran and the sodium alginate wrap the papain under the crosslinking of the citric acid to form a compact interpenetrating network structure, so that the pachymaran and the sodium alginate have high viscosity, enhance the adhesive force, reduce the evaporation of moisture in a dry environment, reduce the entry of moisture in a humid environment and maintain the stability of the moisture, and when the pachymaran and the sodium alginate are mixed with the refined honey for use, the papain is not easily damaged. The problem that honey boluses crack due to too old or too tender honey refining is effectively solved, the slow release property is achieved, stimulation of nourishing functional components to gastrointestinal tracts can be reduced, and the effect of regulating the spleen and the stomach is gently and efficiently achieved for a long time.

The invention discloses an IRF8 polyclonal antibody as well as a preparation method and application thereof, and belongs to the technical field of biology. A prokaryotic expression vector of IRF8 is successfully constructed through methods of RT-PCR, cloning, double enzyme digestion and the like, high-concentration and high-purity target protein is obtained by adopting a nickel column affinity purification technology after induced expression, a New Zealand white rabbit is used as a polyclonal antibody preparation object, recombinant protein and a Freund's adjuvant are mixed, pachymaran is added for co-emulsification treatment, and the recombinant protein is obtained. The immune effect is improved; the determination result shows that when the antigen coating concentration is 1.25 mu g / mL, the titer reaches 1: 2048000, and the titer of the polyclonal antibody added with the pachymaran group is obviously higher than that of a normal control group. The IRF8 polyclonal antibody has excellent specificity and sensitivity to poultry animals, provides a reliable tool for expression detection, positioning analysis and function exploration of IRF8 protein in poultry related disease research, and has important application value.

The invention relates to the technical field of functional food, in particular to application of a pachymaran derivative in functional food for improving intestinal flora and calming heart and tranquilizing mind. The invention relates to application of a pachymaran derivative in functional food for improving intestinal flora and calming heart and tranquilizing mind. The pachymaran derivative is prepared by adopting the following method: S1, sterilizing a carboxymethyl pachymaran solution prepared from pure water at high temperature and high pressure; s2, adjusting the pH value of the obtained solution to 4.5, and adding a biological enzyme into the solution to carry out an enzymatic reaction; s3, carrying out enzyme deactivation, concentration and freeze drying on the sample solution obtained in S2 to obtain the pachymaran derivative. The pachymaran derivative provided by the invention has a remarkable sleep improving effect, and the mechanism of the pachymaran derivative is possibly related to the regulation of the neurotransmitter level in the brain and the improvement of intestinal flora.

The invention belongs to the technical field of fermentation, and particularly relates to a method for inducing generation of water-soluble pachymaran. According to the method, Wolfiporia cocos and Trichoderma longibrachiatum are subjected to staged co-culture, and low-temperature stress at the temperature of 15 DEG C is applied to the key stage of co-culture. The specific strain combination and low-temperature induction have a synergistic effect, so that a water-soluble polysaccharide synthesis and secretion pathway of the poria cocos bacteria is remarkably activated, and the technical bottlenecks of low water-soluble polysaccharide proportion and low yield in the existing fermentation process are solved. The yield of the prepared water-soluble pachymaran can reach 2.35 g / L, the immunoregulatory activity of the water-soluble pachymaran is excellent, macrophages can be effectively promoted to secrete key cell factors such as IL-6 and IL-1beta, and a new technical scheme is provided for developing efficient and high-value pachymaran products.

The present invention provides a nutritional formula food suitable for patients with cognitive impairment with sarcopenia and a preparation method thereof, and relates to the technical field of formula foods, the nutritional formula food comprises the following components: maltodextrin, vegetable oil, whey protein, soybean protein, dietary fibers, fish oil, minerals, carboxymethyl pachymaran, calcium beta-hydroxy-beta-methylbutyrate and ginsenoside, and vitamins. The technical problem that in the prior art, a nutritional formula food for patients with cognitive impairment with sarcopenia is lacked is solved, through the synergistic interaction among ginsenoside, calcium beta-hydroxy-beta-methylbutyrate and carboxymethyl pachymaran, the anti-inflammatory effect is greatly improved, and the effects of providing treatment for the patients with cognitive impairment and providing health care for the patients with cognitive impairment with sarcopenia are achieved. Nutrition can also be provided to support the growth of neuronal cells, neuroinflammation is reduced, the recovery of cognitive functions is promoted, and the attenuation of muscles is slowed down.