42 results about "Pachymaran" patented technology

The invention discloses a beverage capable of improving sleep and a preparation method of the beverage, and belongs to the technical field of fermentation engineering technology and health-care food. Through a specific probiotic fermentation system, a natural raw material extracting solution, sodium glutamate and a humulus lupulus extract are jointly fermented, endogenous GABA is efficiently converted and generated, and the endogenous GABA and functional components such as pachymaran, lily polysaccharide and jujuboside form a polymorphic composite system. The GABA in the prepared beverage is high in bioavailability and good in stability, all the components have a synergistic effect through multiple ways such as intestinal brain axis regulation and neurotransmitter regulation, sleep is effectively improved, and meanwhile the beverage has good flavor and storage stability.

The present invention provides a silicone-modified pullulan, the silicone-modified pullulan being an addition reaction product of the following components (a) and (b): (a) pullulan having a water content of 1.0 mass% or less and a calcium content of less than 100 ppm; and (b) isocyanate group-containing silicone represented by formula (1), wherein the silicone-modified pullulan has a calcium content of less than 100 ppm and a content of the urea group-containing silicone represented by formula (2) of less than 2,000 ppm.

The invention belongs to the field of electrochemical energy storage, and particularly relates to a poly (N-hydroxypropyl acrylamide) / hydroxypropyl pachymaran / calcium chloride hydrogel-based polymer electrolyte and a flexible integrated supercapacitor. According to the invention, N-hydroxypropyl acrylamide is used as a polymeric monomer, hydroxypropyl pachymaran is used as a reinforcing modifier, calcium chloride is used as an electrolyte, borax is used as a cross-linking agent, and a'redox-initiated polymerization-ultraviolet ozone surface modification-synchronous stretching coating assembly 'process is adopted to prepare the composite material. According to the invention, a synergistic effect is formed by copolymerization crosslinking and ultraviolet ozone surface modification, the mechanical property of a GPE body is guaranteed by copolymerization crosslinking, the interface adhesion force is synchronously improved by surface modification, the two parts are adapted in the whole process from network construction to interface optimization, and the mechanical strength and the adhesion property are synchronously improved in mechanism.

The invention belongs to the field of medicines, and particularly relates to a quality detection method of a clearing and deacidification mixture. According to the invention, a characteristic spectrum method for simultaneously detecting 10 main active components (paeoniflorin, puerarin, gentiopicroside, loganic acid, astilbin, benzoylpaeoniflorin, resveratrol, rhein, rhizoma dioscoreae septemlobae A and rhizoma dioscoreae septemlobae B) in the mixture is established for the first time, the limitation of single component quality control is overcome, and the overall quality of a medicine can be evaluated more comprehensively and objectively; by optimizing a sample pretreatment process and chromatographic gradient elution conditions, interference of a complex matrix is effectively eliminated, and good separation of each component is ensured. The method is high in specificity, negative, free of interference and capable of accurately recognizing target components.

The invention belongs to the technical field of animal feeds, and relates to a livestock feed with an immunoregulation function and a preparation method thereof. The feed comprises whey powder, fermented soybean meal, konjaku flour, beet pulp, tabletted corn, baked wheat, whey protein, palm oil, synbiotics powder, composite vitamins, composite minerals, calcium propionate, potassium sorbate and sodium selenite, and the synbiotics powder comprises freeze-dried probiotic powder and prebiotics powder. Probiotics in the probiotic freeze-dried powder are fermented saccharomyces cerevisiae and fermented bacillus subtilis, and the prebiotics powder comprises pachymaran, astragalus polysaccharide, inulin and fructo-oligosaccharide. The fermented saccharomyces cerevisiae and the fermented bacillus subtilis are embedded by adopting modified sodium alginate, the modified sodium alginate is modified by adopting glycine, and nano-montmorillonite and a soluble pore-foaming agent are added for optimization. The prepared feed has the function of regulating immunity.

The application discloses application of low-molecular pachyman in preparation of a medicine for simultaneously relieving hyperuricemia and liver and kidney injury, and belongs to the technical field of biological medicine. The application finds through experiments that the low-molecular pachyman has good uric acid lowering effect, and the cytotoxicity result shows that the low-molecular pachyman (0-2000 mu g / mL) has no significant toxicity to liver and kidney cells; meanwhile, the application also finds that the low-molecular pachyman can relieve liver and kidney injury caused by allopurinol and benzbromarone when lowering uric acid. Therefore, the low-molecular pachyman in the application has a good application prospect in relieving hyperuricemia caused by oxypurinol and antagonizing liver and kidney injury caused by drugs.

The invention discloses an eye pad formula for improving eyesight and soothing eyes and a preparation method thereof, and belongs to the field of eyesight maintenance and health care. The formula of the eye patch is prepared from poria cocos, cochinchinensis, pipewort, selfheal, semen cassiae, morning glory, mint, kapur and fleece-flower root through the combination of raw material differentiation pretreatment, staged extraction, aqueous solution mixing and purification, pure cotton cloth infiltration forming, ancient maintenance and modern sterilization. The problems of stickiness and allergy of the traditional paste eye patch are solved, the skin feeling is fresh and cool, and the eye patch is suitable for various skin types and is particularly suitable for summer or oily skin; through differentiated treatment of raw materials by'fresh / sun-drying / drying in the shade 'and staged extraction by'distillation and soaking', plant volatile components (such as cool and refreshing feeling of mint) are reserved, water-soluble nourishing components (such as pachymaran) are fully dissolved out, and the utilization rate of effective components is greatly improved compared with that of a traditional crushing process.

The application discloses a kind of medicine food homologous sputum-removing and spleen-strengthening compositions and preparation method and application thereof, the composition includes: naringin 120-200 parts, hesperidin 80-100 parts, tuckahoe polysaccharide 150-250 parts, coix seed polysaccharide 80-120 parts, gingerol 10-20 parts, perillaldehyde 5-18 parts, glycyrrhizic acid 10-25 parts and glycyrrhizin flavone 8-24 parts by weight parts.The composition of the application can be prepared into medicine food homologous product, and it is not against disease, but against symptom, and has significant, stable and safe improvement effect on phlegm, throat discomfort, abdominal distension, thick and greasy tongue fur and other phlegm-related symptoms, without obvious toxic and side effects, and meets daily consumption requirements.

The invention provides a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of hypoglycemic products, and relates to the technical field of traditional Chinese medicines. The invention discloses a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: 4-8 parts of ginseng stem and leaf saponin, 8-16 parts of astragalus polysaccharide, 6-12 parts of astragaloside, 8-16 parts of catalpol, 6-12 parts of rehmannia D, 8-16 parts of verbascoside, 3-5 parts of raspberry polysaccharide, 4-8 parts of ellagic acid, 4-8 parts of pachymaran, 5-10 parts of pachymic acid, 8-16 parts of lycium barbarum polysaccharide, 40-62 parts of schisandra chinensis, 20-40 parts of Chinese yam, 40-62 parts of radix ophiopogonis, 40-62 parts of radix trichosanthis and 40-62 parts of rhizoma alismatis. The traditional Chinese medicine raw materials are pretreated by using the high-voltage pulsed electric field, and then ethanol extraction treatment is performed twice, so that the yield of the traditional Chinese medicine extract is high, and the traditional Chinese medicine composition obtained by mixing the traditional Chinese medicine extract with other active ingredients has an excellent effect of treating type II diabetes mellitus.

The invention discloses poria cocos homogeneous polysaccharide as well as a preparation method and application thereof. The poria cocos homogeneous polysaccharide is separated and purified from poria cocos by combining an anion exchange column chromatography technology and a molecular sieve technology, and in-vitro cell research shows that the poria cocos homogeneous polysaccharide has a relatively strong immune activation effect on macrophages, can enhance the phagocytic effect of the macrophages, and can be used for preparing the immunopotentiator. And a basis is provided for research and development of pachymaran health functional products.

The invention discloses a pharmaceutical composition for improving myocardial injury by regulating autoimmunity and application, and relates to the technical field of biological medicines. The pharmaceutical composition for improving myocardial injury by adjusting autoimmunity comprises paeonol and pachymaran, the mass ratio of the paeonol to the pachymaran is (1-2): (1-2), and the invention further provides application of the pharmaceutical composition for improving myocardial injury by adjusting autoimmunity in preparation of drugs for treating myocardial injury. The traditional Chinese medicine composition can improve myocardial fibrosis, regulate CD4 + T cell immune balance and promote angiogenesis, and effectively solves the problems of poor myocardial repair effect after reperfusion injury after myocardial infarction and immune imbalance in a chronic inflammation stage after myocardial infarction.

The invention discloses a nourishing composition for improving spleen and stomach functions and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The nourishing composition for improving the spleen and stomach functions is prepared from an anti-cracking protective agent, endothelium corneum gigeriae galli, rhizoma atractylodis macrocephalae, rhizoma dioscoreae, cooked jujube pulp, coconut powder, honey and a rosemary extract. The anti-cracking protective agent consists of pachymaran, a sodium alginate solution, citric acid and papain; the pachymaran and the sodium alginate wrap the papain under the crosslinking of the citric acid to form a compact interpenetrating network structure, so that the pachymaran and the sodium alginate have high viscosity, enhance the adhesive force, reduce the evaporation of moisture in a dry environment, reduce the entry of moisture in a humid environment and maintain the stability of the moisture, and when the pachymaran and the sodium alginate are mixed with the refined honey for use, the papain is not easily damaged. The problem that honey boluses crack due to too old or too tender honey refining is effectively solved, the slow release property is achieved, stimulation of nourishing functional components to gastrointestinal tracts can be reduced, and the effect of regulating the spleen and the stomach is gently and efficiently achieved for a long time.

The invention discloses an IRF8 polyclonal antibody as well as a preparation method and application thereof, and belongs to the technical field of biology. A prokaryotic expression vector of IRF8 is successfully constructed through methods of RT-PCR, cloning, double enzyme digestion and the like, high-concentration and high-purity target protein is obtained by adopting a nickel column affinity purification technology after induced expression, a New Zealand white rabbit is used as a polyclonal antibody preparation object, recombinant protein and a Freund's adjuvant are mixed, pachymaran is added for co-emulsification treatment, and the recombinant protein is obtained. The immune effect is improved; the determination result shows that when the antigen coating concentration is 1.25 mu g / mL, the titer reaches 1: 2048000, and the titer of the polyclonal antibody added with the pachymaran group is obviously higher than that of a normal control group. The IRF8 polyclonal antibody has excellent specificity and sensitivity to poultry animals, provides a reliable tool for expression detection, positioning analysis and function exploration of IRF8 protein in poultry related disease research, and has important application value.

The invention relates to the technical field of functional food, in particular to application of a pachymaran derivative in functional food for improving intestinal flora and calming heart and tranquilizing mind. The invention relates to application of a pachymaran derivative in functional food for improving intestinal flora and calming heart and tranquilizing mind. The pachymaran derivative is prepared by adopting the following method: S1, sterilizing a carboxymethyl pachymaran solution prepared from pure water at high temperature and high pressure; s2, adjusting the pH value of the obtained solution to 4.5, and adding a biological enzyme into the solution to carry out an enzymatic reaction; s3, carrying out enzyme deactivation, concentration and freeze drying on the sample solution obtained in S2 to obtain the pachymaran derivative. The pachymaran derivative provided by the invention has a remarkable sleep improving effect, and the mechanism of the pachymaran derivative is possibly related to the regulation of the neurotransmitter level in the brain and the improvement of intestinal flora.

The invention belongs to the technical field of fermentation, and particularly relates to a method for inducing generation of water-soluble pachymaran. According to the method, Wolfiporia cocos and Trichoderma longibrachiatum are subjected to staged co-culture, and low-temperature stress at the temperature of 15 DEG C is applied to the key stage of co-culture. The specific strain combination and low-temperature induction have a synergistic effect, so that a water-soluble polysaccharide synthesis and secretion pathway of the poria cocos bacteria is remarkably activated, and the technical bottlenecks of low water-soluble polysaccharide proportion and low yield in the existing fermentation process are solved. The yield of the prepared water-soluble pachymaran can reach 2.35 g / L, the immunoregulatory activity of the water-soluble pachymaran is excellent, macrophages can be effectively promoted to secrete key cell factors such as IL-6 and IL-1beta, and a new technical scheme is provided for developing efficient and high-value pachymaran products.

The invention is suitable for the technical field of functional food preparation, and provides a preparation method of a fungus polysaccharide adjuvant drug composite component and a fungus component compound. The preparation method comprises the following steps: sequentially carrying out physical adsorption and functional integration extraction on four adjuvant raw materials such as shiitake mushrooms and pleurotus nebrodensis by adopting granular and dissolved pachymaran, applying an ultrasonic field in a low-temperature vacuum concentration process for dynamic co-coagulation, and finally forming to obtain the adjuvant composite gel particles with the particle size of 100-500 microns. Further, the adjuvant and conductant drug composite component is used as a wrapping layer, and solid-phase cores of the monarch and ministerial drugs are wrapped by a fluidized bed coating technology to form a fungus component compound with a core-shell space structure; through multiple physical structure design, controllable materialization of a traditional Chinese medicine monarch, minister, assistant and guide compatibility theory is realized, and the prepared product has the advantages of synergistic interaction of components, programmed release and remarkable improvement of immunomodulatory activity.

The invention provides a CS / SA / PPC hydrogel loaded with a lactic acid bacteria source quorum sensing quenching enzyme as well as a preparation method and application of the CS / SA / PPC hydrogel. The preparation method comprises the following steps: adding sodium alginate and pachymaran into a chitosan acetic acid aqueous solution to prepare a chitosan / sodium alginate / pachymaran solution; then adding glycerol to prepare a mixed solution; adding a lactic acid bacteria source quorum sensing quenching enzyme into the mixed solution to prepare a hydrogel solution, and finally drying and forming to obtain the hydrogel. The CS / SA / PPC hydrogel loaded with the lactic acid bacteria source quorum sensing quenching enzyme has excellent mechanical properties, can remarkably reduce the TVB-N value, the TBA value and the total number of bacterial colonies in the salmon storage process, delays muscle tissue degradation, prolongs the shelf life of salmon to 12 days or above, and ensures the eating quality and safety of salmon meat.

The invention relates to soft sweets with functions of dispelling effects of alcohol, protecting liver and regulating intestinal tracts and a preparation method of the soft sweets. According to the soft sweets, mung bean hull powder, a radix puerariae extract, hovenia dulcis thumb flavone and pachymaran serve as core active ingredients, a colloid compounding system (carrageenan / gelatin compounding) is combined, and precise regulation and control of hardness and elasticity are achieved by precisely changing colloid composition. According to the invention, a staged gradient temperature control technology is combined with low-temperature homogenization and integration of dietary fibers, gradient curing and pasteurization processes, so that a preparation technology of the functional soft sweets with nutrition enhancement and taste innovation is formed. According to the efficient soft sweets with the functions of dispelling the effects of alcohol, protecting the liver and regulating the intestinal tract, the functions of dispelling the effects of alcohol and protecting the liver are achieved by delaying ethanol absorption, activating ethanol dehydrogenase to accelerate alcohol metabolism and inhibiting generation of liver toxic metabolites, and the alcohol dispelling efficiency and sensory acceptability are both superior to those of commercially available products.

The application discloses a kind of loaded manganese doped ceria nanoscale enzyme's Pachyman hydrogel and its preparation method and application, it is related to biomedical technical field.The preparation method is first prepared by high-temperature thermal decomposition method fat-soluble manganese doped ceria nanoscale enzyme, then it is surface-modified using distearoyl phosphatidyl ethanolamine to obtain water-soluble nanoscale enzyme;Polyvinyl alcohol solution is mixed uniformly with Pachyman powder, water-soluble nanoscale enzyme, borax solution is added to crosslink and form hydrogel, after freeze-room temperature processing alternately, it is obtained.The energy storage modulus of the prepared hydrogel is 120-350 Pa at pH 6.5-7.2, 37 ℃, and the adhesion is greater than or equal to 8.5 kPa.The hydrogel prepared by the application has good biocompatibility, can efficiently remove active oxygen, relieve intestinal oxidative stress, and has suitable adhesion and degradation characteristics, can be administered by enema, and be used for preparing drugs for treating irritable bowel syndrome.

The invention relates to the technical field of health-care food, and discloses a male reproductive health complex formula health-care product containing egg membrane peptide. Comprising the following raw materials in parts by weight: 10-50 parts of egg membrane peptide, 5-20 parts of a zinc compound, 5-15 parts of vitamin E, 1-10 parts of lycopene, 5-25 parts of pachymaran, 3-12 parts of coenzyme Q10, 5-20 parts of a saw palmetto extract, 5-15 parts of L-carnitine, 10-30 parts of vitamin C, 3-10 parts of a ginkgo biloba extract, 5-20 parts of a maca extract, 5-25 parts of lycium barbarum polysaccharide and 1-8 parts of astaxanthin. The egg membrane peptide is a polypeptide composition prepared from an egg shell membrane through an enzymolysis or fermentation method. The zinc compound is one or more of zinc citrate, zinc glycinate and zinc gluconate. The complex formula has a synergistic effect from multiple dimensions of oxidation resistance, inflammation resistance, energy supply and endocrine regulation, and the concentration, activity, normal morphological rate and DNA integrity of sperms are improved.

The present application relates to a kind of stem cell nanovesicle-polysaccharide composite functional microspheres and its preparation method and application, the present application will stem cell nanovesicle and tremella polysaccharide / tremella polysaccharide conforming polysaccharide, calcium alginate form multilayer functional microsphere sustained-release system.In freeze-drying process, tremella polysaccharide and tremella polysaccharide protect stem cell nanovesicle and form primary functional complex;When reconstituted, stem cell nanovesicle primary functional complex and and sodium alginate, calcium ion, tremella polysaccharide and tremella polysaccharide construct stronger microsphere sustained-release system stem cell nanovesicle @ TFP / PCP-Ca-AGMs, solve the problem that short time of high biological activity nanovesicle in uterine retention, and have excellent anti-inflammatory, anti-fibrosis function.The stem cell nanovesicle-polysaccharide composite functional microspheres of the present application can be produced in clinical scale, and multilayer structure stable sustained-release system is good, can be used for repairing endometrial damage, treatment / prevention of intrauterine adhesion, recovery of fertility, tissue damage and regenerative disorders etc.

The invention is suitable for the technical field of health-care food, and provides an edible mushroom composition with an intestinal flora regulating function and a preparation method of the edible mushroom composition. The edible mushroom composition comprises grifola frondosa polysaccharide, cordyceps militaris polysaccharide, ganoderma sinensis extract, hericium erinaceus polysaccharide, agaricus blazei polysaccharide, lentinan, pleurotus nebrodensis polysaccharide, auricularia polytricha polysaccharide, agaricus bisporus polysaccharide and pachymaran, and the ratio of the materials is optimized based on the theory of monarch, minister, assistant and guide. The preparation method comprises the following steps: carrying out all-component stepped extraction on ganoderma sinensis, carrying out function-oriented graded extraction on other mushrooms, and carrying out a key gradient self-assembly process. According to the method, composite particles with time sequence release characteristics are constructed through a gradient self-assembly process, functional division of rapid release of adjuvant drugs in the upper digestive tract and slow release of monarch drugs in the intestinal tract is achieved, time sequence control of active ingredients is achieved, and the effects of regulating immunity, improving intestinal flora and improving yang deficiency symptoms are achieved.

The invention discloses a synchronous extraction device for pachymaran and triterpene, and relates to the field of extraction equipment. According to the pachymaran and triterpene synchronous extraction device, the forward and reverse rotation adjusting assembly, the outer rotary stirring assembly and the inner rotary stirring assembly are arranged in the shell, and when the rotary driving part rotates forwards to drive the forward and reverse rotation adjusting assembly to operate, the forward and reverse rotation adjusting assembly drives the outer rotary stirring assembly to rotate reversely and drives the inner rotary stirring assembly to rotate forwards at the same time; at the moment, the rotation directions of the inner and outer rotary stirring assemblies are opposite, and the two rotary stirring assemblies improve the turbulence mixing degree of the mixed solvent in the shell and the poria cocos powder, so that the poria cocos powder is uniformly dispersed into the mixed solvent, and different liquid phases in the mixed solvent fully extract pachymaran and triterpenoid substances in the poria cocos powder; the effective substance extraction rate of the poria cocos powder is improved.

The invention belongs to the technical field of biological medicine, and particularly discloses a water-soluble pachymaran composition and application thereof in alcohol metabolism regulation. The mass concentration ratio of the water-soluble pachymaran to the kudzuvine root extract is 1: (1-2), the substitution degree of the water-soluble pachymaran is 0.6-0.7, the kudzuvine root extract is an ethanol extract of kudzuvine root powder, and the water-soluble pachymaran and the kudzuvine root extract play a synergistic role in regulating alcohol metabolism. On one hand, by promoting the functions of enzymes related to ethanol metabolism, the ethanol metabolism and removal efficiency is improved; on the other hand, the adverse effects of alcohol and metabolites thereof on the body are reduced by relieving inflammation and stress response accompanied by alcohol metabolism, so that a good overall effect is shown in the aspects of detoxification and alcohol metabolism regulation. The water-soluble pachymaran composition provided by the invention has the effect of improving the physiological status after alcohol intake, and has a wide application prospect in the fields of hangover alleviating and alcoholic injury protection.

The invention discloses quaternized pachymaran as well as a preparation method and application thereof. The quaternized pachymaran is obtained by replacing hydroxyl on a sugar ring of pachymaran through chemical modification. According to the method, the insoluble pachymaran is subjected to quaternization derivation, and the quaternized pachymaran with good water solubility is obtained after dialysis and purification. According to the preparation method, conditions are mild and safe, quaternized pachymaran is successfully obtained through a 3-chloro-2-hydroxypropyl-trimethyl ammonium chloride solution with low toxicity and good stability, the quaternized pachymaran is good in water solubility and uniform in structure and can load nucleic acid, and the formed polysaccharide-nucleic acid compound has a good anti-inflammatory effect and can be used for preparing the anti-inflammatory drug. In an LPS-induced RAW264.7 cell inflammation model, expression of MIF can be effectively silenced, and the polypeptide has a wide application prospect in the aspect of being used as a transfection nucleic acid reagent.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a refreshing and anti-fatigue traditional Chinese medicine composition and a preparation method thereof. The invention discloses a refreshing and anti-fatigue traditional Chinese medicine composition. Comprising succinylated pachymaran, an ethyl cellulose aqueous dispersion, acetyl tributyl citrate, polyoxyethylene sorbitan monooleate, an ethanol aqueous solution, chitosan oligosaccharide, ginsenoside Rg1 nano-micelles, polyvinylpyrrolidone, deionized water, pseudo-ginseng powder, ginseng powder, a pachymaran extract, a Chinese wolfberry fruit polysaccharide extract and a lotus plumule alkali extract. The composition is prepared from microcrystalline cellulose, cross-linked povidone, colloidal silicon dioxide and magnesium stearate. According to the refreshing and anti-fatigue traditional Chinese medicine composition disclosed by the invention, the inner layer directly forms a nano-fiber net film with an ultra-large specific surface area on the surface of the tablet core through an electrostatic spinning technology, and the nano-fiber net film can generate an extremely strong capillary action after meeting water, so that a rapid disintegration effect is realized.

The invention relates to the technical field of functional food, in particular to a tendon-nourishing and bone-strengthening composition and a preparation method thereof, and the tendon-nourishing and bone-strengthening composition comprises a fermented mulberry leaf polyphenol-sea cucumber glycosamine polymer, clover leaf saponin, a selenium yeast-pachymaran compound, glucosamine, compound nuts, vitamin D, a beef-pork compound, a traditional Chinese medicine compound and cheese; the three functional components of the fermented mulberry leaf polyphenol-sea cucumber glycosamine polymer, the clover leaf saponin and the selenium yeast-pachymaran compound cooperate to effectively block the accumulation and toxic effect of harmful heavy metals in the Chinese herbal medicines in the human body, and normal absorption of trace elements necessary for the human body is not interfered at the same time.

The invention discloses a soft capsule for improving an anxiety state as well as a preparation method and application of the soft capsule, and belongs to the technical field of pharmaceutical preparations. Comprising contents and a capsule shell wrapping the contents. The content consists of a compound extract, phospholipid and emotional fish oil. The compound extract is prepared from bupleurum chinense, salvia miltiorrhiza, cape jasmine, angelica sinensis, bighead atractylodes rhizome, poria cocos, dried ginger, mint and liquorice; the capsule shell comprises chitosan, sodium alginate, a rosemary extract microcapsule, vitamin C palmitate, titanium dioxide, pachymaran and the like, and the rosemary extract microcapsule is prepared from a rosemary extract through pachymaran microencapsulation. Through the synergistic effect of all the components, the compatibility of the compound extract and the emotional fish oil is effectively improved, the stability of an oil phase system is improved, the oxidative rancidity risk of the emotional fish oil is reduced, meanwhile, the emotional fish oil is matched with the gastrointestinal absorption characteristics of people with weakness of the spleen and the stomach, and a pharmaceutical preparation choice is provided for conditioning the anxiety state.

The application belongs to the technical field of biological medicine, and specifically discloses a carboxymethyl Pachyman polysaccharide with double-path immune regulation activity and a preparation method and application thereof. The carboxymethyl Pachyman polysaccharide has a weight average molecular weight of 52 kDa to 267 kDa, is in a sheet or fiber shape under a scanning electron microscope, has an amorphous diffuse peak in an XRD spectrum within 10°~45° at 2θ, and has a Zeta potential absolute value of 40~46 mV in an aqueous solution. Mechanism research shows that the carboxymethyl Pachyman polysaccharide can simultaneously activate two intracellular signal pathways of TLR4-MyD88-NF-κB and TLR4 / TRIF / IRF3, promote macrophage activation, and cooperatively guide the simultaneous secretion of NO, TNF-α, IL-6, IL-1β and IFN-β. The application determines a molecular weight range of the CMP for exerting immune regulation activity, and has a good application prospect in the field of immune regulation drugs.