60results about How to "Enhance immune regulation function" patented technology

The invention refers to a preparation method of ginseng polysaccharide. The method includes the following step: extract it from the ginseng or the marc of the ginseng decocted, filtrate, concentrate and deposit the extracting solution, get the precipitate after centrifugence and dry it with low temperature to get the crude product of ginseng polysaccharide. We get the polysaccharide product after the ginseng polysaccharide goes through the boiling, depositing, filtration, trash extraction, frost thawing, getting rid of the protein and getting the supernatant and the supernatant passes through the concentration with low pressure and drying with low temperature. We can make it into all kinds of forms of prepared drugs after the ginseng polysaccharide passes through the experiments in pharmaceutics. The invention effectively increases the quality of the ginseng polysaccharide injection, fully exerts the immunoloregulation function of the ginseng polysaccharide, increases the anti tumor effect of chemotherapy medicament and is used to reduce the side effect caused by the knubbly radiotherapy and chemotherapy as well as adjuvant for curing the tumor.

The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anti-cancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3′-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.

The present invention belongs to the field of health products, and particularly relates to a processing process and a formula of a Chinese wolfberry-earthworm SOD nutrition oral liquid. The processing process is characterized in that earthworm SOD extraction, concentrated liquid preparation, and nutrition oral liquid preparation. The formula of the Chinese wolfberry-earthworm SOD nutrition oral liquid is characterized by comprising earthworm SOD and adjuvants, wherein the adjuvants comprise tuckahoe, jujube, Chinese wolfberry, donkey-hide glue, mulberry, and white fungus so as to provide the human immune regulation enhancing function, the adjuvants comprise amomum villosum, cinnamomum cassia and clove so as to relieve physical fatigue after taking, and the adjuvants comprise hawthorn, aloe, semen cassiae, lotus leaf and hippophae rhamnoides so as to provide the auxiliary blood fat lowering function.

The invention belongs to the technical field of traditional Chinese medicine and discloses roselle calyx polysaccharides and a preparation method and application. Roselle calyx coarse polysaccharide is extracted from calyx of roselle through steps of hot water reflux extraction, discoloring treatment and alcohol precipitation, and the roselle calyx coarse polysaccharide is further separated and purified through ion exchange column chromatography to obtain four refined polysaccharides. The coarse polysaccharide and the refined polysaccharides have remarkable immunoenhancement activity.

A multi-bacterium composition for regulating immunity by activating, repairing and reconfiguring immune system and preparing immunoregulator, anticancer medicine and health-care food is prepared from two or more lacticacid bacteria through culture. Its preparing process is also disclosed.

The invention relates to a blood pressure-reducing low sodium salt added with potassium chloride and chitosan oligosaccharide and a production method of the blood pressure-reducing low sodium salt. The blood pressure-reducing low sodium salt comprises the following components in percent by weight of 60-83 percent of edible salt, 13-30 percent of potassium chloride, 3-9 percent of chitosan oligosaccharide and 0.1-1.0 percent of silica. The blood pressure-reducing low sodium salt provided by the invention has the advantages that the chitosan oligosaccharide is fused in the edible salt, so that people can take in a proper amount of chitosan oligosaccharide, the blood pressure reducing effect is far higher than that of the low sodium salt on the market; the immune modulating function of a human body can be effectively enhanced, hypertension, hyperlipidemia and hyperglycemia are reduced; according to the condition that the crowd in China is lack of potassium, the adding quantity of the potassium chloride is properly reduced, and the cost is saved under the condition of meeting the demand of replenishing the potassium in the human body; by utilizing a proper quantity of powdery refined salt and silica and other products, the quality problems of layering and blocking and the like are effectively avoided; and raw materials and auxiliary materials all belong to the food grade and are safe without side effects.

The invention tests liver protection and immune regulation functions by feeding a rat and a mouse with an antradiacomphora capsule which is prepared by adopting a special process and solid-state culture, wherein a liver protection test comprises the following steps of: inducing chronic hepatitis of the rat by using carbon tetrachloride twice a week for eight weeks, and measuring GPT and GOT, water content of liver, spleen and liver, liver protein and hydroxyproline content. The antradiacomphora capsule can lighten the rat chronic hepatitis induced by the carbon tetrachloride. A specific immunity test: the test matter is fed to the BALB / c mouse and egg albumen is injected, thereby accelerating the immune cell proliferation capacity and the effect of the immune regulation function generated by an antibody with serological specificity. A non-specific immunity test comprises the following step of: doing an oral test for consecutive six weeks by means of the BALB / c mouse. The invention accelerates the abdominal cavity phagocyte activity, regulates the anti-tumor cytohormone secretion and promotes the effect of the immune regulation function generated by a serological antibody.

The invention relates to the technical field of natural nutritious health food, in particular to a health care product with functions of regulating incretion and increasing immunity and a preparation method thereof. The drug of the invention overcomes the problem that the health effect of the prior art is not ideal. The adopted technical scheme is as follows: the health care product with functions of regulating incretion and increasing immunity comprises the following raw materials in parts by weight: 40-70 parts of shell-broken pine pollen, 10-20 parts of soy protein isolate, 10-30 parts of dextrin, 5-30 parts of povidone K30, 6-10 parts of iso-malto oligosaccharides and 0.5-1.5 parts of magnesium stearate. Compared with the prior art, the invention has the advantage that 1. the health effect is good; and 2. the preparation technology is simple.

The invention relates to a preparation method of ginseng polysaccharide extractive. Ginseng coarse powder is adopted, ethanol of 60 percent to 80 percent which occupies eight times to ten times of the amount of ginseng coarse powder is added to perform reflux extraction for two to three times, decoction dregs is filtered to clean out ethanol, the purified water ten times to fifteen times of the decoction dregs is added, then hydrochloric acid is added, the pH value is regulated to be one to three, boiling-out is performed for half to two hours, the decoction dregs is filtered to repeat boiling-out once, the extracted solution is combined, filtered through and decompressed and condensed, to obtain the extracted concentrated solution, hydrochloric acid is added in the extracted concentrated solution, the pH value is regulated to be one to three, hydrogen peroxide four times to six times of the amount of hydrochloric acid is added and is agitated and thermally preserved under the temperature of 85 DEG C to 95 DEG C for one to three hours, the extracted concentrated solution is cooled to the room temperature and filtered, and the concentrated solution after being decolorized is obtained; the pH value of the concentrated solution after being decolorized is regulated by utilizing NaOH to be three to five, ethanol two times to five times the concentrated solution is added, the concentrated solution is evenly agitated and is allowed to stand, precipitation is leached and cleaned for one time by utilizing ethanol with 60 percent to 80 percent containing HCl with 0.2 percent to 2.0 percent, the precipitate is dissolved through water, the alcohol precipitation washing and the acid alcohol washing are respectively repeated for once, and white ginseng polysaccharide extractive is obtained..

The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anti-cancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3′-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.

A disclosed sea-cucumber coffee formula comprises 10%-50% of sea cucumber powder (sea cucumber peptide powder) and 90%-50% of coffee powder. Sea cucumber powder (sea cucumber peptide powder) and coffee powder are reasonably combined, promote and supplement each other, and give play to synergic effect after being compounded, make up the disadvantage that coffee powder only can resist short-term sport fatigue, and also keeps inherent fragrance and mouthfeel of coffee, and thus when people taste delicious coffee, by exciting nervous centralis, enhancing functions of internal organs, adjusting energy metabolism and nourishing nervous system, the sea cucumber powder and the coffee powder together realize the purposes of well resisting fatigue and enhancing body immunoregulatory function for a long time.

The invention discloses a DN T cell transformation and multiplication method which comprises the following steps: (1) extracting mononuclear cells in an initial sample, and removing CD8<+>T cells and NK cells from the mononuclear cells; (2) culturing the sample obtained in the step (1) in vitro with a culture medium containing a T cell stimulant and cell factors; adding an OX40 activated antibody or an OX40 ligand at the same time in the culturing process; (3) purifying DN T cells after 5-7 days' culture. The method can be implemented without purifying CD4<+>T cells or natural DN T cells, so that the operation difficulty is reduced, the operation efficiency is improved, and the culture period is short; the apoptosis rate of DN T cells in multiplication can be effectively reduced, and the immunosuppression function can be improved; the DN T cell yield is greatly improved as compared with that in the prior art; the obtained DN T cells have remarkable immunosuppression function, the percentage of the proliferated CD4 T cells is reduced to 2.94% as compared with that in the prior art, and the suppression ratio can reach 93%.

The invention provides an external patch for treating female pelvic inflammation and a preparation method thereof, and relates to Chinese medicinal patches and the preparation method thereof. The following raw material medicaments of 25 to 35 mass parts of bupleurum, 15 to 25 mass parts of peony tree root bark, 10 to 20 mass parts of dandelion, 8 to 12 mass parts of safflower, 10 to 20 mass parts of corydalis root, 15 to 25 mass parts of heartleaf houttuynia herb, 20 to 30 mass parts of motherwort, 15 to 25 mass parts of field pennycress, 10 to 20 mass parts of eucommia bark, and 10 to 20 mass parts of chaff flower root are subjected to crushing, extracting, emulsifying and the like to prepare the external patch. The patch is pasted on the lower abdomen of a woman, has quick transdermal administration, can directly reach the lesion site, and can store medicinal property on the lesion site, is convenient and safe, can replace physiotherapy and has better effect than pharmacotherapy, so that patients can be treated in a warm environment.

The invention relates to the field of foods and discloses a composition with an immunoregulation function. The composition with the immunoregulation function is prepared from the raw materials of ginseng and cordycepsmilitaris liquid shaking-flask seed, wherein the mass-to-volume ratio (g / ml) of the ginseng to the cordycepsmilitaris liquid shaking-flask seed is (100-120):(100-180); health food with an immunoregulation function can be prepared from the composition with the immunoregulation function. The composition with the immunoregulation function is obtained by biologically transforming the ginseng with cordycepsmilitaris through bidirectional solid fermentation and can remarkably improve cellular immunity, humoral immunity and NK cell viability so as to improve the immunoregulation function. The health food with the immunoregulation function, which is prepared from the composition provided by the invention has the advantages of simple production technology, stable product quality, clear functional factors, excellent health-care efficacy, small dosage, safety in use, no toxic side effect and the like and is suitable for crowds with low immunity to eat.

The invention discloses a high-calcium oat milk beverage which includes the components as follows, by weight: 20-80% of milk, 2-6% of white granular sugar, 0.5-10% of oat meal, 0.1-0.3% of calcium carbonate, 0.03-0.1% of mid-temperature [alpha]-amylase, 0.05-0.5% of [beta]-glucan, 0.000001-0.000004% of vitamin D, 0.1-0.5% of xanthan gum, 0.05-0.5% of microcrystalline cellulose and the balanced being water. A preparation method of the beverage includes the steps of: heating water to 55-70 DEG C, adding the oat meal and performing gelatinization for 20-40 min, adding the mid-temperature [alpha]-amylase with uniform mixing, maintaining the temperature for 20-40 min to prepare an oat meal solution, mixing the oat meal solution with the milk, white granular sugar, calcium carbonate, [beta]-glucan, vitamin D, xanthan gum and microcrystalline cellulose, and homogenizing and sterilizing the mixture. In the invention, the milk and the oat are combined, wherein the oat is enzymolysed by the amylase, then the calcium carbonate, the [beta]-glucan and the vitamin D are added to improve nutrition, wherein the system also needs addition of the xanthan gum and the microcrystalline cellulose for stabilizing the system to prevent precipitation and water separation.

The present invention may provide a method for producing induced pluripotency stem cell-derived mesenchymal stem cells (IFN gamma-iMSC) pretreated with interferon-gamma; induced pluripotency stem cell-derived mesenchymal stem cells pretreated with interferon-gamma prepared by the method; a pharmaceutical composition for preventing or treating skin diseases, and a cosmetic composition for preventing or improving skin diseases, comprising culture thereof or exosome (IFN gamma-iMSC-exo) isolated therefrom as an active ingredient. When the composition of the present invention is used, it is possible to provide a composition for skin diseases and a stem cell therapeutic agent, which have an improved immunomodulating function over conventional mesenchymal stem cells.

The invention relates to a mango and papaya composite fruit juice beverage and a preparation method thereof, and belongs to the technical field of foods and beverages. The mango and papaya composite fruit juice beverage is prepared through the following steps of (1) preparing mango turbid juice and papaya turbid juice; (2) preparing mango peel essential oil; (3) preparing a mango peel extract; and(4) performing blending. Through the adoption of the preparation method disclosed by the invention, the utilization rate of raw materials is increased, the technology is simple, equipment requirements and energy consumption are not high, and the mango and papaya composite fruit juice beverage is suitable for large-scale industry production. The mango and papaya composite fruit juice beverage prepared by the method is rich in nutrient substances, rich in fragrance and good in mouth feel and cannot include preservatives.

The invention relates to PEGylated CpG oligonucleotide and application of the PEGylated CpG oligonucleotide in the preparation of a medicament for improving the IL-12 expression quantity in serum, a medicament for inducing the immunogenicity to an endogenous antigen such as a tumor antigen and a medicament for stimulating the immunocompetence of B cells, plasmacytoid dendritic cells, myeloid dendritic cells, macrophages and peripheral mononuclear cells in the field of vaccine and tumor immunotherapy administration systems. The PEGylated CpG oligonucleotide has the effects of homeostasis improvement and immunoregulation, and response to persistent antigens in vivo can be improved.

The invention discloses dendrobium officinale healthcare fruit juice. The dendrobium officinale healthcare fruit juice comprises the following raw materials in parts by weight: 3.5 to 10 parts of fresh dendrobium officinale bar, 0.5 to 1 part of saussurea involucrate and 89 to 96 parts of boiled water. The preparation method comprises the following steps: step I, preparing dry dendrobium officinale bar; step II, crushing the dendrobium officinale bar by utilizing a crushing machine, filtering the crushed dendrobium officinale by utilizing a 100-mesh sieve for standby application; step III, washing the saussurea involucrate, then peeling the saussurea involucrate, slicing the saussurea involucrate, then drying the saussurea involucrate slices until the water content is 5 to 10 percent, and crushing the saussurea involucrate slices, and filtering the crushed saussurea involucrate by utilizing a 100-mesh sieve for standby application; step IV: mixing the dendrobium officinale and saussurea involucrate prepared in the steps II and III with boiled water according to a weight ratio, placing into a stirrer, sufficiently stirring and mixing to obtain the dendrobium officinale healthcare fruit juice. The fruit juice has functions for cooling and clearing away the internal heat and is rich in nutrition; the preparation method is simple to operate and reasonable in design.

The invention relates to pungent and spicy deep-fried herba houttuyniae and a producing method thereof. The pungent and spicy deep-fried herba houttuyniae is prepared from fresh herba houttuyniae, chili powder, salt, monosodium glutamate, seed powder of Chinese prickly ash, sesame, star aniseed powder and fennel powder through the steps of cleaning, deep-frying, drying, proportioning, mixing, packaging, and the like. The herba houttuyniae mainly contains various ingredients such as volatile oil, decanoyl acetaldehyde and the like, and the pungent and spicy deep-fried herba houttuyniae as a leisure food, after being taken for a long time, has inhibition and antibacterial effects on various xenorhabdus nematophila, coccus, influenza viruses, leptospira, and the like, and can improve the immune regulating function of human bodies. According to the invention, by unique deep-frying and mixing, the unique fragrance of herba houttuyniae and a pungent and spicy taste are fused together, therefore, the pungent and spicy deep-fried herba houttuyniae is excellent in color, aroma and taste.

The invention discloses an anti-inflammation composition and a preparation method thereof. The anti-inflammation composition comprises, by weight, 10-15 parts of garlic husk extract, 5-10 parts of shaddock peel extract, 8-12 parts of peony extract, 3-5 parts of ginger juice and 0.01-0.05 part of menthol. The anti-inflammation composition has the advantages that garlic husks and shaddock peel are effectively collected and reasonably utilized, and resource waste is avoided; the peony extract and the ginger juice are added to serve as the auxiliary materials, so that the fragrance of the composition can be improved, functions of resisting inflammation and enhancing immune regulation are achieved, safety is achieved, and drug resistance is avoided; paste prepared by using the composition is good in anti-inflammation and antibacterial effect.

The invention relates to a traditional Chinese medicine aerosol for treating upper respiratory diseases of poultry and a preparation method of the traditional Chinese medicine aerosol, and belongs tothe field of animal husbandry and veterinary medicine. The traditional Chinese medicine aerosol for treating the upper respiratory diseases of poultry is prepared from the raw materials in parts by weight: 2 parts of ligustici rhizoma et radix, 1 part of tangerine peel, 0.5-1 part of mint, 0.5-1 part of asariradix et rhizoma, 0.5 part of dried ginger, 2.5-3 parts of ethanol, and 1.5-2 parts of dimethyl ether. The traditional Chinese medicine aerosol is used for treating the upper respiratory diseases of poultry and has excellent curative effect and good atomization effect, and the spray rate is not less than 1.3g / s, so that intensive breeding and dosing are facilitated.

The invention discloses a sow feeding method and belongs to the technical field of pig breeding. The feeding method comprises the following steps: (1) adjusting and controlling of nutrient feeding inthe growing period; (2) adjusting and controlling of nutrient feeding in the gestation period; (3) adjusting and controlling of nutrient feeding in the suckling period. According to the invention, thesows are fed through different feeds at all stages of breeding of the sows, the body of the sows can be guaranteed to be good, oestrus breeding and farrowing can be carried out smoothly, the producedpiglets are good, and the survival rate is high.

The invention discloses an energy-saving electric blanket with a continuous warmth keeping function, comprising an electric blanket body and a timing circuit connected with an external power supply, wherein the electric blanket body is provided with an upper electric blanket region and a lower electric blanket region; the upper electric blanket region is respectively provided with a first heating resistance wire and a first control circuit; the lower electric blanket region is respectively provided with a second heating resistance wire and a second control circuit; the first control circuit is connected with the first heating resistance wire; the second control circuit is connected with the second heating resistance wire; the input ends of the first control circuit and the second control circuit are connected with the timing circuit after being connected in parallel, and the output ends of the first control circuit and the second control circuit are connected with the external power supply after being connected in parallel; and the timing circuit which is an RC (Remote Control) circuit is also internally provided with a circuit control switch for controlling the whole internal circuit. The energy-saving electric blanket is provided with the upper electric blanket region and the lower electric blanket region and is also provided with the timing circuit, so that not only the warmth keeping function of the electric blanket is optimized, but also the energy source is saved.

The present invention relates to a prescription of a main agent which has an immunoregulatory function, and is made by raw materials of the following weight percent: 0 to 100 percent of Bulaocao (angelica keiskei koidzumi), 0 to 100 percent of dendrobium stem, 0 to 100 percent of snow lotus, 0 to 100 percent of antler, 0 to 100 percent of ginseng, and 0 to 100 percent of garlic. The manufacturing method comprises the following steps: (1) weighing the Bulaocao (angelica keiskei koidzumi), dendrobium stem, snow lotus, antler, ginseng and garlic according to the following weight percent; (2) mixing the Bulaocao (angelica keiskei koidzumi), dendrobium stem, snow lotus, antler, ginseng and garlic, using warm water of the same weight as the mixture to dip the mixture for about 3 hours, and boiling the mixture for about 1 hour; (3) distilling the water extract after boiling; (4) crushing the garlic and distilling the garlic juice; (5) mixing the water extract and the garlic juice, pouring the mixture into a centrifugal filter to process the mixture; and (6) canning the filtrate to product the finished product.

The invention discloses an ecological feed for a wild goose, which can improve the disease resistance of the wild goose. The ecological feed for the wild goose is prepared from the following components in parts by mass: 50 to 60 parts of lolium perenne, 1 to 1.5 parts of shell powder, 0.4 to 0.6 part of table salt, 20 to 25 parts of corn powder, 10 to 12 parts of husks, 5 to 7 parts of earthworm powder, 3 to 5 parts of houttuynia cordata and 2 to 4 parts of artemisia annua herb; the lolium perenne, the houttuynia cordata and the artemisia annua herb are crushed into a semi-finished product by using a feed crushing machine; then, the semi-finished material, the shell powder, the table salt, the corn powder, the husks and the earthworm powder are uniformly mixed to obtain the ecological feed for the wild goose. The feed is rich in protein and calcium, and meanwhile, has the effects of helping digestion, and dispelling wind and heat. At current, most main diseases in wild goose cultivation are caused by viruses; the houttuynia cordata and the artemisia annua herb are matched reasonably to achieve an effect of inhibiting the viruses; the immune modulating function of the wild goose can be improved; the fed wild goose is high in disease resistance, does not get sick and grows healthily; the wild goose cultivation cost is greatly reduced.

The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anticancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3′-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.

The present invention discloses an antioxidant beverage and a preparation method and application thereof. The beverage includes the following raw materials in parts by weight: 20-30 parts of garlic skin, 5-10 parts of pomelo peels, 8-12 parts of subshrubby peony flowers, 3-5 parts of fructus mori, 1-2 parts of purple sweet potato enzymatic hydrolysis powder and 0.05-1 part of fructo-oligosaccharide. The purple sweet potato enzymatic hydrolysis powder is powdered solid obtained by subjecting purple sweet potato powder to beta-glucan enzyme treatment. The invention effectively collects the garlic skin and the pomelo peels for rational use to avoid the waste of resources; and the invention is supplemented by mixed juice of subshrubby peony flower extract and the fructus mori, so that the antioxidant beverage has effects in resisting inflammation and enhancing immune regulatory function with aroma enhanced at the same time, and the antioxidant beverage is safety and free of resistance to drugs.

The invention belongs to the technical field of tumor treatment, and discloses a tumor immunomodulator and application thereof. The immunomodulator at least comprises a benzoisoselenazole derivative,preferably comprises a benzoisoselenazole derivative and a platinum anticancer drug. The molar ratio of the benzoisoselenazole derivative to the platinum anticancer drug is (1-99): (1-99). The immunomodulator can be used for tumor therapy, such as early tumor immunomodulation and postoperative tumor recurrence immunomodulation. The coordination effect of apoptosis induction and immunoregulation ofBS makes it possible for BS to be used as a long-term postoperative tumor recurrence control regulator that benefits patients. Furthermore, the combined application of BS and cisplatin will amplify the coordination effect, thus benefiting more clinical patients.

A ventilating health-care wall without plastering features that several steel doges, iron rods, or iron (bamboo) strips are inserted between two lines of vertical bricks or horizontal bricks, the transverse seams between bricks are covered by ceramic tiles, each story has an upturned eave, a transverse window is arranged at 1.5 m height from ground, and the porous brick is used. Its advantages are good ventilation, health-care function, and low cost.