Method for preparing ginseng polysaccharide

A technology of ginseng polysaccharide and ginseng, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as low purity, muscle necrosis, and potential safety hazards, and achieve rapid curative effect and high bioavailability. , the effect of improving product quality

Inactive Publication Date: 2005-02-16
JILIN SIHUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] When ginseng polysaccharide injection is clinically used as an injection, the existing route of administration is intramuscular injection. The main problems of intramuscular injection are pain at the injection site and possible local redness, swelling, congestion, lumps, and even muscle necrosis after long-term injection. reaction, and the raw materials used in production have the problem of low purity due to the preparation process, and there are certain safety hazards

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 10kg of raw sun-dried ginseng, chop it up, decoct and reflux extraction with 75% ethanol for 4 hours, dry the extracted medicinal dregs, add water to decoct three times, add 12 times the amount of water for decoction for 1 hour for the first time, and add Decoct with 10 times the amount of water for 50 minutes, add 10 times the amount of water for the third time and decoct for 30 minutes, combine the decoction, filter, and concentrate the filtrate to 0.2 times the original volume under reduced pressure; add 95% ethanol to control the alcohol content at 75%, the alcohol precipitation solution was refrigerated, let it stand for 24 hours, centrifuged the refrigerated medicinal solution at low temperature for 20 minutes (centrifugal speed: 4000 rpm), collected the precipitate, and dried the precipitate at low temperature to obtain the crude product of ginseng polysaccharide; the crude product of ginseng polysaccharide Add 15 times the amount of water, heat and boil for ...

Embodiment 2

[0025]Take 10kg of raw sun-dried ginseng, chop it up, extract it with 75% ethanol under reflux for 4 hours, dry the dregs after extraction, add water to decoct twice, add 15 times the amount of water to decoct for 90 minutes for the first time, and add 10 times the amount of water for the second time. Double the amount of water and decoct for 60 minutes, combine the decoction, filter, and concentrate the filtrate to 0.3 times the original volume under reduced pressure; add 95% ethanol to control the alcohol content at 85%, refrigerate the alcohol precipitation solution, and let it stand for 30 hours. Centrifuge the refrigerated medicinal liquid with a centrifuge for 30 minutes at low temperature (3000 rpm), collect the precipitate, and dry the precipitate at low temperature to obtain the crude ginseng polysaccharide; add 15 times the amount of water to the crude ginseng polysaccharide, boil it for 30 minutes, and cool down to 40°C Afterwards, filter, add 95% ethanol in the filt...

Embodiment 3

[0028] Take 10kg of raw sun-dried ginseng, chop it, add water to decoct 3 times, first add 15 times the amount of water to decoct for 90 minutes, second time add 12 times the amount of water to decoct for 60 minutes, and third time add 10 times the amount of water to decoct Boil for 60 minutes, combine the decoction, filter, and concentrate the filtrate under reduced pressure to 0.3 times the original volume; add 95% ethanol to control the alcohol content at 85%, refrigerate the ethanol precipitation solution, and let it stand for 36 hours. The liquid was centrifuged in a centrifuge at low temperature for 30 minutes (the centrifugal speed was 4000 rpm), and the precipitate was collected, and the precipitate was dried at low temperature to obtain the crude ginseng polysaccharide; the crude ginseng polysaccharide was boiled for 20 minutes with 10 times the amount of water, cooled to 35°C, filtered, Add 95% ethanol to the filtrate so that the alcohol content is controlled at 80%, ...

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Abstract

The invention refers to a preparation method of ginseng polysaccharide. The method includes the following step: extract it from the ginseng or the marc of the ginseng decocted, filtrate, concentrate and deposit the extracting solution, get the precipitate after centrifugence and dry it with low temperature to get the crude product of ginseng polysaccharide. We get the polysaccharide product after the ginseng polysaccharide goes through the boiling, depositing, filtration, trash extraction, frost thawing, getting rid of the protein and getting the supernatant and the supernatant passes through the concentration with low pressure and drying with low temperature. We can make it into all kinds of forms of prepared drugs after the ginseng polysaccharide passes through the experiments in pharmaceutics. The invention effectively increases the quality of the ginseng polysaccharide injection, fully exerts the immunoloregulation function of the ginseng polysaccharide, increases the anti tumor effect of chemotherapy medicament and is used to reduce the side effect caused by the knubbly radiotherapy and chemotherapy as well as adjuvant for curing the tumor.

Description

technical field [0001] The invention relates to a preparation method of ginseng polysaccharide, which belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Ginseng polysaccharide is the active ingredient of traditional Chinese medicine ginseng, which is a high molecular weight dextran. Ginseng polysaccharides can enhance the immune regulation function of the body and enhance the anti-tumor effect of chemotherapy drugs, and have a significant inhibitory effect on tumors. Experiments have shown that ginseng polysaccharides can induce tumor necrosis factor and interferon-γ, and have killing and inhibiting effects on tumor cells. Tumor necrosis factor is a multifunctional protein molecule produced by activated macrophage / monocyte system, which plays an important physiological role in the body. In the body, tumor necrosis factor can play an anti-tumor effect in three ways: directly killing tumor cells; acting on tumor blood circulation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715C08B37/00
Inventor 郭智华
Owner JILIN SIHUAN PHARM CO LTD
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