5 results about "Stage tumor" patented technology

This disclosure relates to a method for detecting colorectal cancer. The method comprises determining whether an advanced neoplasm is present in a first screening time period and upon determining that an advanced neoplasm is present in the first screening time period, performing colonoscopy in a second screening time period, after the first screening time period, to detect colorectal cancer. There is further provided a method for stratification of a subject comprising upon detection of an advanced neoplasm in a first screening time period, stratifying the subject into a high risk stratification for developing colorectal cancer in a second screening time period. There is further provided a computer implemented method for calculating a risk score for developing colorectal cancer comprising determining patient data; applying a trained machine learning model to the patient data to determine the risk score; and outputting the risk score.

The application provides a kind of nanoparticle, preparation method and its early screening related application of cancer, wherein, nanoparticle includes superparamagnetic nanometer core, cationic polymer modified on the surface of superparamagnetic nanometer core and targeted polypeptide grafted on cationic polymer, the targeted polypeptide can specifically recognize tumor specific antigen protein, and has the modular structure of rigid helix and charge repulsion sequence.The plasma low-abundance protein enrichment nanoparticle provided by the application can be used for the detection of early screening of tumor through liquid biopsy, can significantly improve the detection rate of early tumor, and has important clinical significance.

This invention belongs to the field of biodetection and medical technology, and relates to a high-performance photothermal diagnostic and therapeutic integrated fiber optic probe based on rare-earth nanomaterials. The probe includes a photothermal diagnostic and therapeutic composite material. This material consists of a tumor-specific environmental fluorescence responsive material, 1,8-naphthalimide fluorophore, and Yb that can be used for photothermal therapy. 3+ / Er 3+ The probe is composed of co-doped Bi₂WO₆ nanomaterials. Under 450nm laser excitation, the fluorescently responsive material in the probe emits 550nm green fluorescence in a tumor cell environment, which is received and fed back by the fiber optic probe, enabling specific recognition of tumor cells. After recognition, the fiber optic probe emits fluorescence that can be detected by Yb 3+ / Er 3+ The co-doped Bi₂WO₆ nanomaterials absorb and convert infrared light in the 980nm near-infrared band into photothermal radiation. Under continuous irradiation, the nanomaterials continuously heat up, destroying cell structures and killing tumor cells, thus achieving targeted photothermal monitoring and treatment of tumor cells. This probe is minimally invasive and has high photothermal conversion efficiency, providing a new approach for minimally invasive diagnosis and treatment of early-stage tumors.

This invention discloses a tumor adjuvant nutritional preparation based on *Pterocarya stenoptera* oil, its preparation method, and its application. The active ingredients of this preparation are composed of *Pterocarya stenoptera* oil, ω-3 fatty acids, and arginine in a mass ratio of (1-3):(1-2):(1-2), preferably 2:1:1. The preparation method includes mixing the above components evenly, followed by high-pressure homogenization and aseptic emulsification to produce an oral liquid, enteral nutrition emulsion, or powder. This preparation can effectively improve chemotherapy-induced bone marrow suppression, significantly increase white blood cell, red blood cell, and hemoglobin levels, enhance serum superoxide dismutase activity, reduce oxidative stress damage, and significantly alleviate gastrointestinal adverse reactions such as nausea, vomiting, and loss of appetite in cancer patients undergoing radiotherapy and chemotherapy, improving patients' nutritional status and quality of life, and exhibiting good safety.

This invention belongs to the field of reactive oxygen species (ROS) detection technology, and discloses a composite near-infrared ratiometric fluorescent probe, its synthesis method, and its application. The probe is composed of a cyanine organic fluorescent dye and bovine serum albumin (BSA). By using urea to disrupt the hydrogen bonds, the BSA protein molecule structure is relaxed and denatured, leading to the extension of the protein's peptide chains. These chains then bind to the synthesized organic compound Hcy-Cl to form the probe Hcy-BSA structure. The ROS level in vivo is detected by ratiometric fluorescence intensity changes. ‑ This invention designs a novel composite near-infrared ratiometric fluorescent probe, which achieves the regulation of ClO through changes in ratiometric fluorescence intensity. ‑ The detection method has advantages such as good selectivity, high stability, good biocompatibility and low toxicity, and is expected to become a powerful auxiliary reagent for the early diagnosis of tumors and Alzheimer's disease.