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Application of radix codonopsis pilosulae and radix astragali composition in preparation of medicine for preventing and treating advanced tumor related symptoms

A tumor-related and compositional technology, applied in the field of Shenqi Fuzheng Injection, cancer-related fatigue and/or weight loss drugs, can solve the problems of no treatment and intervention plan, so as to relieve cancer-related fatigue and protect the integrity Sex, increase the expression level and the effect of ATP content

Inactive Publication Date: 2021-11-05
LI MIN PHARM FAB OF LIVZON PHARM GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although nutritional replacement, appropriate exercise, appetite-stimulating drugs, and non-steroidal anti-inflammatory drugs can all be used to improve weight loss in patients with advanced cancer, there is still no standard treatment and intervention plan

Method used

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  • Application of radix codonopsis pilosulae and radix astragali composition in preparation of medicine for preventing and treating advanced tumor related symptoms
  • Application of radix codonopsis pilosulae and radix astragali composition in preparation of medicine for preventing and treating advanced tumor related symptoms
  • Application of radix codonopsis pilosulae and radix astragali composition in preparation of medicine for preventing and treating advanced tumor related symptoms

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation of embodiment 1 Shenqi Fuzheng Injection

[0051] Codonopsis pilosula and Astragalus membranaceus are removed from impurities and processed into decoction pieces. Accurately weigh 400 grams of Codonopsis pilosula and Astragalus membranaceus, rinse with deionized water, add 6400ml of deionized water, heat and boil for 1 hour, and release the extract; add 3600ml of deionized water to the residue, heat and boil for 1 hour, and release the extract Add 3600ml of deionized water to the slag, heat and boil for 0.5 hours to extract, and release the extract; the three extracts are combined, filtered and concentrated into 520ml, and the ethanol with a concentration of more than 85% is added under stirring to make the ethanol content 75%, and it is placed for more than 24 hours , filter recovery ethanol to 440ml, add the ethanol of 95% concentration under stirring to make the ethanol content be 85%, stand more than 24 hours, filter recovery ethanol and concentrate ...

Embodiment 2

[0052] Embodiment 2 animal experiment part:

[0053] (1) Model construction

[0054] Modeling of fatigue mouse model: Before inoculation of CT-26 cells, all nude mice were placed in a swimming box (30cm in height, 25cm in diameter) for adaptive swimming training for 2 days, 5min / day, and the water temperature was 25°C±1°C. Mice with too long and too short swimming times and nude mice with too excited and too quiet were excluded. The cultured CT-26 cells were digested and centrifuged to make about 1×10 7 cells / ml suspension. Disinfect the abdominal skin of mice, take 0.2ml (about 1×10 6 Tumor cells) were inoculated into the peritoneal cavity. One week after the inoculation, the tumor metastasis was observed by PET / CT imaging. After the success of the abdominal metastasis model of colon cancer, the model nude mice were continued to be raised for 2-3 weeks, and the whole body activity of the nude mice was observed. Slow, reduced diet, emaciation, etc., and then observe the fa...

Embodiment 3

[0103] Embodiment 3 cell experiment part:

[0104] (1) Cell recovery, culture and passage

[0105] Take out the cryopreservation tubes of CT26 cells and C2C12 myoblasts from liquid nitrogen, quickly place them in a constant temperature water bath, transfer the cell suspension to the pre-prepared PBS, centrifuge at 250g for 4min, discard the supernatant, and use DMEM complete medium (containing 10% FBS) in 5% CO 2 , Cultured in a constant temperature incubator at 37°C. When the cells covered 80% of the bottom of the culture dish, they were digested with 0.25% trypsin and diluted 1:2 for passage.

[0106] (2) Construction of mitochondrial injury model of C2C12 myoblasts

[0107] Observe that CT26 colon cancer cells and C2C12 myoblasts grow to cover 75cm 2 When the area of ​​the bottom wall of the culture flask is 70%, discard the old medium, digest with 0.25% trypsin, centrifuge at 250g for 5min, discard the supernatant, add DMEM medium and pipette evenly, and adjust the cel...

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Abstract

The invention relates to an application of a radix codonopsis pilosulae and radix astragali composition in preparation of a medicine for preventing and treating advanced tumor related symptoms, in particular to an application of a Shenqifuzheng injection in preparation of a medicine for preventing and treating cancer-related fatigue and / or weight loss of an advanced tumor patient.

Description

technical field [0001] The present invention relates to the application of Codonopsis Radix Astragali composition in the preparation of medicine for treating advanced tumor-related symptoms. More specifically, the present invention relates to the use of Shenqi Fuzheng Injection in the preparation of medicines for treating cancer-related fatigue and / or weight loss in patients with advanced tumors. Background technique [0002] Cancer is currently the main disease that endangers health and causes death clinically. Cancer-related fatigue is one of the most common subjective symptoms in cancer patients. Cancer-related fatigue (CRF) is defined as a persistent, subjective feeling of fatigue related to cancer or its treatment that disrupts normal body function, is out of proportion to activity, and is often accompanied by dysfunction. Compared with ordinary fatigue, cancer-related fatigue has the characteristics of rapid onset, severe severity, long duration, and cannot be reliev...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/08A61P35/00A61K36/344
CPCA61K36/344A61K36/481A61K9/08A61K9/0019A61P35/00A61K2236/331A61K2236/55A61K2300/00
Inventor 林丽珠郭苇郑心婷黄文华孙虹胡海棠
Owner LI MIN PHARM FAB OF LIVZON PHARM GRP
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