Nano composite material, preparation method thereof and application in HIFU synergist

A technology of nanocomposite materials and synergists, applied in the field of nanomaterials and HIFU, can solve the problems of inability to effectively solve the problem of complete ablation of deep lesions, inability to completely ablate tumor recurrence and metastasis, inability to accurately identify tumor tissue boundaries, etc., and achieve internal circulation Short time, long circulation time in the body, and the effect of increasing the active oxygen level

Active Publication Date: 2019-11-15
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the process of clinical promotion of HIFU technology, several key problems hindering its further promotion have been encountered and need to be solved
First, in the process of HIFU treatment, the ultrasonic energy shows the characteristics of rapid attenuation due to tissue absorption during the propagation process in the body. Therefore, for deep lesions, the ablation effect of HIFU will be reduced.
Although it is clinically possible to counteract the influence of tissue absorption by increasing the ultrasonic output power and enhance the ablation effect of HIFU on the lesion tissue, excessive output power will cause tissue damage on the ultrasonic propagation

Method used

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  • Nano composite material, preparation method thereof and application in HIFU synergist
  • Nano composite material, preparation method thereof and application in HIFU synergist
  • Nano composite material, preparation method thereof and application in HIFU synergist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1 Black TiO 2 Nanoparticle preparation

[0094] Black TiO 2 Nanoparticle preparation

[0095] Take nano TiO 2 20mg of powder, placed in a high-pressure hydrogen system, pressure 22.0bar, temperature 450℃, hydrogenation for 5 days, after the reaction is over, black TiO is obtained 2 Nanoparticles.

[0096] Black ZrO 2 Nanoparticle preparation

[0097] Take Nano ZrO 2 30mg of powder, placed in a high pressure hydrogen system, pressure 20.0bar, temperature 350℃, hydrogenation for 5 days, after the reaction is over, black ZrO is obtained 2 Nanoparticles.

[0098] Preparation of black ZnO nanoparticles

[0099] Take 30 mg of nano-ZnO powder and place it in a high-pressure hydrogen system at a pressure of 20.0 bar, a temperature of 350° C., and hydrogenation for 5 days. After the reaction, black ZnO nanoparticles are obtained.

Embodiment 2

[0100] Example 2 Preparation of hollow mesoporous black nanoparticles

[0101] Hollow mesoporous black TiO 2 Nanoparticle preparation

[0102] Reference (Angew.Chem.Int.Ed.2014,53,12590-12593.) method, using a hydrothermal method to prepare carbon spheres with a particle size of 50nm. Take 40mg of carbon balls and disperse in 100mL of absolute ethanol. Take 1mL of tetrabutyl titanate and add it dropwise to the above-mentioned absolute ethanol. After stirring well, take 0.5mL of ammonia water and add it to the above-mentioned absolute ethanol dropwise, react at 40℃ 18 hours. After the reaction, centrifuge for 30 minutes at a speed of 12000 rpm to remove the supernatant, collect the precipitate, dry it at 100°C, transfer it to a tube furnace, and calcinate at 500°C for 2 hours to obtain a hollow medium Porous TiO 2 Nanoparticles. Take hollow mesoporous TiO 2 40mg of nano-particle powder, placed in a high-pressure hydrogen system, pressure 22.0bar, temperature 450℃, hydrogenation ...

Embodiment 3

[0105] Example 3 Preparation of PEG-modified hollow mesoporous black nanoparticles

[0106] PEG modified hollow mesoporous black TiO 2 Nanoparticle preparation

[0107] PEG modified hollow mesoporous black TiO 2 Nanoparticles: Take the hollow mesoporous black TiO prepared in Example 2 2 20 mg of nanoparticles were dispersed in 100 mL of absolute ethanol, 100 mg of PEG (molecular weight 2000) was added, and stirred for 8 hours. The solution was collected, centrifuged at 10,000 rpm for 20 minutes, the supernatant was removed, washed with deionized water, and centrifuged twice. Obtain PEG-modified hollow mesoporous black TiO 2 Nanoparticles.

[0108] PEG modified hollow mesoporous black ZrO 2 Preparation of Nanoparticles and PEG-modified Hollow Mesoporous Black ZnO Nanoparticles

[0109] PEG modified hollow mesoporous black ZrO 2 Preparation of Nanoparticles and PEG-modified Hollow Mesoporous Black ZnO Nanoparticles and PEG-modified Hollow Mesoporous Black TiO 2 The preparation proce...

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Abstract

The invention discloses a nano composite material. The nano composite material is characterized by comprising an inner core component and an outer layer component; the inner core component comprises nano particles; the outer layer component is a multi-layer component including at least one of a stabilizing agent, a medical imaging contrast agent, a chemotherapeutic drug and a tumor-specific ligandor antibody; the mass ratio of the inner core component to the outer layer component is 1:10-1:0.5. The nano composite material has ultrasonic response activity and can efficiently convert absorbed ultrasonic waves into reactive oxide species or thermal energy. The invention further discloses a preparation method of the nano composite material and application in an HIFU synergist. The preparationmethod of the nano composite material is simple, easy to implement and beneficial for large-scale production and popularization; when the nano composite material is used for the HIFU synergist, the ablation effect of HIFU on deep lesions can be improved, the treatment effect on early-stage tumors with small size is improved, the tumor boundary can be subjected to iconography locating and identification, and the damage to the normal tissue of the tumor boundary is reduced.

Description

Technical field [0001] This application relates to a nano composite material, its preparation method and its application in HIFU synergist, belonging to the field of nano materials and HIFU. Background technique [0002] High intensity focused ultrasound (HIFU) is a non-invasive local tumor ablation technique. It focuses high-energy ultrasound to the focal tissue, and realizes the coagulative necrosis of the focal tissue through the instantaneous high temperature effect and cavitation effect produced by the ultrasound. At present, HIFU has been used in the clinical treatment of a variety of tumors, and has shown good therapeutic effects and application prospects in liver cancer, cervical cancer, uterine fibroids and prostate tumors. [0003] However, in the process of clinical promotion of HIFU technology, several key problems that hinder its further promotion need to be solved. First, in the process of HIFU treatment, the ultrasonic energy exhibits the characteristics of rapid a...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/02A61P35/00A61K49/22A61K47/68A61K45/06
CPCA61K41/0057A61K47/02A61P35/00A61K49/221A61K47/68A61K45/06A61K2300/00
Inventor 任文智吴爱国马雪华陈天翔张涛
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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