Nano composite material, preparation method thereof and application in HIFU synergist

Abstract

The invention discloses a nano composite material. The nano composite material is characterized by comprising an inner core component and an outer layer component; the inner core component comprises nano particles; the outer layer component is a multi-layer component including at least one of a stabilizing agent, a medical imaging contrast agent, a chemotherapeutic drug and a tumor-specific ligandor antibody; the mass ratio of the inner core component to the outer layer component is 1:10-1:0.5. The nano composite material has ultrasonic response activity and can efficiently convert absorbed ultrasonic waves into reactive oxide species or thermal energy. The invention further discloses a preparation method of the nano composite material and application in an HIFU synergist. The preparationmethod of the nano composite material is simple, easy to implement and beneficial for large-scale production and popularization; when the nano composite material is used for the HIFU synergist, the ablation effect of HIFU on deep lesions can be improved, the treatment effect on early-stage tumors with small size is improved, the tumor boundary can be subjected to iconography locating and identification, and the damage to the normal tissue of the tumor boundary is reduced.

Description

Technical field [0001] This application relates to a nano composite material, its preparation method and its application in HIFU synergist, belonging to the field of nano materials and HIFU. Background technique [0002] High intensity focused ultrasound (HIFU) is a non-invasive local tumor ablation technique. It focuses high-energy ultrasound to the focal tissue, and realizes the coagulative necrosis of the focal tissue through the instantaneous high temperature effect and cavitation effect produced by the ultrasound. At present, HIFU has been used in the clinical treatment of a variety of tumors, and has shown good therapeutic effects and application prospects in liver cancer, cervical cancer, uterine fibroids and prostate tumors. [0003] However, in the process of clinical promotion of HIFU technology, several key problems that hinder its further promotion need to be solved. First, in the process of HIFU treatment, the ultrasonic energy exhibits the characteristics of rapid a...

AI Technical Summary

Problems solved by technology

[0003] However, in the process of clinical promotion of HIFU technology, several key problems hindering its further promotion have been encountered and need to be solved

First, in the process of HIFU treatment, the ultrasonic energy shows the characteristics of rapid attenuation due to tissue absorption during the propagation process in the body. Therefore, for deep lesions, the ablation effect of HIFU will be reduced.

Although it is clinically possible to counteract the influence of tissue absorption by increasing the ultrasonic output power and enhance the ablation effect of HIFU on the lesion tissue, excessive output power will cause tissue damage on the ultrasonic propagation path. Therefore, increasing the output power cannot effectively solve the problem. Thorough ablation of deep lesions by HIFU

Second, HIFU is a non-invasive tumor ablation technology based on imaging. Therefore, effective detection of tumors, especially small early tumors, by imaging equipment such as MRI is a prerequisite for effective HIFU treatment. Tumor-specific imaging contrast agents for HIFU technology

Third, HIFU cannot accurately identify tumor tissue boundaries during the treatment of solid tumors, which will lead to tumor recurrence and metastasis caused by damage to normal tissues around the tumor during treatment and inability to completely ablate tumor boundaries

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