121results about How to "Improve ablation effect" patented technology

A laser ablation method and apparatus uses a laser device to generate a pulsed laser using a laser device and to project the pulsed laser onto an ablation target to be ablated. A probe is then used to measure an indicative property of the ablation target or of the pulsed laser projected on the ablation target. A control loop is used to optimize ablation effect by generating a feedback signal according to the measured indicative property, sending the feedback signal to a control unit, and adjusting an output parameter of the pulsed laser according to the feedback signal. The measured indicative property may be a size of the laser beam spot or a material composition. The ablation, the feedback and the adjustment may be performed dynamically.

A catheter for ablating body tissue of the interior regions of the heart includes a handle assembly, a shaft, and a distal tip section coupled to the distal end of the shaft. The distal tip section has a non-compliant and non-porous cap that has a tubular wall that defines a bore, and an ablation element that is housed inside the bore and spaced apart from the wall of the cap.

A catheter for ablating body tissue of the interior regions of the heart includes a handle assembly, a shaft, and a distal tip section coupled to the distal end of the shaft. The distal tip section has a non-compliant and non-porous cap that has a tubular wall that defines a bore, and an ablation element that is housed inside the bore and spaced apart from the wall of the cap.

Disclosed is a water-cooled radio frequency tumor extinguishing treatment system, which employs radio frequency heating means to place the target tissue in human body into between the melting electrode and leading electrode, a series resonant circuit is utilized in the radio frequency energy amplification, the rear portion of the melting electrode needle of the cold circulating pinshaped electrode is plated with an insulation coating layer, a bare tip is formed on the front end, thus the radio frequency energy capacity can radiate from around to the leading electrode, as a result, a melting zone is formed. The recirculated cooling water flows from the inlet pipe to the melting electrode needle, and returns to the recirculated cooling water subsystem from the exhaust pipe after heat interchange.

The invention provides a radio frequency ablation instrument and a radio frequency ablation system. The radio frequency ablation instrument comprises a control module used for generating a stimulation signal, a stimulation module used for generating the stimulation signal, a signal detection and processing module used for detecting the relevant parameters of the stimulation signal or the relevant parameter of radio frequency energy, and a radio frequency energy generating module used for generating radio frequency energy. The control module is electrically connected with the stimulation module, the signal detection and processing module and the radio frequency energy generating module. The radio frequency ablation instrument integrates the functions of a stimulation instrument and an ablation instrument and is simple to operate; the time wasted for lap joint of separate instruments is saved, so that the time for operation is saved and the available space and power supply resources of operating rooms are saved. Further, the switching between stimulation and ablation modes can be realized by selecting a single-electrode button or a double-electrode button, so that the requirements for stimulation and ablation of different parts can be met and good stimulation and ablation effects can be achieved.

The invention provides a preparation method of a tumor targeted therapy sustained release preparation. The preparation method comprises the following steps: (1) mixing titanium powder, aluminum powderand graphite powder, ball-milling and pressing, and performing high-temperature sintering under the condition of importing argon gas, thereby obtaining a Ti3AlC2 ceramic material; (2) crushing the material obtained in the step (1) into powder, placing in hydrofluoric acid to react, centrifugally washing, placing in a tetrapropylammonium hydroxide aqueous solution to react, and centrifugally washing to obtain a Ti3C2MXenes material; (3) dropping an aqueous solution of the Ti3C2MXenes material in a mixed aqueous solution of CTAC and TEA to react; and then adding TEOS, reacting under 80 DEG C, and centrifugally washing to obtain an MXene nano-sheet covered by mesoporous silica; and (4), performing polyethylene glycol surface modification on a material obtained in the step (3), covalently combining by using RGD polypeptide, and loading a medicine to obtain the preparation. The tumor targeted therapy sustained release preparation provided by the invention can realize the targeted therapy on tumor and acquire a good tumor-inhibiting effect.

The invention discloses an energy-accumulating microwave ablation needle for 915 MHz, which relates to a disposable therapeutic device. The invention is mainly composed of an ablation needle head, an ablation needle tube and a handle, the tail part of the handle is provided with a fixed frame and an insert which is used for external connection, a coaxial cable connector and a connecting terminal are arranged on the fixed frame, the interior of the ablation needle tube is provided with a microwave coaxial cable and a stainless steel capillary, a temperature sensor is arranged on an end seal of the ablation needle tube, the connecting terminal which is used for connecting the temperature sensor is arranged on the fixed frame, a water inlet and a water outlet are arranged on the fixed frame at the tail part of the handle, and the water outlet is communicated with the ablation needle tube. The microwave ablation needle of the invention is used for the ablation treatment of tumors and lesion tissues, when the invention is worked at the 915MHz microwave condition, the microwave impedance matching is good, the ablation range is big and the coking range of the surrounding solidification region of the needle is small. The invention can be used for the treatment of the ablation of big tumors and tissues with the large lesion range.

The invention relates to a chemical ablation device used for curing atrial fibrillation, in particular to a chemical ablation device which is used for ablation of the pulmonary vein and epicardium through a chemical reagent. The chemical ablation device used for curing the atrial fibrillation comprises a tong handle, a push rod, a tong body, a tong head, a far-side tong nozzle, a near-side tong nozzle, a first pipeline, and a second pipeline. According to the chemical ablation device used for curing the atrial fibrillation, syringe needles on the far-side tong nozzle and on the near-side tong nozzle are used for infusing the chemical ablation reagent to the pulmonary vein and atrium tissue near the pulmonary vein, and then complete ablation of vestibules surrounding the pulmonary vein is obtained with the chemical ablation method, and manufacturing cost of the ablation device and matching equipment is reduced, and cost of an atrial fibrillation surgical operation is greatly reduced.

The invention provides an ablation and mapping system, a control device and a multi-electrode ablation and mapping device. The system comprises: an ablation and mapping control device is used for generating and outputting multi-loop RF energy or single-loop RF energy according to the selection of the user and the set procedure; a stimulation signal is generated according to the predetermined procedure, the measurement result obtained from the measurement performed by the multi-electrode ablation and mapping device utilizing the stimulation signal is received, and whether the ablation is successful is judged according to the measurement result; the multi-electrode ablation and mapping device performs RF ablation for the part to be ablated according to the obtained multi-loop RF energy or single-loop RF energy; the part to be ablated is measured through the stimulation signal generated by the control device, and the measurement result is fed back to the control device. Application of the ablation and mapping system, the control device and the multi-electrode ablation and mapping device can control the ablation degree better, guarantee the ablation effect, decrease risk, reduce times of ablation, and decrease the surgery difficulty.

The invention discloses a titanium oxide nanometer composite material. The titanium oxide nanometer composite material is characterized by comprising titanium oxide nanometer bubbles; the kernels of the titanium oxide nanometer bubbles are gas; the average grain size of the titanium oxide nanometer bubbles is 10-200 nm. The titanium oxide nanometer composite material can achieve multi-modal imaging, and synergic treatment of malignant tumor is achieved through a sensibilization effect of sonodynamic / photodynamic / optical heat and ultrasonic cavitation on chemotherapeutic drugs.

The invention provides a device for recording pulse laser ablation dynamic changes. The device comprises a photoelectric detector, a beam splitter, a high-speed camera and a pulse delay control generator. The beam splitter is arranged on a laser transmitting path of a pulsed laser device, part of pulse laser transmitted by the pulsed laser device is transmitted through the beam splitter and acts on a target to be ablated and the other part of the pulse laser is reflected by the beam splitter to the photoelectric detector. The photoelectric detector is connected with the pulse delay control generator which is connected with the high-speed camera. The high-speed camera is located on one side of the target to be ablated and the lens of the camera aligns with the target to be ablated. The invention further provides a method for recording pulse laser ablation dynamic changes. According to the technical scheme, the defects in the background technology are overcome, and the method is simple, easy to operate, high in recording precision, and capable of being widely applied to the field that the laser and the matter act on each other in the air or under the liquid environment condition.

The invention discloses a novel multi-frequency tumor therapy apparatus. The novel multi-frequency tumor therapy apparatus is characterized by comprising a mechanical unit, a computer unit, a waterway circulation device, a control display module, a three-path optical fiber temperature measurement module, a microwave power source, a radio frequency power source, a radio frequency ablation needle, a microwave ablation needle, a double-path temperature measurement needle, an orientation module and a power module, wherein the mechanical unit comprises an enclosure and a rear enclosure cover; the control display module comprises a touch computer screen and a control panel, which are arranged outside the mechanical unit; the three-path optical fiber temperature measurement module, the microwave power source, the radio frequency power source, the power module and a circulating pump are arranged in the mechanical unit; the waterway circulation device comprises a water storage bag, a recovery bag and the circulating pump connected with the water storage bag and the recovery bag. According to the novel multi-frequency tumor therapy apparatus, the technical advantages of radio frequency ablation and microwave ablation are combined and comprehensively utilized to achieve optimal clinical tumor ablation effects; the novel multi-frequency tumor therapy apparatus is novel in design, convenient to operate and popularize and high in working efficiency and accuracy, and has good using effects.

The invention discloses a radiofrequency ablation device and a radiofrequency ablation control method, and relates to the field of radiofrequency ablation. The radiofrequency ablation device combinesfunctions of radiofrequency ablation with functions of multiple electrodes, radiofrequency power control is independently provided for each electrode, and ablation and the measured electrodes are shared, so that the ablation time is shortened, the ablation difficulty is reduced, the ablation safety is improved, and a better ablation effect is provided. According to the radiofrequency ablation control method, the temperature value of an ablation part is measured in real time, and the radiofrequency power is flexibly controlled so that the ablation degree can be effectively controlled, and the phenomena of incomplete ablation or excessive burning can be avoided.

The invention relates to a cardiovascular surgery tool used to mark and test the electrocardiosignal of left lung vein and guide fusion duct to the fusion part, wherein it uses shape memory alloy to weave fusion guider support, lung vein mark electrode, electrode connecting line, and transmission duct. The invention can confirm better deformation and return preset shape at lung vein. It can mark electrocardiosignal in lung vein, therefore, its heart edge and inner wall can form space to guide fusion duct, to improve surgery success.

The invention relates to an electrode device, an ablation catheter and an ablation system. The ablation system comprises an energy output device and an ablation catheter, and the energy output device is used for selectively conveying ablation energy to the ablation catheter; the ablation catheter comprises a catheter body and a catheter head end, the catheter head end is connected with the far end of the catheter body, the catheter head end comprises an electrode device, the electrode device comprises a first electrode and a second electrode which are axially distributed, the first electrode is located at the head end of the electrode device, and the first electrode and the second electrode are connected through an insulating part; and therefore, the ablation catheter can achieve bipolar pulse ablation, unipolar pulse ablation and radio frequency effects, especially the ablation catheter can also be used for pulse ablation of renal arteries, and the ablation mode is more flexible and convenient.

The invention relates to an ablation catheter device with a mapping function. The device comprises a handle, a wire, a pulse generation circuit, an operation control device, a metal valve, a first catheter and a flexible circuit, wherein the first catheter is located at the far end of the handle, the far end of the first catheter is movably connected with a second catheter, the second catheter and the first catheter are mutually nested, and a catheter head is arranged at the far end of the second catheter; the metal valve is sheet-shaped, one end of the metal valve is connected with the first catheter, the other end of the metal valve is connected with the second catheter, the flexible catheter comprises a non-conductive base material, and the non-conductive base material is fixed on the outer surface of the metal valve; a conductive layer is fixed on the outer surface of the non-conductive base material; and a non-conductive covering material partially covers the outer surface of the conductive layer, and the non-covered part of the conductive layer forms an electrode. The device has the advantages that the device can be well attached to endocardium tissue, ablation and mapping can be achieved, the ablation range and angle are reasonable, and operation is convenient.

A laser ablation method and apparatus uses a laser device to generate a pulsed laser using a laser device and to project the pulsed laser onto an ablation target to be ablated. A probe is then used to measure an indicative property of the ablation target or of the pulsed laser projected on the ablation target. A control loop is used to optimize ablation effect by generating a feedback signal according to the measured indicative property, sending the feedback signal to a control unit, and adjusting an output parameter of the pulsed laser according to the feedback signal. The measured indicative property may be a size of the laser beam spot or a material composition. The ablation, the feedback and the adjustment may be performed dynamically.

The invention provides an electrode assembly, an electrophysiological catheter and an electrophysiological system. The electrode assembly comprises an electrode main body, a sub-electrode assembly and an electric transmission line, wherein the sub-electrode assembly and the electric transmission line are arranged on the electrode main body; the electric transmission line comprises a plurality of ablation lines; the sub-electrode assembly comprises a plurality of first ablation electrodes and a plurality of second ablation electrodes; each ablation line comprises a transmission main line, a first transmission branch line and a second transmission branch line; the first ablation electrodes and the second ablation electrodes are electrically connected with the output ends of the corresponding first transmission branch lines and the output ends of the corresponding second transmission branch lines respectively; and the input ends of the first transmission branch lines and the input ends of the second transmission branch lines are intersected at the transmission main lines. The transmission branch lines of different ablation electrodes are arranged in a parallel manner, so that the resistance value of the ablation lines is reduced, the current resistance of the ablation lines is improved, meanwhile, the ablation boundary of the catheter is also improved, and the ablation depth is increased.

The invention discloses an ultrasonic transducer array, an ultrasonic intervention treatment system and an ultrasonic ablation catheter, and belongs to the technical field of medical instruments. The ultrasonic transducer array comprises a first ultrasonic transducer set including a first ultrasonic transducer for ultrasound ablation, a second ultrasonic transducer set including a second ultrasonic transducer for ultrasonic imaging, a metallic conductive support, wherein the first ultrasonic transducer and the second ultrasonic transducer are jointly installed, and which is respectively connected with the grounding ends of the first ultrasonic transducer and the second ultrasonic transducer, an ablation electrode leading-out wire set respectively connecting with the electrode end of the first ultrasonic transducer, an imaging electrode leading-out wire set respectively connecting with the electrode end of the second ultrasonic transducer, and a common-ground electrode leading-out wire connecting with the metallic conductive support. The ultrasonic transducer array has the advantages of good positioning and ablation effects, and realizes mixing frequencies work. The ultrasonic transducer array can be used for ultrasound ablation and internal lumen imaging.

The invention discloses a nano composite material. The nano composite material is characterized by comprising an inner core component and an outer layer component; the inner core component comprises nano particles; the outer layer component is a multi-layer component including at least one of a stabilizing agent, a medical imaging contrast agent, a chemotherapeutic drug and a tumor-specific ligandor antibody; the mass ratio of the inner core component to the outer layer component is 1:10-1:0.5. The nano composite material has ultrasonic response activity and can efficiently convert absorbed ultrasonic waves into reactive oxide species or thermal energy. The invention further discloses a preparation method of the nano composite material and application in an HIFU synergist. The preparationmethod of the nano composite material is simple, easy to implement and beneficial for large-scale production and popularization; when the nano composite material is used for the HIFU synergist, the ablation effect of HIFU on deep lesions can be improved, the treatment effect on early-stage tumors with small size is improved, the tumor boundary can be subjected to iconography locating and identification, and the damage to the normal tissue of the tumor boundary is reduced.

The invention provides an ablation catheter and an ablation system. The ablation catheter comprises a catheter body, a control handle, a double-deck sacculus and at least one temperature detection unit. The control handle is connected with the proximal end of the catheter body. The double-deck sacculus comprises an outer sacculus and an inner sacculus, the outer sacculus encloses the outside of the inner sacculus, and the outer sacculus and the inner sacculus are both arranged at the distal end of the catheter body. The temperature detection unit is arranged in the space between the inner sacculus and the outer sacculus, and is electrically connected to the control handle through the catheter body. According to the present invention, when temperature information on the outer surface of thedouble-deck sacculus is estimated based on temperature information detected through the temperature detection unit in the ablation catheter and ablation system, the accuracy of the estimated temperature information on the outer surface of the double-deck sacculus can be improved, and furthermore, the ablation effect of the ablation catheter and ablation system can be improved.

Disclosed are photosensitizers that include a polyol moiety covalently bonded to a fused aromatic moiety. Also disclosed is a method for improving UV laser ablation performance of a coating, such as a cationic UV curable coating, by incorporating an oxalyl-containing additive into the cationic UV curable or other coating. Oxalyl-containing sensitizers having the formula Q-O—C(O)—C(O)—O—R1, wherein Q represents a fused aromatic moiety and R1 is an alkyl or aryl group, are also disclosed, as are oxalyl-containing oxetane resins, oxalyl-containing polyester polyols, and cationic UV curable coating formulations that include oxalyl-containing additives.

The embodiment of the invention provides a cooperative pulse generation device, system and method. The cooperative pulse generation device comprises a driving circuit and a pulse generation circuit; the driving circuit receives a first control signal and a second control signal sent by an upper computer, converts the first control signal into a first driving signal and converts the second control signal into a second driving signal; the pulse generation circuit comprises a first power supply, a second power supply, a first pulse generation module and a second pulse generation module; and the first pulse generation module stores electric energy provided by a first power supply and discharges under the control of the first driving signal to form a first pulse signal, and the second pulse generation module stores electric energy provided by a second power supply and discharges under the control of the second driving signal to form a second pulse signal. According to the embodiment, the first pulse signal and / or the second pulse signal with different widths can be selectively formed, so that the purpose of applying the composite pulse to the load is achieved.

The invention relates to the field of medical instruments, and in particular relates to a conformal ablation needle. The prior ablation needle devices have the problems that a tumor cannot be wrappedin a conformal mode, the ablation effect is affected, electrode needles cannot be accurately guided to accurately reach the tumor boundary, and a plurality of electrode needles cannot be distinguished. The invention provides the conformal ablation needle. The conformal ablation needle comprises an interventional catheter, imaging equipment for guiding and positioning, a hollow ablation needle arranged at the end part of the interventional catheter and provided with a sharp end, and an umbrella-shaped electrode needle accommodated in the ablation needle. The ablation needle is arranged at the end part of the interventional catheter and can movably extend out, each electrode needle forming the umbrella-shaped electrode needle is a flexible electrode needle, and the imaging equipment comprises a ultrasonic probe arranged at the insertion end part of the interventional catheter, and an optical fiber lens assembly arranged at the front end of the ablation needle. According to the present invention, irregular tumors can be fully wrapped in a conformal mode, the electrode needles are guided to accurately reach the tumor boundary position, and the position of each electrode needle is distinguished, so that ablation treatment can be conducted on tumor tissue in a targeted mode in the follow-up process.

The invention discloses an ablation catheter which comprises a catheter body and a head electrode. The near end of the head electrode is connected with the far end of the tube body. The outer surface of the head electrode serves as a binding face attached to the target tissue area. And the outer surface is one of a spherical surface, a spherical crown surface and an arc surface. The head electrode is used for transferring ablation energy to the target tissue area for ablation. Due to the fact that the outer surface of the head electrode is the spherical surface or the spherical crown surface or the arc surface, when the ablation catheter is attached to a target tissue area, the head of the ablation catheter can achieve attachment of the head electrode to the target tissue area in any direction, and therefore energy can be accurately and intensively applied to the target tissue area instead of being applied to blood. The target tissue area is ablated more thoroughly, and the ablation effect is better.

The invention provides a self-adaptive follow-up pulse ablation system which comprises a power supply system, an isolation transformer, a high-voltage power supply, an energy storage system, a pulse generation system, a pulse monitoring system, a pulse switching system, an electrode system, a control system, an isolation system, an acquisition system, a positioning system, a follow-up system, an upper computer system and a cloud platform. The optimal treatment parameter range is provided for each treatment process by adopting a cloud platform and an artificial intelligence algorithm, and the pulse (group) parameters are adaptively adjusted in real time in the treatment process, so that the shaking degree and the temperature rise condition of the biological tissue are both within the threshold range, the relative displacement and the relative rotation of the electrode and the treatment part are reduced, and the treatment effect is improved. The optimal treatment effect and the minimum side effect are achieved; meanwhile, the self-adaptive follow-up pulse ablation system and method can reduce the influence of anisotropy of biological tissues at the tumor part, so that the pulse ablation is more uniform, and the ablation effect is better.