Multifunctional synergistic pharmaceutical composition based on adriamycin and construction method of multifunctional synergistic pharmaceutical composition

A doxorubicin and multi-functional technology, applied in the field of pharmaceutical preparations and supramolecular chemistry, can solve the problems of limiting the optimization and application of hydrophobic small molecule compounds containing phenolic hydroxyl conjugates, poor activity of phenolic hydroxyl groups, etc., to prolong the circulation time in the body, Good uniformity, avoiding the effect of protease degradation
CN107952082AActive Publication Date: 2018-04-24CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2018-04-24

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Abstract

The invention relates to a multifunctional synergistic pharmaceutical composition based on adriamycin. According to the pharmaceutical composition, natural hydrophobic small molecules having a conjugated structure are covalently coupled with a polysaccharide skeleton to form an anti-angiogenesis drug, the anti-angiogenesis drug is physically mixed with the conjugated structure-modifying mitochondria damage peptide derivative and adriamycin, and the pharmaceutical composition of a nano size is assembled by virtue of various supramolecular driving forces. The pharmaceutical composition has the advantages of simultaneously regulating a tumor micro environment and tumor cells, reversing the anti-apoptosis characteristics of tumor cells, and maximizing the antitumor effect of the adriamycin. Inaddition, the multifunctional synergistic pharmaceutical composition has the advantages of the adriamycin such as high load, high stability and high targeting. The multifunctional synergistic pharmaceutical composition based on the adriamycin is compatible with corresponding medicinal auxiliary materials to prepare antitumoar drug preparations for injection, oral administration or external use. The multifunctional synergistic pharmaceutical composition is prepared by virtue of a multi-component supramolecular combination construction, so that the operation is simple, and the industrialized production is easy to realize.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations and supramolecular chemistry, and relates to a doxorubicin-based multifunctional synergistic pharmaceutical composition and a construction method thereof. Background technique

[0002] The clinical application of the traditional chemotherapy drug doxorubicin often faces the dilemma of poor curative effect and severe side effects. The poor curative effect of doxorubicin alone is mainly related to the physiological complexity of the tumor. Tumor cells can continue to produce proliferation signals, anti-growth inhibitory signals, initiate anti-apoptotic mechanisms, and at the same time induce angiogenesis and promote tissue invasion and metastasis (Hanahan D, Weinberg R A. The hallmarks of cancer.[J].Cell, 2000 , 100(1):57.). Tumor resistance to apoptosis is mainly related to mitochondria. Mitochondria are originally a "suicide weapon arsenal", but due to changes in the structure and func...

Claims

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