Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

63 results about "Neuroprotective drug" patented technology

Definitions - neuroprotective drugs. Neuroprotective Drugs (n.) 1.(MeSH)Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after.

Application of ferulic acid derivative as neuroprotective drug

The invention relates to application of a ferulic acid derivative to preparation of drugs for treating and / or preventing neurodegenerative diseases related to nerve cell injury. The neurodegenerative diseases includes but not limited Alzheimer's disease, vascular dementia, Parkinson's disease, multiple sclerosis, diabetic neuropathy, ischemia stroke and hemorrhagic stroke.
Owner:SICHUAN UNIV

Polysaccharide extract from Lycium barbarum as neuroprotective agent against beta-amyloid peptide neurotoxicity

InactiveUS20050170028A1Prevent neuronal deathOrganic active ingredientsBiocideDiseaseΒ amyloid peptide
Extracts of Lycium barbarum serve as a neuroprotective agent against β-amyloid peptide neurotoxicity which thus permits their use for the treatment of Alzheimer's disease (AD) and for the prevention of neuronal loss in aging against the accumulation of β-amyloid peptide in the brain. Stress kinases (c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase) are used as a technological platform for screening neuroprotective drugs.
Owner:VERSITECH LTD

PSD-95 inhibitor

The invention relates to the field of medicine synthesis, and discloses a PSD-95 inhibitor. The PSD-95 inhibitor disclosed by the invention is used for preparing a pharmaceutical composition for treating diseases, and the pharmaceutical composition is used for preparing neuroprotective drugs after ischemic brain injury.
Owner:CHENGDU AODA BIOTECHNOLOGY CO LTD

Use of 5.alpha.-androstane (alkyl)-3.beta.,5,6.beta.-triol in preparation of neuroprotective drugs

Disclosed is the use of 5α-androstane(alkyl)-3β,5,6β-triol in preparing neuroprotective drugs. The compound has significant protective effect against neuron injuries caused by cerebral ischemia, spinal cord ischemia or hypoxia and has no obvious toxic reaction within effective dose thereof.
Owner:GUANGZHOU CELLPROTEK PHARMA

Application of nicotinamide phosphoribosyltransferase in preparation of neuroprotective drugs

InactiveCN103961691AStimulate or enhance regenerationPromote repairNervous disorderPeptide/protein ingredientsBrain HypoxiaRisk stroke
Belonging to the pharmaceutical field, the invention relates to application of nicotinamide phosphoribosyltransferase (NAMPT) in preparation of neuroprotective and rehabilitation drugs. Experiments of the invention show that NAMPT recombinant protein can penetrate the blood-brain barrier to significantly reduce the volume of ischemic brain injury and alleviate white matter injury after ischemic brain injury; the NAMPT recombinant protein can significantly improve long-term behaviors after ischemic brain injury; the NAMPT recombinant protein can raise revascularization related factors to enhance revascularization after brain hypoxia and neuron regeneration after brain hypoxia, and promote post-injury neurologic function reestablishment; and by mediating oligodendrocyte regeneration and alleviating the demyelination effect of local lysolecithin, the NAMPT recombinant protein can promote restoration of white matter after injury and strengthen post-injury neurologic function reestablishment. Results show that the NAMPT recombinant protein plays a long-term neuroprotective role in drugs treating cerebral stroke, traumatic brain injury and multiple sclerosis, and can be used as a neuroprotective drug to treat acute and chronic injury caused by brain stroke.
Owner:FUDAN UNIV

Chrysotoxine bibenzyl derivative and preparation method and application thereof

The present invention discloses a chrysotoxine bibenzyl derivative shown as a formula I. R1 represents C=O, CH2, NH, S=O or a covalent bond; R2 represents alkyl, phenyl, substituted phenyl, benzene ring substituted C1-3 alkyl, C5-C6 cycloalkyl, and a pentabasic or hexahydric unsaturated heterocyclic group containing one or more O, S and N. The invention also discloses a simple and efficient preparation method of the chrysotoxine bibenzyl derivative, and application of the derivative to the preparation of neuroprotective drugs and drugs for treating Alzheimer disease. The chrysotoxine 4-O-substituted bibenzyl derivative has significant protective effect on A beta-induced neuronal apoptosis, and is a potential novel chemical entity for the treatment of AD.
Owner:CHINA PHARM UNIV

Mixed-element terpene compound and preparation method and application thereof

The invention relates to a mixed-element terpene compound and an application thereof. The preparation method comprises the following steps: extracting and separating a Durimane Meroterpenoid compoundfrom fermentation liquor of South China Sea soft coral co-epiphytic fungi Alternanthera sp. The mixed-element terpenoid compound can effectively inhibit excitability of mouse primary cerebral cortex neurons, can relieve the stimulation effect of epilepsy inducer 4-aminopyridine on neurons, and can be used for development of neuroprotective drugs. The invention provides a lead compound and a novelactive skeleton for research and development of neuroprotective drugs, and is beneficial to development and utilization of marine medicinal resources.
Owner:子辰海洋医药科技(上海)有限公司

New codonopsis pilosula alkynol compound as well as preparation method and application thereof and pharmaceutical composition thereof

The invention discloses a new codonopsis pilosula alkynol compound 1 extracted from codonopsis pilosula, a preparation method thereof, a pharmaceutical composition containing a new codonopsis pilosula alkynol compound and application in a neuroprotective drug, especially senile dementia. Pharmacological experiments show that the compound embodies neuroprotection activity and has good neuroprotection activity in a sodium nitroprusside injury primary neuron model and a glutamic acid-induced primary neuron toxicity model. A structural formula of the compound 1 is as shown in the specification.
Owner:NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Novel application of betulin derivatives in preparation of drugs for repairing nerve injury

The invention provides a novel application of betulin derivatives shown in structural formulas I, II, III, IV, V, VI, VII, VIII, IX and X or pharmaceutically acceptable salts and pharmaceutical compositions of the betulin derivatives in preparation of medicines for repairing nerve injury. The compound can be further used for preparing medicines for treating neurodegenerative diseases, traumatic brain injury and stroke. According to the invention, the medicinal field of the betulin derivative modified by the mother nucleus structure is expanded, and a new choice is provided for developing neuroprotective drugs.
Owner:NANTONG UNIVERSITY

Application of dicarboxylic acid and ester compounds thereof

The invention provides an application of dicarboxylic acid and ester compounds thereof and in particular relates to an application of the compounds to preparation of neuroprotective drugs. In a chemical formula in the specification, R1 is hydrogen or methyl; R2 is isopropyl or isobutyl; R3 is carboxyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, borneol oxycarbonyl or 5-tetrazole; a is 0 or 1; b is 0 or 1; c is an integer from 1 to 4; b is 0 when a is 0; b is 0 or 1 when a is 1. The compounds have relatively strong protective effects on glutamate-induced neuron damages.
Owner:NANJING MEDICAL UNIV

Indole N-glycoside compound, extraction method, and application in preparing drugs for preventing and treating nervous system diseases

The invention discloses an indole N-glycoside compound, an extraction method, and an application in preparing drugs for preventing and treating nervous system diseases. The indole N-glycoside compoundhas a structure represented by a formula (I) in the specification. The indole N-glycoside compound of the invention can effectively protect PC12 cell damages caused by CoCl2, and the result suggeststhat the compound of the invention can be used as a neuroprotective drug.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE

PSD-95 inhibitor

The invention relates to the field of medicine synthesis, and discloses a PSD-95 inhibitor. The PSD-95 inhibitor disclosed by the invention is used for preparing a pharmaceutical composition for treating diseases and an application of the pharmaceutical composition in preparing a neuroprotective drug after ischemic brain injury.
Owner:CHENGDU AODA BIOTECHNOLOGY CO LTD

Application of Terreumol A in preparation of neuroprotective drug

InactiveCN105078955AOrganic active ingredientsNervous disorderApoptosisChromaffin tumor
The invention discloses an application of Terreumol A in preparation of a neuroprotective drug and belongs to the field of drugs. The research shows that an apoptosis model of rat chromaffin tumor cell strains PC12 cultured in vitro can be effectively established with the application of 20 mu mol / L of Abeta25-35; Terreumol A can be partially resistant to Abeta25-35 induced PC12 apoptosis and can be further researched and developed to prepare the neuroprotective drug.
Owner:林天样

Application of composition containing MG 53 mutant in preparation of neuroprotective drugs

PendingCN108310365AMeeting long-term treatment needsEasy to learnNervous disorderPeptide/protein ingredientsAtaxia-telangiectasiaMultiple system atrophy (MSA)
The invention discloses application of a composition containing an MG 53 mutant in preparation of neuroprotective drugs. The research results prove that the MG53 mutant has a prominent neuroprotectiveeffect and can cross the blood-brain barrier, thus being applied to prevention or treatment of multiple neurodegenerative diseases such as ischemic stroke, brain atrophy, senile dementia, multiple system atrophy, brain atrophy, motor neuron diseases, ataxia telangiectasia, spinal muscular atrophy and optic atrophy.
Owner:MUDANJIANG YOUBO PHARMA CO LTD

Novel quinolone alkaloid in Evodia rutaecarpa, and preparation method, application and pharmaceutical composition of such quinolone alkaloid

The invention discloses a novel quinolone alkaloid compound 1 extracted from Evodia rutaecarpa, a preparation method of the novel quinolone alkaloid compound, a pharmaceutical composition containing the novel quinolone alkaloid compound and application thereof to neuroprotective drugs, in particular to drugs for treating the Alzheimer's disease. Pharmacological experiments show that neuroprotective activity is embodied in the novel quinolone alkaloid compound, in other words, the novel quinolone alkaloid compound has excellent neuroprotective activity in a sodium-nitroprusside-induced primary neuron damage model and a glutamate-induced primary neuron toxicity model.
Owner:NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Application of caspofungin in preparation of neuroprotective drugs

The invention relates to an application of caspofungin in preparation of neuroprotective drugs, and belongs to the field of biological medicines. It is found that the caspofungin is used for inhibiting or treating neuronal or axonal degeneration, is especially used for treating vision-related neurodegeneration and nervous system diseases, more especially has the protective effect on the vision-related neurodegeneration, can remarkably relieve retinal ganglion cell and axonal damage, and has the nerve cell protection function.
Owner:CENT SOUTH UNIV

Neuroprotective drug for cerebral arterial thrombosis

The invention discloses a neuroprotective drug for cerebral arterial thrombosis, and belongs to the field of biotechnology drugs. The drug is prepared by taking a DNA tetrahedron as an active component and adding pharmaceutically acceptable auxiliary components. The drug disclosed by the invention can be used for effectively protecting cranial nerves and greatly reducing the infarction area caused by cerebral arterial thrombosis, and can be used for improving the behavioral capacity of patients with relatively light illness conditions; and for patients with relatively severe illness, the illness can be stabilized, and the treatment window period is prolonged.
Owner:SICHUAN UNIV

Application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs

The invention discloses application of 4-methoxybenzyl alcohol in preparation of neuroprotective drugs. 4-methoxybenzyl alcohol may reduce injury of primary cortical neurons OGD / Rep of fetal rats and neuron morphological structure injury and increase survival rate of OGD / Rep injured cortex; the release of OGD / Rep injured cortical neuron NO is reduced, activity of SOD (superoxide dismutase) in cells is improved, generation of MDA (methane dicarboxylic aldehyde) is inhibited, apoptosis of nerve cells may be inhibited through significant up-regulation of Bcl-2 protein expression and down-regulation of Bax protein and Caspase-3 protein expression, neuroprotective effect is good, neuroprotective drugs may be produced, and nerve injury is reduced; in addition, the 4-methoxybenzyl alcohol may promote synapse growth of nerve cells, up-regulate synapse growth related proteins, promote repair of the nerve cells and treat nerve injury.
Owner:YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE

Biflavone compound with neuroprotective effect and extraction and separation method thereof

The invention relates to the technical field of traditional Chinese medicines, in particular to a biflavone compound extracted from maidenhair flowers as well as a preparation method and application thereof. The molecular formula of the biflavone compound is C33H24O16, the biflavone compound is named as 8,8'-methylene bis(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-chromone, the chemical structural formula of the biflavone compound is shown in the specification, and the biflavone compound is used for preparing neuroprotective drugs. The preparation method sequentially comprises the following steps: ethanol extraction, n-butyl alcohol extraction, silica gel column chromatography, polyamide, and Sephadex LH-20. According to the method, the biflavone compound with high purity can be simply, conveniently and quickly extracted and separated, has a neuroprotective effect, can be prepared into tablets, granules, capsules and other dosage forms by being supplemented with pharmaceutically common auxiliary materials, and is used for improving and treating depression and other neurological diseases. Therefore, the biflavone compound can be used as a natural product to develop new drugsof traditional Chinese medicines, and has a wide application prospect.
Owner:大连五舟神草健康科技有限公司

New Codonopsis Alcohol Compounds, Preparation Method, Application and Pharmaceutical Composition thereof

The invention discloses a new codonopsis pilosula alkynol compound 1 extracted from codonopsis pilosula, a preparation method thereof, a pharmaceutical composition containing a new codonopsis pilosula alkynol compound and application in a neuroprotective drug, especially senile dementia. Pharmacological experiments show that the compound embodies neuroprotection activity and has good neuroprotection activity in a sodium nitroprusside injury primary neuron model and a glutamic acid-induced primary neuron toxicity model. A structural formula of the compound 1 is as shown in the specification.
Owner:NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Oxidized isoaporphine alkaloid derivative as well as preparation method and anti-depression application thereof

The invention discloses an oxidized isoaporphine alkaloid derivative with a structure as shown in a formula I, wherein R1 and R2 are independently selected from H, F, Cl and methoxyl respectively; and n is an integer of 2-6. An in-vitro activity experiment shows that the oxidized isoaporphine alkaloid derivative has relatively good protection activity on corticosterone-induced PC12 cell injury, which indicates that the corticosterone-induced PC12 cell injury has a neuroprotection function; in-vivo anti-depression drug effect evaluation shows that the oxidized isoaporphine alkaloid derivative can remarkably increase the moving distance and the moving speed in an open field experiment and remarkably shorten the immobility time in a tail suspension experiment and a forced swimming immobility experiment, which indicates that the oxidized isoaporphine alkaloid derivative can remarkably improve the depression state. The invention also discloses an application of the oxidized isoaporphine alkaloid derivative in preparation of an antidepressant drug. The invention also discloses an application of the oxidized isoaporphine alkaloid derivative in preparation of a neuroprotective drug.
Owner:CHINA PHARM UNIV

Drug composition of amantadine hydrochloride and medical application of drug composition

The invention discloses a drug composition of amantadine hydrochloride and medical application of the drug composition. The drug composition of the amantadine hydrochloride is prepared from the amantadine hydrochloride and a natural product compound (I) separated from the dry leaf of radix notoginseng and having a novel structure; when the amantadine hydrochloride and the natural product compound (I) are singly used, a neuroprotective effect is weaker; when the amantadine hydrochloride and the natural product compound (I) are combinedly used, the neuroprotective effect is remarkably improved. The drug composition can be developed into a neuroprotective drug, and has outstanding substantive distinguishing features and a remarkable progress in comparison to the prior art.
Owner:WENZHOU JUYICHUANG TECH CO LTD

Application of depsidone compound in preparation of neuroprotective drugs

The invention discloses an application of a depsidone compound in preparation of neuroprotective drugs. The depsidone compound is proved to significantly improve the survival rate of cerebral cortex nerve cells, and has an extremely significant reversal effect on MPP+ induced cerebral cortex nerve cell damage; in addition, the depsidone compound is efficient and free of toxic and side effects on patients. Therefore, the depsidone compound can be applied to preparation of the neuroprotective drugs, preparation of drugs for relieving / reversing MPP+ induced nerve cell damage and preparation of drugs for preventing / treating neurodegenerative diseases. A new technology, a new method and a new means are provided for efficiently treating neurodegenerative diseases, especially Parkinson's disease,and a good application prospect and a wide development space are achieved.
Owner:GUANGDONG OCEAN UNIVERSITY +1

A novel sesquiterpene compound and its preparation method and application

The invention discloses the compound represented by formula (A), or its stereoisomer, or its salt, or its solvate, or its prodrug, or its metabolite. The test results show that the sesquiterpene compound provided by the invention can effectively protect nerve cells, and its protective effect is even better than that of the positive control drug. Therefore, the sesquiterpene compound provided by the present invention, or its stereoisomer, or its salt, or its solvate, or its prodrug, or its metabolite is used in the preparation of neuroprotective drugs, especially in the preparation of preventive and / Or in medicines for the treatment of neurodegenerative diseases, it has a good application prospect. The invention provides a new option for clinically screening and / or preparing neuroprotective drugs.
Owner:CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE

Active ingredients, extraction method and application in the preparation of neuroprotective drugs

The present invention relates to the active ingredient of A. chinensis, which is characterized in that it comprises oleanolic acid-type triterpenoid saponins and / or phenylacetonitrile glycosides, and the structural formula of the oleanolic acid-type triterpenoid saponins is as follows: The structural formula of phenylacetonitrile glycosides is shown below: . The present invention also provides a preparation method of the active ingredient of the Fructus Arugulae. According to the experiment, the invention finds that the active components of Fructus chinensis have a good protective effect on the oxidative damage of nerve cells NSC34, and can be used for preparing neuroprotective drugs or health care products.
Owner:HENAN UNIVERSITY

Application of (22trans)-3β-hydroxy-cholesta-5,22-dien-24-one in neuroprotective drugs

The invention relates to a compound (22-trans)-3beta-hydroxyl-cholester-5,22-diene-24-ketone, a preparation method and an application thereof. The compound is obtained through extraction from Caulerpa racemosa, pressure reduction and concentration, extraction, silica gel column chromatography and gel column chromatography purification; which has the structure which is measured via a rationalize constant and defined via a spectrum data analysis. Multiple in-vitro SH-SY5Y cell injury neuroprotection experiments prove that the compound has obvious protection effect to beta-amyloid protein 25-35(Abeta-25-35)injury-SY5Y cell, and can be used for preparing the neuroprotectants and medicines to prevent and treat Alzheimer's disease.
Owner:南通药享科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products