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Active ingredients, extraction method and application in the preparation of neuroprotective drugs

An active ingredient, the technology of Radix chinensis, applied in the field of pharmacy, can solve the problem of not having Radix chinensis and other problems, and achieve the effects of no cytotoxicity, less technical difficulty, and abundant resources.

Active Publication Date: 2021-04-09
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the application of Semen chinensis in protecting nerves

Method used

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  • Active ingredients, extraction method and application in the preparation of neuroprotective drugs
  • Active ingredients, extraction method and application in the preparation of neuroprotective drugs
  • Active ingredients, extraction method and application in the preparation of neuroprotective drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]The heterospermia active ingredient, which includes a pier-type triterpenoid sapase-based compound and / or a phenycetonitrile compound, and the structural formula of the ostrid acid-type triterpenoid saponide compound 1 is shown below:

[0038];

[0039]The structural formula of the phenylacetitrid compound 2 is as follows:

[0040].

[0041]The method of preparing the active ingredient of the above-mentioned cyancy is specifically including the steps of:

[0042]1) Three times of flashing of the brittle blue-razor or fried blue 葙子 9.5kg using 50% ethanol 50L (first flash extraction 3 min, second flash extraction 5 min, the third flashes 5 min) Ethanol gradient elution, 20% ethanol eluent, reduced pressure recovery solvent, resulting in 20% ethanol dipping A; 60% ethanol eluent, reduced pressure recovery solvent, resulting in 60% ethanol dip B;

[0043]2) Dissolve 20% ethanol dip, dissolve with 20 ml of methanol, silica gel, via thin layer chromatographic silica gel chromatography, select a vo...

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PUM

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Abstract

The present invention relates to the active ingredient of A. chinensis, which is characterized in that it comprises oleanolic acid-type triterpenoid saponins and / or phenylacetonitrile glycosides, and the structural formula of the oleanolic acid-type triterpenoid saponins is as follows: The structural formula of phenylacetonitrile glycosides is shown below: . The present invention also provides a preparation method of the active ingredient of the Fructus Arugulae. According to the experiment, the invention finds that the active components of Fructus chinensis have a good protective effect on the oxidative damage of nerve cells NSC34, and can be used for preparing neuroprotective drugs or health care products.

Description

Technical field[0001]The present invention is in the field of pharmaceutical technology, and more particularly to the effective components of bluebutoma (sputum perne-type triterpenoids and / or phenylacetonitrid compounds), extraction methods and their applications in the preparation of neuroprotective drugs or health products.Background technique[0002]The nerve degenerative disease is characterized by the sexual injury of neuronal cells and the loss of neurons. As time is degraded, the movement or cognitive function is damaged, which belongs to a class of disability, severe death. Complex disease. Common neurodegenerative diseases include Alzheimer's disease (AD), myocytic latochages (ALS), Parkinson Disease (PD), Huntington (HD), and spinal cord cerebellar disorders (SCA). Although the pathology of neurodegenerative diseases is still unclear, many reports have revealed that oxidation stress, resulting in a large number of reactive oxygen free radicals (ROS) and DNA oxidation. In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00C07H15/203C07H1/06A61P25/28A23L33/11A23L33/105
CPCA23V2002/00A23L33/105A23L33/11A61P25/28C07H1/06C07H15/203C07J63/008A23V2200/322A23V2250/2136
Inventor 丛悦郭敬功沈姗师冰洋
Owner HENAN UNIVERSITY
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