Active ingredients, extraction method and application in the preparation of neuroprotective drugs

An active ingredient, the technology of Radix chinensis, applied in the field of pharmacy, can solve the problem of not having Radix chinensis and other problems, and achieve the effects of no cytotoxicity, less technical difficulty, and abundant resources.
CN110204589BActive Publication Date: 2021-04-09HENAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
HENAN UNIVERSITY
Publication Date
2021-04-09

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Abstract

The present invention relates to the active ingredient of A. chinensis, which is characterized in that it comprises oleanolic acid-type triterpenoid saponins and / or phenylacetonitrile glycosides, and the structural formula of the oleanolic acid-type triterpenoid saponins is as follows: The structural formula of phenylacetonitrile glycosides is shown below: . The present invention also provides a preparation method of the active ingredient of the Fructus Arugulae. According to the experiment, the invention finds that the active components of Fructus chinensis have a good protective effect on the oxidative damage of nerve cells NSC34, and can be used for preparing neuroprotective drugs or health care products.
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Description

Technical field

[0001] The present invention is in the field of pharmaceutical technology, and more particularly to the effective components of bluebutoma (sputum perne-type triterpenoids and / or phenylacetonitrid compounds), extraction methods and their applications in the preparation of neuroprotective drugs or health products.Background technique

[0002] The nerve degenerative disease is characterized by the sexual injury of neuronal cells and the loss of neurons. As time is degraded, the movement or cognitive function is damaged, which belongs to a class of disability, severe death. Complex disease. Common neurodegenerative diseases include Alzheimer's disease (AD), myocytic latochages (ALS), Parkinson Disease (PD), Huntington (HD), and spinal cord cerebellar disorders (SCA). Although the pathology of neurodegenerative diseases is still unclear, many reports have revealed that oxidation stress, resulting in a large number of reactive oxygen free radicals (ROS) and DNA oxidation. In ...

Claims

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