266 results about "Oleanonic acid" patented technology

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

A pharmaceutical composition for preventing or treating hepatitis C is provided, including oleanolic acid derivatives as an active ingredient and a pharmaceutically acceptable carrier. A method for preventing or treating hepatitis C in a subject in need thereof is also provided by administering the subject the pharmaceutical composition given above.

Bougainvillea glabra triterpenoid saponin compounds comprise a triterpenoid saponin with a skeleton containing oleanolic acid, wherein the 3-site of the oleanolic acid is connected with 1'-site of beta-D-pyran glucuronic acid by an oxygen atom, and comprise other two derivates with the same skeleton structure; and the compound as shown in formula (I) is preferable, in the formula (I), R1 is methyl or hydrogen and R2 is hydrogen or beta-D-pyran xylose. The bougainvillea glabra triterpenoid saponin compounds 1-3 are new plant sourced hypoglycemic drugs. Pharmaceutical compositions with the compounds as active ingredients and a preparation method and application thereof in making the hypoglycemic drugs are provided.

The invention discloses a special lubricating oil for mechanical gears. The special lubricating oil for mechanical gears is composed of phosphite, talcum powder, phosphoric acid, sorbitol, p-hydroxy benzyl aldehyde, methyl citrate, monomethyl citrate, tetrahydropalmatine, mesembryanthemoidigenic acid, isodehydrocostus lactone, lupeol palmitate, oleanonic acid, naphthenic oil, butter, tetrahydroxyethyl ammonium swelling oily agent, aluminum disulfide, aromatic hydrocarbon, paraffin base, succimide succinate, boron nitride, fish gallbladder, fatty soap, glycerol, polyalkenyl succinimide, graphite, amino monothioester and molybdenum dialkyldithiocarbamate. Compared with the prior art, the special lubricating oil for mechanical gears can lower the loss of engine oil, increases the environment-friendly effect of the original special engine oil, enhances the adhesion of lubricating oil, increases the lubricating effect of the engine oil, and lowers the friction, so that the mechanical gears can well operate, thereby enhancing the service life of the machine. Thus, the special lubricating oil for mechanical gears has popularization and application value.

The invention discloses a new medical application of oleanolic acid in cervical cancer resistance, and also discloses clinically acceptable pharmaceutical preparations such as tables, capsules, pills, injections and the like which are prepared by using oleanolic acid as a pharmaceutical raw material. The oleanolic acid pharmaceutical preparation of the present invention comprises 1%-99% of oleanolic acids and 99%-1% medicinal excipients (including other compatible drugs). The oleanolic acid and the pharmaceutical preparations thereof provided by the invention have an excellent anti-cervical cancer effect which is represented by significant inhibitory activity against in vitro human cervical cancer cells and significant tumor inhibitory activity against a transplanted tumor in nude mice of the cancer cell. In addition, the active components of the pharmaceutical preparation are traditional Chinese medicine extracts, so the preparation has the advantage of less toxic and side effect than chemotherapeutic drugs.

The invention discloses triterpene-2-alpha-hydroxylase MAA45, related biological materials thereof and application of the triterpene two-bit alpha-hydroxylase MAA45 and the related biological materials in preparing maslinic acid and corosolic acid. The triterpene two-bit alpha-hydroxylase MAA45 is the following protein shown as A1), or A2) or A3), wherein A1) represents protein with an amino acid sequence being the sequence 1 in a sequence table, A2) represents protein which has the same function and is obtained by substituting or missing or adding one or more amino acid residues to the amino acid sequence shown in the sequence 1, and A3) represents fused protein obtained by connecting labels to the N terminal or / and C terminal of A1) or A2). It is proved through experiments that maslinic acid can be prepared from MAA45 with oleanolic acid as a substrate, corosolic acid can be prepared from MAA45 with ursonic acid as a substrate, MAA45 and coding genes thereof can be used for preparing maslinic acid and corosolic acid, and MAA45 can be used for catalyzing triterpene two-bit alpha-hydroxylation.

The invention discloses a method for extracting oleanolic acid from chaenomeles fruit and preparing an oleanolic acid standard. The method comprises the following steps of: cleaning the chaenomeles fruit, drying the chaenomeles fruit in the shade, crushing the chaenomeles fruit into powder, dissolving the powder by using ethanol, performing ultrasonic aided extraction to obtain a crude extract, adding the crude extract into water for dissolving, adding saturated aqueous solution of n-butanol, performing extraction for many times, concentrating the extract to obtain an extract substance, dissolving the extract substance, performing nano-filtration to obtain sample solution of the oleanolic acid, and performing preliminary purification of macroporous resin, silica gel column chromatography,high performance liquid chromatography (HPLC), chromatographic separation and refining on the obtained sample solution to obtain the oleanolic acid standard. The method is simple and convenient in operation, and the oleanolic acid has high yield and high purity and can be made into the standard.

The invention provides a method for extracting an ursolic acid and oleanolic acid mixture from glossy privet fruit. The method comprises the following steps: firstly hydrolyzing ursolic acid and oleanolic acid, which exist in sugar ligands, in glossy privet fruit into free state by adopting acid hydrolysis technology so as to preferentially separate extraction materials rich in ursolic acid and oleanolic acid, and then removing fat-soluble organic compounds from the materials with petroleum ether; then by adopting alkaline ethanol mixed solvent, performing ultrasonic extraction, washing and ethanol dissolution and the like, to obtain a target product. The overall treatment amount is reduced; the impurities in ursolic acid and oleanolic acid extracted through mixed solvent can be decreased; free-state ursolic acid and oleanolic acid are converted into sodium salts, more easily entering the extraction solvent, through the used mixed extraction solvent; cells can be broken through ultrasonic extraction, and the capability of separating ursolic acid and oleanolic acid from plant cells and entering the extraction solvent can be enhanced. Therefore, through the technology, the extraction of ursolic acid and oleanolic acid in the glossy privet fruit can be improved, the usage amount of the extraction solvent can be greatly reduced, the energy consumption is less, and the cost for preparing the target product can be obviously lowered.

The invention provides a preparation method and applications of a lamivudine twin drug. Lamivudine, and ursolic acid or oleanolic acid are condensed into the lamivudine-ursolic acid or lamivudine-oleanolic acid twin drug at a low temperature by using ethyl chloroacetate (ethyl bromoacetate) or ethyl chloropropionate (ethyl bromopropionate) as the linking group. The twin drug possibly has a dual-action mechanism; and the twin drug has the action of antivirus, and also has the actions of resisting inflammations, protecting the liver cell membranes, improving the liver function and resisting fibrosis. Thus, the invention organically combines the antivirus therapy and the liver protection treatment and provides a new concept for the research and development of drugs for treating hepatitis.