266 results about "Oleanonic acid" patented technology

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

The invention provides a method for extracting an ursolic acid and oleanolic acid mixture from glossy privet fruit. The method comprises the following steps: firstly hydrolyzing ursolic acid and oleanolic acid, which exist in sugar ligands, in glossy privet fruit into free state by adopting acid hydrolysis technology so as to preferentially separate extraction materials rich in ursolic acid and oleanolic acid, and then removing fat-soluble organic compounds from the materials with petroleum ether; then by adopting alkaline ethanol mixed solvent, performing ultrasonic extraction, washing and ethanol dissolution and the like, to obtain a target product. The overall treatment amount is reduced; the impurities in ursolic acid and oleanolic acid extracted through mixed solvent can be decreased; free-state ursolic acid and oleanolic acid are converted into sodium salts, more easily entering the extraction solvent, through the used mixed extraction solvent; cells can be broken through ultrasonic extraction, and the capability of separating ursolic acid and oleanolic acid from plant cells and entering the extraction solvent can be enhanced. Therefore, through the technology, the extraction of ursolic acid and oleanolic acid in the glossy privet fruit can be improved, the usage amount of the extraction solvent can be greatly reduced, the energy consumption is less, and the cost for preparing the target product can be obviously lowered.