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266 results about "Oleanonic acid" patented technology
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Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
ActiveUS7915402B2Suppresses demyelinationSuppresses transectionNervous disorderAntipyreticPerylene derivativesPharmaceutical Substances
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Owner:REATA PHARMA INC
Triterpene compositions and methods for use thereof
Owner:RES DEVMENT FOUND
Triterpene compositions and methods for use thereof
InactiveUS20060073222A1None of potential benefitsAntibacterial agentsBiocideApoptosisAcacia victoriae
Owner:RES DEVMENT FOUND
Method of treating non-insulin dependent diabetes mellitus and related complications
InactiveUS20050019435A1Block slow down conversionRelieve peripheral symptomBiocideUnknown materialsInsulin dependent diabetesCoptis
A method of treating non-insulin dependent diabetes mellitus comprising the step of providing a composition comprising a predetermined amount of berberine and a predetermined amount of catalpol, wherein said berberine and said catalpol are major active ingredients of said composition. The composition may further comprise a predetermined amount of oleanolic acid as another active ingredient. The berberine is obtained from natural herbs selected from the group of Berberis, Chelidonium, Stephniz, Coptis, Phellodendron, and Ziziphus, the catalpol is obtained from natural herbs selected from the group of Rehmannia, Verbascum, Panulownia, Glubularia and Adonis, and the oleanolic acid is obtained from natural herbs selected from the group of Olea, Swertia, Astrantia, Lonicera and Beta.
Owner:YOUNG JEFFREY
Triterpene compositions and methods for use thereof
The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
Owner:RES DEVMENT FOUND
Pharmaceutical composition and method for preventing or treating hepatitis c
A pharmaceutical composition for preventing or treating hepatitis C is provided, including oleanolic acid derivatives as an active ingredient and a pharmaceutically acceptable carrier. A method for preventing or treating hepatitis C in a subject in need thereof is also provided by administering the subject the pharmaceutical composition given above.
Owner:IND TECH RES INST
Oleanolic acid triterpene with A ring and C ring both containing multiple oxygen-containing substituents and use thereof
The invention provides an oleanolic acid triterpenoid, whose A ring and C ring contain multiple oxygen substituents, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell, thereby being applied in the preparation of anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene, thereby being applied in the preparation of anti-inflammatory agent. The formula (1) is represented as above.
Owner:ZHEJIANG UNIV
Method for extracting maslinic acid and oleanolic acid containing mixture from olea europaea L. pomace
ActiveCN103169771AReduce manufacturing costSimple process routeAntibacterial agentsAntipyreticWater solubleAqueous solution
The invention discloses a method for extracting a maslinic acid and oleanolic acid containing mixture from olea europaea L. pomace. The method comprises the following steps of: extracting an extract from the olea europaea L. pomace in an 80-95wt% (weight percent) ethanol aqueous solution, concentrating the extract, redissolving the extract in a 20-70wt% ethanol aqueous solution, adsorbing by using a macroporous adsorption resin, removing water-soluble impurities by using a water-washing resin column, desorbing by using a desorbing solution, mixing the desorbing solution, recovering the desorbing solution, and drying to obtain a maslinic acid and oleanolic acid containing extract. The mixture extracted from the olea europaea L. pomace contains more than 30% of maslinic acid and more than 23% of oleanolic acid.
Owner:TIANYUAN OIL OLIVE TECH DEV LONGMAN
Delta<13(18)>-CDDO derivative, its preparation method and its use in pharmacy
The invention relates to the field of medicines, concretely relates to an oleanolic acid derivative represented by formula I and pharmaceutically acceptable salts, and a preparation method and a medicinal use thereof, and belongs to the field of biomedicines. The preparation method of the above compounds has the advantages of mild condition, simple operation, high yield and very strong practicality. Results of pharmacological experiments show that the compounds have excellent anti-inflammatory and antitumor activities, and can be clinically used as medicines for treating diseases and tumors caused by various inflammations.
Owner:CHINA PHARM UNIV
Oleanolic acid and its derivative, preparation method and use
InactiveCN1724556AClear processEnhanced inhibitory effectOrganic active ingredientsSkeletal disorderDrugCarbonyl group
Disclosed is the derivatives of oleanolic acid parent nucleus which introduces functional groups including carbonyl, hydroxyl and double bonds, the oleanolic acid derivatives 1-9 have the molecular structure disclosed in the specification, the preparing process for the oleanolic acid consists of protecting the 3-hydroxy of the oleanolic acid 1 with acetyl, reacting and removing protecting groups. The invention can be applied into the preparation of medicament and health food for resisting osteoporosis.
Owner:NANJING UNIV
2-substituted oleanolic acid derivative, method preparing for same, and application thereof
The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-substituted oleanolic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.
Owner:HANGZHOU BENSHENG PHARMA
Bougainvillea glabra triterpenoid saponin, hpyerglycemic drugs with triterpenoid saponin as active component and preparation method and application thereof
ActiveCN104910240AReduce lossesLow costOrganic active ingredientsSugar derivativesUronic acidTriterpenoid saponin
Bougainvillea glabra triterpenoid saponin compounds comprise a triterpenoid saponin with a skeleton containing oleanolic acid, wherein the 3-site of the oleanolic acid is connected with 1'-site of beta-D-pyran glucuronic acid by an oxygen atom, and comprise other two derivates with the same skeleton structure; and the compound as shown in formula (I) is preferable, in the formula (I), R1 is methyl or hydrogen and R2 is hydrogen or beta-D-pyran xylose. The bougainvillea glabra triterpenoid saponin compounds 1-3 are new plant sourced hypoglycemic drugs. Pharmaceutical compositions with the compounds as active ingredients and a preparation method and application thereof in making the hypoglycemic drugs are provided.
Owner:XISHUANGBANNA TROPICAL BOTANICAL GARDEN CHINESE ACAD OF SCI
Improved rail lubricating grease
The invention discloses improved rail lubricating grease prepared from the following raw materials in parts by weight: 3-9 parts of tetrahydropalmatine, 1-3 parts of potassium dihydrogen phosphate, 2-6 parts of isodehydrocostus lactone, 3-7 parts of oleanonic acid, 1.5-4 parts of oleic acid, 2.5-6 parts of dialkyl calcium benzene sulfonate, 2-4 parts of imidazoline, 4-6 parts of alkylphenol sulfide, 1-5 parts of sodium citrate, 1.5-6 parts of polyacrylate copolymerization emulsion, 1-4 parts of alkyl naphthalene, 6-10 parts of thickening agent and 2-6 parts of extreme-pressure additive. The improved rail lubricating grease disclosed by the invention can form a lubricating layer between a rail and an object to reduce the friction between the rail and the object and prolong the service life of the rail, and has a certain cooling effect at the same time.
Owner:QINGDAO KANGTAIXIN ENVIRONMENTAL PROTECTION TECH
Special lubricating oil for mechanical gears
InactiveCN106635323AExtended service lifeImprove adhesionLubricant compositionGlycerolPhosphoric acid
The invention discloses a special lubricating oil for mechanical gears. The special lubricating oil for mechanical gears is composed of phosphite, talcum powder, phosphoric acid, sorbitol, p-hydroxy benzyl aldehyde, methyl citrate, monomethyl citrate, tetrahydropalmatine, mesembryanthemoidigenic acid, isodehydrocostus lactone, lupeol palmitate, oleanonic acid, naphthenic oil, butter, tetrahydroxyethyl ammonium swelling oily agent, aluminum disulfide, aromatic hydrocarbon, paraffin base, succimide succinate, boron nitride, fish gallbladder, fatty soap, glycerol, polyalkenyl succinimide, graphite, amino monothioester and molybdenum dialkyldithiocarbamate. Compared with the prior art, the special lubricating oil for mechanical gears can lower the loss of engine oil, increases the environment-friendly effect of the original special engine oil, enhances the adhesion of lubricating oil, increases the lubricating effect of the engine oil, and lowers the friction, so that the mechanical gears can well operate, thereby enhancing the service life of the machine. Thus, the special lubricating oil for mechanical gears has popularization and application value.
Owner:HUAIYIN INSTITUTE OF TECHNOLOGY
Anti-cervical cancer effect of oleanolic acid and pharmaceutical preparation thereof
InactiveCN102133219AEnhanced inhibitory effectNo obvious side effectsOrganic active ingredientsAntineoplastic agentsCancer cellSide effect
The invention discloses a new medical application of oleanolic acid in cervical cancer resistance, and also discloses clinically acceptable pharmaceutical preparations such as tables, capsules, pills, injections and the like which are prepared by using oleanolic acid as a pharmaceutical raw material. The oleanolic acid pharmaceutical preparation of the present invention comprises 1%-99% of oleanolic acids and 99%-1% medicinal excipients (including other compatible drugs). The oleanolic acid and the pharmaceutical preparations thereof provided by the invention have an excellent anti-cervical cancer effect which is represented by significant inhibitory activity against in vitro human cervical cancer cells and significant tumor inhibitory activity against a transplanted tumor in nude mice of the cancer cell. In addition, the active components of the pharmaceutical preparation are traditional Chinese medicine extracts, so the preparation has the advantage of less toxic and side effect than chemotherapeutic drugs.
Owner:林秀坤
Chinese medicine preparation for treating rheumatism and preparation and use
InactiveCN1682748AAvoid toxic effectsSignificant effectOrganic active ingredientsAntipyreticSide effectAnemone
The Chinese medicine preparation, Fengshi'an, for treating rheumatism has the effective component 3-O-alpha-L-pyranorhamnose (1->2)-beta-D-xylopyranose-oleanolic acid-28-O-alpha-L-pyranorhamnose(1->4) beta-D-pyranoglucose (1->6) beta-D-glucopyranoside, named flaccid anemone saponin W3, and with molecular expression of C59H96O25. Flaccid anemone saponin W3 is prepared with coarse flaccid anemone rhizome powder, and through reflux extraction, concentration, adsorption and elution in macroposrous resin, adsorption and elution in dry silicon gel column and liquid separation. Flaccid anemone saponin W3 is further prepared into Chinese medicine preparation with flaccid anemone saponin W3 content over 90 wt%, and the Chinese medicine preparation is used in treating rheumatic diseases with high curative effect and less toxic side effect.
Owner:湖北中医学院
Platinum (II) coordination complex and preparing method and application thereof
ActiveCN105713047AHas antitumor potentialGood in vitro inhibitory activityPlatinum organic compoundsAntineoplastic agentsPotassium tetrachloroplatinateOxygen
The invention discloses a platinum (II) coordination complex and a preparing method and application thereof. The preparing method includes the steps that active natural products such as oleanolic acid and ursodesoxycholic acid and derivatives of the active natural products serve as ligand; potassium tetrachloroplatinate(II) and ammonia or (R,R)-cyclohexanediamine are subjected to coordination reaction under the condition of potassium iodide, then iodide ions are removed through silver nitrate under the light shielding condition, and the mixture and sodium salt of ursodesoxycholic acid or oleanolic acid or the derivatives of oleanolic acid are reacted to obtain the product. The platinum (II) coordination complex has the good in-vitro antitumor activity, and can be applied to preparing medicine for treating malignant tumor.
Owner:SOUTHEAST UNIV
Method for preparing sapogenin through chenopodium quinoa willdL seed coat and separation and quantification method of sapogenin
InactiveCN109810163AIncrease profitImprove economyComponent separationSteroidsHydrolysateEvaporation
The invention provides a method for preparing sapogenin through chenopodium quinoa willdL seed coat and a separation and quantification method of the sapogenin, and belongs to the technical field of biological product processing. The method for preparing the sapogenin through the chenopodium quinoa willdL seed coat comprises the following steps that firstly, the chenopodium quinoa willdL seed coat, complex enzyme and deionized water are mixed and enzymolyzed to obtain enzymatic hydrolysate; then the enzymatic hydrolysate and ethyl alcohol are mixed, chenopodium quinoa willdL saponin in the enzymatic hydrolysate is extracted through ultrasonic waves, solid-liquid separation is conducted, and a chenopodium quinoa willdL saponin extracting solution is obtained; then the chenopodium quinoa willdL saponin extracting solution and hydrochloric acid are mixed and subjected to acidolysis to obtain acidolysis liquid; and finally, the acidolysis liquid is extracted through petroleum ether to obtain extract liquor, and a solvent in the extract liquor is removed through evaporation, and the sapogenin is obtained. According to the method, the chenopodium quinoa willdL seed coat serves as a raw material to prepare the sapogenin, the natural sapogenin raw material can be provided for a professional pharmaceutical factory, the comprehensive utilization rate and the economic added value of chenopodium quinoa willdL can further be increased, and reuse and sustainable development of resources are facilitated. The invention further provides a method for simultaneous separation and quantification of oleanolic acid and hederagenin in the chenopodium quinoa willdL seed coat through UPLC-MS.
Owner:QINGHAI NORMAL UNIV
Extraction and purification method of triterpene acid in seabuckthorns, triterpene acid, triterpenoid saponin and application of triterpene acid and triterpenoid saponin
InactiveCN109111496AStay in shapeAnti agingSugar derivativesMetabolism disorderTriterpenoid CompoundChemistry
The invention provides an extraction and purification method of triterpene acid in seabuckthorns, triterpene acid, triterpenoid saponin and application of the triterpene acid and the triterpenoid saponin and relates to the technical field of extraction and purification. The extraction and purification method of the triterpene acid in the seabuckthorns comprises the following steps of (a) extracting ursolic acid, oleanolic acid and derivatives thereof in seabuckthorn peels with an organic solvent to obtain an extract; (b) treating the extract with an alkali solution firstly, then treating the extract with an acid solution to obtain ursolic acid solid and oleanolic acid solid, and dissolving the ursolic acid solid and the oleanolic acid solid into the organic solvent to obtain a mixed solution; (c) adsorbing the ursolic acid and the oleanolic acid in the mixed solution with macroporous resin, and performing elution and concentration with an eluent after adsorption is finished to obtain acrude product; and (d) adopting HPLC or HSCCC to perform separation on the ursolic acid and the oleanolic acid in the crude product. In the extraction and purification method provided by the invention, the separation effect of the ursolic acid and the oleanolic acid is good, the purity of the ursolic acid reaches up to 97.6 percent or above, and the purity of the oleanolic acid reaches up to 98.2percent or above.
Owner:QINGHAI TSINGHUA BIOTRY BIO TECH
Nanoparticles of eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier and preparation
InactiveCN107115323AGood water solubilityImprove stabilityOrganic active ingredientsPharmaceutical non-active ingredientsSolubilitySide effect
The invention discloses a preparation method of nanoparticles of an eight-arm PEG (polyethylene glycol)-oleanolic acid drug carrier. The preparation method comprises steps as follows: eight-arm PEG and oleanolic acid are subjected to an esterification reaction, and a conjugate of eight-arm PEG-oleanolic acid is obtained; 10-hydroxycamptothecine is wrapped with eight-arm PEG-oleanolic acid through self-assembly, and the nanoparticles are obtained. The nanoparticles have a double-layer structure, the outer layer is hydrophilic PEG, and the inner layer is hydrophobic oleanolic acid drug and 10-hydroxycamptothecine. The preparation method has the advantages that the drug loading capacity is greatly increased with the adoption of PEG; the water solubility and stability of oleanolic acid are increased, and the half-life period of oleanolic acid is prolonged; pH sensitive release of the drug in tumor cells can be realized; the toxic and side effects on normal tissue are reduced; the preparation process is simple and easy to operate.
Owner:BEIJING FORESTRY UNIVERSITY
Extract of total triterpenes in dracocephalum moldavica and preparation method and application thereof
ActiveCN101785799AHas hepatoprotective effectDigestive systemAntiviralsTriterpeneDracocephalum moldavica
The invention relates to a method for extracting triterpenoids in dracocephalum moldavica. The extract of total triterpenes in dracocephalum moldavica is immediately obtained through concentration, hot water washing, alkali dissolving, acid precipitation, decolorization and purification by adsorption column chromatography of extracting solution of ethanol in dracocephalum moldavica. The content of total triterpenes in dracocephalum moldavica extract is not lower than 50% and the total content of oleanolic acid and ursolic acid is not lower than 80% of the content of total triterpenes. The extract of total triterpenes in dracocephalum moldavica has the effect of protecting livers and can be used for preparing drugs for liver diseases.
Owner:北京化药科创医药科技发展有限公司
Pickled Papaya wine and preparation method thereof
ActiveCN105368668AFull of nutritionIncrease the juice yieldAlcoholic beverage preparationBiotechnologyFruit wine
The invention discloses a pickled papaya wine and a preparation method thereof, wherein the preparation method comprises following specific steps: juicing pickled papaya to obtain pickled papaya residue and pickled papaya juice; activating acidic yeast, and adding it into the pickled papaya juice for fermentation to obtain pickled papaya fermented wine; soaking the pickled papaya residue in 75% edible alcohol for 3-4 months to obtain soaked fruit wine; mixing the soaked fruit wine and the pickled papaya fermented wine to obtain the pickled papaya wine. The preparation process is simple, papaya juicing rate is high, the pickled papaya wine prepared has high content of oleanolic acid, high nutrient content and delicious taste.
Owner:云南喝对酒酒业有限公司 +1
Triterpene-2-alpha-hydroxylase MAA45, related biological materials thereof and application of triterpene two-bit alpha-hydroxylase MAA45 and related biological materials in preparing maslinic acid and corosolic acid
The invention discloses triterpene-2-alpha-hydroxylase MAA45, related biological materials thereof and application of the triterpene two-bit alpha-hydroxylase MAA45 and the related biological materials in preparing maslinic acid and corosolic acid. The triterpene two-bit alpha-hydroxylase MAA45 is the following protein shown as A1), or A2) or A3), wherein A1) represents protein with an amino acid sequence being the sequence 1 in a sequence table, A2) represents protein which has the same function and is obtained by substituting or missing or adding one or more amino acid residues to the amino acid sequence shown in the sequence 1, and A3) represents fused protein obtained by connecting labels to the N terminal or / and C terminal of A1) or A2). It is proved through experiments that maslinic acid can be prepared from MAA45 with oleanolic acid as a substrate, corosolic acid can be prepared from MAA45 with ursonic acid as a substrate, MAA45 and coding genes thereof can be used for preparing maslinic acid and corosolic acid, and MAA45 can be used for catalyzing triterpene two-bit alpha-hydroxylation.
Owner:TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
Method for extracting oleanolic acid from chaenomeles fruit and preparing oleanolic acid standard
InactiveCN102229638AThe extraction and separation process is simple and rigorousReliable methodSteroidsChromatographic separationFiltration
The invention discloses a method for extracting oleanolic acid from chaenomeles fruit and preparing an oleanolic acid standard. The method comprises the following steps of: cleaning the chaenomeles fruit, drying the chaenomeles fruit in the shade, crushing the chaenomeles fruit into powder, dissolving the powder by using ethanol, performing ultrasonic aided extraction to obtain a crude extract, adding the crude extract into water for dissolving, adding saturated aqueous solution of n-butanol, performing extraction for many times, concentrating the extract to obtain an extract substance, dissolving the extract substance, performing nano-filtration to obtain sample solution of the oleanolic acid, and performing preliminary purification of macroporous resin, silica gel column chromatography,high performance liquid chromatography (HPLC), chromatographic separation and refining on the obtained sample solution to obtain the oleanolic acid standard. The method is simple and convenient in operation, and the oleanolic acid has high yield and high purity and can be made into the standard.
Owner:ANHUI AGRICULTURAL UNIVERSITY
Method for improving content of betulin and oleanolic acid in birch cell by utilizing MeJA (methyl-jasmonate) and SA (salicyl acid)
InactiveCN102943104AShorten the production cycleNo pollution in the processFermentationBiologyCulture mediums
The invention belongs to the field of biological engineering, and particularly relates to a method for improving the content of betulin and oleanolic acid in a birch cell by utilizing MeJA (methyl-jasmonate) and SA (salicyl acid), which comprises the following steps of: inoculating a birch tissure culture seedling stem to NT + 0.1 mg / L of 6-BA and 0.01 mg / L of TDZ culture mediums to induce birch callus, and obtaining a birch suspension cell with high content of total triterpenes through multi-time subculture, screening and suspension culture; inoculating the screened cell into the same liquid culture medium, wherein the inoculation amount is 3g / 100ml; adding 100mu Mum / L of MeJA and 50mg / L of SA when the shake culture is performed at the seventh day; after 24-48h, obtaining the product; and detecting the content of total triterpenes, betulin and oleanolic acid in the cell. Through the comparison of the two kinds of processing methods, the content of total triterpenes is improved by 21.6-31.7%, the content of oleanolic acid is improved by 277.4-369.34%, and the content of betulin is improved by 44.42-179.58%. The application of the invention provides a new path for solving the problem of shortage of natural plant drug resources and realizing large-scale industrial production of betulin and oleanolic acid drugs.
Owner:NORTHEAST FORESTRY UNIVERSITY +2
Recombinant Yarrowia lipolytica for heterogeneous synthesis of beta-amyrin and oleanolic acid and construction method
The invention discloses recombinant Yarrowia lipolytica for heterogeneous synthesis of beta-amyrin and oleanolic acid and a construction method. The construction method comprises the step of introducing an optimized beta-amyrin synthase coding gene, an optimized oleanolic acid synthase coding gene and an optimized cytochrome-NADPH-reductase 1 coding gene into Yarrowia lipolytica, thereby obtaininga recombinant strain 2. Proven by experiments, the recombinant Yarrowia lipolytica capable of yielding the beta-amyrin and the oleanolic acid is obtained through a homologous recombination method, and thus, the yield of the beta-amyrin and the oleanolic acid is increased; and the method disclosed by the invention provides a foundation for artificial synthesis of the beta-amyrin and the oleanolicacid.
Owner:TIANJIN UNIV
Method for extracting ursolic acid and oleanolic acid mixture from glossy privet fruit
InactiveCN104370992AHigh extraction rateReduce processingSteroidsBiotechnologySimple Organic Compounds
Owner:HUAIYIN TEACHERS COLLEGE
Oleanolic acid derivatives, and preparation method and application thereof
ActiveCN102838651AGood for lowering blood sugarInhibit blood sugar riseOrganic active ingredientsMetabolism disorderHydrogenPhenyl group
The invention belongs to the technical field of medicines capable of lowering blood sugar, and provides oleanolic acid derivatives disclosed as Formula I and salts thereof, wherein n=1, 2, 3 or 4; and R1 and R2 can be hydrogen, C1-C4 straight-chain or branched-chain alkyl group, carboxyl group, phenyl group, halogen or halogenated methyl group, or R3 is straight-chain or branched-chain alkyl group. The invention also relates to a preparation method of the compounds and salts thereof, a medicinal composition which uses the compounds as active effective constituents, and application of the compounds in medicines for lowering blood sugar.
Owner:TIANJIN INSTITUTE OF PHARMA RESEARCH
Traditional Chinese medicine composition for treating climacteric syndrome, and preparation method and quality detection method thereof
ActiveCN103690782ASignificant effectNo obvious side effectsComponent separationInanimate material medical ingredientsSide effectClinical efficacy
The invention discloses a traditional Chinese medicine composition for treating climacteric syndrome, and a preparation method and a quality detection method thereof. The traditional Chinese medicine composition is composed of the following components in parts by weight: 25-45 parts of glossy privet fruit, 10-20 parts of sealwort, 10-20 parts of dogwood, 10-20 parts of wolfberry fruit, 10-20 parts of eclipta, 13-23 parts of radix polygonum multiflorum preparata, 5-15 parts of coptis chinensis, 10-22 parts of rhizoma anemarrhenae, 10-22 parts of dragon bone, 5-14 parts of oyster, 8-18 parts of buckeye, 5-15 parts of fingered citron, 5-15 parts of radix scrophulariae, 6-18 parts of citron and 5-14 parts of cortex albiziae. The preparation method of the traditional Chinese medicine composition is scientific and reasonable. The quality standards include a method for identifying the wolfberry fruit, the coptis chinensis and the rhizoma anemarrhenae and a method for measuring the content of oleanolic acid. Pharmacodynamic tests achieve excellent test results and toxicity tests indicate that the clinical given dosage is safe; therefore, the traditional Chinese medicine composition is a safe and effective drug for treating the climacteric syndrome; the traditional Chinese medicine composition has the advantages of accurate therapeutic principle, novel formula, strong efficacy targeting performance, accurate clinical effects and no obvious toxic or side effects.
Owner:刘照振
Preparation method and applications of lamivudine twin drug
InactiveCN101766632AHas antiviral effectImprove liver functionOrganic active ingredientsDigestive systemHepatic inflammationPropanoic acid
The invention provides a preparation method and applications of a lamivudine twin drug. Lamivudine, and ursolic acid or oleanolic acid are condensed into the lamivudine-ursolic acid or lamivudine-oleanolic acid twin drug at a low temperature by using ethyl chloroacetate (ethyl bromoacetate) or ethyl chloropropionate (ethyl bromopropionate) as the linking group. The twin drug possibly has a dual-action mechanism; and the twin drug has the action of antivirus, and also has the actions of resisting inflammations, protecting the liver cell membranes, improving the liver function and resisting fibrosis. Thus, the invention organically combines the antivirus therapy and the liver protection treatment and provides a new concept for the research and development of drugs for treating hepatitis.
Owner:CHINA PHARM UNIV
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