11 results about "Oleanonic acid" patented technology

This invention provides a method for preparing camellia oil rich in oleanolic acid, comprising the following steps: (1) washing and draining fresh camellia fruit shells and / or tea leaves, then pulverizing them after vacuum freeze-drying to obtain freeze-dried powder A, and pulverizing dried camellia seed kernels to obtain seed kernel powder B. (2) mixing freeze-dried powder A and seed kernel powder B at a mass ratio of 1:(15-20). (3) adding a 25%-35% ethanol aqueous solution as an extraction solvent to the mixed raw materials, wherein the mass-volume ratio (g:mL) of the mixed raw materials to the extraction solvent is 1:(3-4); using a high-speed shearing device to vigorously stir and crush the mixed system for 3-10 minutes to achieve full cell wall disruption of the plant cells. (4) heating and reflux extraction; (5) three-phase separation and solvent reuse. This method has a high efficiency in transferring oleanolic acid from the raw materials to the oil phase.

The application belongs to the technical field of medicine, and discloses a pentacyclic triterpene derivative, a preparation method and medical application of the pentacyclic triterpene derivative, which uses alpha-hederin or oleanolic acid as raw material, and utilizes esterification reaction or amidation reaction aiming at the carboxyl of C-28 to prepare the pentacyclic triterpene derivative. The pentacyclic triterpene derivative prepared by the application has the effects of anti-inflammation, anti-oxidation and anti-apoptosis, and the synthesis method is simple, the raw material is cheap and easy to obtain, and is suitable for industrial application.

This invention discloses an injectable AuPd-Fe single-atom nanozyme composite drug-derived antibacterial hydrogel, its preparation method, and its applications, belonging to the field of biomedical nanomaterials technology. This invention uses an iron-based single-atom nanozyme with an irregular octahedral carbon framework structure as the core catalytic carrier, and in situ loads ultra-small AuPd alloy nanoparticles onto its surface to obtain the AuPd-Fe single-atom nanozyme. Then, using the AuPd-Fe single-atom nanozyme as the active center and oleanolic acid drug-derived hydrogel as the delivery carrier, the AuPd-Fe single-atom nanozyme is uniformly dispersed in the three-dimensional network of the OA hydrogel through physical embedding and hydrogen bonding, resulting in the injectable AuPd-Fe single-atom nanozyme composite drug-derived antibacterial hydrogel. The provided antibacterial hydrogel exhibits excellent ocular surface biocompatibility, no significant corneal toxicity, and no systemic organ damage. It also shows significant clinical application potential for blinding ocular infections such as drug-resistant bacterial keratitis and corneal ulcers.

The application provides a tumor inhibiting composition and a preparation method and application thereof, and belongs to the technical field of medicines. After mesoporous carbon nanotubes are oxidized and chlorinated, oleanolic acid dithiocarbamate conjugate and (2-hydroxypropyl)-beta-cyclodextrin are coupled, drugs are loaded, a protein liposome solution is added, ultrasonic treatment is carried out, centrifugal separation is carried out, unloaded drug-loaded carbon nanotubes are removed, supernatant is freeze-dried, and the tumor inhibiting composition is prepared. The tumor inhibiting composition greatly improves the drug loading capacity of the nanosystem, the synergistic effect of multiple drugs, the anti-tumor effect, realizes the effects of targeting, slow and controlled release of drugs, improves the drug utilization rate, reduces the intake amount of drugs, reduces side effects, and improves the compliance of patients.

The invention discloses an oleanolic acid acylhydrazone derivative as well as a preparation method and application thereof. The oleanolic acid acylhydrazone derivatives have a structural formula shown in the following formula I. In the structural formula, R is selected from halogen-substituted pyridine and hydroxyl-substituted naphthyl. The invention provides a series of oleanolic acid acylhydrazone derivatives with novel structures, and the oleanolic acid acylhydrazone derivatives have relatively good inhibition effects on human breast cancer cells MDA-MB-231 and human pancreatic cancer cells Mia paca-2, and can be used for preparing an anti-cancer drug. The compound can be used for preparing anti-tumor drugs.

This invention provides oleanolic acid-modified HG-type pectin nanomicelles, their preparation method, and applications. The preparation method of the HG-type pectin nanomicelles includes: esterifying 3,3'-dithiodipropionic acid and oleanolic acid to obtain SS-OA; esterifying SS-OA and HG-type pectin to obtain oleanolic acid-modified HG-type pectin; dissolving the oleanolic acid-modified HG-type pectin and dispersing it ultrasonically to obtain oleanolic acid-modified HG-type pectin nanomicelles. The oleanolic acid-modified HG-type pectin nanomicelles of this invention combine the functional activities of HG-type pectin and oleanolic acid, as well as the redox responsiveness of 3,3'-dithiodipropionic acid, constructing nanomicelles that respond to ROS generated during alcohol metabolism. They exhibit amphiphilicity and good biocompatibility, and can be used to prepare drugs to alleviate chronic alcoholic liver injury.

The application discloses a preparation method and application of probiotics improved based on natural products, and the method comprises the following steps: step 1, preparation of oleanolic acid-xylo-oligosaccharide co-assembled nanoparticles; step 2, preparation of quercetin-iron metal phenolic network solution; step 3, preparation of inner-layer quercetin-iron metal phenolic network coated probiotics; and step 4, preparation of outer-layer oleanolic acid-xylo-oligosaccharide co-assembled nanoparticles coated probiotics. The improved probiotics take natural triterpene small molecules oleanolic acid, prebiotic xylo-oligosaccharide and polyphenol quercetin as construction units, construct an inner-outer double-layer nanostructure coating on the surface of the bacteria, can significantly improve the survival rate of the probiotics in the gastrointestinal tract and oxidative stress environment, and effectively remove or reduce excessive active oxygen in the inflammatory microenvironment. The preparation method is simple and the conditions are mild, and the application provides a new technical scheme for the prevention and treatment of intestinal inflammation related diseases by using the natural product combined improved probiotics.

Present invention relates to the use of hydroxytyrosol (HT), maslinic acid (MA) and oleanolic acid (OA) as additive in feed for a domesticated animal at very early days of life or from birth. The invention provides an additive with particular amounts of these three ingredients and an additivated feedstuff ready to use comprising said additive.