6 results about "Bibenzyl" patented technology

The invention discloses a cyclization continuous flow synthesis process of iminodibenzyl. 2, 2 '-diamino bibenzyl is used as a raw material, polyphosphoric acid is used as a cyclization agent, toluene is used as a dispersion medium, the efficient heat and mass transfer characteristic of the microchannel reactor is utilized, the reaction temperature is controlled within 85 + / -2 DEG C, meanwhile, the material ratio and the retention time are optimized, generation of high-polymer impurities is inhibited from the source, no remarkable high-polymer impurities exist in reaction liquid, a rectification purification process is not needed, and the production cost is reduced. And washing the toluene layer with phosphoric acid, washing with clear water, and crystallizing to obtain a high-purity qualified product. In the product obtained by the process, the content of high polymer impurities is less than or equal to 0.003 wt%, the residue of 2, 2 '-diamino bibenzyl is less than or equal to 0.0002 wt%, the purity of the product is more than or equal to 99.8%, and the molar yield reaches 93.2%; the toluene solvent recycling rate is greater than or equal to 95%, the discharge amount of three wastes is reduced by more than 70% compared with that of a traditional intermittent process, and the method has the advantages of product quality improvement, production efficiency improvement and environmental protection, and can be directly applied to large-scale production of antiepileptic drug oxcarbazepine and carbamazepine intermediates.

This invention belongs to the field of synthetic biology and microbial engineering, and discloses a chemical-biological method for preparing the isopentenyl bibenzyl compound 2-isopentenyl-3,3',4',5-tetrahydroxybibenzyl (NPB-1575) which has anti-ischemic stroke activity. The specific disclosed method includes: (1) chemically synthesizing the substrate dihydropiperidine; (2) constructing an engineered Escherichia coli strain based on the isopentenyl utilization pathway, co-expressing hydroxyethylthiazol kinase, isopentenyl phosphokinase, isopentenyl pyrophosphate isomerase and specific isopentenyl transferase, and efficiently synthesizing the isopentenyl donor; (3) using this strain to catalyze dihydropiperidine in whole cells, the yield in a 200L fermenter can reach 2.54g / L, which is nearly 40 times higher than the existing method; (4) obtaining NPB-1575 with a purity >98.5% by macroporous adsorption resin and normal / reversed phase chromatography and recrystallization. This method uses readily available raw materials, involves simple steps, is environmentally friendly, and yields high purity, laying the foundation for the development of NPB-1575 as a new drug for ischemic stroke and showing significant application potential.

The invention discloses a crucible descent growth method of a large-size bibenzyl scintillation crystal, and relates to a growth method of a bibenzyl scintillation crystal. The method aims at solving the technical problem that the quality of crystals obtained through an existing bibenzyl single crystal solution growth method is poor, a bibenzyl raw material is sealed in a quartz crucible of a capillary structure, the raw material is melted and a stable solid-liquid interface is formed by precisely controlling the temperature field of a furnace body and the descending rate of the crucible, and the bibenzyl single crystal is obtained. And then enabling the crucible to pass through a temperature gradient region at a constant rate to realize directional solidification growth of the bibenzyl single crystal, and then carrying out cooling annealing treatment. The diameter of the prepared bibenzyl scintillation crystal is 25 mm, the length of an equal-diameter section reaches 80 mm, the light-induced decay time of the bibenzyl scintillation crystal is 2.7 ns, the light yield and the decay time of the bibenzyl scintillation crystal under the excitation of a 137 Cs radioactive source are 21600 ph / Mev and 3.71 ns respectively, and the bibenzyl scintillation crystal can be used in the field of ray detection and imaging devices.

The present application relates to a preparation method and application of Dendrobium candidum extract, and belongs to the technical field of plant extraction. The present application realizes physical disruption of cell structure by using ultra-low temperature crushing technology, and avoids degradation of heat-sensitive components. A complex system of cellulase, pectinase and neutral protease is used for synergistic enzymolysis at 35-45 DEG C and pH 5-6, which efficiently hydrolyzes cell wall components and releases bound anti-inflammatory active ingredients. Subsequently, Ruminococcus lactaris is used for anaerobic fermentation, and the beta-glucosidase secreted by the bacteria hydrolyzes the bibenzyl aglycone, the metabolic product lactic acid promotes the protonation of alkaloids to form water-soluble salts, and the exopolysaccharide forms a complex active ingredient with the dendrobium polysaccharide; the fermentation broth is filtered, and is compounded with the ultrafiltration purified water extract obtained by ultrasonic assisted extraction at a ratio of (2-4):1, and finally high-purity extract is obtained by freeze-drying. The extract can be released controllably in the gastrointestinal tract, and the inhibition rate of LPS-induced inflammation is better than that of traditional processes, and can be used in the field of intestinal anti-inflammatory.

The invention belongs to the technical field of organic synthesis, and discloses a 2, 2 '-diamino bibenzyl product and a hydrogenation synthesis method thereof. The synthesis method comprises the following steps: adding 2, 2 '-dinitrobibenzyl, an organic solvent and a platinum-carbon catalyst into a pressure-resistant reactor, heating reaction materials to 80-140 DEG C under inert atmosphere replacement and protection, then introducing hydrogen gas until the pressure is 0.8-1.5 MPa, carrying out a catalytic hydrogenation reaction, and separating a product to obtain 2, 2'-diamino bibenzyl. According to the synthesis method, platinum carbon is used as the hydrogenation catalyst of 2, 2 '-diamino bibenzyl, the catalyst has the advantages of being high in safety coefficient, high in catalytic activity and high in catalytic reaction selectivity, the content of intermediate products can be effectively reduced, the product purity is improved, the activity is not reduced after the catalyst is recycled, the method is suitable for industrial production, and the production cost is effectively reduced.

The application relates to a composite anion exchange membrane and a preparation method, and belongs to the technical field of anion exchange membrane water electrolysis hydrogen production, and is composed of inorganic matter and a crosslinked anion exchange membrane, the inorganic matter is coated on the crosslinked anion exchange membrane, the structure of the main chain of the crosslinked anion exchange membrane is shown in a general formula (I): in the formula, n=2-8; x=50, which is a percentage, and the corresponding anion is OH ‑ , I ‑ , or Br ‑ ; Ar is biphenyl, terphenyl or bibenzyl; the inorganic matter is zirconium dioxide, titanium dioxide, magnesium oxide, di-aluminum trioxide, zinc oxide, tri-iron tetroxide, di-iron trioxide or copper oxide. The composite anion exchange membrane has the characteristics of high ion conductivity, excellent size stability and alkali resistance; secondly, the polar inorganic matter is coated, the binding force between a catalyst layer and a membrane layer can be increased, the micro gap between a membrane electrode assembly (MEA) can be relieved, the mass transfer resistance can be reduced, and the performance of a water electrolysis single cell can be enhanced.