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Application of caspofungin in preparation of neuroprotective drugs

A neuroprotective and caspofungin technology, applied in the field of biomedicine, can solve problems such as less adverse reactions, protect nerve cells, reduce optic ganglion cell and axon damage, and reduce retinal ganglion cell damage and axonal degeneration. reduced effect

Pending Publication Date: 2020-10-13
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Caspofungin has good inhibitory activity against Candida, Aspergillus, etc., and is currently mainly used for the treatment of invasive Aspergillus, with few adverse reactions, but whether it can inhibit axon and neuron degeneration has not been reported yet

Method used

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  • Application of caspofungin in preparation of neuroprotective drugs
  • Application of caspofungin in preparation of neuroprotective drugs
  • Application of caspofungin in preparation of neuroprotective drugs

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Embodiment Construction

[0032] The following description describes alternative embodiments of the invention to teach those of ordinary skill in the art how to implement and reproduce the invention. In order to teach the technical solutions of the present invention, some conventional aspects have been simplified or omitted.

[0033] The following experiments will further illustrate its drug activity.

[0034] Animal experiments: The protective effect of caspofungin on NMDA-induced glaucoma model mice.

[0035] Implemented drugs: caspofungin was purchased from a reagent company.

[0036] Caspofungin was dissolved in DMSO.

[0037] Experimental animals:

[0038] 6-8 week old C57 healthy male mice were selected. The experimental animals were reared for a week in an environment with a temperature of 25 °C, a relative humidity of 60%, free drinking water, and regular and quantitative conditions, and then injected into the vitreous cavity according to the experimental requirements.

[0039] Modeling me...

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PUM

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Abstract

The invention relates to an application of caspofungin in preparation of neuroprotective drugs, and belongs to the field of biological medicines. It is found that the caspofungin is used for inhibiting or treating neuronal or axonal degeneration, is especially used for treating vision-related neurodegeneration and nervous system diseases, more especially has the protective effect on the vision-related neurodegeneration, can remarkably relieve retinal ganglion cell and axonal damage, and has the nerve cell protection function.

Description

technical field [0001] The invention relates to the application of caspofungin in the preparation of neuroprotective drugs, and belongs to the field of biological medicine. Background technique [0002] Neuronal or axonal degeneration is a hallmark of many neurodegenerative diseases, including glaucoma, retinitis pigmentosa, age-related macular degeneration, retinal detachment, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Conditions such as traumatic injuries to the brain and spinal cord. Neurodegenerative diseases and injuries are a huge and resulting economic burden for patients and their families, and developing effective approaches to treat neurodegenerative diseases and nervous system injuries is of great importance. [0003] Glaucoma is the leading cause of irreversible blindness in the world. Its main risk factors and pathogenesis are pathological increased intraocular pressure, retinal ganglion cell degeneration and progressive death,...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P25/00A61P25/02A61P27/02A61P27/06A61P25/16A61P25/28A61P25/14A61P21/00
CPCA61K38/12A61P25/00A61P25/02A61P27/02A61P27/06A61P25/16A61P25/28A61P25/14A61P21/00
Inventor 罗秀菊彭靖杰夏晓波彭军宋伟涛周媛静
Owner CENT SOUTH UNIV
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