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Application of fenretin in the preparation of neuroprotective drugs
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A kind of fennomide and drug technology, which is applied in the application field of fennomide in the preparation of neuroprotective drugs, and can solve problems such as unreported
Active Publication Date: 2022-02-15
SHIJIAZHUANG YILING PHARMA
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Problems solved by technology
At present, fenmelamine is used to treat brain degenerative diseases, such as Parkinson's syndrome and Alzheimer's disease, but there is no report on ischemia and cerebral hemorrhage
Method used
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Embodiment 1
[0020] The preparation of embodiment 1 fenretide tablet
[0021] Take by weighing 150g of fenloramine, 20g of cornstarch, 325g of lactose, and 5g of magnesium stearate that have been pulverized through a 200-mesh sieve, fully mix fenmelamine, cornstarch, and lactose, and use 50ml of purified water as a binder to prepare Make soft material, granulate with 18-mesh sieve, dry at 60°C, pass through 16-mesh sieve for dry granules, add magnesium stearate and mix well, press 0.5g / tablet, and press into tablets to make 981 tablets in total finished product.
Embodiment 2
[0022] The preparation of embodiment 2 fenlelam capsules
[0023] Weigh 75g of fenmelamine, 212g of cornstarch, 10g of dextrin, and 3g of magnesium stearate that have been crushed through a 200-mesh sieve, mix the fenmelamine and cornstarch thoroughly, and use 25ml of purified water at 60°C to dissolve the dextrin Dissolved into a paste as a binder, made into a soft material, granulated with a 20-mesh sieve, dried at 65°C, passed through a 18-mesh sieve for granulation, added magnesium stearate and mixed evenly, 0.3g per capsule Put it into No. 1 capsule, and make 961 finished products in total.
Embodiment 3
[0024] The preparation of embodiment 3 fenrexamine granules
[0025] Weigh 150g of fenloramine, 7339g of sucrose powder, 1g of food flavor and 10g of soluble starch that have been crushed through a 200-mesh sieve. The soluble starch is brewed into starch slurry as a binder to make a soft material. After being granulated with a 20-mesh sieve, it is dried at 60°C. The dry granules are sieved through a 18-mesh sieve for granulation. The 7.5g / bag can be packed into bags. A total of 973 bags of finished products were made.
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Abstract
The application of fennomide in the preparation of neuroprotective drugs belongs to the technical field of neuroprotective drugs. The application of fennomide in drugs for the treatment or prevention of cranial nerve injury is made by adding fennomide into pharmaceutically acceptable excipients to prepare clinically usable drugs. pharmaceutical dosage form. Specifically, the application of fennomide in the preparation of a medicament for the treatment or prevention of nerve damage caused by cerebral hemorrhage, or the application of fennomide in the preparation of a medicament for the treatment or prevention of nerve injury caused by cerebral ischemia-reperfusion. Tests have confirmed that fennomide has a neuroprotective effect, and can effectively treat or prevent nerve injury caused by cerebral ischemia-reperfusion, nerve injury caused by cerebral hemorrhage, and various neurological injuries such as Guillain-Barre.
Description
technical field [0001] The invention belongs to the technical field of neuroprotective drugs, and relates to a new application of feredin, in particular to the application of feredin in the preparation of neuroprotective drugs. Background technique [0002] Fenamelamine (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl ) acrylamide) molecular structural formula is as follows: [0003] [0004] Fenamelamine is a derivative of cinnamon amide, and its compound structure has been disclosed in Chinese Patent CN1445211 (publication number). And its pharmaceutical composition and use". [0005] Cranial nerve injury includes traumatic brain injury, sequelae of cerebrovascular sclerosis (cerebral hemorrhage, cerebral thrombosis), sequelae of encephalitis and meningitis, sequelae of demyelinating diseases and other sequelae of cerebrovascular diseases. At present, fenretin is used to treat brain degenerative diseases, such as Par...
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